Milad Rasouli | Kharazmi University Of Tehran (original) (raw)

Papers by Milad Rasouli

Vaccines

Rheumatoid arthritis (RA) is a chronic inflammatory joint disorder that causes systemic inflammat... more Rheumatoid arthritis (RA) is a chronic inflammatory joint disorder that causes systemic inflammation, autoimmunity, and joint abnormalities that result in permanent disability. Exosomes are nanosized extracellular particles found in mammals (40–100 nm). They are a transporter of lipids, proteins, and genetic material involved in mammalian cell–cell signaling, biological processes, and cell signaling. Exosomes have been identified as playing a role in rheumatoid arthritis-related joint inflammation (RA). Uniquely functioning extracellular vesicles (EVs) are responsible for the transport of autoantigens and mediators between distant cells. In addition, paracrine factors, such as exosomes, modulate the immunomodulatory function of mesenchymal stem cells (MSCs). In addition to transporting genetic information, exosomes convey miRNAs between cells and have been studied as drug delivery vehicles. In animal models, it has been observed that MSCs secrete EVs with immunomodulatory properties...

Pharmaceutical and Biomedical Research

Background: Primordial follicle includes an oocyte surrounded by a layer of somatic cells called ... more Background: Primordial follicle includes an oocyte surrounded by a layer of somatic cells called Granulosa Cells (GCs). GCs, also known as nurse cells, are an important protective element for the growth and survival of oocytes. Oocytes, which lack some of the metabolic processes, require granulosa cells for their development. Objectives: This manuscript was provided to explain the protocol of GCs primary culture extracted from NMRI mice ovaries. Methods: For choosing the optimum protocol, we used two methods with different culture mediums to obtain more GCs and expedite the process. Hematoxylin and Eosin (H&E) staining and flow cytometry were used to analyze the type of extracted cells from ovaries. Besides, we evaluated the effect of crocin and DPP as two common natural products in Iran on the proliferation of these cells via MTT assay. Results: Second protocol method and alpha-MEM culture medium were chosen based on the results. Our findings from HE staining and flow cytometry pro...

Bulletin of the American Physical Society, Mar 15, 2021

Scientific Reports

Sterilization of saffron packaging and maintaining the quality of saffron content are the main pr... more Sterilization of saffron packaging and maintaining the quality of saffron content are the main priorities in saffron preservation. Common modalities do not offer lasting saffron preservation and it is urgent to develop novel packaging approaches from renewable resources and prevent packaging waste. Here, simultaneous decontamination and quality maintenance of saffron is demonstrated, for the first time, through the synergistic application of nano-clay-loaded carboxymethyl cellulose (CMC)/polyvinyl alcohol (PVA) nanocomposites (CNCs) and cold plasmas (CP). Compared to the separate uses of CP and CMC/PVA/nano clay, our results confirm the synergies between CP and CMC/PVA/nano clay cause complete inactivation of Escherichia coli bacteria, while not significantly affecting the concentrations of the essential saffron components (safranal, crocin, and picrocrocin). Overall, the CP-treated CMC/PVA/nano clay fosters saffron preservation, through contamination removal and quality maintenance...

Scientific Reports

In this work, Sn and Ag doped PbS/PVA nanocomposites, in three different concentrations were succ... more In this work, Sn and Ag doped PbS/PVA nanocomposites, in three different concentrations were successfully prepared using the low-cost and simple method of chemical bath deposition (CBD). X-ray diffraction patterns confirmed the formation of the PbS cubic phase in all of the nanocomposites. FE-SEM images showed that PbS NPs are cubic in shape and the doping can alter the shape of grains. DLS analysis applied for solution NPs exhibited a 175 nm size distribution for PbS NPs and decreased by doping Ag and Sn to almost 100 nm and 110 nm, respectively. Optical absorption spectra showed the blue phenomena and the band gaps of Sn: PbS/PVA and Ag: PbS/PVA nanocomposites increased with adding Sn and Ag from 3.08 eV for pure PVA/PbS to 3.33 eV for Sn doped and 3.43 eV for Ag-doped samples. The nonlinear refractive index is decreased from 0.55 m2 W−1 for pure PVA/PbS to 0.11 m2 W−1 and 0.13 m2 W−1 for Sn and Ag-doped samples, respectively. Hence, doping Ag and Sn enhanced the optical sensitivi...

ECS Meeting Abstracts

As the photoanode material, TiO2 is the backbone of cost-effective dye-sensitized solar cells. He... more As the photoanode material, TiO2 is the backbone of cost-effective dye-sensitized solar cells. Herein, we propose a green, low-cost, and environmentally friendly synthesis method for titanium dioxide nanotubes using the anodizing process. The anodizing process was carried out in a chemical cell, and the effect of voltage and anodizing time on the creation of pure titanium dioxide nanotubes was investigated. A grade 4 titanium sheet with a thickness of 1 mm was utilized to make titanium oxide nanotubes. First, the titanium sheet was sliced into 1.5 × 1.5 cm squares, and the samples were sanded and polished with SiC sanding sheets ranging in grade from 180 to 3000. After that, the samples were immersed in an ultrasonic bath for 15 minutes to degrease and remove surface impurities in an equal amount of acetone-ethanol solution. A two-electrode cell was utilized for anodizing, with a graphite electrode as the cathode, a titanium sample as the anode, and an electrolyte solution containin...

ECS Meeting Abstracts

We used a three-step anodization procedure to produce titanium oxide (TiO2) nanotubes in order to... more We used a three-step anodization procedure to produce titanium oxide (TiO2) nanotubes in order to investigate the effects of varied electrolyte concentrations and anodization voltages on optical characteristics. Different electrolyte solution concentrations and anodization voltages altered wall thicknesses and tube diameters, according to our observations from the XRD pattern, TEM pictures, and optical examinations. While the band gap and band edge values of TiO2 nanotubes altered with different anodization voltages, the band gap, and band edge values remained constant. Furthermore, we discovered that at various electrolyte solution concentrations, the optimum solution concentration for growing compact TiO2 nanotubes is 70 percent porosity. Various morphologies of TiO2 nanostructures, such as sheet, rod, and tube, were obtained in the next section of the study by modifying the experimental settings (e.g., growth methods, differently used gases, and process temperatures). Titanium di...

ECS Meeting Abstracts

Over the last two decades, engineering the optical properties of nanoscale structures (nanowires,... more Over the last two decades, engineering the optical properties of nanoscale structures (nanowires, quantum dots, and nanotubes), i.e., band gap, absorption, and photoluminescence radiation, which can be manipulated in sulfide-based semiconductor materials, has received a lot of attention. Due to their tunable characteristics, these materials were introduced for potential applications ranging from medicine and communications to energy and various sensors (1). In addition, chemical synthesis methods provide the desired structure, material, reproducibility, and possibility of large-scale production, along with sustainable industrialization and foster innovation of these material systems. Polyvinyl-alcohol (PVA) is one of the functional polymers, in addition to the ability to stabilize the nanomaterial solution, which can change the optical properties of the material (2). Currently, the majority of sulfide-based nanomaterials are cadmium, lead, and silver, which have shown a wide range o...

Optical Materials Express

In this study, CdS, CuS, and Ag2S nanoparticles (NPs) were synthesized by a chemical bath procedu... more In this study, CdS, CuS, and Ag2S nanoparticles (NPs) were synthesized by a chemical bath procedure in the presence of polyvinyl alcohol (PVA) as a polymer stabilizer. Morphological studies followed by X-ray diffraction (XRD) and atomic force microscopy (AFM) revealed monolithic and small size NPs. The average crystalline size of CdS, Ag2S, and CuS nanocomposites was 18.1, 26.7, and 21.7 nm, respectively. UV-Vis absorption and photoluminescence (PL) spectra of samples showed a near-infrared region (NIR) emission peak for CuS. The bandgap of samples measured using absorption data was 3.48, 2.75, and 2.30 eV for CdS, Ag2S, and CuS NPs, respectively. Nonlinear optical properties, including nonlinear refractive index and nonlinear absorption of the NPs, were measured by the Z-scan technique under a 632.8 nm wavelength He-Ne CW laser. PVA/Ag2S nanocomposite displayed reverse saturable absorbance (RSA) and self-focusing, while PVA/CdS and PVA/CuS displayed saturable absorbance and self-de...

Environmental Science and Pollution Research, 2022

2020 IEEE International Conference on Plasma Science (ICOPS), 2020

2020 IEEE International Conference on Plasma Science (ICOPS), 2020

Here, we investigate the effect of CAP and PAM on the proliferation and apoptosis of carboplatin-... more Here, we investigate the effect of CAP and PAM on the proliferation and apoptosis of carboplatin-resistant SKOV-3 and GCS normal ovarian cells. We cultured GCS cells and the carboplatin-resistant SKOV-3 cells in vitro until the exponential growth phase and then treated with the different exposure time of CAP and PAM. We performed MTT assay to determine the proliferation of ovarian cells. Besides, morphological change and apoptosis and necrosis of cells were evaluated. Our results revealed that CAP and PAM with inducing selective effect, overcome the carboplatin resistance in human ovarian cancer. we found that there was a significant difference in the response of normal and cancer cells to CAP and PAM treatments. Our results showed that normal cells are more sensitive to CAP treatment. Thus, under CAP treatment, we found a further decrease in normal cell survival respect to PAM treatment. Given that the main difference between CAP and PAM methods is in the physical factors used in CAP treatment, it is expected that normal cells have been more sensitized than cancer cells to physical factors, such as the electric field and UV radiation. It is a promising finding because PAM can cover essential drawbacks of CAP treatment. Taken together, our data suggest that physical factors along with chemical factors have important role roles in the selective induction of CAP on ovarian cells.

Submitted for the SES20 Meeting of The American Physical Society Stimulation of granulosa cells v... more Submitted for the SES20 Meeting of The American Physical Society Stimulation of granulosa cells via non-thermal plasma and natural products MILAD RASOULI, NADIA FALLAH, OMOL BANIN PAKTINAT, ELAHEH AMINI, Kharazmi University-Steroidogenesis is a process which cholesterol is converted to biologically active steroid hormones. The role of steroid hormones from fetal life to adulthood regulate by a wide variety of developmental and physiological processes. Qualitative regulation determining the type of steroid to be produced is mediated by many enzymes and cofactors. Steroidogenic enzymes fall into two groups: cytochrome P45 (CYP) or HSD enzymes and hydroxysteroid dehydrogenases. Granulosa cells are responsible for estrogens synthesis and essential for the development and survival of oocyte. Non-thermal plasma is a cocktail of chemical and physical factors such as short-lived reactive species, long-lived reactive species, electromagnetic field, and ultraviolet radiation. Recently, plasma has attracted attention in various fields of medicine. Here, we examine for the first time the efficiency of plasma, Crocus sativus L., and Date palm pollen (DPP) on Granulosa cells which are important and necessary for ovarian steroidogenesis. Based on our observation, we expect plasma acts ac a steroidogenesis inducer agent.

Surface & Coatings Technology, 2009

This research has studied the effect of N2/(N2+Ar) flow rate ratio (F (N2)) on the microstructure... more This research has studied the effect of N2/(N2+Ar) flow rate ratio (F (N2)) on the microstructure and anticorrosive property of zirconium nitride (ZrN) films deposited on AISI stainless steel (SS) 304 substrates. ZrN films were deposited using ion beam sputtering technique and their corrosion resistance has been investigated via electrochemical test using 0.5 M H2SO4 solution. The thickness of the films

Plasma Processes and Polymers, 2021

Bulletin of the American Physical Society, 2020

Journal of Diabetes & Metabolic Disorders, 2021

Ever-increasing demands on improving efficiencies of wound healing procedures are a strong drivin... more Ever-increasing demands on improving efficiencies of wound healing procedures are a strong driving force for the development of replacement approaches. This review focuses on wound healing management from the point of formation to the point of healing procedures. The most important usual healing modality with key characteristic is explained and their limitations are discussed. Novel interesting approaches are presented with a concentration of the unique features and action mechanisms. Special attention is paid to gas plasma and nanotechnology impact on wound healing management from fundamental processes to beneficial outcomes. Challenges and opportunities for the future trend that combined common protocols and emerging technologies are discussed.

Ovarian cancer (OC) is associated with a high rate of resistance to most chemotherapy drugs and t... more Ovarian cancer (OC) is associated with a high rate of resistance to most chemotherapy drugs and thus novel therapies are crucial to overcoming these obstacles. The technological advances in nanotechnology make it possible to adapt these approaches for the treatment of chemo-resistant OC. In parallel, it is also evident that this emerging technology plays crucial roles in other medical areas including wound healing, treatment of viral infection and applications in dentistry. With the advancement of nanotechnology, nano dependent therapies are attractive viable alternatives to conventional therapies for various diseases, especially cancers. Nanoparticles (NPs) are a suitable platform for cytotoxic agent delivery and aiding early diagnosis of disease, which can lead to improving outcomes for these patients. Gas plasma oncotherapy is an innovative modality and shows huge potentials in cancer treatment and may emerge as the fifth cancer treatment modality together with surgery, radiother...

Cold atmospheric pressure plasma (CAP) is emerging as new healthcare technology and it has a high... more Cold atmospheric pressure plasma (CAP) is emerging as new healthcare technology and it has a high potential through physical and chemical effects for cancer treatment. Recently, CAP, plasma activated liquid (PAL), and nanomaterial have been significant advances in oncotherapy. Reactive oxygen-nitrogen species (RONS), electrical field, and other agents generated by CAP interact with cells and induce selective responses between the malignant and normal cells. Nanomedicine enhances therapeutic effectiveness and decreases the side effects of traditional treatments due to their target delivery and dispersion in tumor tissue. There are various nanocarriers (NCs) which based on their properties can be used for the delivery of different agents. The combination of gas plasma and nanomaterials technologies is a new multimodal treatment in cancer treatment, therefore, is expected that the conjunction of these technologies addresses many of the oncology challenges. This chapter provides a frame...

Vaccines

Rheumatoid arthritis (RA) is a chronic inflammatory joint disorder that causes systemic inflammat... more Rheumatoid arthritis (RA) is a chronic inflammatory joint disorder that causes systemic inflammation, autoimmunity, and joint abnormalities that result in permanent disability. Exosomes are nanosized extracellular particles found in mammals (40–100 nm). They are a transporter of lipids, proteins, and genetic material involved in mammalian cell–cell signaling, biological processes, and cell signaling. Exosomes have been identified as playing a role in rheumatoid arthritis-related joint inflammation (RA). Uniquely functioning extracellular vesicles (EVs) are responsible for the transport of autoantigens and mediators between distant cells. In addition, paracrine factors, such as exosomes, modulate the immunomodulatory function of mesenchymal stem cells (MSCs). In addition to transporting genetic information, exosomes convey miRNAs between cells and have been studied as drug delivery vehicles. In animal models, it has been observed that MSCs secrete EVs with immunomodulatory properties...

Pharmaceutical and Biomedical Research

Background: Primordial follicle includes an oocyte surrounded by a layer of somatic cells called ... more Background: Primordial follicle includes an oocyte surrounded by a layer of somatic cells called Granulosa Cells (GCs). GCs, also known as nurse cells, are an important protective element for the growth and survival of oocytes. Oocytes, which lack some of the metabolic processes, require granulosa cells for their development. Objectives: This manuscript was provided to explain the protocol of GCs primary culture extracted from NMRI mice ovaries. Methods: For choosing the optimum protocol, we used two methods with different culture mediums to obtain more GCs and expedite the process. Hematoxylin and Eosin (H&E) staining and flow cytometry were used to analyze the type of extracted cells from ovaries. Besides, we evaluated the effect of crocin and DPP as two common natural products in Iran on the proliferation of these cells via MTT assay. Results: Second protocol method and alpha-MEM culture medium were chosen based on the results. Our findings from HE staining and flow cytometry pro...

Bulletin of the American Physical Society, Mar 15, 2021

Scientific Reports

Sterilization of saffron packaging and maintaining the quality of saffron content are the main pr... more Sterilization of saffron packaging and maintaining the quality of saffron content are the main priorities in saffron preservation. Common modalities do not offer lasting saffron preservation and it is urgent to develop novel packaging approaches from renewable resources and prevent packaging waste. Here, simultaneous decontamination and quality maintenance of saffron is demonstrated, for the first time, through the synergistic application of nano-clay-loaded carboxymethyl cellulose (CMC)/polyvinyl alcohol (PVA) nanocomposites (CNCs) and cold plasmas (CP). Compared to the separate uses of CP and CMC/PVA/nano clay, our results confirm the synergies between CP and CMC/PVA/nano clay cause complete inactivation of Escherichia coli bacteria, while not significantly affecting the concentrations of the essential saffron components (safranal, crocin, and picrocrocin). Overall, the CP-treated CMC/PVA/nano clay fosters saffron preservation, through contamination removal and quality maintenance...

Scientific Reports

In this work, Sn and Ag doped PbS/PVA nanocomposites, in three different concentrations were succ... more In this work, Sn and Ag doped PbS/PVA nanocomposites, in three different concentrations were successfully prepared using the low-cost and simple method of chemical bath deposition (CBD). X-ray diffraction patterns confirmed the formation of the PbS cubic phase in all of the nanocomposites. FE-SEM images showed that PbS NPs are cubic in shape and the doping can alter the shape of grains. DLS analysis applied for solution NPs exhibited a 175 nm size distribution for PbS NPs and decreased by doping Ag and Sn to almost 100 nm and 110 nm, respectively. Optical absorption spectra showed the blue phenomena and the band gaps of Sn: PbS/PVA and Ag: PbS/PVA nanocomposites increased with adding Sn and Ag from 3.08 eV for pure PVA/PbS to 3.33 eV for Sn doped and 3.43 eV for Ag-doped samples. The nonlinear refractive index is decreased from 0.55 m2 W−1 for pure PVA/PbS to 0.11 m2 W−1 and 0.13 m2 W−1 for Sn and Ag-doped samples, respectively. Hence, doping Ag and Sn enhanced the optical sensitivi...

ECS Meeting Abstracts

As the photoanode material, TiO2 is the backbone of cost-effective dye-sensitized solar cells. He... more As the photoanode material, TiO2 is the backbone of cost-effective dye-sensitized solar cells. Herein, we propose a green, low-cost, and environmentally friendly synthesis method for titanium dioxide nanotubes using the anodizing process. The anodizing process was carried out in a chemical cell, and the effect of voltage and anodizing time on the creation of pure titanium dioxide nanotubes was investigated. A grade 4 titanium sheet with a thickness of 1 mm was utilized to make titanium oxide nanotubes. First, the titanium sheet was sliced into 1.5 × 1.5 cm squares, and the samples were sanded and polished with SiC sanding sheets ranging in grade from 180 to 3000. After that, the samples were immersed in an ultrasonic bath for 15 minutes to degrease and remove surface impurities in an equal amount of acetone-ethanol solution. A two-electrode cell was utilized for anodizing, with a graphite electrode as the cathode, a titanium sample as the anode, and an electrolyte solution containin...

ECS Meeting Abstracts

We used a three-step anodization procedure to produce titanium oxide (TiO2) nanotubes in order to... more We used a three-step anodization procedure to produce titanium oxide (TiO2) nanotubes in order to investigate the effects of varied electrolyte concentrations and anodization voltages on optical characteristics. Different electrolyte solution concentrations and anodization voltages altered wall thicknesses and tube diameters, according to our observations from the XRD pattern, TEM pictures, and optical examinations. While the band gap and band edge values of TiO2 nanotubes altered with different anodization voltages, the band gap, and band edge values remained constant. Furthermore, we discovered that at various electrolyte solution concentrations, the optimum solution concentration for growing compact TiO2 nanotubes is 70 percent porosity. Various morphologies of TiO2 nanostructures, such as sheet, rod, and tube, were obtained in the next section of the study by modifying the experimental settings (e.g., growth methods, differently used gases, and process temperatures). Titanium di...

ECS Meeting Abstracts

Over the last two decades, engineering the optical properties of nanoscale structures (nanowires,... more Over the last two decades, engineering the optical properties of nanoscale structures (nanowires, quantum dots, and nanotubes), i.e., band gap, absorption, and photoluminescence radiation, which can be manipulated in sulfide-based semiconductor materials, has received a lot of attention. Due to their tunable characteristics, these materials were introduced for potential applications ranging from medicine and communications to energy and various sensors (1). In addition, chemical synthesis methods provide the desired structure, material, reproducibility, and possibility of large-scale production, along with sustainable industrialization and foster innovation of these material systems. Polyvinyl-alcohol (PVA) is one of the functional polymers, in addition to the ability to stabilize the nanomaterial solution, which can change the optical properties of the material (2). Currently, the majority of sulfide-based nanomaterials are cadmium, lead, and silver, which have shown a wide range o...

Optical Materials Express

In this study, CdS, CuS, and Ag2S nanoparticles (NPs) were synthesized by a chemical bath procedu... more In this study, CdS, CuS, and Ag2S nanoparticles (NPs) were synthesized by a chemical bath procedure in the presence of polyvinyl alcohol (PVA) as a polymer stabilizer. Morphological studies followed by X-ray diffraction (XRD) and atomic force microscopy (AFM) revealed monolithic and small size NPs. The average crystalline size of CdS, Ag2S, and CuS nanocomposites was 18.1, 26.7, and 21.7 nm, respectively. UV-Vis absorption and photoluminescence (PL) spectra of samples showed a near-infrared region (NIR) emission peak for CuS. The bandgap of samples measured using absorption data was 3.48, 2.75, and 2.30 eV for CdS, Ag2S, and CuS NPs, respectively. Nonlinear optical properties, including nonlinear refractive index and nonlinear absorption of the NPs, were measured by the Z-scan technique under a 632.8 nm wavelength He-Ne CW laser. PVA/Ag2S nanocomposite displayed reverse saturable absorbance (RSA) and self-focusing, while PVA/CdS and PVA/CuS displayed saturable absorbance and self-de...

Environmental Science and Pollution Research, 2022

2020 IEEE International Conference on Plasma Science (ICOPS), 2020

2020 IEEE International Conference on Plasma Science (ICOPS), 2020

Here, we investigate the effect of CAP and PAM on the proliferation and apoptosis of carboplatin-... more Here, we investigate the effect of CAP and PAM on the proliferation and apoptosis of carboplatin-resistant SKOV-3 and GCS normal ovarian cells. We cultured GCS cells and the carboplatin-resistant SKOV-3 cells in vitro until the exponential growth phase and then treated with the different exposure time of CAP and PAM. We performed MTT assay to determine the proliferation of ovarian cells. Besides, morphological change and apoptosis and necrosis of cells were evaluated. Our results revealed that CAP and PAM with inducing selective effect, overcome the carboplatin resistance in human ovarian cancer. we found that there was a significant difference in the response of normal and cancer cells to CAP and PAM treatments. Our results showed that normal cells are more sensitive to CAP treatment. Thus, under CAP treatment, we found a further decrease in normal cell survival respect to PAM treatment. Given that the main difference between CAP and PAM methods is in the physical factors used in CAP treatment, it is expected that normal cells have been more sensitized than cancer cells to physical factors, such as the electric field and UV radiation. It is a promising finding because PAM can cover essential drawbacks of CAP treatment. Taken together, our data suggest that physical factors along with chemical factors have important role roles in the selective induction of CAP on ovarian cells.

Submitted for the SES20 Meeting of The American Physical Society Stimulation of granulosa cells v... more Submitted for the SES20 Meeting of The American Physical Society Stimulation of granulosa cells via non-thermal plasma and natural products MILAD RASOULI, NADIA FALLAH, OMOL BANIN PAKTINAT, ELAHEH AMINI, Kharazmi University-Steroidogenesis is a process which cholesterol is converted to biologically active steroid hormones. The role of steroid hormones from fetal life to adulthood regulate by a wide variety of developmental and physiological processes. Qualitative regulation determining the type of steroid to be produced is mediated by many enzymes and cofactors. Steroidogenic enzymes fall into two groups: cytochrome P45 (CYP) or HSD enzymes and hydroxysteroid dehydrogenases. Granulosa cells are responsible for estrogens synthesis and essential for the development and survival of oocyte. Non-thermal plasma is a cocktail of chemical and physical factors such as short-lived reactive species, long-lived reactive species, electromagnetic field, and ultraviolet radiation. Recently, plasma has attracted attention in various fields of medicine. Here, we examine for the first time the efficiency of plasma, Crocus sativus L., and Date palm pollen (DPP) on Granulosa cells which are important and necessary for ovarian steroidogenesis. Based on our observation, we expect plasma acts ac a steroidogenesis inducer agent.

Surface & Coatings Technology, 2009

This research has studied the effect of N2/(N2+Ar) flow rate ratio (F (N2)) on the microstructure... more This research has studied the effect of N2/(N2+Ar) flow rate ratio (F (N2)) on the microstructure and anticorrosive property of zirconium nitride (ZrN) films deposited on AISI stainless steel (SS) 304 substrates. ZrN films were deposited using ion beam sputtering technique and their corrosion resistance has been investigated via electrochemical test using 0.5 M H2SO4 solution. The thickness of the films

Plasma Processes and Polymers, 2021

Bulletin of the American Physical Society, 2020

Journal of Diabetes & Metabolic Disorders, 2021

Ever-increasing demands on improving efficiencies of wound healing procedures are a strong drivin... more Ever-increasing demands on improving efficiencies of wound healing procedures are a strong driving force for the development of replacement approaches. This review focuses on wound healing management from the point of formation to the point of healing procedures. The most important usual healing modality with key characteristic is explained and their limitations are discussed. Novel interesting approaches are presented with a concentration of the unique features and action mechanisms. Special attention is paid to gas plasma and nanotechnology impact on wound healing management from fundamental processes to beneficial outcomes. Challenges and opportunities for the future trend that combined common protocols and emerging technologies are discussed.

Ovarian cancer (OC) is associated with a high rate of resistance to most chemotherapy drugs and t... more Ovarian cancer (OC) is associated with a high rate of resistance to most chemotherapy drugs and thus novel therapies are crucial to overcoming these obstacles. The technological advances in nanotechnology make it possible to adapt these approaches for the treatment of chemo-resistant OC. In parallel, it is also evident that this emerging technology plays crucial roles in other medical areas including wound healing, treatment of viral infection and applications in dentistry. With the advancement of nanotechnology, nano dependent therapies are attractive viable alternatives to conventional therapies for various diseases, especially cancers. Nanoparticles (NPs) are a suitable platform for cytotoxic agent delivery and aiding early diagnosis of disease, which can lead to improving outcomes for these patients. Gas plasma oncotherapy is an innovative modality and shows huge potentials in cancer treatment and may emerge as the fifth cancer treatment modality together with surgery, radiother...

Cold atmospheric pressure plasma (CAP) is emerging as new healthcare technology and it has a high... more Cold atmospheric pressure plasma (CAP) is emerging as new healthcare technology and it has a high potential through physical and chemical effects for cancer treatment. Recently, CAP, plasma activated liquid (PAL), and nanomaterial have been significant advances in oncotherapy. Reactive oxygen-nitrogen species (RONS), electrical field, and other agents generated by CAP interact with cells and induce selective responses between the malignant and normal cells. Nanomedicine enhances therapeutic effectiveness and decreases the side effects of traditional treatments due to their target delivery and dispersion in tumor tissue. There are various nanocarriers (NCs) which based on their properties can be used for the delivery of different agents. The combination of gas plasma and nanomaterials technologies is a new multimodal treatment in cancer treatment, therefore, is expected that the conjunction of these technologies addresses many of the oncology challenges. This chapter provides a frame...