Expression of p-STAT3 in human gastric carcinoma: Significant correlation in tumour invasion and prognosis (original) (raw)

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• Authors:

  • Yuichi Yakata
  • Toshiyuki Nakayama
  • Ayumi Yoshizaki
  • Takafumi Kusaba
  • Kenichiro Inoue
  • Ichiro Sekine

• View Affiliations
  Affiliations: Department of Tumor and Diagnostic Pathology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8523, Japan

• Published online on: February 1, 2007 https://doi.org/10.3892/ijo.30.2.437

• Pages: 437-442

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Abstract

Signal transducers and activators of transcription (STATs) belong to a family of transcription factors activated in response to cytokines and growth factors. Constitutive activation of STAT3 has been observed in a growing number of tumour-derived cell lines, as well as in tumor specimens from human cancers. Our aim was to determine the relationship between the expression of phosphorylated STAT3 (p-STAT3) and clinicopathological factors in human gastric adenocarcinoma. One-hundred and eleven cases of surgically resected human gastric adenocarcinoma were studied by immunohistochemistry. Fifty-five (49.5%) cases showed positive staining for the p-STAT3 proteins. The expression of p-STAT3 was significantly correlated with several clinicopathological factors. Moreover, expression of p-STAT3 was detected by Western blot analysis in 2 different kinds of cultured human gastric carcinoma cell lines and 4 cases of gastric carcinoma tissue obtained at surgery. Western blot analysis confirmed the presence of p-STAT3 in these specimens. In univariate survival analysis, p-STAT3 expression was associated with inferior survival (p<0.05). Constitutive activation of STAT3 may play an important role in the tumorigenesis of gastric adenocarcinoma, and the detailed mechanism of STAT3 signaling pathway in gastric adenocarcinoma deserves further investigation.

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• Impact Factor: 4.5
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• CiteScore: 9.6
• CiteScore Rank: Q1: #66/404 Oncology
• Source Normalized Impact per Paper (SNIP): 0.88
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Spandidos Publications style

Yakata Y, Nakayama T, Yoshizaki A, Kusaba T, Inoue K and Sekine I: Expression of p-STAT3 in human gastric carcinoma: Significant correlation in tumour invasion and prognosis. Int J Oncol 30: 437-442, 2007.

APA

Yakata, Y., Nakayama, T., Yoshizaki, A., Kusaba, T., Inoue, K., & Sekine, I. (2007). Expression of p-STAT3 in human gastric carcinoma: Significant correlation in tumour invasion and prognosis. International Journal of Oncology, 30, 437-442. https://doi.org/10.3892/ijo.30.2.437

MLA

Yakata, Y., Nakayama, T., Yoshizaki, A., Kusaba, T., Inoue, K., Sekine, I."Expression of p-STAT3 in human gastric carcinoma: Significant correlation in tumour invasion and prognosis". International Journal of Oncology 30.2 (2007): 437-442.

Chicago

Yakata, Y., Nakayama, T., Yoshizaki, A., Kusaba, T., Inoue, K., Sekine, I."Expression of p-STAT3 in human gastric carcinoma: Significant correlation in tumour invasion and prognosis". International Journal of Oncology 30, no. 2 (2007): 437-442. https://doi.org/10.3892/ijo.30.2.437