Phoebe Magdy | National Research Center of Egypt (original) (raw)
Papers by Phoebe Magdy
Hemoglobin, 2017
Thalassemia is a disorder of hemoglobin (Hb) synthesis characterized by chronic hemolysis. In b-t... more Thalassemia is a disorder of hemoglobin (Hb) synthesis characterized by chronic hemolysis. In b-thalassemias major (b-TM), patients require regular transfusion at an early age due to severe anemia. Subsequently, intensive chelation therapy is initiated to mitigate the effects of the resultant iron overload. Clinical disease burden and the demanding treatment can affect health-related quality of life (HRQoL) outcomes in this population. The aim of this study was to assess HRQoL outcomes in Egyptian pediatric thalassemia patients. Patients were enrolled simultaneously from the hematology clinic at the National Research Institute in Cairo, Egypt. The Arabic version of SF36 tool was used to assess HRQoL outcomes. Socioeconomic data were collected by patient and parent interviews. Clinical data were collected by review of medical records. One hundred and thirty patients and 60 controls were enrolled, with a mean age of 5.4 ± 3.2 years and 6.3 ± 3.0, respectively. The HRQoL outcome scores were lower in all domains in the thalassemia group compared to the control group (p ¼ 0.0001). Transfusion-dependent (TD) patients had lower HRQoL scores compared to nontransfusion-dependent (NTD) patients (p ¼ 0.0001). Patient education and maternal education were independently associated with better HRQoL scores (p ¼ 0.007, p ¼ 0.028, respectively). Residents of rural areas reported lower scores compared to urban residents (p ¼ 0.026). Thalassemia was associated with lower HRQoL scores, in all domains, compared to HRQoL in unaffected controls. Chronic transfusion independence, patient education, and maternal education were all associated with higher HRQoL scores. Psychological, social, and economic support for families with thalassemia are all essential tools to improve HRQoL outcomes.
The Middle East Journal of Medical Genetics (Online), 2022
Background: Bone marrow failure syndromes are a group of diseases that could be inherited as cong... more Background: Bone marrow failure syndromes are a group of diseases that could be inherited as congenital or acquired aplastic anemia. Fanconi anemia (FA) is the commonest cause of congenital aplastic anemia. Aim: This study reports patients with congenital aplastic anemia aiming to reveal the clinical and cytogenetic differences between the two groups, (non-Fanconi and Fanconi anemia) also to compare between patients included in this study with those from different ethnic populations. Patients and Methods: 204 patients with aplastic anemia were included (101 non-Fanconi and 103 Fanconi). Induction of chromosomal breakage by DEB was done to all patients to confirm the diagnosis of FA and to determine the degree of chromosomal breakage. Results: Mean age of non-FA and FA patients was 10 ± 4.24 and 9 ± 4.61 years respectively with high consanguinity rate (65% 79% respectively). 24.7% of non-FA patients exhibited very severe aplastic anemia, while the majority (72.2%) exhibited severe aplastic anemia. Few patients (1.9%) had non-severe form. While, in FA patients, very severe aplastic anemia was present in 10.6%; 84.4% had severe form and 4.8 % had non-severe form. These results were significant between the two groups (p=0.02). 12.6% of FA patients showed mosaic DEB results. Comparing FA cases with one cell line and those with two cell lines regarding patients' percentiles, hematological abnormalities and degree of severity revealed no significant difference. Conclusion: This study reports a large number of Egyptian patients diagnosed as congenital aplastic anemia with relatively high number of FA patients due to higher rate of consanguinity in Egypt. FA accounts for a significant percentage of congenital aplastic anemia and should be ruled out stressing on congenital anomalies and hematologic findings. Further evaluation of patients who share similar phenotypes and genetic studies are highly recommended to identify the dominant FA types in Egypt.
Journal of the International Academy of Periodontology, Oct 1, 2018
The success of any surgical procedure is predominately influenced by the pattern of its wound hea... more The success of any surgical procedure is predominately influenced by the pattern of its wound healing. The objective of the present study was to assess gingival crevicular fluid (GCF) and serum matrix metalloproteinase-8 (MMP-8) levels during the early healing phase of root coverage procedures. MMP-8 levels on days four and seven were correlated with the wound healing index (WHI) to evaluate the presence of MMP-8 during early post-surgical wound healing after root coverage procedures. Fifteen isolated maxillary Miller's Class I/Class II recession defects in systemically and periodontally healthy patients in the age range of 25 - 57 years were treated with coronally advanced flap and sub-epithelial connective tissue graft (CAF + SCTG). GCF and serum samples were collected at baseline, day four, day seven and six months after surgery from the gingival sulcus of the recession defect. A contralateral tooth with clinically healthy gingiva was used as control and samples were collecte...
Journal of the International Academy of Periodontology, 2018
BACKGROUND AND OBJECTIVES The success of any surgical procedure is predominately influenced by th... more BACKGROUND AND OBJECTIVES The success of any surgical procedure is predominately influenced by the pattern of its wound healing. The objective of the present study was to assess gingival crevicular fluid (GCF) and serum matrix metalloproteinase-8 (MMP-8) levels during the early healing phase of root coverage procedures. MMP-8 levels on days four and seven were correlated with the wound healing index (WHI) to evaluate the presence of MMP-8 during early post-surgical wound healing after root coverage procedures. MATERIALS AND METHODS Fifteen isolated maxillary Miller's Class I/Class II recession defects in systemically and periodontally healthy patients in the age range of 25 - 57 years were treated with coronally advanced flap and sub-epithelial connective tissue graft (CAF + SCTG). GCF and serum samples were collected at baseline, day four, day seven and six months after surgery from the gingival sulcus of the recession defect. A contralateral tooth with clinically healthy gingi...
Journal of Child Science
Prader–Willi syndrome (PWS) is the commonest genetic cause of obesity. Oxidative stress and chron... more Prader–Willi syndrome (PWS) is the commonest genetic cause of obesity. Oxidative stress and chronic low-grade inflammation play a crucial role in the pathogenesis of obesity. Alterations of vitamin D (25-OHD) levels are commonly encountered with obesity. The aim of this study was to analyze serum chemerin, oxidized low-density lipoprotein (ox-LDL), and 25-OHD values in pediatric PWS patients in comparison with obese healthy children and nonobese control groups, highlighting possible correlations with body mass index (BMI) and obesity. Twenty-six PWS Egyptian patients and 26 obese healthy individuals referred to the outpatient clinic of the Clinical Genetics Department, National Research Centre, Cairo, Egypt, and 20 control patients with matching age and sex were enrolled in the study. Patients were clinically diagnosed and confirmed by routine cytogenetic and fluorescence in-situ hybridization analysis. Anthropometric measurements were performed, and BMI was calculated by weight/hei...
Journal of prosthodontics : official journal of the American College of Prosthodontists, Jan 16, 2017
To evaluate the clinical and radiographic outcomes following the application of autogenous bone (... more To evaluate the clinical and radiographic outcomes following the application of autogenous bone (ABG)/melatonin composite graft around immediate implants in the esthetic zone compared to ABG alone. Twenty-six patients with two nonrestorable anterior/premolar teeth were randomly classified into two equal groups. Dental implants were immediately inserted either with ABG (control group) or ABG/melatonin (test group). Outcome measures were peri-implant sulcus depth (PD), gingival index (GI), and wound healing scores. Cone beam computed tomography (CBCT) was recorded at baseline, 6, and 9 months. At the end of the study, a significant difference was shown in the mean of marginal bone loss between the control group (1.91 mm ± 0.42) and the test group (0.84 mm ± 0.34) at p = 0.0001. The test group showed a significant gain in bone density, 500.73 ± 40.92, versus 420.14 ± 38.33 in the control group (p = 0.0001). There was a statistically significant difference between the control group (0.6...
Hemoglobin, 2017
Thalassemia is a disorder of hemoglobin (Hb) synthesis characterized by chronic hemolysis. In β-t... more Thalassemia is a disorder of hemoglobin (Hb) synthesis characterized by chronic hemolysis. In β-thalassemias major (β-TM), patients require regular transfusion at an early age due to severe anemia. Subsequently, intensive chelation therapy is initiated to mitigate the effects of the resultant iron overload. Clinical disease burden and the demanding treatment can affect health-related quality of life (HRQoL) outcomes in this population. The aim of this study was to assess HRQoL outcomes in Egyptian pediatric thalassemia patients. Patients were enrolled simultaneously from the hematology clinic at the National Research Institute in Cairo, Egypt. The Arabic version of SF36 tool was used to assess HRQoL outcomes. Socioeconomic data were collected by patient and parent interviews. Clinical data were collected by review of medical records. One hundred and thirty patients and 60 controls were enrolled, with a mean age of 5.4 ± 3.2 years and 6.3 ± 3.0, respectively. The HRQoL outcome scores...
Hemoglobin, 2017
Thalassemia is a disorder of hemoglobin (Hb) synthesis characterized by chronic hemolysis. In b-t... more Thalassemia is a disorder of hemoglobin (Hb) synthesis characterized by chronic hemolysis. In b-thalassemias major (b-TM), patients require regular transfusion at an early age due to severe anemia. Subsequently, intensive chelation therapy is initiated to mitigate the effects of the resultant iron overload. Clinical disease burden and the demanding treatment can affect health-related quality of life (HRQoL) outcomes in this population. The aim of this study was to assess HRQoL outcomes in Egyptian pediatric thalassemia patients. Patients were enrolled simultaneously from the hematology clinic at the National Research Institute in Cairo, Egypt. The Arabic version of SF36 tool was used to assess HRQoL outcomes. Socioeconomic data were collected by patient and parent interviews. Clinical data were collected by review of medical records. One hundred and thirty patients and 60 controls were enrolled, with a mean age of 5.4 ± 3.2 years and 6.3 ± 3.0, respectively. The HRQoL outcome scores were lower in all domains in the thalassemia group compared to the control group (p ¼ 0.0001). Transfusion-dependent (TD) patients had lower HRQoL scores compared to nontransfusion-dependent (NTD) patients (p ¼ 0.0001). Patient education and maternal education were independently associated with better HRQoL scores (p ¼ 0.007, p ¼ 0.028, respectively). Residents of rural areas reported lower scores compared to urban residents (p ¼ 0.026). Thalassemia was associated with lower HRQoL scores, in all domains, compared to HRQoL in unaffected controls. Chronic transfusion independence, patient education, and maternal education were all associated with higher HRQoL scores. Psychological, social, and economic support for families with thalassemia are all essential tools to improve HRQoL outcomes.
The Middle East Journal of Medical Genetics (Online), 2022
Background: Bone marrow failure syndromes are a group of diseases that could be inherited as cong... more Background: Bone marrow failure syndromes are a group of diseases that could be inherited as congenital or acquired aplastic anemia. Fanconi anemia (FA) is the commonest cause of congenital aplastic anemia. Aim: This study reports patients with congenital aplastic anemia aiming to reveal the clinical and cytogenetic differences between the two groups, (non-Fanconi and Fanconi anemia) also to compare between patients included in this study with those from different ethnic populations. Patients and Methods: 204 patients with aplastic anemia were included (101 non-Fanconi and 103 Fanconi). Induction of chromosomal breakage by DEB was done to all patients to confirm the diagnosis of FA and to determine the degree of chromosomal breakage. Results: Mean age of non-FA and FA patients was 10 ± 4.24 and 9 ± 4.61 years respectively with high consanguinity rate (65% 79% respectively). 24.7% of non-FA patients exhibited very severe aplastic anemia, while the majority (72.2%) exhibited severe aplastic anemia. Few patients (1.9%) had non-severe form. While, in FA patients, very severe aplastic anemia was present in 10.6%; 84.4% had severe form and 4.8 % had non-severe form. These results were significant between the two groups (p=0.02). 12.6% of FA patients showed mosaic DEB results. Comparing FA cases with one cell line and those with two cell lines regarding patients' percentiles, hematological abnormalities and degree of severity revealed no significant difference. Conclusion: This study reports a large number of Egyptian patients diagnosed as congenital aplastic anemia with relatively high number of FA patients due to higher rate of consanguinity in Egypt. FA accounts for a significant percentage of congenital aplastic anemia and should be ruled out stressing on congenital anomalies and hematologic findings. Further evaluation of patients who share similar phenotypes and genetic studies are highly recommended to identify the dominant FA types in Egypt.
Journal of the International Academy of Periodontology, Oct 1, 2018
The success of any surgical procedure is predominately influenced by the pattern of its wound hea... more The success of any surgical procedure is predominately influenced by the pattern of its wound healing. The objective of the present study was to assess gingival crevicular fluid (GCF) and serum matrix metalloproteinase-8 (MMP-8) levels during the early healing phase of root coverage procedures. MMP-8 levels on days four and seven were correlated with the wound healing index (WHI) to evaluate the presence of MMP-8 during early post-surgical wound healing after root coverage procedures. Fifteen isolated maxillary Miller's Class I/Class II recession defects in systemically and periodontally healthy patients in the age range of 25 - 57 years were treated with coronally advanced flap and sub-epithelial connective tissue graft (CAF + SCTG). GCF and serum samples were collected at baseline, day four, day seven and six months after surgery from the gingival sulcus of the recession defect. A contralateral tooth with clinically healthy gingiva was used as control and samples were collecte...
Journal of the International Academy of Periodontology, 2018
BACKGROUND AND OBJECTIVES The success of any surgical procedure is predominately influenced by th... more BACKGROUND AND OBJECTIVES The success of any surgical procedure is predominately influenced by the pattern of its wound healing. The objective of the present study was to assess gingival crevicular fluid (GCF) and serum matrix metalloproteinase-8 (MMP-8) levels during the early healing phase of root coverage procedures. MMP-8 levels on days four and seven were correlated with the wound healing index (WHI) to evaluate the presence of MMP-8 during early post-surgical wound healing after root coverage procedures. MATERIALS AND METHODS Fifteen isolated maxillary Miller's Class I/Class II recession defects in systemically and periodontally healthy patients in the age range of 25 - 57 years were treated with coronally advanced flap and sub-epithelial connective tissue graft (CAF + SCTG). GCF and serum samples were collected at baseline, day four, day seven and six months after surgery from the gingival sulcus of the recession defect. A contralateral tooth with clinically healthy gingi...
Journal of Child Science
Prader–Willi syndrome (PWS) is the commonest genetic cause of obesity. Oxidative stress and chron... more Prader–Willi syndrome (PWS) is the commonest genetic cause of obesity. Oxidative stress and chronic low-grade inflammation play a crucial role in the pathogenesis of obesity. Alterations of vitamin D (25-OHD) levels are commonly encountered with obesity. The aim of this study was to analyze serum chemerin, oxidized low-density lipoprotein (ox-LDL), and 25-OHD values in pediatric PWS patients in comparison with obese healthy children and nonobese control groups, highlighting possible correlations with body mass index (BMI) and obesity. Twenty-six PWS Egyptian patients and 26 obese healthy individuals referred to the outpatient clinic of the Clinical Genetics Department, National Research Centre, Cairo, Egypt, and 20 control patients with matching age and sex were enrolled in the study. Patients were clinically diagnosed and confirmed by routine cytogenetic and fluorescence in-situ hybridization analysis. Anthropometric measurements were performed, and BMI was calculated by weight/hei...
Journal of prosthodontics : official journal of the American College of Prosthodontists, Jan 16, 2017
To evaluate the clinical and radiographic outcomes following the application of autogenous bone (... more To evaluate the clinical and radiographic outcomes following the application of autogenous bone (ABG)/melatonin composite graft around immediate implants in the esthetic zone compared to ABG alone. Twenty-six patients with two nonrestorable anterior/premolar teeth were randomly classified into two equal groups. Dental implants were immediately inserted either with ABG (control group) or ABG/melatonin (test group). Outcome measures were peri-implant sulcus depth (PD), gingival index (GI), and wound healing scores. Cone beam computed tomography (CBCT) was recorded at baseline, 6, and 9 months. At the end of the study, a significant difference was shown in the mean of marginal bone loss between the control group (1.91 mm ± 0.42) and the test group (0.84 mm ± 0.34) at p = 0.0001. The test group showed a significant gain in bone density, 500.73 ± 40.92, versus 420.14 ± 38.33 in the control group (p = 0.0001). There was a statistically significant difference between the control group (0.6...
Hemoglobin, 2017
Thalassemia is a disorder of hemoglobin (Hb) synthesis characterized by chronic hemolysis. In β-t... more Thalassemia is a disorder of hemoglobin (Hb) synthesis characterized by chronic hemolysis. In β-thalassemias major (β-TM), patients require regular transfusion at an early age due to severe anemia. Subsequently, intensive chelation therapy is initiated to mitigate the effects of the resultant iron overload. Clinical disease burden and the demanding treatment can affect health-related quality of life (HRQoL) outcomes in this population. The aim of this study was to assess HRQoL outcomes in Egyptian pediatric thalassemia patients. Patients were enrolled simultaneously from the hematology clinic at the National Research Institute in Cairo, Egypt. The Arabic version of SF36 tool was used to assess HRQoL outcomes. Socioeconomic data were collected by patient and parent interviews. Clinical data were collected by review of medical records. One hundred and thirty patients and 60 controls were enrolled, with a mean age of 5.4 ± 3.2 years and 6.3 ± 3.0, respectively. The HRQoL outcome scores...