intissar haddiya | Université Mohamed Premier (original) (raw)

Papers by intissar haddiya

International Journal of Nephrology and Renovascular Disease, Sep 30, 2023

Beta-blockers include a large spectrum of drugs with various specific characteristics, and a well... more Beta-blockers include a large spectrum of drugs with various specific characteristics, and a well-known cardioprotective efficacy. They are recommended in heart failure, hypertension and arrhythmia. Their use in chronic hemodialysis patients is still controversial, mainly because of the lack of specific randomized clinical trials. Large observational studies and two important clinical trials have reported almost unanimously their efficacy in chronic hemodialysis patients, which seems to be related to their levels of dialyzability and cardioselectivity. A recent meta-analysis suggested that high dialyzable beta-blockers are correlated to a reduced risk of all-cause mortality and cardiovascular complications compared with low dialyzable beta-blockers. Despite their benefits, betablockers may have adverse effects, such as intradialytic hypotension with low dialyzability beta-blockers or the risk of sub-therapeutic plasma concentration of high dialyzable ones during dialysis sessions. Both cases are linked to adverse cardiovascular events. A solution for both high and low dialyzable drugs could be their administration after dialysis sessions. Futhermore, the bulk of existing literature seems to favor cardioselective beta-blockers with moderate-to-high dialyzability as the ideal agents in dialysis patients, but further, larger studies are needed. This review aims to analyze beta-blockers' characteristics, indications and evidencebased role in chronic hemodialysis patients.

NDT Plus, 2009

bAsic reseArch on biocomPAtibility, immunology, inflAmmAtion And fibrosis miRNA589 Regulate Epith... more bAsic reseArch on biocomPAtibility, immunology, inflAmmAtion And fibrosis miRNA589 Regulate Epithelial-Mesenchymal Transition in Human Peritoneal Mesothelial Cells Background: microRNAs (miRNA, miR) are thought to interact with multiple mRNAs resulting in either translational repression or degradation which is involved in the EMT process. Since miRNAs distributed with tissue specificity, the role of miRNAs in peritoneal fibrosis remains unknown. Our unpressed data showed that expression of miRNA589 was notably decreased in HPMCs isolated from patients undergoing long-term continuous ambulatory peritoneal dialysis (CAPD). Objective: To determine if miRNA589 regulates the EMT induced by TGFβ1 in human peritoneal mesothelial cell line (HMrSV5 cells). Methods: HMrSV5 cells were divided into three groups: control group (only FBS-free DMEM/F12), TGF-β1 group (treated with TGF-1 5 ng/ml for 24h) and pre-miR-5891 group (pre-treated with pre-miR-589 to up-regulate the level of miR-589, and treated with TGF-1 5 ng/ml for 24h). The level of miRNA589 was determined by realtime PCR. The expressions of ZO-1, vimentin, E-cadherinin HPMCs were determined by immunofluorescence, realtime PCR, and Western blot, respectively. Result: In vitro,TGF1 led to up-regulation of vimentin and downregulation of ZO-1 as well as E-cadherin in HMrSV5 cells, which suggested EMT was induced. The changes were accompanied with notably decreased level of miRNA589 in HMrSV5 cells treated by TGF1. Over-expression of miRNA589 by transfection with pre-miRNA589 partially reversed these EMT changes. Conclusion: miRNA589 mediates TGF1-induced EMT in human peritoneal mesothelial cells.

DOAJ (DOAJ: Directory of Open Access Journals), Jun 1, 2012

La dialyse péritonéale chez les patients de moins de vingt ans: expérience d'un centre hospitalie... more La dialyse péritonéale chez les patients de moins de vingt ans: expérience d'un centre hospitalier universitaire marocain

Elsevier Masson, May 12, 2014

Néphrologie & Thérapeutique, 2016

recueillent respectivement 55 % et 49 % des réponses. Pour les patients, l'élément majeur dans le... more recueillent respectivement 55 % et 49 % des réponses. Pour les patients, l'élément majeur dans le maintien de leur élan vital est l'optimisme et les encouragements de leur néphrologue (60 % vs 20 % pour les néphrologues, p < 0,05). L'âge (OR 2,49 [1,14-5,46], p < 0,05) et le genre (OR 0,37 [0,18-0,77], p < 0,05) des néphrologues sont associés de faç on indépendante à ce résultat : les hommes et les néphrologues plus âgés ont davantage conscience de l'impact de leurs encouragements sur la qualité de vie de leurs patients. Discussion Le rôle du néphrologue est essentiel dans le maintien de l'élan vital et de la qualité de vie du patient insuffisant rénal. La bonne représentativité des répondants est à pondérer par un probable biais de sélection : les réponses à ce questionnaire proviennent peut-être des patients et des néphrologues entretenant une très bonne relation. Conclusion Cette première enquête nationale souligne l'intérêt d'évaluer l'élan vital et la qualité de vie du patient IRC non dialysé par un questionnaire adapté qui pourrait être rempli en amont de chaque consultation. Déclaration de liens d'intérêts Ce travail a été soutenu financièrement par le laboratoire Roche.

Annals of Medicine & Surgery, 2022

Introduction Central venous Occlusion (CVO) is a serious complication that occurs mainly in patie... more Introduction Central venous Occlusion (CVO) is a serious complication that occurs mainly in patients with long term central venous catheters for dialysis. It remains a challenge in vascular surgery. Case presentation We report a case of a patient with end-stage kidney disease (ESKD), who was admitted for chronic occlusion of the superior and inferior vena cava and underwent a right subclavian artery to right atrium (RA) bypass using polytetrafuloroetylene (PTFE) graft. Clinical discussion Central venous catheters remains the main cause of CVO in ESKD. Although the endovascular therapy is the main approach in the treatment of CVO, the surgical bypass to the RA is often the last resort to preserve vascular access in hemodialysis patients. The autologous vein and bovine arterial bypass remains better than PTFE grafts in terms of long term patency. Conclusion fistulas as a first approach for dialysis access must be privileged at the expense of central catheters. However bypass to RA by mini thoracotomy incision remains as an excellent option for dialysis access in ESKD with CVO.

Néphrologie & Thérapeutique, 2021

Poster session 8: Registries and cohorts, 2018

Introduction As a consequence of increased SLE patients survival, patients with long disease dura... more Introduction As a consequence of increased SLE patients survival, patients with long disease duration represent a significant proportion of our cohorts. This study aims to evaluate health resource use and the 6 months costs in patients with SLE with long disease duration. Methods The economic evaluation was performed in terms of cost-of-illness analysis as part of a larger study enrolling SLE patients with at least 15 years of disease duration regularly followed at our unit. At enrollment, the following information were collected: disease activity (SLEDAI), organ damage (SLICC-DI score), comorbidities, treatment patterns; in addition to clinical data, patients were required to complete an ad-hoc questionnaire for the collection of facts relevant for the estimation of the economic dimension and covering the previous six-months. Such a time frame was considered to be appropriate as recall period. Direct health (drugs, hospitalizations, emergency visits, specialists visits, laboratory tests and instrumental examination) and non-health costs (transportation and accommodation) as well as indirect costs because of productivity loss were estimated. Results 51 adult patients with long disease duration were recruited (98% female, mean age 49±11 years, median disease duration 17 years, IQR 15-23). Median (IQR) SLEDAI score was 2 (0-4), median SLICC-DI was 1 (0-2). The median (IQR) direct health costs per patients over the previous 6 months resulted 410C ¼ (201-1687); indirect costs because of productivity lost were 130C ¼ (0-356). The median overall cost to the Society was 473C ¼ (327-2148); the presence of comorbid conditions resulted associated with higher overall cost for the Society (552C ¼ [327-1807] vs 264C ¼ [94-1164] p=0.046); disease activity and damage at enrollment were not associated with costs increase in this cohort. Conclusions This cohort of patients with long lasting disease is characterised by low disease activity and mild organ damage; in this setting, the disease burden on the single patient and family is significant and the costs to the Society are influenced by the presence of comorbidities.

Néphrologie & Thérapeutique, 2018

Déclaration de liens d'intérêts Les auteurs n'ont pas précisé leurs éventuels liens d'intérêts.

Néphrologie & Thérapeutique, 2019

Néphrologie & Thérapeutique, 2019

Fig. 1 42,3 % des donneurs récusés ont été exclus. Déclaration de liens d'intérêts Les auteurs dé... more Fig. 1 42,3 % des donneurs récusés ont été exclus. Déclaration de liens d'intérêts Les auteurs déclarent ne pas avoir de liens d'intérêts.

Néphrologie & Thérapeutique, 2019

Biomedical Journal of Scientific & Technical Research, 2018

Néphrologie & Thérapeutique, 2017

Néphrologie & Thérapeutique, 2017

Arab journal of nephrology and transplantation, Sep 1, 2013

Introduction: Membranous nephropathy (MN) in the context of rheumatoid arthritis (RA), is often a... more Introduction: Membranous nephropathy (MN) in the context of rheumatoid arthritis (RA), is often an iatrogenic complication due to the nephrotoxic effects of antirheumatic drugs. Rare cases of non-iatrogenic association between these two diseases were reported in the literature. Case report: A 30-year-old female patient presented in September 2005 with nephrotic syndrome. Renal biopsy showed features consistent with MN. Search for etiology was negative, particularly lupus serology which remained negative throughout the course of her illness. Accordingly, she was diagnosed as a case of idiopathic MN. Initially, she was treated with angiotensin converting enzyme inhibitors and angiotensin receptor blockers which maintained her protein excretion below nephrotic range for two years. Her nephrotic syndrome then relapsed and was treated with steroids and chlorambucil, according to the Ponticelli protocol. A few months later, she presented with early morning joint stiffness, polyarthritis involving the small joints of the hands, and strongly positive rheumatoid factor, fulfilling the diagnostic criteria of rheumatoid arthritis (RA). Her serum creatinine remained normal and a second renal biopsy revealed the same features of MN. Her RA was treated with pulsed methylprednisolone followed by oral steroids and methotrexate resulting in remission of the joints disease and the nephrotic syndrome. Remission was maintained for the last two years up to the time of this report. Conclusion: We hereby report a case of secondary membranous nephropathy that preceded the onset of rheumatoid arthritis by three years.

Saudi Journal of Kidney Diseases and Transplantation, 2015

Type 2 diabetes mellitus (T2DM) is associated with an increased risk of progression toward end-st... more Type 2 diabetes mellitus (T2DM) is associated with an increased risk of progression toward end-stage renal disease and cardiovascular (CV) risk mortality. To investigate this association, we studied 637 patients with T2DM in the Eastern area of Morocco. The mean follow-up period was 42 ± 11 months. At the baseline visit, 22.8%, 59.1% and 18.1% of the patients had normo-albuminuria, micro-albuminuria and macro-albuminuria, respectively. Of all patients, 51.6% had a history of hypertension and 37.4% had hypertension on admission. At the end of follow-up, rapid progression (estimated glomerular filtration rate &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;5 mL/min/1.73 m 2 /year) was observed in 24.1% of the cases and the frequency of occurrence of CV events was 5%, 18.5% and 32.5% in the normo-, micro- and macro-albuminuria groups, respectively (P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.001). In multivariate analysis, arterial hypertension was identified as an independent risk factor related to diabetic kidney disease (DKD, P = 0.04) and occurrence of CV events (P = 0.02), while albuminuria was not identified as an independent risk factor, either for DKD or for the occurrence of CV events. Our study found that hypertension was an independent risk factor for the DKD and the occurrence of the CV events in T2DM patients.

Néphrologie & Thérapeutique, 2012

Case Reports in Cardiology, 2013

Calcium channel blockers (CCBs) are prescribed in a wide variety of cardiovascular conditions. Ne... more Calcium channel blockers (CCBs) are prescribed in a wide variety of cardiovascular conditions. Nevertheless, they remain a major cause of cardiovascular drug overdose that often leads to a lethal outcome. We report the case of an intoxication with amlodipine, which caused severe hypotension, in a young woman. The patient was initially treated with fluids, calcium gluconate, and Dobutamine without effect. She then received hyperinsulinemia euglycemia therapy. A rise in blood pressure (BP) was observed two hours after insulin was started. The next day, the insulin infusion was stopped and seven days later the patient was discharged from the hospital after psychiatric consultation. The positive inotropic effect of insulin therapy in our patient supports previous findings that suggest its use as a first-line therapy in the management of CCBs overdose.

Néphrologie & Thérapeutique, 2013

International Journal of Nephrology and Renovascular Disease, Sep 30, 2023

Beta-blockers include a large spectrum of drugs with various specific characteristics, and a well... more Beta-blockers include a large spectrum of drugs with various specific characteristics, and a well-known cardioprotective efficacy. They are recommended in heart failure, hypertension and arrhythmia. Their use in chronic hemodialysis patients is still controversial, mainly because of the lack of specific randomized clinical trials. Large observational studies and two important clinical trials have reported almost unanimously their efficacy in chronic hemodialysis patients, which seems to be related to their levels of dialyzability and cardioselectivity. A recent meta-analysis suggested that high dialyzable beta-blockers are correlated to a reduced risk of all-cause mortality and cardiovascular complications compared with low dialyzable beta-blockers. Despite their benefits, betablockers may have adverse effects, such as intradialytic hypotension with low dialyzability beta-blockers or the risk of sub-therapeutic plasma concentration of high dialyzable ones during dialysis sessions. Both cases are linked to adverse cardiovascular events. A solution for both high and low dialyzable drugs could be their administration after dialysis sessions. Futhermore, the bulk of existing literature seems to favor cardioselective beta-blockers with moderate-to-high dialyzability as the ideal agents in dialysis patients, but further, larger studies are needed. This review aims to analyze beta-blockers' characteristics, indications and evidencebased role in chronic hemodialysis patients.

NDT Plus, 2009

bAsic reseArch on biocomPAtibility, immunology, inflAmmAtion And fibrosis miRNA589 Regulate Epith... more bAsic reseArch on biocomPAtibility, immunology, inflAmmAtion And fibrosis miRNA589 Regulate Epithelial-Mesenchymal Transition in Human Peritoneal Mesothelial Cells Background: microRNAs (miRNA, miR) are thought to interact with multiple mRNAs resulting in either translational repression or degradation which is involved in the EMT process. Since miRNAs distributed with tissue specificity, the role of miRNAs in peritoneal fibrosis remains unknown. Our unpressed data showed that expression of miRNA589 was notably decreased in HPMCs isolated from patients undergoing long-term continuous ambulatory peritoneal dialysis (CAPD). Objective: To determine if miRNA589 regulates the EMT induced by TGFβ1 in human peritoneal mesothelial cell line (HMrSV5 cells). Methods: HMrSV5 cells were divided into three groups: control group (only FBS-free DMEM/F12), TGF-β1 group (treated with TGF-1 5 ng/ml for 24h) and pre-miR-5891 group (pre-treated with pre-miR-589 to up-regulate the level of miR-589, and treated with TGF-1 5 ng/ml for 24h). The level of miRNA589 was determined by realtime PCR. The expressions of ZO-1, vimentin, E-cadherinin HPMCs were determined by immunofluorescence, realtime PCR, and Western blot, respectively. Result: In vitro,TGF1 led to up-regulation of vimentin and downregulation of ZO-1 as well as E-cadherin in HMrSV5 cells, which suggested EMT was induced. The changes were accompanied with notably decreased level of miRNA589 in HMrSV5 cells treated by TGF1. Over-expression of miRNA589 by transfection with pre-miRNA589 partially reversed these EMT changes. Conclusion: miRNA589 mediates TGF1-induced EMT in human peritoneal mesothelial cells.

DOAJ (DOAJ: Directory of Open Access Journals), Jun 1, 2012

La dialyse péritonéale chez les patients de moins de vingt ans: expérience d'un centre hospitalie... more La dialyse péritonéale chez les patients de moins de vingt ans: expérience d'un centre hospitalier universitaire marocain

Elsevier Masson, May 12, 2014

Néphrologie & Thérapeutique, 2016

recueillent respectivement 55 % et 49 % des réponses. Pour les patients, l'élément majeur dans le... more recueillent respectivement 55 % et 49 % des réponses. Pour les patients, l'élément majeur dans le maintien de leur élan vital est l'optimisme et les encouragements de leur néphrologue (60 % vs 20 % pour les néphrologues, p < 0,05). L'âge (OR 2,49 [1,14-5,46], p < 0,05) et le genre (OR 0,37 [0,18-0,77], p < 0,05) des néphrologues sont associés de faç on indépendante à ce résultat : les hommes et les néphrologues plus âgés ont davantage conscience de l'impact de leurs encouragements sur la qualité de vie de leurs patients. Discussion Le rôle du néphrologue est essentiel dans le maintien de l'élan vital et de la qualité de vie du patient insuffisant rénal. La bonne représentativité des répondants est à pondérer par un probable biais de sélection : les réponses à ce questionnaire proviennent peut-être des patients et des néphrologues entretenant une très bonne relation. Conclusion Cette première enquête nationale souligne l'intérêt d'évaluer l'élan vital et la qualité de vie du patient IRC non dialysé par un questionnaire adapté qui pourrait être rempli en amont de chaque consultation. Déclaration de liens d'intérêts Ce travail a été soutenu financièrement par le laboratoire Roche.

Annals of Medicine & Surgery, 2022

Introduction Central venous Occlusion (CVO) is a serious complication that occurs mainly in patie... more Introduction Central venous Occlusion (CVO) is a serious complication that occurs mainly in patients with long term central venous catheters for dialysis. It remains a challenge in vascular surgery. Case presentation We report a case of a patient with end-stage kidney disease (ESKD), who was admitted for chronic occlusion of the superior and inferior vena cava and underwent a right subclavian artery to right atrium (RA) bypass using polytetrafuloroetylene (PTFE) graft. Clinical discussion Central venous catheters remains the main cause of CVO in ESKD. Although the endovascular therapy is the main approach in the treatment of CVO, the surgical bypass to the RA is often the last resort to preserve vascular access in hemodialysis patients. The autologous vein and bovine arterial bypass remains better than PTFE grafts in terms of long term patency. Conclusion fistulas as a first approach for dialysis access must be privileged at the expense of central catheters. However bypass to RA by mini thoracotomy incision remains as an excellent option for dialysis access in ESKD with CVO.

Néphrologie & Thérapeutique, 2021

Poster session 8: Registries and cohorts, 2018

Introduction As a consequence of increased SLE patients survival, patients with long disease dura... more Introduction As a consequence of increased SLE patients survival, patients with long disease duration represent a significant proportion of our cohorts. This study aims to evaluate health resource use and the 6 months costs in patients with SLE with long disease duration. Methods The economic evaluation was performed in terms of cost-of-illness analysis as part of a larger study enrolling SLE patients with at least 15 years of disease duration regularly followed at our unit. At enrollment, the following information were collected: disease activity (SLEDAI), organ damage (SLICC-DI score), comorbidities, treatment patterns; in addition to clinical data, patients were required to complete an ad-hoc questionnaire for the collection of facts relevant for the estimation of the economic dimension and covering the previous six-months. Such a time frame was considered to be appropriate as recall period. Direct health (drugs, hospitalizations, emergency visits, specialists visits, laboratory tests and instrumental examination) and non-health costs (transportation and accommodation) as well as indirect costs because of productivity loss were estimated. Results 51 adult patients with long disease duration were recruited (98% female, mean age 49±11 years, median disease duration 17 years, IQR 15-23). Median (IQR) SLEDAI score was 2 (0-4), median SLICC-DI was 1 (0-2). The median (IQR) direct health costs per patients over the previous 6 months resulted 410C ¼ (201-1687); indirect costs because of productivity lost were 130C ¼ (0-356). The median overall cost to the Society was 473C ¼ (327-2148); the presence of comorbid conditions resulted associated with higher overall cost for the Society (552C ¼ [327-1807] vs 264C ¼ [94-1164] p=0.046); disease activity and damage at enrollment were not associated with costs increase in this cohort. Conclusions This cohort of patients with long lasting disease is characterised by low disease activity and mild organ damage; in this setting, the disease burden on the single patient and family is significant and the costs to the Society are influenced by the presence of comorbidities.

Néphrologie & Thérapeutique, 2018

Déclaration de liens d'intérêts Les auteurs n'ont pas précisé leurs éventuels liens d'intérêts.

Néphrologie & Thérapeutique, 2019

Néphrologie & Thérapeutique, 2019

Fig. 1 42,3 % des donneurs récusés ont été exclus. Déclaration de liens d'intérêts Les auteurs dé... more Fig. 1 42,3 % des donneurs récusés ont été exclus. Déclaration de liens d'intérêts Les auteurs déclarent ne pas avoir de liens d'intérêts.

Néphrologie & Thérapeutique, 2019

Biomedical Journal of Scientific & Technical Research, 2018

Néphrologie & Thérapeutique, 2017

Néphrologie & Thérapeutique, 2017

Arab journal of nephrology and transplantation, Sep 1, 2013

Introduction: Membranous nephropathy (MN) in the context of rheumatoid arthritis (RA), is often a... more Introduction: Membranous nephropathy (MN) in the context of rheumatoid arthritis (RA), is often an iatrogenic complication due to the nephrotoxic effects of antirheumatic drugs. Rare cases of non-iatrogenic association between these two diseases were reported in the literature. Case report: A 30-year-old female patient presented in September 2005 with nephrotic syndrome. Renal biopsy showed features consistent with MN. Search for etiology was negative, particularly lupus serology which remained negative throughout the course of her illness. Accordingly, she was diagnosed as a case of idiopathic MN. Initially, she was treated with angiotensin converting enzyme inhibitors and angiotensin receptor blockers which maintained her protein excretion below nephrotic range for two years. Her nephrotic syndrome then relapsed and was treated with steroids and chlorambucil, according to the Ponticelli protocol. A few months later, she presented with early morning joint stiffness, polyarthritis involving the small joints of the hands, and strongly positive rheumatoid factor, fulfilling the diagnostic criteria of rheumatoid arthritis (RA). Her serum creatinine remained normal and a second renal biopsy revealed the same features of MN. Her RA was treated with pulsed methylprednisolone followed by oral steroids and methotrexate resulting in remission of the joints disease and the nephrotic syndrome. Remission was maintained for the last two years up to the time of this report. Conclusion: We hereby report a case of secondary membranous nephropathy that preceded the onset of rheumatoid arthritis by three years.

Saudi Journal of Kidney Diseases and Transplantation, 2015

Type 2 diabetes mellitus (T2DM) is associated with an increased risk of progression toward end-st... more Type 2 diabetes mellitus (T2DM) is associated with an increased risk of progression toward end-stage renal disease and cardiovascular (CV) risk mortality. To investigate this association, we studied 637 patients with T2DM in the Eastern area of Morocco. The mean follow-up period was 42 ± 11 months. At the baseline visit, 22.8%, 59.1% and 18.1% of the patients had normo-albuminuria, micro-albuminuria and macro-albuminuria, respectively. Of all patients, 51.6% had a history of hypertension and 37.4% had hypertension on admission. At the end of follow-up, rapid progression (estimated glomerular filtration rate &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;5 mL/min/1.73 m 2 /year) was observed in 24.1% of the cases and the frequency of occurrence of CV events was 5%, 18.5% and 32.5% in the normo-, micro- and macro-albuminuria groups, respectively (P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.001). In multivariate analysis, arterial hypertension was identified as an independent risk factor related to diabetic kidney disease (DKD, P = 0.04) and occurrence of CV events (P = 0.02), while albuminuria was not identified as an independent risk factor, either for DKD or for the occurrence of CV events. Our study found that hypertension was an independent risk factor for the DKD and the occurrence of the CV events in T2DM patients.

Néphrologie & Thérapeutique, 2012

Case Reports in Cardiology, 2013

Calcium channel blockers (CCBs) are prescribed in a wide variety of cardiovascular conditions. Ne... more Calcium channel blockers (CCBs) are prescribed in a wide variety of cardiovascular conditions. Nevertheless, they remain a major cause of cardiovascular drug overdose that often leads to a lethal outcome. We report the case of an intoxication with amlodipine, which caused severe hypotension, in a young woman. The patient was initially treated with fluids, calcium gluconate, and Dobutamine without effect. She then received hyperinsulinemia euglycemia therapy. A rise in blood pressure (BP) was observed two hours after insulin was started. The next day, the insulin infusion was stopped and seven days later the patient was discharged from the hospital after psychiatric consultation. The positive inotropic effect of insulin therapy in our patient supports previous findings that suggest its use as a first-line therapy in the management of CCBs overdose.

Néphrologie & Thérapeutique, 2013