Rachid Touzani | Université Mohamed Premier (original) (raw)
Papers by Rachid Touzani
![Research paper thumbnail of Aerial Oxidation of Phenol/Catechol in the Presence of Catalytic Amounts of [(Cl)2Mn(RCOOET)], RCOOET= Ethyl-5-Methyl-1-(((6-Methyl-3-Nitropyridin-2-yl)Amino)Methyl)-1H-Pyrazole-3-Carboxylate](https://attachments.academia-assets.com/120569780/thumbnails/1.jpg)
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Medicinal chemistry, 2016
Journal of Molecular Structure, 2020
Moroccan Journal of Chemistry, Jul 11, 2017
Two tripodal pyrazolic ligands: N,N-bis((3,5-dimethyl-1H-pyrazol-1-yl)methy)-2,4-difluoroaniline ... more Two tripodal pyrazolic ligands: N,N-bis((3,5-dimethyl-1H-pyrazol-1-yl)methy)-2,4-difluoroaniline ( 2Fpyr 1 ) and N,N-bis((1H-pyrazol-1-yl)methyl)-2,4-difluoroaniline ( 2Fpyr 2 ) were synthetized in good yiels. Then we applied them against corrosion of mild steel in HCl 1M solution. Weight loss measurement give us the inhibition efficiencies values reached 80.2 % for 2Fpyr1 and 77.3 % for 2Fpyr 2 at the concentration 10 -3 , then by changing the temperature from 313K to 343 K, which give us the activation and adsorption parameters, and we reveal from it that the ligands 2Fpyr 1 were adsorbed according to Langmuir Isotherm, but 2Fpyr 2 were was adsorbed according to El-Awady adsorption Isotherm, we obtain these results using certain isotherms as Langmuir, Freundlich, Temkin, Frumkin, Florry-Huggins, Adejo-Ekwenchi and El-Awady. We conclude from polarization curves that all the ligands are mixed type inhibitors (anodic and cathodic type inhibitors), and from the impedance diagrams in the Nyquist presentation which are in the form of one half loop because that the corrosion is controlled by charge transfer process. We used GAUSSIAN 09W program to do theoretical investigations by considering the Density Functional Theory (DFT) method to calculate quantum parameters as E HOMO , E LUMO , ∆E HOMO -E LUMO and μ dipolar moment that allows us to confirm experimental results obtained from gravimetric and electrochemical studies.
Current Drug Delivery, May 17, 2021
Der Pharmacia Lettre, 2014
Journal of Molecular Liquids, 2020
Journal of Cluster Science, 2020
A novel [Ni4(µ3-O)4] twisted cubane complex, Ni4Cl2(NN)2(ONN)2(NNO)2(H2O)2·2THF, was prepared fro... more A novel [Ni4(µ3-O)4] twisted cubane complex, Ni4Cl2(NN)2(ONN)2(NNO)2(H2O)2·2THF, was prepared from a crude mixture of three bidentate ligands. A mixture of ethyl 1-(hydroxymethyl)-3-methyl-1H-pyrazole-5-carboxylate (HONN) and ethyl 1-(hydroxyl-methyl)-5-methyl-1H-pyrazole-3-carboxylate (NNOH) were added to ethyl 3-methyl-1H-pyrazole-5-carboxylate (NNH) then mixed to NiCl2·6H2O solution under ambient conditions. Reaction progress was monitored via infrared and ultraviolet–visible spectroscopies and energy-dispersive X-ray spectroscopy was used to analyze the product. Reaction yields for cluster synthesis were very good. Single crystal structure determination for the cluster indicates a novel [Ni4(µ3-O)4] twisted cubane structure with octahedral geometry around each of the Ni(II) centers in Ni4Cl2(NN)2(ONN)2(NNO)2(H2O)2·2THF. The lattice is stabilized by hydrogen bonding and H–π\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}pi\pipi\end{document} stacking. Hirshfeld surface analysis (HSA) corroborates the single crystal structure determination results. The cluster displays significant thermal stability under open atmosphere conditions; it decomposes in three steps at high temperature. The cluster demonstrates promising results as a catalyst; it promoted the complete oxidation of catechol to o-Quinone in under mild conditions.
The study of corrosion processes and their inhibition by organic inhibitors is a very active fiel... more The study of corrosion processes and their inhibition by organic inhibitors is a very active field of research. The presence of nitrogen, oxygen, phosphorous and sulphur in the organic molecules has a major effect on the inhibition efficiency and consequently on the phenomenon of adsorption on some metals surface. A great number of heterocyclic compounds were found to be excellent inhibitors of copper and steel corrosion. The inhibition effect mainly depends on some physicochemical and electronic properties of the organic inhibitor which relate to its functional groups, steric effects, electronic density of donor atoms, and orbital character of donating electrons. DFT Quantum chemical methods have already proven to be very useful in determining the molecular structure as well as elucidating the electronic structure and reactivity. Thus, it has become a common practice to carry out quantum chemical calculations in corrosion inhibition studies.
Herein we report the synthesis of new tridentate (N,N,N) compounds 3-6 and bidentate (N,N or N,O)... more Herein we report the synthesis of new tridentate (N,N,N) compounds 3-6 and bidentate (N,N or N,O) compounds 8-10 based on pyrazole moieties and quinoxaline, with the opportunity to change easily structure and substituents. These methods take advantage of the vast number of commercially available starting materials containing functional and aliphatic or aromatic amines. X-ray structures for two compounds were investigated.
![Research paper thumbnail of 3-[Benzyl-(1,5-dimethyl-1H-pyrazol-3-ylmethyl)-amino]-propionitrile](https://attachments.academia-assets.com/116150429/thumbnails/1.jpg)
](![Research paper thumbnail of 1-{[Benzyl-(2-cyano-ethyl)-amino]-methyl}-5-methyl-1H-pyrazole-3-carboxylic acid ethyl ester](https://attachments.academia-assets.com/116150424/thumbnails/1.jpg)
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In the present work, the molecular interactions of four amino acid compounds were simulated throu... more In the present work, the molecular interactions of four amino acid compounds were simulated through the density functional theory (DFT) indexes to study their inhibitive properties. The prototype inhibitors previously synthesized 2-amino-N-decylacetamide (G), 2-amino-N-decylpropionamide (A), 2-amino-N-decyl-3-methylbutyramide (V), and 2-amino-N-decyl-3-(4-hydroxyphenyl)propionamide (T) were used to test the accuracy of this calculation. The generalized gradient approximation (GGA) was the ab initio approach used to optimize the ground state of the molecules. The simulation of molecular dynamics with force field (AMBER) was calculated to obtain the interaction energy between the metallic surface and the inhibitor molecules. A strong correlation of the global and local indexes with the inhibiting capacity was observed. The inhibitive properties of compounds on mild steel in an aqueous hydrochloric acid solution agreed well with those derived from the reactivity and selectivity indexes in gaseous phase.
International Journal of Electrochemical Science
The inhibitive effect three quinoxalines derivatives named (2Z)-1-(4-chlorophenyl)-2-[(3E)-3-[2-(... more The inhibitive effect three quinoxalines derivatives named (2Z)-1-(4-chlorophenyl)-2-[(3E)-3-[2-(4chlorophenyl)-2-oxoethylidene]-3,4-dihydroquinoxalin-2(1H)-ylidene]ethanone (Q4), (2Z)-2-[(3E)-3-(2-oxo-2-phenylethylidene)-3,4-dihydroquinoxalin-2(1H)-ylidene]-1-phenylethanone (Q5) and (Z)-2-((E)-3-(2-oxo-2-phenylethylidene)-3,4-dihydroquinoxalin-2(1H)-ylidene)-1-phenylethanone (Q6) on the corrosion of copper in 2 M HNO 3 has been investigated at 303 K. The study was carried out using weight loss measurements, potentiodynamic polarisation and electrochemical impedance spectroscopy (EIS) methods). Results obtained show that Q4 is the best inhibitor and its inhibition efficiency (E %) increases with the increase of inhibitor concentration and reached up to 90 % for Q4 at 10 −3 M. Potentiodynamic polarisation studies clearly reveal that the presence of inhibitors does not change the mechanism of hydrogen evolution and that they act as mixed inhibitors with predominance at cathodic range.
Plants
The purpose of this study was to determine the chemical composition of the essential oil of Lavan... more The purpose of this study was to determine the chemical composition of the essential oil of Lavandula officinalis from Morocco using the GC-MS technique and assess the antibacterial effects against seven pathogenic bacteria strains isolated from the food origins of Salmonella infantis, Salmonella kentucky, Salmonella newport, three serotypes of Escherichia coli (O114H8K11, O127K88ac, O127H40K11) and Klebsiella. Tests of sensitivity were carried out on a solid surface using the Disc Diffusion Method. Results showed that E. coli and S.newport were sensitive to Lavandula officinalis essential oil. Minimum inhibitory concentrations (MIC) were determined using the method of agar dilution. The antibacterial results showed that four strains (three serotypes of E. coli, and S. newport) were remarkedly sensitive to Lavandula officinalis essential oil, giving MIC values of 88.7 µg/mL and 177.5 µg/mL. The molecular docking of the main oil products with the E. coli target protein 1VLY, showed t...
Indonesian Journal of Science and Technology
This study was conceived to work on Artemisia herba alba essential oils (EOs) originating from Ea... more This study was conceived to work on Artemisia herba alba essential oils (EOs) originating from Eastern Morocco. We investigated the chemical properties and determined the antiradical scavenging activity. The GC-MS technique was used to elucidate the chemical composition of the two studied regions. Jerada Eo was distinguished by the existence of 1,6-Dimethylhepta-1,3,5-triene (36.44%), Camphor (22.50%), and Thujone (7.21%). While, Taourirt EO was found to be rich in Camphor (55.31%), Eucalyptol (14.64%), and Camphene (9.95%). Moreover, the free radical scavenging ability (DPPH•), and ferric reducing power assay (FRAP) were conducted. The EOs tested are found to be weakly active and to have important antioxidant potential. The docking study was also carried out by theoretical investigation with molecular docking of four active predominating components (1,6-dimethylhepta-1,3,5-triene; Chrysanthone; Eucalyptol; Alpha-pinene) against S protein of SARS-CoV‑2, and all the four ligands were...
Catalysts
Herein, new substituted ligands based on pyrazole (L1–L4) were synthesized via a one-step by cond... more Herein, new substituted ligands based on pyrazole (L1–L4) were synthesized via a one-step by condensing (1H-pyrazole-1-yl) methanol with different primary amine compounds. The present work utilized the catalytic properties of the in situ complexes formed by these ligands with various copper (II) salts viz. Cu(CH3COO)2, CuSO4, CuCl2, and Cu(NO3)2 for the oxidation of catechol to o-quinone. The studies showed that the catalytic activities depend on the nature and concentration of the ligand, the nature of the counterion, and the solvent. It was observed that the complex formed by L2 and Cu(CH3COO)2 exhibited good catalytic activity in methanol with Vmax of 41.67 µmol L−1 min−1 and Km of 0.02 mol L−1.
Indonesian Journal of Science and Technology
In this work, we are interested in finding new catalysts for catecholase, whose principle is base... more In this work, we are interested in finding new catalysts for catecholase, whose principle is based on the oxidation reaction of catechol to o-quinone. We approached the synthesis of the threes tripod ligands based on pyrazole in a condensation reaction and its characterization by IR, 13C NMR, 1H NMR spectroscopy, then we evaluated the catalytic properties of certain complexes formed in situ to catalyze the oxidation reaction of catechols to o-quinones. The aim is to find the right models to reproduce the catalytic activity of the enzyme (catecholase), we used complexes formed in situ by pyrazole derivatives with Copper salts. Among these complexes, the complex L4/Cu(CH3COO)2 showed good catalytic activity of the combination (1ligand/2metal) in MeOH for this reaction, with a speed Vmax equal to 69.38 μmol.L-1.min-1 and a low value of Km equal to 0.019 mol.L-1. We have demonstrated that the nature of concentration, ligand, solvent, and copper salts, influenced strongly the catecholase...
Molecules
Bayoud disease affects date palms in North Africa and the Middle East, and many researchers have ... more Bayoud disease affects date palms in North Africa and the Middle East, and many researchers have used various methods to fight it. One of those methods is the chemical use of synthetic compounds, which raises questions centred around the compounds and common features used to prepare targeted molecules. In this review, 100 compounds of tested small molecules, collected from 2002 to 2022 in Web of Sciences, were divided into ten different classes against the main cause of Bayoud disease pathogen Fusarium oxysporum f. sp. albedinis (F.o.a.) with structure–activity relationship (SAR) interpretations for pharmacophore site predictions as (δ−···δ−), where 12 compounds are the most efficient (one compound from each group). The compounds, i.e., (Z)-1-(1.5-Dimethyl-1H-pyrazole-3-yl)-3-hydroxy but-2-en-1-one 7, (Z)-3-(phenyl)-1-(1,5-dimethyl-1H-pyrazole-3-yl)-3-hydroxyprop-2-en-1-one 23, (Z)-1-(1,5-Dimethyl-1H-pyrazole-3-yl)-3-hydroxy-3-(pyridine-2-yl)prop-2-en-1-one 29, and 2,3-bis-[(2-hydro...
Molecules, 2022
The need for biodegradable and biocompatible polymers is growing quickly, particularly in the bio... more The need for biodegradable and biocompatible polymers is growing quickly, particularly in the biomedical and environmental industries. Cellulose acetate, a natural polysaccharide, can be taken from plants and modified with polycaprolactone to improve its characteristics for a number of uses, including biomedical applications and food packaging. Cellulose acetate-g-polycaprolactone was prepared by a three-step reaction: First, polymerization of ε-caprolactone via ring-opening polymerization (ROP) reaction using 2-hydroxyethyl methacrylate (HEMA) and functionalization of polycaprolactone(PCL) by introducing NCO on the hydroxyl end of the HEMA-PCL using hexamethyl lenediisocyanate(HDI) were carried out. Then, the NCO–HEMA-PCL was grafted onto cellulose acetate (using the “grafting to” method). The polycaprolactone grafted cellulose acetate was confirmed by FTIR, the thermal characteristics of the copolymers were investigated by DSC and TGA, and the hydrophobicity was analyzed via water...
Medicinal chemistry, 2016
Journal of Molecular Structure, 2020
Moroccan Journal of Chemistry, Jul 11, 2017
Two tripodal pyrazolic ligands: N,N-bis((3,5-dimethyl-1H-pyrazol-1-yl)methy)-2,4-difluoroaniline ... more Two tripodal pyrazolic ligands: N,N-bis((3,5-dimethyl-1H-pyrazol-1-yl)methy)-2,4-difluoroaniline ( 2Fpyr 1 ) and N,N-bis((1H-pyrazol-1-yl)methyl)-2,4-difluoroaniline ( 2Fpyr 2 ) were synthetized in good yiels. Then we applied them against corrosion of mild steel in HCl 1M solution. Weight loss measurement give us the inhibition efficiencies values reached 80.2 % for 2Fpyr1 and 77.3 % for 2Fpyr 2 at the concentration 10 -3 , then by changing the temperature from 313K to 343 K, which give us the activation and adsorption parameters, and we reveal from it that the ligands 2Fpyr 1 were adsorbed according to Langmuir Isotherm, but 2Fpyr 2 were was adsorbed according to El-Awady adsorption Isotherm, we obtain these results using certain isotherms as Langmuir, Freundlich, Temkin, Frumkin, Florry-Huggins, Adejo-Ekwenchi and El-Awady. We conclude from polarization curves that all the ligands are mixed type inhibitors (anodic and cathodic type inhibitors), and from the impedance diagrams in the Nyquist presentation which are in the form of one half loop because that the corrosion is controlled by charge transfer process. We used GAUSSIAN 09W program to do theoretical investigations by considering the Density Functional Theory (DFT) method to calculate quantum parameters as E HOMO , E LUMO , ∆E HOMO -E LUMO and μ dipolar moment that allows us to confirm experimental results obtained from gravimetric and electrochemical studies.
Current Drug Delivery, May 17, 2021
Der Pharmacia Lettre, 2014
Journal of Molecular Liquids, 2020
Journal of Cluster Science, 2020
A novel [Ni4(µ3-O)4] twisted cubane complex, Ni4Cl2(NN)2(ONN)2(NNO)2(H2O)2·2THF, was prepared fro... more A novel [Ni4(µ3-O)4] twisted cubane complex, Ni4Cl2(NN)2(ONN)2(NNO)2(H2O)2·2THF, was prepared from a crude mixture of three bidentate ligands. A mixture of ethyl 1-(hydroxymethyl)-3-methyl-1H-pyrazole-5-carboxylate (HONN) and ethyl 1-(hydroxyl-methyl)-5-methyl-1H-pyrazole-3-carboxylate (NNOH) were added to ethyl 3-methyl-1H-pyrazole-5-carboxylate (NNH) then mixed to NiCl2·6H2O solution under ambient conditions. Reaction progress was monitored via infrared and ultraviolet–visible spectroscopies and energy-dispersive X-ray spectroscopy was used to analyze the product. Reaction yields for cluster synthesis were very good. Single crystal structure determination for the cluster indicates a novel [Ni4(µ3-O)4] twisted cubane structure with octahedral geometry around each of the Ni(II) centers in Ni4Cl2(NN)2(ONN)2(NNO)2(H2O)2·2THF. The lattice is stabilized by hydrogen bonding and H–π\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}pi\pipi\end{document} stacking. Hirshfeld surface analysis (HSA) corroborates the single crystal structure determination results. The cluster displays significant thermal stability under open atmosphere conditions; it decomposes in three steps at high temperature. The cluster demonstrates promising results as a catalyst; it promoted the complete oxidation of catechol to o-Quinone in under mild conditions.
The study of corrosion processes and their inhibition by organic inhibitors is a very active fiel... more The study of corrosion processes and their inhibition by organic inhibitors is a very active field of research. The presence of nitrogen, oxygen, phosphorous and sulphur in the organic molecules has a major effect on the inhibition efficiency and consequently on the phenomenon of adsorption on some metals surface. A great number of heterocyclic compounds were found to be excellent inhibitors of copper and steel corrosion. The inhibition effect mainly depends on some physicochemical and electronic properties of the organic inhibitor which relate to its functional groups, steric effects, electronic density of donor atoms, and orbital character of donating electrons. DFT Quantum chemical methods have already proven to be very useful in determining the molecular structure as well as elucidating the electronic structure and reactivity. Thus, it has become a common practice to carry out quantum chemical calculations in corrosion inhibition studies.
Herein we report the synthesis of new tridentate (N,N,N) compounds 3-6 and bidentate (N,N or N,O)... more Herein we report the synthesis of new tridentate (N,N,N) compounds 3-6 and bidentate (N,N or N,O) compounds 8-10 based on pyrazole moieties and quinoxaline, with the opportunity to change easily structure and substituents. These methods take advantage of the vast number of commercially available starting materials containing functional and aliphatic or aromatic amines. X-ray structures for two compounds were investigated.
In the present work, the molecular interactions of four amino acid compounds were simulated throu... more In the present work, the molecular interactions of four amino acid compounds were simulated through the density functional theory (DFT) indexes to study their inhibitive properties. The prototype inhibitors previously synthesized 2-amino-N-decylacetamide (G), 2-amino-N-decylpropionamide (A), 2-amino-N-decyl-3-methylbutyramide (V), and 2-amino-N-decyl-3-(4-hydroxyphenyl)propionamide (T) were used to test the accuracy of this calculation. The generalized gradient approximation (GGA) was the ab initio approach used to optimize the ground state of the molecules. The simulation of molecular dynamics with force field (AMBER) was calculated to obtain the interaction energy between the metallic surface and the inhibitor molecules. A strong correlation of the global and local indexes with the inhibiting capacity was observed. The inhibitive properties of compounds on mild steel in an aqueous hydrochloric acid solution agreed well with those derived from the reactivity and selectivity indexes in gaseous phase.
International Journal of Electrochemical Science
The inhibitive effect three quinoxalines derivatives named (2Z)-1-(4-chlorophenyl)-2-[(3E)-3-[2-(... more The inhibitive effect three quinoxalines derivatives named (2Z)-1-(4-chlorophenyl)-2-[(3E)-3-[2-(4chlorophenyl)-2-oxoethylidene]-3,4-dihydroquinoxalin-2(1H)-ylidene]ethanone (Q4), (2Z)-2-[(3E)-3-(2-oxo-2-phenylethylidene)-3,4-dihydroquinoxalin-2(1H)-ylidene]-1-phenylethanone (Q5) and (Z)-2-((E)-3-(2-oxo-2-phenylethylidene)-3,4-dihydroquinoxalin-2(1H)-ylidene)-1-phenylethanone (Q6) on the corrosion of copper in 2 M HNO 3 has been investigated at 303 K. The study was carried out using weight loss measurements, potentiodynamic polarisation and electrochemical impedance spectroscopy (EIS) methods). Results obtained show that Q4 is the best inhibitor and its inhibition efficiency (E %) increases with the increase of inhibitor concentration and reached up to 90 % for Q4 at 10 −3 M. Potentiodynamic polarisation studies clearly reveal that the presence of inhibitors does not change the mechanism of hydrogen evolution and that they act as mixed inhibitors with predominance at cathodic range.
Plants
The purpose of this study was to determine the chemical composition of the essential oil of Lavan... more The purpose of this study was to determine the chemical composition of the essential oil of Lavandula officinalis from Morocco using the GC-MS technique and assess the antibacterial effects against seven pathogenic bacteria strains isolated from the food origins of Salmonella infantis, Salmonella kentucky, Salmonella newport, three serotypes of Escherichia coli (O114H8K11, O127K88ac, O127H40K11) and Klebsiella. Tests of sensitivity were carried out on a solid surface using the Disc Diffusion Method. Results showed that E. coli and S.newport were sensitive to Lavandula officinalis essential oil. Minimum inhibitory concentrations (MIC) were determined using the method of agar dilution. The antibacterial results showed that four strains (three serotypes of E. coli, and S. newport) were remarkedly sensitive to Lavandula officinalis essential oil, giving MIC values of 88.7 µg/mL and 177.5 µg/mL. The molecular docking of the main oil products with the E. coli target protein 1VLY, showed t...
Indonesian Journal of Science and Technology
This study was conceived to work on Artemisia herba alba essential oils (EOs) originating from Ea... more This study was conceived to work on Artemisia herba alba essential oils (EOs) originating from Eastern Morocco. We investigated the chemical properties and determined the antiradical scavenging activity. The GC-MS technique was used to elucidate the chemical composition of the two studied regions. Jerada Eo was distinguished by the existence of 1,6-Dimethylhepta-1,3,5-triene (36.44%), Camphor (22.50%), and Thujone (7.21%). While, Taourirt EO was found to be rich in Camphor (55.31%), Eucalyptol (14.64%), and Camphene (9.95%). Moreover, the free radical scavenging ability (DPPH•), and ferric reducing power assay (FRAP) were conducted. The EOs tested are found to be weakly active and to have important antioxidant potential. The docking study was also carried out by theoretical investigation with molecular docking of four active predominating components (1,6-dimethylhepta-1,3,5-triene; Chrysanthone; Eucalyptol; Alpha-pinene) against S protein of SARS-CoV‑2, and all the four ligands were...
Catalysts
Herein, new substituted ligands based on pyrazole (L1–L4) were synthesized via a one-step by cond... more Herein, new substituted ligands based on pyrazole (L1–L4) were synthesized via a one-step by condensing (1H-pyrazole-1-yl) methanol with different primary amine compounds. The present work utilized the catalytic properties of the in situ complexes formed by these ligands with various copper (II) salts viz. Cu(CH3COO)2, CuSO4, CuCl2, and Cu(NO3)2 for the oxidation of catechol to o-quinone. The studies showed that the catalytic activities depend on the nature and concentration of the ligand, the nature of the counterion, and the solvent. It was observed that the complex formed by L2 and Cu(CH3COO)2 exhibited good catalytic activity in methanol with Vmax of 41.67 µmol L−1 min−1 and Km of 0.02 mol L−1.
Indonesian Journal of Science and Technology
In this work, we are interested in finding new catalysts for catecholase, whose principle is base... more In this work, we are interested in finding new catalysts for catecholase, whose principle is based on the oxidation reaction of catechol to o-quinone. We approached the synthesis of the threes tripod ligands based on pyrazole in a condensation reaction and its characterization by IR, 13C NMR, 1H NMR spectroscopy, then we evaluated the catalytic properties of certain complexes formed in situ to catalyze the oxidation reaction of catechols to o-quinones. The aim is to find the right models to reproduce the catalytic activity of the enzyme (catecholase), we used complexes formed in situ by pyrazole derivatives with Copper salts. Among these complexes, the complex L4/Cu(CH3COO)2 showed good catalytic activity of the combination (1ligand/2metal) in MeOH for this reaction, with a speed Vmax equal to 69.38 μmol.L-1.min-1 and a low value of Km equal to 0.019 mol.L-1. We have demonstrated that the nature of concentration, ligand, solvent, and copper salts, influenced strongly the catecholase...
Molecules
Bayoud disease affects date palms in North Africa and the Middle East, and many researchers have ... more Bayoud disease affects date palms in North Africa and the Middle East, and many researchers have used various methods to fight it. One of those methods is the chemical use of synthetic compounds, which raises questions centred around the compounds and common features used to prepare targeted molecules. In this review, 100 compounds of tested small molecules, collected from 2002 to 2022 in Web of Sciences, were divided into ten different classes against the main cause of Bayoud disease pathogen Fusarium oxysporum f. sp. albedinis (F.o.a.) with structure–activity relationship (SAR) interpretations for pharmacophore site predictions as (δ−···δ−), where 12 compounds are the most efficient (one compound from each group). The compounds, i.e., (Z)-1-(1.5-Dimethyl-1H-pyrazole-3-yl)-3-hydroxy but-2-en-1-one 7, (Z)-3-(phenyl)-1-(1,5-dimethyl-1H-pyrazole-3-yl)-3-hydroxyprop-2-en-1-one 23, (Z)-1-(1,5-Dimethyl-1H-pyrazole-3-yl)-3-hydroxy-3-(pyridine-2-yl)prop-2-en-1-one 29, and 2,3-bis-[(2-hydro...
Molecules, 2022
The need for biodegradable and biocompatible polymers is growing quickly, particularly in the bio... more The need for biodegradable and biocompatible polymers is growing quickly, particularly in the biomedical and environmental industries. Cellulose acetate, a natural polysaccharide, can be taken from plants and modified with polycaprolactone to improve its characteristics for a number of uses, including biomedical applications and food packaging. Cellulose acetate-g-polycaprolactone was prepared by a three-step reaction: First, polymerization of ε-caprolactone via ring-opening polymerization (ROP) reaction using 2-hydroxyethyl methacrylate (HEMA) and functionalization of polycaprolactone(PCL) by introducing NCO on the hydroxyl end of the HEMA-PCL using hexamethyl lenediisocyanate(HDI) were carried out. Then, the NCO–HEMA-PCL was grafted onto cellulose acetate (using the “grafting to” method). The polycaprolactone grafted cellulose acetate was confirmed by FTIR, the thermal characteristics of the copolymers were investigated by DSC and TGA, and the hydrophobicity was analyzed via water...