Cancer Cell Lines Part 1 (original) (raw)
Overview
Editors:
- John R. W. Masters
- University College London, London, UK
- Bernhard Palsson
- Dept. of Bioengineering, University of California, San Diego, USA
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About this book
Continuous cell lines derived from human cancers are the most widely used resource in laboratory-based cancer research. The first 3 volumes of this series on Human Cell Culture are devoted to these cancer cell lines. The chapters in these first 3 volumes have a common aim. Their purpose is to address 3 questions of fundamental importance to the relevance of human cancer cell lines as model systems of each type of cancer: 1. Do the cell lines available accurately represent the clinical presentation? 2. Do the cell lines accurately represent the histopathology of the original tumors? 3. Do the cell lines accurately represent the molecular genetics of this type of cancer? The cancer cell lines available are derived, in most cases, from the more aggressive and advanced cancers. There are few cell lines derived from low grade organ-confined cancers. This gap can be filled with conditionally immortalized human cancer cell lines. We do not know why the success rate for establishing cell lines is so low for some types of cancer and so high for others. The histopathology of the tumor of origin and the extent to which the derived cell line retains the differentiated features of that tumor are critical. The concept that a single cell line derived from a tumor at a particular site is representative of tumors at that site is naïve and misleading.
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Table of contents (16 chapters)
Renal Cell Cancer
- Thomas Ebert, Aristoteles Anastasiadis, Neil H. Bander
Pages 231-249
- Thomas Ebert, Aristoteles Anastasiadis, Neil H. Bander
Editors and Affiliations
University College London, London, UK
John R. W. Masters
Dept. of Bioengineering, University of California, San Diego, USA
Bernhard Palsson
Bibliographic Information
- Book Title: Cancer Cell Lines Part 1
- Editors: John R. W. Masters, Bernhard Palsson
- Series Title: Human Cell Culture
- DOI: https://doi.org/10.1007/0-306-46872-7
- Publisher: Springer Dordrecht
- eBook Packages: Springer Book Archive
- Copyright Information: Springer Science+Business Media Dordrecht 1999
- Hardcover ISBN: 978-0-7923-5143-6Published: 31 October 1998
- Softcover ISBN: 978-94-017-3824-8Published: 13 November 2013
- eBook ISBN: 978-0-306-46872-8Published: 11 April 2006
- Series ISSN: 1389-2142
- Edition Number: 1
- Number of Pages: X, 293
- Topics: Cancer Research, Cell Biology, Oncology, Internal Medicine