結合部位とは何？ わかりやすく解説 Weblio辞書 (original) (raw)

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ウィキペディアウィキペディア

結合部位

出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2024/04/08 09:56 UTC 版)

生化学および分子生物学において、結合部位（けつごうぶい、英: Binding site）は、他の分子と特異的（英語版）に結合するタンパク質などの高分子上の領域である[1]。高分子の結合相手は、しばしばリガンドと呼ばれる[2]。リガンドは、他のタンパク質（タンパク質-タンパク質相互作用をもたらす[3]）、酵素基質[4]、セカンドメッセンジャー、ホルモン、またはアロステリック調節因子[5]を含むことができる。結合事象は、常にではないが、タンパク質の機能を変化させるコンホメーション変化を伴うことがよくある[6]。タンパク質の結合部位への結合は、ほとんどの場合は可逆的（一過性および非共有結合）であるが、共有結合的な可逆的[7]または不可逆的[8]でありうる。

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結合部位

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