Sicheri F, et al. (1997) (original) (raw)

Reference: Sicheri F, et al. (1997)

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Abstract

The crystal structure of the haematopoietic cell kinase Hck has been determined at 2.6/2.9 A resolution. Inhibition of enzymatic activity is a consequence of intramolecular interactions of the enzyme's Src-homology domains SH2 and SH3, with concomitant displacement of elements of the catalytic domain. The conformation of the active site has similarities with that of inactive cyclin-dependent protein kinases.

Reference Type

Journal Article

Authors

Sicheri F, Moarefi I, Kuriyan J

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