Ayush Shukla | Yale University (original) (raw)

Papers by Ayush Shukla

Circulation

Introduction: Post MI tachycardia is associated with increase in cardiac morbidity and mortality.... more Introduction: Post MI tachycardia is associated with increase in cardiac morbidity and mortality. We aimed to assess efficacy and safety of ivabradine to control heart rate in post MI tachycardia patients in whom beta-blockers were intolerant. Hypothesis: We hypothesized that ivabradine in post MI tachycardia patients effectively control heart rate without deteriorating effects on hemodynamics. Methods: STEMI patients with sinus tachycardia (heart rate >120/min) who had intolerance to beta blocker were enrolled. Important exclusions were cardiogenic shock, second /third-degree atrioventricular block, Killip class III/ IV. Patient’s invasive hemodynamic parameters such as MAP (Mean Arterial Pressure), iSV (indexed Stroke Volume), CVP (Central Venous Pressure), cardiac output and cardiac index were measured with help of Edwards LifeSciences Flotrac monitor. Patients received ivabradine till heart rate control (<100/min.) was achieved. The primary objectives were to study ivabrad...

The FASEB Journal, 2015

Influenza is a rapidly mutating RNA virus causing mortality and morbidity in humans.The three dif... more Influenza is a rapidly mutating RNA virus causing mortality and morbidity in humans.The three different strains of influenza are characterized by different surface glycoproteins. Hemagglutinin (HA)...

Circulation, 2021

Introduction: Despite recent advancement in management of Heart failure (HF), the accessibility a... more Introduction: Despite recent advancement in management of Heart failure (HF), the accessibility and affordability of this treatment is still an issue in developing countries. Hypothesis: We aimed to assess etiological and pharmacological profile of heart failure patients in our study. Methods: The study population consisted of 407 patients with chronic heart failure aged >18 years attending as outpatient. Acute Heart Failure and patients hospitalized for Acute Heart Failure within 4 weeks were excluded. The diagnosis of heart failure was made in accordance with 2016 ESC guidelines for the Heart failure. Patients were stratified into those with reduced ejection fraction(HFrEF: when EF < 40%), preserved ejection fraction (HFpEF: when EF > 50%), and those with mid-range ejection fraction (HFmrEF; when EF = 40-50%). Results: The mean age of the cohort was 58.8 years & 64.4% (n = 262) were males. The overall mean left ventricular ejection fraction (LVEF) of the cohort was 38.47±...

2021 IEEE Mysore Sub Section International Conference (MysuruCon), 2021

Paper-based Microfluidic devices are of great importance and interest due to their portability, v... more Paper-based Microfluidic devices are of great importance and interest due to their portability, versatility, and ease to handle. Microfluidic devices can be made using a wide variety of materials ranging from cellulose to glass or polymer and each type can bring different functionalities depending on the applications. The present experiment includes trials using various substrates, borders, and fluid materials. In this work, 2D microfluidic channels over Canvas sheets and tissue papers have been addressed using a ballpoint pen, marker pen, and correction pen ink to ascertain the suitability of an economical point-of-care device. Investigations revealed that correction pen ink was much easier, quicker, and more reliable than the other ink forms. This was further extended to develop a 3D microfluidic structure over tissue paper using the origami technique. Successful designing of one inlet - four outlet port for the diagnostic purpose was realized. Further, the technique was employed to print the image of an Eiffel tower through stored dry color. These examples highlight paper-based microfluidic devices as a major point-of-care diagnostic tool that can be used to detect biological/chemical changes and be manufactured using simple household stuffs.

Research Journal of Pharmacy and Technology, 2017

Old age, physical and mental disabilities tend to hinder a person's day to day life. This pap... more Old age, physical and mental disabilities tend to hinder a person's day to day life. This paper deals with a smart wheelchair that aids the elderly and disabled in their daily lives inside their houses. Since old age and disability comes with various impairments like loss of sight, hearing disability, problems in mobility and cognitive disabilities this wheelchair helps the person using it to move from place to place by controlling the wheelchair through his voice and gesture control through a mobile application. It takes into account the various problems faced by the old and disabled people, hence it provides various modes of mobility for the users and benefits a larger group of users. As the wheelchair moves it detects obstacles, alerts the user and changes its direction automatically. There is an option to set reminders regarding medicines, meals and appointments etc. The system facilitates the user to store his/her medical history and based on that the system predicts medici...

The FASEB Journal, 2017

Zika is a flavivirus similar to dengue and West Nile viruses. The Zika virus was first isolated i... more Zika is a flavivirus similar to dengue and West Nile viruses. The Zika virus was first isolated in the Zika forest in Uganda in 1947. Rapid proliferation of Zika can be attributed to a lack of immu...

Proceedings of the Advances in Robotics on - AIR '17, 2017

Ever since the inception of Robotics, it has served as a great collaborative platform for researc... more Ever since the inception of Robotics, it has served as a great collaborative platform for researchers from the fields of mechanical engineering, electrical engineering, and computer science. Robot Operating System (ROS), one of the biggest middleware framework for robotics has lead to high paced research and development around the globe. In this paper, we present our work on developing a low-cost ROS enabled education platform for Indian research institutes. This paper begins with our learning of ROS using KUKA youBot and later goes on to discuss in detail the development of the indigenous platform: RoboMuse 4.0 and its integration with ROS.

Journal of Pharmacognosy and Phytochemistry, 2018

A two year extensive field survey was carried out in 12 different forest fringe villages of Assam... more A two year extensive field survey was carried out in 12 different forest fringe villages of Assam lies especially between Nagaon and Golaghat district and alongside of Kaziranga National Park, to collect information on the uses of wild medicinal herbs by inhabiting tribal populations. The “transect walk” method of participatory rural appraisal (PRA) were adopted during survey and the data were analyzed through Use-value valuation technique. This research documented 34 medicinal herbs which were using by tribal to treat 27 human infirmities like jaundice,diarrhoea, dysentery, coughs, colds and other ailments. The Use-value data indicate that there is a high degree of consensus among informants regarding treatment of various ailments. However, due to the influence of climate change and other anthropological activities, this spoken folklore is at the verge of extinction. Therefore, appropriate measures need to be taken to conserve and enhance these wild medicinal herbs in fringe forest...

Journal of emerging technologies and innovative research, 2020

Power cables that are used to a supply electrical power is placed underground to avoid unwanted i... more Power cables that are used to a supply electrical power is placed underground to avoid unwanted interference. This makes it very tough to determine the exact location of the faults that occur. A fault might occur due to a many of reasons such as digging, earthquake, construction work, etc. The maintenance process related to that particular line is difficult due to unknown location of the fault in the line. In this paper, we want to present the working of a self-made hardware model illustrating the detection of faults in underground power lines using Ohm's law. The voltage drop is measured across regular intervals of the line. As soon as the fault occurs, the voltage drop across each interval varies in accordance with the Ohm's law. AT Mega 16 micro controller has been used in the hardware model. The project detects the location of fault in underground cable lines from the base station to exact location in kilometers use the micro controller kit. In metropolitan areas, the electrical cable runs in undergrounds instead of overhead lines. Whenever the fault occurs in underground cable it is tough to detect the exact location of the fault for process of repairing that particular cable. The underground fault detection system finds the exact location of the fault.

2018 18th International Conference on Control, Automation and Systems (ICCAS), 2018

Over the years, mobile robots have proven to be of significant assistance to humans in various do... more Over the years, mobile robots have proven to be of significant assistance to humans in various domains including domestic applications, agriculture, manufacturing, and defense. In this paper, we have focused on a domestic application, more specifically the development of a custom designed low cost mobile robot - RoboMuse 4.0, into a highly capable mobile assistant. From following a person around carrying his or her load, to acting as a mobile guide which is capable of autonomously charging itself by docking into a charging station, we have concentrated on automating the mobile functions of an assistant. This was achieved through various subtasks including simultaneous localization and mapping, autonomous exploration, point to point navigation, and autonomous docking and charging. The performance of the robot was also evaluated through various established and customized tests, the results of which have also been included in this paper.

The aim of this paper is to study the behavior of M-40 grade of concrete having mix proportion of... more The aim of this paper is to study the behavior of M-40 grade of concrete having mix proportion of 1:1.62:2.83 with w/c of 0.45 and to determine the compressive, split tensile and flexural strength of concrete reinforced with steel fibres. Four percentages of steel fibres (0%, 1%, 1.5% & 2%) having aspect ratio 50 were used. Cement was replaced with two percentages (40%, 60%) of Class F fly ash.All the tests were performed according to bureau of Indian standards. The results obtained were compared and examined with respect to the control specimen. The advantage of adding steel fibre in concrete is that it enhances its overall strength especially the flexural and split tensile strength. The optimum percentage of adding flyash and steel fibres was determined to be 40% and 2% which showed the maximum improvement in tensile and flexural strength.

2021 10th IEEE International Conference on Communication Systems and Network Technologies (CSNT), 2021

In the coming years, farmers will face challenges to feed the increasing number of populations. T... more In the coming years, farmers will face challenges to feed the increasing number of populations. They need to ensure food security and reduce the dependency on imports. The effective use of new technologies to increase the efficiency of farming will help the farmers to meet the need of increased population AI and IOT related automation to be designed to improve the way a farmer operates for various tasks. We propose a framework for IoT based Soil Nutrition and Plant Disease detection which uses various sensors to collect the plant-related data in form of images at different time intervals using MY THINGS smart sensor and Soil sensors such as proximal soil sensor (PSS) to test the soil fertility which helps to analyze the condition of soil new cultivation, ploughing, water or the land for harvesting. Temperature sensors are also used. Water quality sensors are used that will keep monitoring the quality of the water. All the data will we be sent to the farmer with the help of the IoT. For image classification, Local binary thresholding is used. At harvesting time robot performs image recognition and classification. The farmer will enter the required data to use the robotic arm to automatically harvest the crop. The arm is proposed to have four degrees of freedom and will be driven by the motors. Robotic arms will identify the crop using image recognition and will put that batch in the appropriate basket to be considered by the farmer for analysis. With regular monitoring, this proposed framework can greatly aid the farmers in maintaining crop health as well as quality.

Urbanisation, 2020

Weekly markets or ‘ hafta bazaars’ are an important part of India’s cultural and traditional mili... more Weekly markets or ‘ hafta bazaars’ are an important part of India’s cultural and traditional milieu. These informal markets are held once a week at a particular place, within varying time slots, and cater to a diverse spectrum of consumers. Although these markets are important from both an economic and a cultural point of view, they have not been documented properly. A team of researchers has attempted to comprehensively document Delhi’s weekly markets by mapping their locations, products sold and the days and timings at which they are held. This article offers a geographical overview of these markets through the creation of an innovative web portal—the first such attempt to showcase and digitise these invincible economic hubs on a single platform. Lessons from this exercise could pave the way for future research to unearth the administrative and economic models that underpin the efficient and sustainable functioning of the hafta bazaars.

Brazilian Journal of Cardiovascular Surgery, 2019

Objective: To study the response of myocardial ischemia/ reperfusion injury (MI/RI) in rats to si... more Objective: To study the response of myocardial ischemia/ reperfusion injury (MI/RI) in rats to simulated geomagnetic activity. Methods: In a simulated strong geomagnetic outbreak, the MI/RI rat models were radiated, and their area of myocardial infarction, hemodynamic parameters, creatine kinase (CK), lactate dehydrogenase (LDH), melatonin, and troponin I values were measured after a 24-hour intervention. Results: Our analysis indicates that the concentrations of troponin I in the geomagnetic shielding+operation group were lower than in the radiation+operation group (P<0.05), the concentrations of melatonin in the shielding+operation group and normal+operation group were higher than in the radiation + operation group (P<0.01), and the concentrations of CK in the shielding + operation group were lower than in the radiation + operation group and normal + operation group (P<0.05). Left ventricular developed pressure (LVDP) and ± dP/dtmax in the radiation+operation group were lower than in the shielding + operation group and normal+operation group (P<0.01). Left ventricular end-diastolic pressure (LEVDP) in the shielding + operation group was higher than in the normal + operation group (P<0.05). There was no significant difference in area of myocardial infarction and LDH between the shielding + operation group and the radiation + operation group. Conclusion: Our data suggest that geomagnetic activity is important in regulating myocardial reperfusion injury. The geomagnetic shielding has a protective effect on myocardial injury, and the geomagnetic radiation is a risk factor for aggravating the cardiovascular and cerebrovascular diseases.

SSRN Electronic Journal, 2019

Solar air heaters are renewable energy thermo technology, used for space heating in which the rad... more Solar air heaters are renewable energy thermo technology, used for space heating in which the radiant energy is captured in an absorber plate which is emitted by the sun with the temperature variation of 8×10 6 to 40×10 6 K in its center.Enhancement of the heat transfer can be done by improving the thermo hydraulic performance of a solar air heater by considering both the thermal and hydraulic characteristics of the collector simultaneously with respect to smooth duct. Absorber plate, a solar thermal collector, is relevant to act as an application of Artificial Roughness, which is the most approved method for the improvement of thermal performance of solar air heaters as it is financial loss due to friction. In addition to this, it is difficult task for the designer to select the optimal roughness geometry for specific Applications. Although, Roughness Geometry and Investigation Techniques gained a notable scientific interest in recent years, still there is a need of significant improvement to cater the wide range of real world problems. This research paper aims to fulfil the identified research gap among the multiple existing researches for the better comparison and estimation of appropriate solar air heater application.

Journal of clinical and diagnostic research : JCDR, 2017

Combined hereditary thrombophilia is an uncommon entity associated with higher risk of early onse... more Combined hereditary thrombophilia is an uncommon entity associated with higher risk of early onset thrombosis. We report a case of 39-year-old male with combined deficiency of natural anticoagulants (protein C, S and anti thrombin) along with hyper homocystenemia and factor V Leiden mutation, presenting with life threatening bilateral pulmonary embolism. The clinical implications of combined thrombophilia are also discussed.

Revista Brasileira de Hematologia e Hemoterapia, 2017

International journal of Emerging Trends in Science and Technology, 2016

Effective cost estimation is one of the most important and complex tasks in development of any so... more Effective cost estimation is one of the most important and complex tasks in development of any software project. The stakeholders require a simple and effective model to enable them to make an efficient estimate of the software development cost. Estimation, basically, means to predict the value and predictions tend to go wrong. The whole process requires a huge amount of data, which is often challenging to collect, hence, making the whole process challenging. In this paper, we try to illustrate various existing cost estimation models proposed over the years and finally present a comparison between them. The paper also tries to pinpoint the various reasons for errors in cost estimation.

JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH, 2016

A 14-year-old male presented with generalised weakness, high grade fever and progressive pallor f... more A 14-year-old male presented with generalised weakness, high grade fever and progressive pallor for 1 month. On examination he had pallor and fever. There was no lymphadenopathy or organomegaly. On routine haemogram he had pancytopenia, haemoglobin (Hb) 7 gm%, Total Leukocyte Count (TLC) was 3700/ ul and platelet count was 45000/ul. Differential Leucocyte count revealed 85% lymphocytes. No immature cells were seen. Serum biochemical parameters including serum bilirubin, liver enzymes, glucose, vitamin B12, folic acid and creatinine were within normal range. Viral serology was negative. These findings provisionally ruled out megaloblastic anaemia and viral infection. A provisional diagnosis of bone marrow failure was made and bone marrow aspiration and biopsy was done for further evaluation to rule out any hematopoietic neoplasm. Bone marrow smears revealed markedly hypo-cellular particles rich in fat. All hematopoietic elements were markedly reduced, with predominant population of lymphocytes (72%) and plasma cells (6%). In addition, the Leishmann stained bonemarrow smear also revealed few sheathed microfilariae of Wuchereria bancrofti with tail end free from nuclei [Table/ Fig-1]. The patient was started on DEC along with cyclosporine and supporting transfusions. At 6 month follow-up patient had recovered peripheral blood counts.