Paul Ndom | Yaoundé - Academia.edu (original) (raw)
Papers by Paul Ndom
Genes and Immunity, May 20, 2019
Several studies published to date report associations between human leukocyte antigen (HLA) allel... more Several studies published to date report associations between human leukocyte antigen (HLA) alleles and different types of Kaposi's Sarcoma (KS). However, there is little concordance between the HLA alleles identified and the populations studied. To test whether HLA alleles associate with KS in a Cameroonian case-control study, we performed high-resolution HLA typing in KSHV seropositive individuals. Among HIV-positive individuals, carriers of HLA-B*14:01 were at a significantly higher risk of AIDS-KS (p = 0.033). For HIV-negative patients, a gene-wise comparison of allele frequencies identified the HLA-B (p = 0.008) and-DQA1 (p = 0.002) loci as possible risk factors for endemic KS. Our study provides additional understanding of genetic determinants of KS and their implications in disease pathogenesis. Further validation of these findings is needed to define the functional relevance of these associations.
International Journal of Cancer, Jun 15, 2022
In sub-Saharan Africa, Kaposi’s sarcoma-associated herpesvirus (KSHV) is endemic, and Kaposi’s sa... more In sub-Saharan Africa, Kaposi’s sarcoma-associated herpesvirus (KSHV) is endemic, and Kaposi’s sarcoma (KS) is a significant public health problem. Until recently, KSHV genotype analysis was performed using variable gene regions, representing a small fraction of the genome, and thus the contribution of sequence variation to viral transmission or pathogenesis are understudied. We performed near full-length KSHV genome sequence analysis on samples from 43 individuals selected from a large Cameroonian KS case-control study. KSHV genomes were obtained from 21 KS patients and 22 control participants. Phylogenetic analysis of the K1 region indicated the majority of sequences were A5 or B1 subtypes and all three K15 alleles were represented. Unique polymorphisms in the KSHV genome were observed including large gene deletions. We found evidence of multiple distinct KSHV genotypes in three individuals. Additionally, our analyses indicate that recombination is prevalent suggesting that multiple KSHV infections may not be uncommon overall. Most importantly, a detailed analysis of KSHV genomes from KS patients and control participants did not find a correlation between viral sequence variations and disease. Our study is the first to systematically compare near full-length KSHV genome sequences between KS cases and controls in the same endemic region to identify possible sequence variations associated with disease risk.
The Breast, Jun 1, 2012
Hepatocellular carcinoma is a common cancer in Africa. The risk factors are well known and avoida... more Hepatocellular carcinoma is a common cancer in Africa. The risk factors are well known and avoidable in most cases (hepatitis B, hepatitis C, aflatoxin and alcohol). Vaccination against hepatitis B and the fight against aflatoxin are efficient contributions to the fight against liver cancer. The costly nature of these measures in Africa is an impediment to the fight against liver cancer in Africa.
PAMJ clinical medicine, 2023
HEALTH SCIENCES AND DISEASES, Feb 29, 2016
Réponse hématologique chez les patients atteints de leucémie myéloïde chronique sous imatinib Che... more Réponse hématologique chez les patients atteints de leucémie myéloïde chronique sous imatinib Chetcha et al _____________________________________________________________________________________________
Background Childhood cancer is the sixth leading cause of global cancer burden. Indeed, 90% of ch... more Background Childhood cancer is the sixth leading cause of global cancer burden. Indeed, 90% of childhood cancer cases occur in low-middle-income countries (LMICs), where mortality can be 4-5 times higher than in high income settings. In addition, many LMICs lack data on pediatric oncology for policy development and resource prioritization. In this paper, we describe the state of pediatric cancer care and treatment in Cameroon. Procedure We conducted cross-sectional survey in July 2020, which enabled us to collect data from two hospitals providing pediatric oncology services in Cameroon. We collected data on service availability, human resource capacity, frequent cancer types, treatment dropout, primary reasons for drop out, disclosure of status, and management of oncology data. Result The surveyed hospitals offered both pediatric chemotherapy and palliative care services; however, none offered nuclear medicine or radiotherapy services. In terms of workforce, human resources were gro...
Cancer Epidemiology, Biomarkers & Prevention
Background: The Nigerian Breast Cancer Study (NBCS) model is a new risk assessment tool developed... more Background: The Nigerian Breast Cancer Study (NBCS) model is a new risk assessment tool developed for predicting risk of invasive breast cancer in Nigeria. Its applicability outside of Nigeria remains uncertain as it has not been validated in other sub-Saharan Africa populations. Methods: We conducted a case–control study among women with breast cancer and controls ascertained in Cameroon and Uganda from 2011 to 2016. Structured questionnaire interviews were performed to collect risk factor characteristics. The NBCS model, the Gail model, the Gail model for Black population, and the Black Women's Health Study model were applied to the Cameroon and Uganda samples separately. Nigerian as well as local incidence rates were incorporated into the models. Receiver-Operating Characteristic analyses were performed to indicate discriminating capacity. Results: The study included 550 cases (mean age 46.8 ± 11.9) and 509 controls (mean age 46.3 ± 11.7). Compared with the other three models...
HEALTH SCIENCES AND DISEASES, Jun 30, 2021
Rôle du Programme National de Lutte contre le Cancer dans l'élaboration de politiques saines et l... more Rôle du Programme National de Lutte contre le Cancer dans l'élaboration de politiques saines et la création d'environnements favorables à la prévention du cancer au Cameroun (2004-2019
Cancer Research, 2021
Background: Women of African ancestry across the diaspora have low risk of developing breast canc... more Background: Women of African ancestry across the diaspora have low risk of developing breast cancer compared to women of European ancestry. However, they suffer the highest mortality rates because of the disproportionate burden of young onset aggressive hormone receptor negative breast cancer. To implement strategies for early detection and prevention, it is critically important to develop better risk assessment tools. The Nigerian Breast Cancer Study (NBCS) model is a new risk assessment tool developed for the individual estimation of absolute risk of invasive breast cancer in Nigeria. Its applicability outside of Nigeria remains uncertain as it has not been validated in other Sub-Sahara African (SSA) populations. Methods: We conducted a case-control study among women with breast cancer and controls ascertained in Cameroon and Uganda from 2011 to 2016. Structured questionnaire interviews were performed to collect demographic and reproductive characteristics. The NBCS model, the Gai...
Introduction : La douleur represente l’un des symptomes les plus frequents chez les patients canc... more Introduction : La douleur represente l’un des symptomes les plus frequents chez les patients cancereux, sa prevalence est estimee a 80% et sa prise en charge au cours de la maladie cancereuse demeure un enjeu important. Le but ce travail etait de determiner les caracteristiques de la douleur cancereuse et d’en evaluer la prise en charge.Materiels et methodes : Il s’est agi d’une etude descriptive menee du 4 Janvier au 30 Avril 2017, nous avons inclus tout patient douloureux ayant un diagnostic anatomopathologique de cancer et ayant beneficie d’une prise en charge de la douleur. L’efficacite du traitement etait evaluee a l’aide de l’index de Cleeland et de facon subjective par les echelles d’evaluation de douleur. L’analyse des donnees a ete faite a partir du logiciel SPSS version 20.Resultats : Au total 166 patients ont ete inclus. La prevalence de la douleur etait de 76,2% (n= 166). La tumeur representait la principale cause de la douleur (94,6%). La prise en charge de la douleur d...
Background: The incidence of cancers is increasing worldwide, particularly in the developing coun... more Background: The incidence of cancers is increasing worldwide, particularly in the developing countries as shown by recent cancer stastics from the WHO. It is even anticipated that with the increase in life expentancy, consequent upon inproved standard of living and globalization, the burden of cancers will increase within this millenium. With respective to cancer of the prostate, it is the most common type of cancer in urology. In developing countries, diagnostic is done at a late stage of evolution. In Cameroon, data on prostate cancer are scanty whereas the incidence of this disease is increasing. Objective: This article is designed to describe the epidemiological features of prostate cancer at the General Hospital of YaoundA©. Patients and methods: A 4-year retrospective study of patients seen with the diagnosis of cancer at the Medical Oncology unit of the YaoundA© General Hospital between January 2012 and December 2015. The demographic pattern (age of patients, socio profession...
HEALTH SCIENCES AND DISEASES, 2020
RESUME Contexte. Les standards, options et recommandations pour la conduite a tenir devant une le... more RESUME Contexte. Les standards, options et recommandations pour la conduite a tenir devant une lesion de diagnostic anatomo-cytopathologique preconisent la mise a disposition par les cliniciens de renseignements cliniques les plus exhaustifs possible pour un plein accomplissement du travail du pathologiste, contribuant a minimiser les erreurs. Cet aspect a retenu notre attention et nous a menes a la realisation de cette etude sur le niveau de renseignement des fiches cliniques adressees au service d’anatomie pathologique. Materiels et methodes . Notre etude etait transversale et portait sur 500 bulletins d’examens recus et colliges de facon aleatoire de 2016 a 2017. La retranscription s’est faite par une grille d’observation portant sur l’identification, la nature de l’examen, la provenance et les caracteristiques cliniques. Resultats. Les examens comportaient 63,8% d’histologie, et 36,2% de cytologie. Les hopitaux de 1ere categorie etaient les premiers demandeurs d’examens avec 73,...
Pan African Medical Journal, 2011
Management of cancer patients in low-resource communities presents enormous challenges. Breast ca... more Management of cancer patients in low-resource communities presents enormous challenges. Breast cancer is a public health problem in Cameroon and occurs mostly in elderly women. The predominant histological type is a duct carcinoma. Lobular carcinoma in teenagers is rare. In this report we present a case of bilateral invasive lobular carcinoma of the breast that was confirmed on biopsies in a 22-year-old female. We present this rare finding and review the pathological, clinical and radiographic challenges of the disease. Nodules in the breast from patients of any age should be submitted for histology. Public education is beneficial and should be intensified.
Advances in breast cancer research, 2015
This study aimed to estimate the survival rate of breast cancer in a group of patients followed u... more This study aimed to estimate the survival rate of breast cancer in a group of patients followed up at the Yaoundé General Hospital in Cameroon. A retrospective review of records of patients managed for breast cancer between 1995 and 2007 was carried out at the Yaoundé General Hospital. Survival analysis was carried out with survival defined as the time between the date of unequivocal diagnosis of cancer and the date of last follow-up or death. Survival curves were plotted in R.3.1.1 software. Mean age of the patients was 47.5 ± 12.36 years. Most of the patients (67.9%) presented with advanced breast cancer disease (stage III and IV). Overall patient survival rate was 30% at 5 years and 13.2% at 10 years. Median overall survival time was 2 (1.9-3) years. There was a correlation between survival and the stage of disease. The highest survival rates were recorded in stages I and II while the lowest rates were recorded in stage IV. There was no statistically significant difference in survival among the age groups (p = 0.15). Overall survival rates of breast cancer are 30% at 5 years and 13.2% at 10 years among Cameroonian patients and are lower compared with 90% and 82% respectively at 5 years and 10 years in some developed countries.
HEALTH SCIENCES AND DISEASES, Aug 17, 2015
Décrire certains marqueurs de la réponse immunitaire au cours du sarcome de Kaposi (SK). MATÉRIEL... more Décrire certains marqueurs de la réponse immunitaire au cours du sarcome de Kaposi (SK). MATÉRIEL ET MÉTHODES : Etude descriptive dans le Service d'Oncologie Médicale de l'Hôpital Général de Yaoundé, constituée de patients présentant un SK et naïfs de tout traitement anticancéreux. Les taux sanguins des LTCD4 + , IgG anti-HHV8, et des cytokines inflammatoires IL-6 et IL-10, ont été mesurés et leurs valeurs corrélées avec les données démographiques et cliniques des patients. RÉSULTATS : Sur les 52 patients retenus, 61.5% étaient de sexe masculin. La moyenne d'âge était de 42.27±11.48 ans. L'association du SK à l'infection à VIH a été retrouvée, divisant notre échantillon en deux groupes : celui présentant le SK épidémique (SK+VIH) à 90.4%, et celui avec un SK endémique à 9.6%. 50% d'atteinte exclusive des membres inférieurs a été observée, avec les macules comme lésion cutanée majoritaire. La recherche en IgG a été positive chez 92.3% des patients, avec une valeur médiane de 3.12UI. Le taux médian de LTCD4 + a été de 170cellules/mm 3 , avec 79% des patients immunodéprimés. Seul le SK endémique a eu des patients immunocompétents. La valeur médiane des taux d'IL-6 a été de 2.05g/ml, et celle d'IL-10 de 3.08g/ml, avec respectivement 54 et 56% des patients présentant des valeurs anormales. Les valeurs anormales d'Il-6 ont été associées à l'âge avancé, à la présence de l'infection à VIH et à la prise des ARV. CONCLUSION : La réponse immunitaire au cours du SK, au sein de notre échantillon, se traduit par la présence des taux anormaux des cytokines IL-6 et IL-10, la présence des IgG anti-HHV8 et les taux bas de LTCD4 + .
Pan African Medical Journal
Journal of Cancer Therapy
Background: The world of cancer care is an emotional place, given the severity of the disease bei... more Background: The world of cancer care is an emotional place, given the severity of the disease being treated, the heavy workload, the suffering of patients, and the high number of deaths. The nursing staff who work there may be exposed to constant stress from these factors. This study aimed to explore the psychological experience of the nursing staff of the Medical Oncology Department of the Yaoundé General Hospital. Methods: We carried out a crosssectional study, in June 2017, involving the nursing staff of the Medical Oncology Department of the Yaoundé General Hospital. Results: Sixteen out of 18 nurses were interviewed. All had worked in at least one other department prior to Oncology. The number of years of experience in Oncology ranged from less than one year to 13 years. The choice of the Oncology department was involuntary for 100% of the staff; of these, 62% had intentions of changing departments. Twenty-five percent had applied for a change of department, which was unsuccessful. Stress was expressed by 94% of the staff; 93% thought that there was a solution to the stress experienced on a daily basis in the Oncology department. The main solutions proposed to manage this stress were: support for the staff, provision of work materials, and staff training. Conclusion: The nursing staff of the Medical Oncology Department of the Yaoundé General Hospital experiences a high level of stress and are in need of solutions.
HEALTH SCIENCES AND DISEASES, 2020
RESUME Les cancers primitifs de l'uretre sont rares aussi bien chez l'homme que chez la f... more RESUME Les cancers primitifs de l'uretre sont rares aussi bien chez l'homme que chez la femme. En effet, tous les cancers primitifs de l'uretre representent 1% des tumeurs malignes de l'appareil urinaire. La forme histologique la plus frequente de l'uretre est le carcinome epidermoide. Le diagnostic est tardif et le plus souvent pose en periode des complications. Il repose essentiellement sur la clinique et l'examen de l'uretre sous anesthesie, des biopsies locales et l'IRM. Le traitement est fonction du stade de la lesion et de sa localisation. Malgre un traitement agressif reposant sur une chirurgie d'exerese mutilante associee ou non a une radiotherapie et chimiotherapie, le taux de survie demeure tres faible. L’interet des cas vient de cette rarete et de l’absence de consensus international pour la prise en charge. ABSTRACT Primitive cancers of the urethra rarely affect men or women. In fact, the primary cancers of the urethra account for 1...
Le Mali medical, 2013
AIM The objective was to describe the clinical and therapeutic aspects of breast cancer at the Ya... more AIM The objective was to describe the clinical and therapeutic aspects of breast cancer at the Yaounde Gynaeco-Obstetric and Pediatric Hospital, which is a referral centre for gynecological malignancies. METHODS It was a retrospective descriptive study over a period of four years, from June 1st 2003 to May 31st 2007. RESULTS Sixty five patients were identified during the study period. The mean age and parity were respectively 42.9 ±13.6 years and 3.9 ± 2.1. The mean age of onset of the first menses was 14.0 ± 1.5 years. Most patients were under 50 (72.3%) and had given birth at least once (89.2%). Non menopausal period (75.4%) and breastfeeding (76.9%) were frequently found. The patients consulted 9.2 ± 3.4 months after the onset of symptoms, with 78.5% of cases arriving at a local advanced clinical stage. Ductal carcinoma accounted for 75.4% of histological types, SBR grades 1 and 2 being the most frequent (89.2%). Chemotherapy (69.2% of the cases) and surgery (67.7% of the cases) ...
clinics in Mother and Child Health, 2007
With the aim of studying the epidemiological characteristics of ocular and orbital metastasis in ... more With the aim of studying the epidemiological characteristics of ocular and orbital metastasis in the Cameroonian context, we carried out a retrospective study over a 13 year period in two reference hospitals in Cameroon. Files of patients with the diagnosis of either ocular or orbital metastasis were analysed. Eighteen out of 36177 files were retained (4.9 per 10 000), of which 11 were women and 7 men, with a mean age of 54.8 years. There were 62.5% cases of localised ocular metastasis and 66.6% affected the left eye. Visual impairment was the main and constant symptom whereas a non-rhegmatogenic retinal detachment was observed in 75% of cases. The localisation of the primary tumor was the breast in 8 of 18 cases, and overall, 9 cases of adenocarcinomas were noted. We conclude that, this pathology which apparently seems infrequent, needs to be looked for systematically, given its poor prognosis. Dans le but d'etudier les caracteristiques epidemiologiques des metastases oculo-orb...
Genes and Immunity, May 20, 2019
Several studies published to date report associations between human leukocyte antigen (HLA) allel... more Several studies published to date report associations between human leukocyte antigen (HLA) alleles and different types of Kaposi's Sarcoma (KS). However, there is little concordance between the HLA alleles identified and the populations studied. To test whether HLA alleles associate with KS in a Cameroonian case-control study, we performed high-resolution HLA typing in KSHV seropositive individuals. Among HIV-positive individuals, carriers of HLA-B*14:01 were at a significantly higher risk of AIDS-KS (p = 0.033). For HIV-negative patients, a gene-wise comparison of allele frequencies identified the HLA-B (p = 0.008) and-DQA1 (p = 0.002) loci as possible risk factors for endemic KS. Our study provides additional understanding of genetic determinants of KS and their implications in disease pathogenesis. Further validation of these findings is needed to define the functional relevance of these associations.
International Journal of Cancer, Jun 15, 2022
In sub-Saharan Africa, Kaposi’s sarcoma-associated herpesvirus (KSHV) is endemic, and Kaposi’s sa... more In sub-Saharan Africa, Kaposi’s sarcoma-associated herpesvirus (KSHV) is endemic, and Kaposi’s sarcoma (KS) is a significant public health problem. Until recently, KSHV genotype analysis was performed using variable gene regions, representing a small fraction of the genome, and thus the contribution of sequence variation to viral transmission or pathogenesis are understudied. We performed near full-length KSHV genome sequence analysis on samples from 43 individuals selected from a large Cameroonian KS case-control study. KSHV genomes were obtained from 21 KS patients and 22 control participants. Phylogenetic analysis of the K1 region indicated the majority of sequences were A5 or B1 subtypes and all three K15 alleles were represented. Unique polymorphisms in the KSHV genome were observed including large gene deletions. We found evidence of multiple distinct KSHV genotypes in three individuals. Additionally, our analyses indicate that recombination is prevalent suggesting that multiple KSHV infections may not be uncommon overall. Most importantly, a detailed analysis of KSHV genomes from KS patients and control participants did not find a correlation between viral sequence variations and disease. Our study is the first to systematically compare near full-length KSHV genome sequences between KS cases and controls in the same endemic region to identify possible sequence variations associated with disease risk.
The Breast, Jun 1, 2012
Hepatocellular carcinoma is a common cancer in Africa. The risk factors are well known and avoida... more Hepatocellular carcinoma is a common cancer in Africa. The risk factors are well known and avoidable in most cases (hepatitis B, hepatitis C, aflatoxin and alcohol). Vaccination against hepatitis B and the fight against aflatoxin are efficient contributions to the fight against liver cancer. The costly nature of these measures in Africa is an impediment to the fight against liver cancer in Africa.
PAMJ clinical medicine, 2023
HEALTH SCIENCES AND DISEASES, Feb 29, 2016
Réponse hématologique chez les patients atteints de leucémie myéloïde chronique sous imatinib Che... more Réponse hématologique chez les patients atteints de leucémie myéloïde chronique sous imatinib Chetcha et al _____________________________________________________________________________________________
Background Childhood cancer is the sixth leading cause of global cancer burden. Indeed, 90% of ch... more Background Childhood cancer is the sixth leading cause of global cancer burden. Indeed, 90% of childhood cancer cases occur in low-middle-income countries (LMICs), where mortality can be 4-5 times higher than in high income settings. In addition, many LMICs lack data on pediatric oncology for policy development and resource prioritization. In this paper, we describe the state of pediatric cancer care and treatment in Cameroon. Procedure We conducted cross-sectional survey in July 2020, which enabled us to collect data from two hospitals providing pediatric oncology services in Cameroon. We collected data on service availability, human resource capacity, frequent cancer types, treatment dropout, primary reasons for drop out, disclosure of status, and management of oncology data. Result The surveyed hospitals offered both pediatric chemotherapy and palliative care services; however, none offered nuclear medicine or radiotherapy services. In terms of workforce, human resources were gro...
Cancer Epidemiology, Biomarkers & Prevention
Background: The Nigerian Breast Cancer Study (NBCS) model is a new risk assessment tool developed... more Background: The Nigerian Breast Cancer Study (NBCS) model is a new risk assessment tool developed for predicting risk of invasive breast cancer in Nigeria. Its applicability outside of Nigeria remains uncertain as it has not been validated in other sub-Saharan Africa populations. Methods: We conducted a case–control study among women with breast cancer and controls ascertained in Cameroon and Uganda from 2011 to 2016. Structured questionnaire interviews were performed to collect risk factor characteristics. The NBCS model, the Gail model, the Gail model for Black population, and the Black Women's Health Study model were applied to the Cameroon and Uganda samples separately. Nigerian as well as local incidence rates were incorporated into the models. Receiver-Operating Characteristic analyses were performed to indicate discriminating capacity. Results: The study included 550 cases (mean age 46.8 ± 11.9) and 509 controls (mean age 46.3 ± 11.7). Compared with the other three models...
HEALTH SCIENCES AND DISEASES, Jun 30, 2021
Rôle du Programme National de Lutte contre le Cancer dans l'élaboration de politiques saines et l... more Rôle du Programme National de Lutte contre le Cancer dans l'élaboration de politiques saines et la création d'environnements favorables à la prévention du cancer au Cameroun (2004-2019
Cancer Research, 2021
Background: Women of African ancestry across the diaspora have low risk of developing breast canc... more Background: Women of African ancestry across the diaspora have low risk of developing breast cancer compared to women of European ancestry. However, they suffer the highest mortality rates because of the disproportionate burden of young onset aggressive hormone receptor negative breast cancer. To implement strategies for early detection and prevention, it is critically important to develop better risk assessment tools. The Nigerian Breast Cancer Study (NBCS) model is a new risk assessment tool developed for the individual estimation of absolute risk of invasive breast cancer in Nigeria. Its applicability outside of Nigeria remains uncertain as it has not been validated in other Sub-Sahara African (SSA) populations. Methods: We conducted a case-control study among women with breast cancer and controls ascertained in Cameroon and Uganda from 2011 to 2016. Structured questionnaire interviews were performed to collect demographic and reproductive characteristics. The NBCS model, the Gai...
Introduction : La douleur represente l’un des symptomes les plus frequents chez les patients canc... more Introduction : La douleur represente l’un des symptomes les plus frequents chez les patients cancereux, sa prevalence est estimee a 80% et sa prise en charge au cours de la maladie cancereuse demeure un enjeu important. Le but ce travail etait de determiner les caracteristiques de la douleur cancereuse et d’en evaluer la prise en charge.Materiels et methodes : Il s’est agi d’une etude descriptive menee du 4 Janvier au 30 Avril 2017, nous avons inclus tout patient douloureux ayant un diagnostic anatomopathologique de cancer et ayant beneficie d’une prise en charge de la douleur. L’efficacite du traitement etait evaluee a l’aide de l’index de Cleeland et de facon subjective par les echelles d’evaluation de douleur. L’analyse des donnees a ete faite a partir du logiciel SPSS version 20.Resultats : Au total 166 patients ont ete inclus. La prevalence de la douleur etait de 76,2% (n= 166). La tumeur representait la principale cause de la douleur (94,6%). La prise en charge de la douleur d...
Background: The incidence of cancers is increasing worldwide, particularly in the developing coun... more Background: The incidence of cancers is increasing worldwide, particularly in the developing countries as shown by recent cancer stastics from the WHO. It is even anticipated that with the increase in life expentancy, consequent upon inproved standard of living and globalization, the burden of cancers will increase within this millenium. With respective to cancer of the prostate, it is the most common type of cancer in urology. In developing countries, diagnostic is done at a late stage of evolution. In Cameroon, data on prostate cancer are scanty whereas the incidence of this disease is increasing. Objective: This article is designed to describe the epidemiological features of prostate cancer at the General Hospital of YaoundA©. Patients and methods: A 4-year retrospective study of patients seen with the diagnosis of cancer at the Medical Oncology unit of the YaoundA© General Hospital between January 2012 and December 2015. The demographic pattern (age of patients, socio profession...
HEALTH SCIENCES AND DISEASES, 2020
RESUME Contexte. Les standards, options et recommandations pour la conduite a tenir devant une le... more RESUME Contexte. Les standards, options et recommandations pour la conduite a tenir devant une lesion de diagnostic anatomo-cytopathologique preconisent la mise a disposition par les cliniciens de renseignements cliniques les plus exhaustifs possible pour un plein accomplissement du travail du pathologiste, contribuant a minimiser les erreurs. Cet aspect a retenu notre attention et nous a menes a la realisation de cette etude sur le niveau de renseignement des fiches cliniques adressees au service d’anatomie pathologique. Materiels et methodes . Notre etude etait transversale et portait sur 500 bulletins d’examens recus et colliges de facon aleatoire de 2016 a 2017. La retranscription s’est faite par une grille d’observation portant sur l’identification, la nature de l’examen, la provenance et les caracteristiques cliniques. Resultats. Les examens comportaient 63,8% d’histologie, et 36,2% de cytologie. Les hopitaux de 1ere categorie etaient les premiers demandeurs d’examens avec 73,...
Pan African Medical Journal, 2011
Management of cancer patients in low-resource communities presents enormous challenges. Breast ca... more Management of cancer patients in low-resource communities presents enormous challenges. Breast cancer is a public health problem in Cameroon and occurs mostly in elderly women. The predominant histological type is a duct carcinoma. Lobular carcinoma in teenagers is rare. In this report we present a case of bilateral invasive lobular carcinoma of the breast that was confirmed on biopsies in a 22-year-old female. We present this rare finding and review the pathological, clinical and radiographic challenges of the disease. Nodules in the breast from patients of any age should be submitted for histology. Public education is beneficial and should be intensified.
Advances in breast cancer research, 2015
This study aimed to estimate the survival rate of breast cancer in a group of patients followed u... more This study aimed to estimate the survival rate of breast cancer in a group of patients followed up at the Yaoundé General Hospital in Cameroon. A retrospective review of records of patients managed for breast cancer between 1995 and 2007 was carried out at the Yaoundé General Hospital. Survival analysis was carried out with survival defined as the time between the date of unequivocal diagnosis of cancer and the date of last follow-up or death. Survival curves were plotted in R.3.1.1 software. Mean age of the patients was 47.5 ± 12.36 years. Most of the patients (67.9%) presented with advanced breast cancer disease (stage III and IV). Overall patient survival rate was 30% at 5 years and 13.2% at 10 years. Median overall survival time was 2 (1.9-3) years. There was a correlation between survival and the stage of disease. The highest survival rates were recorded in stages I and II while the lowest rates were recorded in stage IV. There was no statistically significant difference in survival among the age groups (p = 0.15). Overall survival rates of breast cancer are 30% at 5 years and 13.2% at 10 years among Cameroonian patients and are lower compared with 90% and 82% respectively at 5 years and 10 years in some developed countries.
HEALTH SCIENCES AND DISEASES, Aug 17, 2015
Décrire certains marqueurs de la réponse immunitaire au cours du sarcome de Kaposi (SK). MATÉRIEL... more Décrire certains marqueurs de la réponse immunitaire au cours du sarcome de Kaposi (SK). MATÉRIEL ET MÉTHODES : Etude descriptive dans le Service d'Oncologie Médicale de l'Hôpital Général de Yaoundé, constituée de patients présentant un SK et naïfs de tout traitement anticancéreux. Les taux sanguins des LTCD4 + , IgG anti-HHV8, et des cytokines inflammatoires IL-6 et IL-10, ont été mesurés et leurs valeurs corrélées avec les données démographiques et cliniques des patients. RÉSULTATS : Sur les 52 patients retenus, 61.5% étaient de sexe masculin. La moyenne d'âge était de 42.27±11.48 ans. L'association du SK à l'infection à VIH a été retrouvée, divisant notre échantillon en deux groupes : celui présentant le SK épidémique (SK+VIH) à 90.4%, et celui avec un SK endémique à 9.6%. 50% d'atteinte exclusive des membres inférieurs a été observée, avec les macules comme lésion cutanée majoritaire. La recherche en IgG a été positive chez 92.3% des patients, avec une valeur médiane de 3.12UI. Le taux médian de LTCD4 + a été de 170cellules/mm 3 , avec 79% des patients immunodéprimés. Seul le SK endémique a eu des patients immunocompétents. La valeur médiane des taux d'IL-6 a été de 2.05g/ml, et celle d'IL-10 de 3.08g/ml, avec respectivement 54 et 56% des patients présentant des valeurs anormales. Les valeurs anormales d'Il-6 ont été associées à l'âge avancé, à la présence de l'infection à VIH et à la prise des ARV. CONCLUSION : La réponse immunitaire au cours du SK, au sein de notre échantillon, se traduit par la présence des taux anormaux des cytokines IL-6 et IL-10, la présence des IgG anti-HHV8 et les taux bas de LTCD4 + .
Pan African Medical Journal
Journal of Cancer Therapy
Background: The world of cancer care is an emotional place, given the severity of the disease bei... more Background: The world of cancer care is an emotional place, given the severity of the disease being treated, the heavy workload, the suffering of patients, and the high number of deaths. The nursing staff who work there may be exposed to constant stress from these factors. This study aimed to explore the psychological experience of the nursing staff of the Medical Oncology Department of the Yaoundé General Hospital. Methods: We carried out a crosssectional study, in June 2017, involving the nursing staff of the Medical Oncology Department of the Yaoundé General Hospital. Results: Sixteen out of 18 nurses were interviewed. All had worked in at least one other department prior to Oncology. The number of years of experience in Oncology ranged from less than one year to 13 years. The choice of the Oncology department was involuntary for 100% of the staff; of these, 62% had intentions of changing departments. Twenty-five percent had applied for a change of department, which was unsuccessful. Stress was expressed by 94% of the staff; 93% thought that there was a solution to the stress experienced on a daily basis in the Oncology department. The main solutions proposed to manage this stress were: support for the staff, provision of work materials, and staff training. Conclusion: The nursing staff of the Medical Oncology Department of the Yaoundé General Hospital experiences a high level of stress and are in need of solutions.
HEALTH SCIENCES AND DISEASES, 2020
RESUME Les cancers primitifs de l'uretre sont rares aussi bien chez l'homme que chez la f... more RESUME Les cancers primitifs de l'uretre sont rares aussi bien chez l'homme que chez la femme. En effet, tous les cancers primitifs de l'uretre representent 1% des tumeurs malignes de l'appareil urinaire. La forme histologique la plus frequente de l'uretre est le carcinome epidermoide. Le diagnostic est tardif et le plus souvent pose en periode des complications. Il repose essentiellement sur la clinique et l'examen de l'uretre sous anesthesie, des biopsies locales et l'IRM. Le traitement est fonction du stade de la lesion et de sa localisation. Malgre un traitement agressif reposant sur une chirurgie d'exerese mutilante associee ou non a une radiotherapie et chimiotherapie, le taux de survie demeure tres faible. L’interet des cas vient de cette rarete et de l’absence de consensus international pour la prise en charge. ABSTRACT Primitive cancers of the urethra rarely affect men or women. In fact, the primary cancers of the urethra account for 1...
Le Mali medical, 2013
AIM The objective was to describe the clinical and therapeutic aspects of breast cancer at the Ya... more AIM The objective was to describe the clinical and therapeutic aspects of breast cancer at the Yaounde Gynaeco-Obstetric and Pediatric Hospital, which is a referral centre for gynecological malignancies. METHODS It was a retrospective descriptive study over a period of four years, from June 1st 2003 to May 31st 2007. RESULTS Sixty five patients were identified during the study period. The mean age and parity were respectively 42.9 ±13.6 years and 3.9 ± 2.1. The mean age of onset of the first menses was 14.0 ± 1.5 years. Most patients were under 50 (72.3%) and had given birth at least once (89.2%). Non menopausal period (75.4%) and breastfeeding (76.9%) were frequently found. The patients consulted 9.2 ± 3.4 months after the onset of symptoms, with 78.5% of cases arriving at a local advanced clinical stage. Ductal carcinoma accounted for 75.4% of histological types, SBR grades 1 and 2 being the most frequent (89.2%). Chemotherapy (69.2% of the cases) and surgery (67.7% of the cases) ...
clinics in Mother and Child Health, 2007
With the aim of studying the epidemiological characteristics of ocular and orbital metastasis in ... more With the aim of studying the epidemiological characteristics of ocular and orbital metastasis in the Cameroonian context, we carried out a retrospective study over a 13 year period in two reference hospitals in Cameroon. Files of patients with the diagnosis of either ocular or orbital metastasis were analysed. Eighteen out of 36177 files were retained (4.9 per 10 000), of which 11 were women and 7 men, with a mean age of 54.8 years. There were 62.5% cases of localised ocular metastasis and 66.6% affected the left eye. Visual impairment was the main and constant symptom whereas a non-rhegmatogenic retinal detachment was observed in 75% of cases. The localisation of the primary tumor was the breast in 8 of 18 cases, and overall, 9 cases of adenocarcinomas were noted. We conclude that, this pathology which apparently seems infrequent, needs to be looked for systematically, given its poor prognosis. Dans le but d'etudier les caracteristiques epidemiologiques des metastases oculo-orb...