Description of an atypical Toxoplasma gondii isolate from a case of congenital toxoplasmosis in northeastern Brazil. | Read by QxMD (original) (raw)
Case Reports
Journal Article
Renata Pimentel Bandeira de Melo, Flaviana Santos Wanderley, Wagnner José Nascimento Porto, Camila de Morais Pedrosa, Clare M Hamilton, Maria Heloísa Gomes Silva de Oliveira, Müller Ribeiro-Andrade, Renata Camila da Silva Rêgo, Frank Katzer, Rinaldo A Mota
We report a case of severe congenital toxoplasmosis that involved an atypical T. gondii genotype in a newborn baby from Alagoas state in Northeastern Brazil. A pregnant woman presented IgM and IgG anti-T. gondii antibodies, as detected by the chemiluminescence immunoassay on the second trimester of pregnancy. A mouse bioassay was performed using umbilical cord blood and one isolate was obtained. The isolate was designated TgCTBrAL1 and genetic characterization revealed genotype ToxoDB #162. Genotype results of the rhoptry genes, ROP5 and ROP18, could predict the high virulence of the isolate in mice, which was confirmed by an in vivo virulence assay. This is the first report of generating a T. gondii isolate from a newborn baby with congenital toxoplasmosis in Northeastern Brazil.
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