canan aykut bingöl | Yeditepe University (original) (raw)

Papers by canan aykut bingöl

Yeditepe tıp dergisi, 2013

International Conference on Biomedical Engineering, Feb 17, 2006

Yeditepe tıp dergisi, 2014

Journal of International Medical Research, Oct 27, 2016

Neurological Sciences and Neurophysiology, 2019

Yeditepe Medical Journal, 2014

European review for medical and pharmacological sciences

Cortical dysplasia (CD) is associated with several behavioral disorders in both the pediatric and... more Cortical dysplasia (CD) is associated with several behavioral disorders in both the pediatric and the adult population. The effect of melatonin on behavioral disorders in rats generated CD has not been investigated so far. To investigate the effects of melatonin administration on activity and anxietic behavior of neonatal rats in a model of CD. Newborn Sprague-Dawley rats (n=21) were randomized into three groups. On postnatal day 1, one freeze lesion was carried out in 14 rats between bregma and lambda to create a CD model. Another group of neonatal rats served as control group (n=7). Those 14 rats were either administered melatonin (n=7) or vehicle solution (n=7). Melatonin treatment (4 mg/kg/day, i.p.) was initiated ten days after induction of cold injury and continued for three weeks. Animal activity and anxiety were analyzed by using open field and elevated plus maze tests 24h after the last melatonin administration (day 32) in a blind manner. It was observed that CD induced ani...

2007 29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2007

Clinical Neurophysiology, 2014

European Journal of Radiology, 2011

The utility of DWI with high b-value in ischemic stroke is still unsettled. The purpose of this s... more The utility of DWI with high b-value in ischemic stroke is still unsettled. The purpose of this study is to compare high b-value (3000) and standard b-value (1000) diffusion-weighted images in patients with ischemic stroke at 3T. 27 patients with acute stroke who were admitted to the hospital during the first 24h after symptom onset were included in this study. All patients had a brain MRI study with stroke protocol including standard (b=1000) DWI and high b-value (b=3000) DWI sequences at 3T MR scanner. Number and localization of the lesions were assessed MR signal intensities (SI), signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR), contrast ratio (CR) and apparent diffusion coefficient (ADC) values of the lesions and normal parenchyma on DWI with b=1000 and b=3000 sequences were measured. All patients with acute stroke revealed hyperintense lesions due to restricted diffusion on DWI with both b-values. However, lesions of restricted diffusion were more conspicuous in b=3000 value DWI than b=1000, and additional 4 ischemic lesions were detected on b=3000 DWI. SNR, CNR, SI and also ADC values in both stroke area and normal parenchyma were lower at b=3000 than the value at b=1000. At b=3000, CR was significantly greater than b=1000 images. Although quantitative analysis shows higher SI, SNR and CNR values with standard b-value (b=1000) diffusion-weighted imaging, using higher b-value may still be beneficial in detecting additional subtle lesions in patients whose clinical findings are not correlated with standard b-value DWI in stroke.

European Journal of Radiology, 2011

The purpose of the study was to investigate the role of Diffusion Tensor Imaging (DTI) and Diffus... more The purpose of the study was to investigate the role of Diffusion Tensor Imaging (DTI) and Diffusion Tensor Tractography (DTT) on the corticospinal tract alterations due to space occupying lesions in the brainstem before and after surgical resection. Pre- and post-surgical DTI data were acquired in 14 patients undergoing surgical resection of brainstem lesions. Patterns of corticospinal tract (CST) alteration on DTT were compared with the neurological exams of the patients pre- and post-operatively. DTT, especially in 3D movie format, seemed very helpful for evaluating the relationship of the lesions with the corticospinal tracts for surgical approach. None of the patients developed additional motor deficit related to surgery except one patient who presented with cerebellar ataxia after surgery. All of the patients with normal CST on DTT presented without motor deficit on neurological exam. The sensitivity, specificity, positive predictive and negative predictive values of DTT before surgery were 100%, 63.6%, 42.9% and 100%, and the corresponding values after surgery were 100%, 96%, 75% and 100% respectively. Although it has low specificity before surgery, DTT is a potentially useful technique in evaluating the effects of brainstem lesions and surgical resection on the relevant corticospinal tracts with high negative predictive value and higher specificity after surgery.

Epilepsy & Behavior, 2013

The aim of this study was to evaluate the type, duration, etiology, treatment, and outcome of sta... more The aim of this study was to evaluate the type, duration, etiology, treatment, and outcome of status epilepticus (SE) episodes, among patients aged 16-50 years. A total of 101 SE episodes in 88 young adult patients fulfilled our criteria. The mean age was 32 years. Status epilepticus episodes were most frequently observed in patients 21-30 years of age. A total of 53% of the patients were male, and 57% had pre-existing epilepsy. Seventy of the 101 episodes were convulsive SE. The most common etiology was withdrawal of or change in antiepileptic drugs (AEDs), seen in 31% of the SE episodes. This study included treatment of SE with traditional AEDs. Sixty-six episodes were treated successfully with intravenous infusion of 18-mg/kg phenytoin, and six episodes were treated with 10-mg/kg phenytoin. A total of 28% of the SE episodes remained refractory to first-line treatment, which was related to the duration of SE and mortality. The outcome was death in 14% of the patients due to underlying etiologies in the hospital.

Clinical Neurophysiology, 2008

s of the 13th European Congress of Clinical Neurophysiology / Clinical Neurophysiology 119 (2008)... more s of the 13th European Congress of Clinical Neurophysiology / Clinical Neurophysiology 119 (2008), S1–S131 S59 THO32 The role of dynamic electrodiagnostic studies in cervical spondylothic myelopathy Geysu Karlikaya 1, Beyza Citci 1 , Mesut Yilmaz 3, Hasan Huseyin Karadeli 1 , Canan Aykut Bingol 1, Sedat Dalbayrak 3 , Sait Naderi 2 1Yeditepe University Hospital, Department of Neurology; 2Yeditepe University Hospital, Department of Neurosurgery; 3 Lutfi Kirdar Kartal Research and Training Hospital Department of Neurosurgery Purpose: The diagnosis of cervical spondylothic myelopathy (CSM) can be challenging. Physical findings, radiological studies and electrophysiological studies are all important for the diagnosis of CSM. Electrophysiological studies, such as electromyography and evoked potentials demonstrate the functional status of the nervous system, therefore they are especially important for making treatment decisions in patients with mild clinical findings and severe radiological findings. Recently dynamic Magnetic Resonance Imaging studies assist physicians during management decisions. However the role of dynamic electrophysiological studies is unclear. The aim of this study is to review the role of dynamic electrophysiological studies in the evaluation of CSM. Methods: We studied 72 patients with CSM and 15 controls with somatosensorial and motor evoked potentials during neck in the neutral position, after neck flexion and extension. Results: The most common finding was prolonged central motor conduction time in myelopathy patients. Overall MEP abnormalities were found in 23 (32%). Patients and SEP abnormalities in 13 (18,5%) .patients. With dynamic MEP and SEP combined 25 patients had abnormalities (34.7%, while only 19 patients (26.3%) had abnormal neutral position MEP and/or SEP studies Conclusion: MEP is more useful than SEP in the diagnosis of CSM. Dynamic electrodiagnostic studies may have a extra 10% valuable role, compared to rest evoked potentials in diagnosing patients with CSM. THO33 Electrophysiological investigation of a long latency response recorded from the seventh intercostal space after phrenic nerve electrical stimulation Tiphaine Rouaud 1, Armelle Magot 1, Pierre Guiheneuc 1 , André Truffert 2, Yann Pereon 1 1Laboratoire d’Explorations Fonctionnelles, Centre de Référence Maladies Neuromusculaires Rares, University Hospital, Nantes, France; 2Clinique de Neurologie, Unité ENMG et des Affections Neuromusculaires, University Hospital, Geneve, Switzerland Introduction: The phrenic nerve stimulation induces an early motor diaphragmatic response recorded from the seventh intercostal space. Interestingly, it also elicits a delayed response of undetermined origin. The objective of this study was to determine the electrophysiological characteristics and the neuroanatomical pathways underlying this response. Methods: Seven healthy volunteers and seven patients (cervical spinal cord injury: 6; isolated right phrenic nerve palsy: 1) were included in the study. Phrenic nerve conduction studies were performed according to standard procedures. The long latency response (LLR) was searched for in all subjects by performing electrical stimulation of the left and right phrenic nerves, the left median nerve and the left tibial nerve. It was recorded from the seventh intercostal space. Results: Whatever the stimulated nerve, the LLR was recorded in all healthy volunteers. It was specifically elicited by nociceptive stimulations. Mean latency was 94 ms (range: 76-109 ms; right phrenic nerve stimulation). Waveforms were polyphasic with highly variable amplitude (wide interand intra-individual variability). Latency was correlated with the nociceptive perception of the stimulation. The LLR was also present in the patient with the phrenic nerve palsy. It was absent in 5 out of 6 cervical spinal cord injured patients. Discussion: This LLR probably reflects seventh intercostal muscle activity rather than diaphragm muscle one. It likely represents a polysynaptic and multisegmental spinal response, conveyed by small-diameter nociceptive fibers under supraspinal control. Conclusion: By analogy with the nociceptive component of the lower limb flexion reflex, it is suggested that the LLR recorded at the seventh intercostal space might constitutes an alarm and withdrawal spinal reflex response. THO34 Electrophysiological studies in asymptomatic patients with vitamin B12 deficiency Füsun Mayda Domaç, Geysu Karlikaya, Yilmaz Çetinkaya, Mehmet Gencer, Tülin Tanridağ, Onder Us Electrodiagnostic Neurology, Marmara University, Istanbul, Turkey Purpose: The neurological syndromes associated with vitamin B12 deficiency include myelopathy, neuropathy, and less often, optic nerve atrophy. The present study was conducted to evaluate the electrophysiological profile of vitamin B12 deficiency and whether a correlation exists between the disease process and the various electrophysiological parameters. Method: Asymptomatic and…

Clinical Neurophysiology, 2008

Amaç: Bu çalışmanın amacı politerapi altındaki (birden fazla antiepileptik kullanan) epilepsi has... more Amaç: Bu çalışmanın amacı politerapi altındaki (birden fazla antiepileptik kullanan) epilepsi hastalarının demografik, klinik, nörolojik muayene ve görüntüleme sonuçlarının incelenerek politerapi ihtiyacına eşlik eden faktörlerin belirlenmesidir. Hastalar ve Yöntem: Marmara Üniversite Hastanesi Epilepsi polikliniğinde takipli 785 epileptik hastanın dosyası retrospektif olarak taranıp, hazırlanan formlar doldurulmuştur. Hastalar monoterapi ya da politerapi kullanmalarına göre gruplanmıştır. İki grup demografik veriler, klinik özellikler, nörolojik muayene ve görüntüleme sonuçları açısından Student-t ve ki-kare testleri ile karşılaştırılmıştır. Bulgular: Politerapi kullanan hasta grubunda öyküde kraniyotomi, intrakraniyal tümör, basit parsiyel nöbet ve konvülsif status epileptikus, nörolojik muayenede patolojik bulgu görülmesi, EEG, kranial görüntüleme (MR/BT) ve SPECT’de patoloji saptanması monoterapi kullanan hasta grubundan daha yüksek bulunmuştur. Sonuç: Politerapi epilepsi tedavi...

Marmara Medical Journal, 2012

Amaç: Bu çalışmanın amacı politerapi altındaki (birden fazla antiepileptik kullanan) epilepsi has... more Amaç: Bu çalışmanın amacı politerapi altındaki (birden fazla antiepileptik kullanan) epilepsi hastalarının demografik, klinik, nörolojik muayene ve görüntüleme sonuçlarının incelenerek politerapi ihtiyacına eşlik eden faktörlerin belirlenmesidir. Hastalar ve Yöntem: Marmara Üniversite Hastanesi Epilepsi polikliniğinde takipli 785 epileptik hastanın dosyası retrospektif olarak taranıp, hazırlanan formlar doldurulmuştur. Hastalar monoterapi ya da politerapi kullanmalarına göre gruplanmıştır. İki grup demografik veriler, klinik özellikler, nörolojik muayene ve görüntüleme sonuçları açısından Student-t ve ki-kare testleri ile karşılaştırılmıştır. Bulgular: Politerapi kullanan hasta grubunda öyküde kraniyotomi, intrakraniyal tümör, basit parsiyel nöbet ve konvülsif status epileptikus, nörolojik muayenede patolojik bulgu görülmesi, EEG, kranial görüntüleme (MR/BT) ve SPECT'de patoloji saptanması monoterapi kullanan hasta grubundan daha yüksek bulunmuştur. Sonuç: Politerapi epilepsi tedavisinde önemli bir basamaktır. Ancak ilaç-ilaç etkileşimi olasılığı ve artan ilaç yan etkileri nedeniyle ilk seçenek olarak kabul edilmemektedir. Politerapi kullanacak hastaların monoterapi ile nöbetleri kontrol altına alınabilen hastalardan farklılıkların belirlenmesi, politerapi ihtiyacının tedavinin öncesinde tahmin edilmesi açısından faydalı olacaktır.

Neurology, Psychiatry and Brain Research, 2011

To determine the electroencephalographic (EEG) response to intravenous bolus administration of di... more To determine the electroencephalographic (EEG) response to intravenous bolus administration of diazepam during status epilepticus (SE), we retrospectively evaluated the time to the disappearance of epileptiform activity in EEG recordings after 10 mg intravenous bolus administration of diazepam, and examined the relationship of this response time to the duration, etiology, and outcome of SE. Patients with SE who responded positively to diazepam administration (n = 53; 37 women, 16 men), aged 17-88 years were recruited from our SE registry. According to their response time to intravenous administration of diazepam, patients were divided into four subgroups: Group I response times ranged from 20 to 60 s, group II from 61 to 120 s, group III from 121-180 s, and group IV from 181 to 360 s. The duration of SE was 10.76 ± 3.46 h in the first group and 27.00 ± 12.57 h in the last group. According to the etiology, patients with central nervous system tumors and metabolic disorders were the fastest responders, whereas those with cerebrovascular diseases and withdrawal of antiepileptic drugs were the slowest responders. This study revealed a positive correlation between the response time to diazepam administration and seizure duration during status epilepticus. Response time may have a role in predicting outcome of status epilepticus treatment, in particular, the effects of diazepam. Thus, longer-duration EEGs are indicated.

Neurological Research, 2008

Objective: Glycine transporter-1 (GLYT1) is an early marker of neural development and involved in... more Objective: Glycine transporter-1 (GLYT1) is an early marker of neural development and involved in the excitatory transmission in cortex. The study was designed to investigate the expression of GLYT1 in different parts of the brain by immunohistochemistry in the rat cortical dysplasia model. Methods: On postnatal day 0, one freeze lesion was carried out on ten rats between bregma and lambda on the skull in the right hemisphere for 5 seconds. Six weeks later, rats were transcardially perfused with fixative and then their brains were removed for both hamotoxylineosine (H&E) staining for histopathology and immunohistochemistry staining for glial fibrillary acidic protein (GFAP) for astrocytic activity and GLYT1 in the cortical dysplastic region and other rostral brain regions involving epileptogenesis such as hippocampus, pyriform cortex, amygdala, thalamus and substantia nigra. Results: GFAP immunoreactivity showed clusters of glial cells in the area of the microgyrus. Dense GLYT1 expression was localized to superficial layer of microgyric cortex and around the microgyrus. GLYT1 immunoreactivity was not detected in the other rostral regions. Discussion: GLYT1 stained superficial structures might correspond to immature neuron and higher concentrations of GLYT1 around microgyrus might be correlated with increased excitatory mechanisms in these regions.

Yeditepe tıp dergisi, 2013

International Conference on Biomedical Engineering, Feb 17, 2006

Yeditepe tıp dergisi, 2014

Journal of International Medical Research, Oct 27, 2016

Neurological Sciences and Neurophysiology, 2019

Yeditepe Medical Journal, 2014

European review for medical and pharmacological sciences

Cortical dysplasia (CD) is associated with several behavioral disorders in both the pediatric and... more Cortical dysplasia (CD) is associated with several behavioral disorders in both the pediatric and the adult population. The effect of melatonin on behavioral disorders in rats generated CD has not been investigated so far. To investigate the effects of melatonin administration on activity and anxietic behavior of neonatal rats in a model of CD. Newborn Sprague-Dawley rats (n=21) were randomized into three groups. On postnatal day 1, one freeze lesion was carried out in 14 rats between bregma and lambda to create a CD model. Another group of neonatal rats served as control group (n=7). Those 14 rats were either administered melatonin (n=7) or vehicle solution (n=7). Melatonin treatment (4 mg/kg/day, i.p.) was initiated ten days after induction of cold injury and continued for three weeks. Animal activity and anxiety were analyzed by using open field and elevated plus maze tests 24h after the last melatonin administration (day 32) in a blind manner. It was observed that CD induced ani...

2007 29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2007

Clinical Neurophysiology, 2014

European Journal of Radiology, 2011

The utility of DWI with high b-value in ischemic stroke is still unsettled. The purpose of this s... more The utility of DWI with high b-value in ischemic stroke is still unsettled. The purpose of this study is to compare high b-value (3000) and standard b-value (1000) diffusion-weighted images in patients with ischemic stroke at 3T. 27 patients with acute stroke who were admitted to the hospital during the first 24h after symptom onset were included in this study. All patients had a brain MRI study with stroke protocol including standard (b=1000) DWI and high b-value (b=3000) DWI sequences at 3T MR scanner. Number and localization of the lesions were assessed MR signal intensities (SI), signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR), contrast ratio (CR) and apparent diffusion coefficient (ADC) values of the lesions and normal parenchyma on DWI with b=1000 and b=3000 sequences were measured. All patients with acute stroke revealed hyperintense lesions due to restricted diffusion on DWI with both b-values. However, lesions of restricted diffusion were more conspicuous in b=3000 value DWI than b=1000, and additional 4 ischemic lesions were detected on b=3000 DWI. SNR, CNR, SI and also ADC values in both stroke area and normal parenchyma were lower at b=3000 than the value at b=1000. At b=3000, CR was significantly greater than b=1000 images. Although quantitative analysis shows higher SI, SNR and CNR values with standard b-value (b=1000) diffusion-weighted imaging, using higher b-value may still be beneficial in detecting additional subtle lesions in patients whose clinical findings are not correlated with standard b-value DWI in stroke.

European Journal of Radiology, 2011

The purpose of the study was to investigate the role of Diffusion Tensor Imaging (DTI) and Diffus... more The purpose of the study was to investigate the role of Diffusion Tensor Imaging (DTI) and Diffusion Tensor Tractography (DTT) on the corticospinal tract alterations due to space occupying lesions in the brainstem before and after surgical resection. Pre- and post-surgical DTI data were acquired in 14 patients undergoing surgical resection of brainstem lesions. Patterns of corticospinal tract (CST) alteration on DTT were compared with the neurological exams of the patients pre- and post-operatively. DTT, especially in 3D movie format, seemed very helpful for evaluating the relationship of the lesions with the corticospinal tracts for surgical approach. None of the patients developed additional motor deficit related to surgery except one patient who presented with cerebellar ataxia after surgery. All of the patients with normal CST on DTT presented without motor deficit on neurological exam. The sensitivity, specificity, positive predictive and negative predictive values of DTT before surgery were 100%, 63.6%, 42.9% and 100%, and the corresponding values after surgery were 100%, 96%, 75% and 100% respectively. Although it has low specificity before surgery, DTT is a potentially useful technique in evaluating the effects of brainstem lesions and surgical resection on the relevant corticospinal tracts with high negative predictive value and higher specificity after surgery.

Epilepsy & Behavior, 2013

The aim of this study was to evaluate the type, duration, etiology, treatment, and outcome of sta... more The aim of this study was to evaluate the type, duration, etiology, treatment, and outcome of status epilepticus (SE) episodes, among patients aged 16-50 years. A total of 101 SE episodes in 88 young adult patients fulfilled our criteria. The mean age was 32 years. Status epilepticus episodes were most frequently observed in patients 21-30 years of age. A total of 53% of the patients were male, and 57% had pre-existing epilepsy. Seventy of the 101 episodes were convulsive SE. The most common etiology was withdrawal of or change in antiepileptic drugs (AEDs), seen in 31% of the SE episodes. This study included treatment of SE with traditional AEDs. Sixty-six episodes were treated successfully with intravenous infusion of 18-mg/kg phenytoin, and six episodes were treated with 10-mg/kg phenytoin. A total of 28% of the SE episodes remained refractory to first-line treatment, which was related to the duration of SE and mortality. The outcome was death in 14% of the patients due to underlying etiologies in the hospital.

Clinical Neurophysiology, 2008

s of the 13th European Congress of Clinical Neurophysiology / Clinical Neurophysiology 119 (2008)... more s of the 13th European Congress of Clinical Neurophysiology / Clinical Neurophysiology 119 (2008), S1–S131 S59 THO32 The role of dynamic electrodiagnostic studies in cervical spondylothic myelopathy Geysu Karlikaya 1, Beyza Citci 1 , Mesut Yilmaz 3, Hasan Huseyin Karadeli 1 , Canan Aykut Bingol 1, Sedat Dalbayrak 3 , Sait Naderi 2 1Yeditepe University Hospital, Department of Neurology; 2Yeditepe University Hospital, Department of Neurosurgery; 3 Lutfi Kirdar Kartal Research and Training Hospital Department of Neurosurgery Purpose: The diagnosis of cervical spondylothic myelopathy (CSM) can be challenging. Physical findings, radiological studies and electrophysiological studies are all important for the diagnosis of CSM. Electrophysiological studies, such as electromyography and evoked potentials demonstrate the functional status of the nervous system, therefore they are especially important for making treatment decisions in patients with mild clinical findings and severe radiological findings. Recently dynamic Magnetic Resonance Imaging studies assist physicians during management decisions. However the role of dynamic electrophysiological studies is unclear. The aim of this study is to review the role of dynamic electrophysiological studies in the evaluation of CSM. Methods: We studied 72 patients with CSM and 15 controls with somatosensorial and motor evoked potentials during neck in the neutral position, after neck flexion and extension. Results: The most common finding was prolonged central motor conduction time in myelopathy patients. Overall MEP abnormalities were found in 23 (32%). Patients and SEP abnormalities in 13 (18,5%) .patients. With dynamic MEP and SEP combined 25 patients had abnormalities (34.7%, while only 19 patients (26.3%) had abnormal neutral position MEP and/or SEP studies Conclusion: MEP is more useful than SEP in the diagnosis of CSM. Dynamic electrodiagnostic studies may have a extra 10% valuable role, compared to rest evoked potentials in diagnosing patients with CSM. THO33 Electrophysiological investigation of a long latency response recorded from the seventh intercostal space after phrenic nerve electrical stimulation Tiphaine Rouaud 1, Armelle Magot 1, Pierre Guiheneuc 1 , André Truffert 2, Yann Pereon 1 1Laboratoire d’Explorations Fonctionnelles, Centre de Référence Maladies Neuromusculaires Rares, University Hospital, Nantes, France; 2Clinique de Neurologie, Unité ENMG et des Affections Neuromusculaires, University Hospital, Geneve, Switzerland Introduction: The phrenic nerve stimulation induces an early motor diaphragmatic response recorded from the seventh intercostal space. Interestingly, it also elicits a delayed response of undetermined origin. The objective of this study was to determine the electrophysiological characteristics and the neuroanatomical pathways underlying this response. Methods: Seven healthy volunteers and seven patients (cervical spinal cord injury: 6; isolated right phrenic nerve palsy: 1) were included in the study. Phrenic nerve conduction studies were performed according to standard procedures. The long latency response (LLR) was searched for in all subjects by performing electrical stimulation of the left and right phrenic nerves, the left median nerve and the left tibial nerve. It was recorded from the seventh intercostal space. Results: Whatever the stimulated nerve, the LLR was recorded in all healthy volunteers. It was specifically elicited by nociceptive stimulations. Mean latency was 94 ms (range: 76-109 ms; right phrenic nerve stimulation). Waveforms were polyphasic with highly variable amplitude (wide interand intra-individual variability). Latency was correlated with the nociceptive perception of the stimulation. The LLR was also present in the patient with the phrenic nerve palsy. It was absent in 5 out of 6 cervical spinal cord injured patients. Discussion: This LLR probably reflects seventh intercostal muscle activity rather than diaphragm muscle one. It likely represents a polysynaptic and multisegmental spinal response, conveyed by small-diameter nociceptive fibers under supraspinal control. Conclusion: By analogy with the nociceptive component of the lower limb flexion reflex, it is suggested that the LLR recorded at the seventh intercostal space might constitutes an alarm and withdrawal spinal reflex response. THO34 Electrophysiological studies in asymptomatic patients with vitamin B12 deficiency Füsun Mayda Domaç, Geysu Karlikaya, Yilmaz Çetinkaya, Mehmet Gencer, Tülin Tanridağ, Onder Us Electrodiagnostic Neurology, Marmara University, Istanbul, Turkey Purpose: The neurological syndromes associated with vitamin B12 deficiency include myelopathy, neuropathy, and less often, optic nerve atrophy. The present study was conducted to evaluate the electrophysiological profile of vitamin B12 deficiency and whether a correlation exists between the disease process and the various electrophysiological parameters. Method: Asymptomatic and…

Clinical Neurophysiology, 2008

Amaç: Bu çalışmanın amacı politerapi altındaki (birden fazla antiepileptik kullanan) epilepsi has... more Amaç: Bu çalışmanın amacı politerapi altındaki (birden fazla antiepileptik kullanan) epilepsi hastalarının demografik, klinik, nörolojik muayene ve görüntüleme sonuçlarının incelenerek politerapi ihtiyacına eşlik eden faktörlerin belirlenmesidir. Hastalar ve Yöntem: Marmara Üniversite Hastanesi Epilepsi polikliniğinde takipli 785 epileptik hastanın dosyası retrospektif olarak taranıp, hazırlanan formlar doldurulmuştur. Hastalar monoterapi ya da politerapi kullanmalarına göre gruplanmıştır. İki grup demografik veriler, klinik özellikler, nörolojik muayene ve görüntüleme sonuçları açısından Student-t ve ki-kare testleri ile karşılaştırılmıştır. Bulgular: Politerapi kullanan hasta grubunda öyküde kraniyotomi, intrakraniyal tümör, basit parsiyel nöbet ve konvülsif status epileptikus, nörolojik muayenede patolojik bulgu görülmesi, EEG, kranial görüntüleme (MR/BT) ve SPECT’de patoloji saptanması monoterapi kullanan hasta grubundan daha yüksek bulunmuştur. Sonuç: Politerapi epilepsi tedavi...

Marmara Medical Journal, 2012

Amaç: Bu çalışmanın amacı politerapi altındaki (birden fazla antiepileptik kullanan) epilepsi has... more Amaç: Bu çalışmanın amacı politerapi altındaki (birden fazla antiepileptik kullanan) epilepsi hastalarının demografik, klinik, nörolojik muayene ve görüntüleme sonuçlarının incelenerek politerapi ihtiyacına eşlik eden faktörlerin belirlenmesidir. Hastalar ve Yöntem: Marmara Üniversite Hastanesi Epilepsi polikliniğinde takipli 785 epileptik hastanın dosyası retrospektif olarak taranıp, hazırlanan formlar doldurulmuştur. Hastalar monoterapi ya da politerapi kullanmalarına göre gruplanmıştır. İki grup demografik veriler, klinik özellikler, nörolojik muayene ve görüntüleme sonuçları açısından Student-t ve ki-kare testleri ile karşılaştırılmıştır. Bulgular: Politerapi kullanan hasta grubunda öyküde kraniyotomi, intrakraniyal tümör, basit parsiyel nöbet ve konvülsif status epileptikus, nörolojik muayenede patolojik bulgu görülmesi, EEG, kranial görüntüleme (MR/BT) ve SPECT'de patoloji saptanması monoterapi kullanan hasta grubundan daha yüksek bulunmuştur. Sonuç: Politerapi epilepsi tedavisinde önemli bir basamaktır. Ancak ilaç-ilaç etkileşimi olasılığı ve artan ilaç yan etkileri nedeniyle ilk seçenek olarak kabul edilmemektedir. Politerapi kullanacak hastaların monoterapi ile nöbetleri kontrol altına alınabilen hastalardan farklılıkların belirlenmesi, politerapi ihtiyacının tedavinin öncesinde tahmin edilmesi açısından faydalı olacaktır.

Neurology, Psychiatry and Brain Research, 2011

To determine the electroencephalographic (EEG) response to intravenous bolus administration of di... more To determine the electroencephalographic (EEG) response to intravenous bolus administration of diazepam during status epilepticus (SE), we retrospectively evaluated the time to the disappearance of epileptiform activity in EEG recordings after 10 mg intravenous bolus administration of diazepam, and examined the relationship of this response time to the duration, etiology, and outcome of SE. Patients with SE who responded positively to diazepam administration (n = 53; 37 women, 16 men), aged 17-88 years were recruited from our SE registry. According to their response time to intravenous administration of diazepam, patients were divided into four subgroups: Group I response times ranged from 20 to 60 s, group II from 61 to 120 s, group III from 121-180 s, and group IV from 181 to 360 s. The duration of SE was 10.76 ± 3.46 h in the first group and 27.00 ± 12.57 h in the last group. According to the etiology, patients with central nervous system tumors and metabolic disorders were the fastest responders, whereas those with cerebrovascular diseases and withdrawal of antiepileptic drugs were the slowest responders. This study revealed a positive correlation between the response time to diazepam administration and seizure duration during status epilepticus. Response time may have a role in predicting outcome of status epilepticus treatment, in particular, the effects of diazepam. Thus, longer-duration EEGs are indicated.

Neurological Research, 2008

Objective: Glycine transporter-1 (GLYT1) is an early marker of neural development and involved in... more Objective: Glycine transporter-1 (GLYT1) is an early marker of neural development and involved in the excitatory transmission in cortex. The study was designed to investigate the expression of GLYT1 in different parts of the brain by immunohistochemistry in the rat cortical dysplasia model. Methods: On postnatal day 0, one freeze lesion was carried out on ten rats between bregma and lambda on the skull in the right hemisphere for 5 seconds. Six weeks later, rats were transcardially perfused with fixative and then their brains were removed for both hamotoxylineosine (H&E) staining for histopathology and immunohistochemistry staining for glial fibrillary acidic protein (GFAP) for astrocytic activity and GLYT1 in the cortical dysplastic region and other rostral brain regions involving epileptogenesis such as hippocampus, pyriform cortex, amygdala, thalamus and substantia nigra. Results: GFAP immunoreactivity showed clusters of glial cells in the area of the microgyrus. Dense GLYT1 expression was localized to superficial layer of microgyric cortex and around the microgyrus. GLYT1 immunoreactivity was not detected in the other rostral regions. Discussion: GLYT1 stained superficial structures might correspond to immature neuron and higher concentrations of GLYT1 around microgyrus might be correlated with increased excitatory mechanisms in these regions.