Electrolytes and Anion Gap - Testing.com (original) (raw)
Test Quick Guide
Electrolytes are minerals that help control fluid levels in the body, regulate acid-base balance, and enable the function of muscles and nerves.
An electrolyte panel is a blood test that measures the levels of the electrolytes sodium, chloride, potassium, and bicarbonate. This panel is frequently included in overall health tests like a basic metabolic panel (BMP) or comprehensive metabolic panel (CMP). Measuring electrolytes can help diagnose and monitor a broad range of health conditions.
Electrolytes carry a positive or negative electrical charge. Using the measured levels of electrolytes, the anion gap calculates the difference between those positively and negatively charged electrolytes. The body tries to maintain neutrality between these electrical charges, so changes in the anion gap can help show an acid-base imbalance in the body.
About the Test
Purpose of the test
The purpose of an electrolyte panel is to measure the amount of sodium, potassium, chloride, and bicarbonate in the blood. These are all minerals known as electrolytes. Measuring these electrolytes enables a calculation of the anion gap.
Electrolytes help regulate nerve and muscle function, maintain a balance of acidity and alkalinity in the blood, and control the blood’s water content. Tests of electrolyte levels can be used for diagnosing and monitoring different health conditions. The anion gap demonstrates electrolyte and acid-base imbalances.
Diagnosis is the process of figuring out the cause of your symptoms. Because electrolytes affect numerous bodily processes, an electrolyte panel can help doctors determine if these minerals’ abnormal levels contribute to symptoms.
Monitoring is the way that a doctor can track your health over time. Repeat measurements of electrolytes can show if treatment has resolved abnormal electrolyte levels. In addition, an electrolyte panel can help detect side effects of medications.
What does the test measure?
The electrolyte panel measures sodium, potassium, chloride, and bicarbonate blood levels.
- Sodium: This positively-charged electrolyte plays a vital role in regulating the amount of fluid in the body. It also facilitates normal nerve and muscle activity.
- Potassium: This is positively charged and important for many functions of cells, muscles, and nerves.
- Chloride: Negatively charged, this works with other electrolytes to control fluid levels and the acid-base balance in the body.
- Bicarbonate: This is a negatively-charged electrolyte. In addition to helping to regulate acid-base balance, bicarbonate transports carbon dioxide (CO2) in the blood. Bicarbonate levels may also be referred to as CO2 levels.
The anion gap is not a test itself; instead, it is a mathematical calculation based on electrolyte measurements. It compares the levels of positively and negatively charged electrolytes, which can provide information about the body’s acid-base balance.
When should I get this test?
Your doctor will decide whether you need an electrolyte panel and anion gap. In many cases, these measurements will be included if you have a test like a BMP or CMP.
Your doctor may recommend electrolyte testing if you have signs of a condition that could be related to an electrolyte imbalance. Examples of symptoms that may prompt electrolyte testing include:
- Weakness or fatigue
- Irregular heartbeat
- Muscle twitching, cramps, or paralysis
- Nausea and/or vomiting
If you have already been diagnosed with an electrolyte disorder, your doctor may prescribe an electrolyte panel and anion gap to see if your condition has improved, worsened, or stayed the same.
In some cases, a doctor may measure your electrolytes even if you do not have any symptoms. This may occur as part of blood work during a regular health checkup; however, professional medical organizations generally do not recommend electrolyte testing if you don’t have symptoms.
Finding an Electrolyte Panel Test
How can I get an electrolyte panel test?
A physician typically orders the electrolyte panel. The test is conducted in a doctor’s office, laboratory, hospital, or similar medical setting.
Can I take the test at home?
There is no at-home testing option to measure electrolytes in the blood.
How much does the test cost?
Several factors influence the cost of an electrolyte panel, including where the test is done, whether it is part of a larger battery of tests, and your health insurance status.
The total cost of the test can include several separate medical services, such as:
- The health care provider who draws your blood
- The laboratory that processes and analyzes your blood sample
- The health care providers who interpret your results and discuss them with you
Most health insurance covers the cost of tests ordered by a physician. If you are uncertain about coverage contact your insurance provider to clarify your costs before you take the test.
Taking the Electrolyte Panel Test
An electrolyte panel test can be performed quickly with a blood draw in a medical setting like a hospital, doctor’s office, or laboratory.
Before the test
No preparation is needed for an electrolyte panel. If you are getting other tests at the same time, you might receive instructions relevant to those tests, such as not eating or drinking for several hours beforehand. Your physician will tell you if you must adhere to any special instructions before the test.
During the test
A phlebotomist, who specializes in drawing blood, will locate a vein in your arm. After disinfecting the skin, they will insert a needle into the vein and withdraw a small amount of blood into a tube or vial.
You may feel a slight sting when the needle is inserted or removed, but this will not last more than a few minutes. After withdrawing the needle, the phlebotomist will bandage the area.
The test usually takes less than five minutes.
After the test
There are no restrictions, such as limitations related to exercise or food intake, following an electrolyte panel. Any remaining symptoms, such as slight bruising or pain in your arm, should resolve quickly. If you have any ongoing effects after the test, contact your health care provider.
Electrolyte Panel Test Results
Receiving test results
Results should be available within a few business days, but you can ask your physician when to expect your results. If your test is done in the hospital, a physician may be able to get the results much more quickly, sometimes within minutes to hours.
You might receive your results via an electronic health portal or a telephone call from your doctor’s office. If you are hospitalized, a doctor will usually discuss your results with you at the bedside.
Interpreting test results
Your electrolyte panel results will show the concentrations of sodium, potassium, chloride, and bicarbonate in your blood. The amounts are measured and reported in millimoles per liter (mmol/L) or milliequivalents per liter (mEq/L). If other tests were conducted at the same time, you might see other measurements on your test report.
The test report typically includes reference ranges for each electrolyte. These values are what the laboratory considers to be the expected values if you are healthy. Reference ranges may vary slightly from laboratory to laboratory. Because of variations in values and interpretation, it is important to discuss your results with your physician before drawing any conclusions about your electrolyte levels.
Many different health conditions can cause abnormal levels of electrolytes. Interpreting your test result involves considering which electrolyte levels are abnormal, whether they are high or low, your symptoms, and your health history. Some health issues that can affect electrolyte levels and the anion gap include:
- Changes to fluid intake or fluid loss from the body
- Disorders affecting the kidneys, liver, lungs, adrenal glands, or heart
- Malnutrition, gastrointestinal problems, or changes to how nutrients are absorbed
- Use of certain medications, including those that can affect fluid levels or acid-base balance
Talk to your doctor to understand the specific results of your electrolyte panel and what it means for your health.
The best way to understand your test results is to discuss them with your health care provider. Here are some questions you might ask:
Were any of my electrolyte levels abnormally high or low?
What follow-up tests do you recommend based on my test results?
Do I need to change my medications?
Should I be concerned about my results?
What can I do to correct any abnormal results?
Resources
- Centers for Disease Control and Prevention: Sodium, Potassium and Health Learn More
- Merck Manuals: Overview of Acid-Base Balance Learn More
- National Library of Medicine: Fluid and Electrolyte Balance Learn More
Sources
A.D.A.M. Medical Encyclopedia. Basic Metabolic Panel. Updated May 1, 2021. Accessed November 29, 2022. https://medlineplus.gov/ency/article/003462.htm
A.D.A.M. Medical Encyclopedia. Chloride Test – Blood. Updated May 1, 2021. Accessed November 29, 2022. https://medlineplus.gov/ency/article/003485.htm
A.D.A.M. Medical Encyclopedia. CO2 Blood Test. Updated May 1, 2021. Accessed November 29, 2022. https://medlineplus.gov/ency/article/003469.htm
A.D.A.M. Medical Encyclopedia. Electrolytes. Updated November 6, 2021. Accessed November 29, 2022. https://medlineplus.gov/ency/article/002350.htm
A.D.A.M. Medical Encyclopedia. Potassium Test. Updated May 1, 2021. Accessed November 29, 2022. https://medlineplus.gov/ency/article/003484.htm
A.D.A.M. Medical Encyclopedia. Sodium Blood Test. Updated November 6, 2021. Accessed November 29, 2022. https://medlineplus.gov/ency/article/003481.htm
American Board of Internal Medicine. ABIM Laboratory Test Reference Ranges. Revised January 2022. Accessed November 29, 2022. https://www.abim.org/Media/bfijryql/laboratory-reference-ranges.pdf
Centor RM. Chapter 196: Serum Total Carbon Dioxide. In: Walker HK, Hall WD, Hurst JW, eds. Clinical Methods: The History, Physical, and Laboratory Examinations. Third Edition. Accessed November 29, 2022. https://www.ncbi.nlm.nih.gov/books/NBK308/
Emmett M, Szerlip H. Approach to the Adult With Metabolic Acidosis. In: Sterns RH, ed. UpToDate. Updated May 4, 2022. Accessed November 29, 2022. https://www.uptodate.com/contents/approach-to-the-adult-with-metabolic-acidosis
Givler DN, Givler A. Health Screening. In: StatPearls. Updated August 24, 2022. Accessed November 29, 2022. https://www.ncbi.nlm.nih.gov/books/NBK436014/
Good Stewardship Working Group. The “Top 5” Lists in Primary Care: Meeting the Responsibility of Professionalism. Arch Intern Med. 2011;171(15):1385-1390. doi:10.1001/archinternmed.2011.231
Lewis JL III. Acid-base Disorders. Merck Manual Professional Version. Updated September 2022. Accessed November 29, 2022. https://www.merckmanuals.com/professional/endocrine-and-metabolic-disorders/acid-base-regulation-and-disorders/acid-base-disorders
Lewis JL III. Hyperkalemia. Merck Manual Professional Version. Updated September 2022. Accessed November 29, 2022. https://www.merckmanuals.com/professional/endocrine-and-metabolic-disorders/electrolyte-disorders/hyperkalemia
Lewis JL III. Hypernatremia. Merck Manual Professional Version. Updated September 2022. Accessed November 29, 2022. https://www.merckmanuals.com/professional/endocrine-and-metabolic-disorders/electrolyte-disorders/hypernatremia
Lewis JL III. Hypokalemia. Merck Manual Professional Version. Updated September 2022. Accessed November 29, 2022. https://www.msdmanuals.com/professional/endocrine-and-metabolic-disorders/electrolyte-disorders/hypokalemia
Lewis JL III. Hyponatremia. Merck Manual Professional Version. Updated September 2022. Accessed November 29, 2022. https://www.msdmanuals.com/en-au/professional/endocrine-and-metabolic-disorders/electrolyte-disorders/hyponatremia
Lewis JL III. Metabolic Acidosis. Merck Manual Professional Version. Updated September 2022. Accessed November 29, 2022. https://www.merckmanuals.com/professional/endocrine-and-metabolic-disorders/acid-base-regulation-and-disorders/metabolic-acidosis
Lewis JL III. Metabolic Alkalosis. Merck Manual Professional Version. Updated September 2022. Accessed November 29, 2022. https://www.merckmanuals.com/professional/endocrine-and-metabolic-disorders/acid-base-regulation-and-disorders/metabolic-alkalosis
Lewis JL III. Overview of Acid-base Balance. Merck Manual Consumer Version. Updated September 2022. Accessed November 29, 2022. https://www.msdmanuals.com/home/hormonal-and-metabolic-disorders/acid-base-balance/overview-of-acid-base-balance
Lewis JL III. Overview of Disorders of Potassium Concentration. Merck Manual Professional Version. Updated September 2022. Accessed November 29, 2022. https://www.msdmanuals.com/professional/endocrine-and-metabolic-disorders/electrolyte-disorders/overview-of-disorders-of-potassium-concentration
Lewis JL III. Overview of Electrolytes. Merck Manual Consumer Version. Updated September 2022. Accessed November 29, 2022. https://www.merckmanuals.com/home/hormonal-and-metabolic-disorders/electrolyte-balance/overview-of-electrolytes
Lewis JL III. Overview of Potassium’s Role in the Body. Merck Manual Consumer Version. Updated September 2022. Accessed November 29, 2022. https://www.merckmanuals.com/home/hormonal-and-metabolic-disorders/electrolyte-balance/overview-of-potassiums-role-in-the-body
Lewis JL III. Overview of Sodium’s Role in the Body. Merck Manual Consumer Version. Updated September 2022. Accessed November 29, 2022. https://www.merckmanuals.com/home/hormonal-and-metabolic-disorders/electrolyte-balance/overview-of-sodiums-role-in-the-body
MedlinePlus. National Library of Medicine. Comprehensive Metabolic Panel (CMP). Updated September 9, 2021. Accessed November 29, 2022. https://medlineplus.gov/lab-tests/comprehensive-metabolic-panel-cmp/
MedlinePlus: National Library of Medicine. Anion Gap Blood Test. Updated April 7, 2022. Accessed November 29, 2022. https://medlineplus.gov/lab-tests/anion-gap-blood-test/
MedlinePlus: National Library of Medicine. Carbon Dioxide (CO2) in the Blood. Updated August 3, 2022. Accessed November 29, 2022. https://medlineplus.gov/lab-tests/carbon-dioxide-co2-in-blood/
MedlinePlus: National Library of Medicine. Chloride Blood Test. Updated April 8, 2022. Accessed November 29, 2022. https://medlineplus.gov/lab-tests/chloride-blood-test/
MedlinePlus: National Library of Medicine. Electrolyte Panel. Updated September 13, 2021. Accessed November 29, 2022. https://medlineplus.gov/lab-tests/electrolyte-panel/
MedlinePlus: National Library of Medicine. Potassium Blood Test. Updated August 3, 2022. Accessed November 29, 2022. https://medlineplus.gov/lab-tests/potassium-blood-test/
MedlinePlus: National Library of Medicine. Sodium Blood Test. Updated June 2, 2022. Accessed November 29, 2022. https://medlineplus.gov/lab-tests/sodium-blood-test/
Pandey DG, Sharma S. Biochemistry, Anion Gap. In: StatPearls. Updated July 18, 2022. Accessed November 29, 2022. https://www.ncbi.nlm.nih.gov/books/NBK539757/
Sharma S, Hashmi MF, Aggarwal S. Hyperchloremic Acidosis. In: StatPearls. Updated August 18, 2022. Accessed November 29, 2022. https://www.ncbi.nlm.nih.gov/books/NBK482340/
Shrimanker I, Bhattarai S. Electrolytes. In: StatPearls. Updated July 25, 2022. Accessed November 29, 2022. https://www.ncbi.nlm.nih.gov/books/NBK541123/
Uysal E, Acar YA, Kutur A, Cevik E, Salman N, Tezel O. How Reliable Are Electrolyte and Metabolite Results Measured by a Blood Gas Analyzer in the ED? Am J Emerg Med. 2016;34(3):419-424. doi:10.1016/j.ajem.2015.11.025
Wilczynski C. Anion Gap. In: Hermelin D, ed. Medscape. Updated November 15, 2019. Accessed November 29, 2022. https://emedicine.medscape.com/article/2087291
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