Hio-Been Han | Yonsei University (original) (raw)
Papers by Hio-Been Han
Scientific Data
This work provides an EEG dataset collected from nine mice during the sleep deprivation (SD) para... more This work provides an EEG dataset collected from nine mice during the sleep deprivation (SD) paradigm for the sleep science community. It includes 9-day of continuous recording of the frontal and parietal EEG, accelerometer, and 2-hour of high-density EEG (HD-EEG) under SD and SD-free conditions. Eighteen hours of SD were conducted on 5 consecutive days. The HD-EEG data were saved in the EEGLAB format and stored as the brain imaging data structure (BIDS). These datasets can be used to (i) compare mouse HD-EEG to human HD-EEG, (ii) track oscillatory activities of the sleep EEG (e.g., slow waves, spindles) across the cortical regions under different conditions of sleep pressure, and (iii) investigate the cortical traveling waves in the mouse brain. We also provided Python code for basic analyses of this dataset, including the detection of slow waves and sleep spindles. We hope that our dataset will reveal hidden activities during sleep and lead to a better understanding of the functio...
A set of screw and high-density EEG data obtained from freely-moving mice (mus musculus). Details... more A set of screw and high-density EEG data obtained from freely-moving mice (mus musculus). Details of experimental method are described in the original research article using the same dataset [Kim et al., 2017, PNAS].
Biomedicines
Traumatic brain injury (TBI) leads to long-term cognitive impairments, with an increased risk for... more Traumatic brain injury (TBI) leads to long-term cognitive impairments, with an increased risk for neurodegenerative and psychiatric disorders. Among these various impairments, olfactory dysfunction is one of the most common symptoms in TBI patients. However, there are very few studies that show the association between olfactory dysfunction and repetitive TBI. To investigate the effects of repetitive TBI on olfactory functioning and the related pathological neuronal injuries in mice, we applied a weight-drop model of TBI and performed neuropathological examinations and electroencephalography (EEG) in olfactory-bulb-associated areas. Through neuropathological examinations, we found significant increases of amyloid precursor protein (APP) and phosphorylated Tau (p-Tau) (S202/T205) in olfactory-bulb-associated areas. Neuronal atrophy in the lateral anterior olfactory nucleus (AOL), granule layer olfactory bulb (GrO), and dorsal tenia tecta (DTT) was also found to be correlated with p-Ta...
A set of high-density EEG (electroencephalogram) recording obtained from awake, freely-moving mic... more A set of high-density EEG (electroencephalogram) recording obtained from awake, freely-moving mice (mus musculus). Details of experimental method are described in the original research article using the same dataset [Hwang et al., 2019, Brain Structure and Function].
A set of high-density EEG (electroencephalogram) recording obtained from awake, freely-moving mic... more A set of high-density EEG (electroencephalogram) recording obtained from awake, freely-moving mice (mus musculus). Details of experimental method are described in the original research article using the same dataset [Hwang et al., 2019, Brain Structure and Function].
Gamma band oscillations (GBO, 30 – 80 Hz, centered on 40 Hz) are related to cortical representati... more Gamma band oscillations (GBO, 30 – 80 Hz, centered on 40 Hz) are related to cortical representation of perceptual integration after binding sensory and/or perceptual elements. One question is how rapidly changing local features are bound together to one sensation and how GBO are distributed over the cortex during this process. Here, we designed visual stimuli paradigm for mice based on conventional random-dot kinematogram (RDK) display, and investigated the cortical GBO. RDK is composed on a number of rapidly moving particles with no preferred direction (incoherent stimulus) or with preferred direction (coherent stimulus). Static image was given as well. In coherent stimulus, randomly distributed particles moved to one direction, appearing an optic flow. We found that GBO are induced in RDK paradigm in mouse visual cortex for all types of stimuli, but in a stronger way for moving particles. No difference in visual GBO was observed between incoherent and coherent stimuli. On the other hand, GBO in frontal cortex were induced significantly only for coherent stimulus accompanied by statistically significant increase in frontal-visual connectivity and intra-frontal connectivity. These results indicate that frontal GBO are related to the representation of perceptual integration of fast moving local features into global motion, suggesting the involvement of frontal GBO in the global processing of optic flow. These observations are consistent with the previous findings in human RDK studies, but the first in mouse to the best of our knowledge.
International Journal of Neuropsychopharmacology, 2016
Experimental Neurobiology, 2016
SummaryThe medial prefrontal cortex (mPFC) and basolateral amygdala (BLA) are involved in the reg... more SummaryThe medial prefrontal cortex (mPFC) and basolateral amygdala (BLA) are involved in the regulation of defensive behavior under threat, but their engagement in flexible behavior shifts remains unclear. Here, we report the oscillatory activities of mPFC-BLA circuit in reaction to a naturalistic threat, created by a predatory robot in mice. Specifically, we found dynamic frequency tuning among two different theta rhythms (∼5 or ∼10 Hz) was accompanied by agile changes of two different defensive behaviors (freeze or flight). By analyzing flight trajectories, we also found that high beta (∼30 Hz) is engaged in the top-down process for goal-directed flights and accompanied by a reduction in fast gamma (60–120 Hz, peak near 70 Hz). The elevated beta nested the fast gamma activity by its phase more strongly. Our results suggest that the mPFC-BLA circuit has a potential role in oscillatory gear shifting allowing flexible information routing for behavior switches.HighlightsWhen threaten...
Traumatic brain injury (TBI) leads to long-term cognitive impairments with an increased risk for ... more Traumatic brain injury (TBI) leads to long-term cognitive impairments with an increased risk for neurodegenerative and psychiatric disorders. Among these various impairments, olfactory dysfunction is one of the most common symptoms in TBI patients. However, there are very few studies that show the association between olfactory dysfunction and repetitive TBI, which accounts for the majority of all head injuries. In this present study, we investigated the effects of repetitive TBI on olfactory functioning and the related pathological neuronal injuries in mice. Through pathological examination, we found a significant increase in p-Tau (S202/T205) in olfactory bulb-associated areas such as the Anterior Olfactory Nucleus (AON), Pyriform Cortex (PC), Tenia Tecta (TT), and Olfactory Tubercle (OT). Neuronal atrophy in the Lateral Anterior Olfactory Nucleus (AOL), Granule Layer Olfactory Bulb (GrO), and Dorsal Tenia Tecta (DTT) was also found to be correlated with p-Tau levels. Furthermore, ...
Science Advances
Social cognition requires neural processing, yet a unifying method linking particular brain activ... more Social cognition requires neural processing, yet a unifying method linking particular brain activities and social behaviors is lacking. Here, we embedded mobile edge computing (MEC) and light emitting diodes (LEDs) on a neurotelemetry headstage, such that a particular neural event of interest is processed by the MEC and subsequently an LED is illuminated, allowing simultaneous temporospatial visualization of that neural event in multiple, socially interacting mice. As a proof of concept, we configured our system to illuminate an LED in response to gamma oscillations in the basolateral amygdala (BLA gamma) in freely moving mice. We identified (i) BLA gamma responses to a spider robot, (ii) affect-related BLA gamma during conflict, and (iii) formation of defensive aggregation under a threat by the robot, and reduction of BLA gamma responses in the inner-located mice. Our system can provide an intuitive framework for examining brain-behavior connections in various ecological situations...
Scientific Data
We present high-density EEG datasets of auditory steady-state responses (ASSRs) recorded from the... more We present high-density EEG datasets of auditory steady-state responses (ASSRs) recorded from the cortex of freely moving mice with or without optogenetic stimulation of basal forebrain parvalbumin (BF-PV) neurons, known as a subcortical hub circuit for the global workspace. The dataset of ASSRs without BF-PV stimulation (dataset 1) contains raw 36-channel EEG epochs of ASSRs elicited by 10, 20, 30, 40, and 50 Hz click trains and time stamps of stimulations. The dataset of ASSRs with BF-PV stimulation (dataset 2) contains raw 36-channel EEG epochs of 40-Hz ASSRs during BF-PV stimulation with latencies of 0, 6.25, 12.5, and 18.75 ms and time stamps of stimulations. We provide the datasets and step-by-step tutorial analysis scripts written in Python, allowing for descriptions of the event-related potentials, spectrograms, and the topography of power. We complement this experimental dataset with simulation results using a time-dependent perturbation on coupled oscillators. This publicl...
SUMMARYThe complexity of human perceptual system has often been investigated through its atypical... more SUMMARYThe complexity of human perceptual system has often been investigated through its atypical function; the illusion. Here, I introduce a new visual illusion induced by rotational motion binding, which leads to a gestalt perception of illusory object rhythmically popping out and fading away. In this illusion, observers reported non-existing rhythm out of rotating Gabor patches (e.g., local rotation) that also have orbital trajectory with opposite direction (e.g., global rotation), only under the particular combinations of parameters. This illusory rhythmicity was four times faster than the average of global/local rotational speed. Image reconstruction using the response-triggered average revealed the rhythmicity is explained by the circular alignment of array, demonstrating the effect of repeated contour integration and its perceptual consequences.
Theta-band (4-12 Hz) activities in the frontal cortex have been thought to be a key mechanism of ... more Theta-band (4-12 Hz) activities in the frontal cortex have been thought to be a key mechanism of sustained attention and goal-related behaviors, forming a phase-coherent network with task-related sensory cortices for integrated neuronal ensembles. However, recent visual task studies found that selective attention attenuates stimulus-related theta power in the visual cortex, suggesting a functional dissociation of cortical theta oscillations. To investigate this contradictory behavior of cortical theta, a visual Go/No-Go task was performed with electroencephalogram recording in mice. During the No-Go period, transient theta oscillations were observed in both the frontal and visual cortices, but theta oscillations of the two areas were prominent in different trial epochs. By separating trial epochs based on subjects' short-term performance, we found that frontal theta was prominent in good-performance epochs, while visual theta was prominent in bad-performance epochs, exhibiting a...
Frontiers in Neuroscience
Brain Structure and Function
Scientific Data
This work provides an EEG dataset collected from nine mice during the sleep deprivation (SD) para... more This work provides an EEG dataset collected from nine mice during the sleep deprivation (SD) paradigm for the sleep science community. It includes 9-day of continuous recording of the frontal and parietal EEG, accelerometer, and 2-hour of high-density EEG (HD-EEG) under SD and SD-free conditions. Eighteen hours of SD were conducted on 5 consecutive days. The HD-EEG data were saved in the EEGLAB format and stored as the brain imaging data structure (BIDS). These datasets can be used to (i) compare mouse HD-EEG to human HD-EEG, (ii) track oscillatory activities of the sleep EEG (e.g., slow waves, spindles) across the cortical regions under different conditions of sleep pressure, and (iii) investigate the cortical traveling waves in the mouse brain. We also provided Python code for basic analyses of this dataset, including the detection of slow waves and sleep spindles. We hope that our dataset will reveal hidden activities during sleep and lead to a better understanding of the functio...
A set of screw and high-density EEG data obtained from freely-moving mice (mus musculus). Details... more A set of screw and high-density EEG data obtained from freely-moving mice (mus musculus). Details of experimental method are described in the original research article using the same dataset [Kim et al., 2017, PNAS].
Biomedicines
Traumatic brain injury (TBI) leads to long-term cognitive impairments, with an increased risk for... more Traumatic brain injury (TBI) leads to long-term cognitive impairments, with an increased risk for neurodegenerative and psychiatric disorders. Among these various impairments, olfactory dysfunction is one of the most common symptoms in TBI patients. However, there are very few studies that show the association between olfactory dysfunction and repetitive TBI. To investigate the effects of repetitive TBI on olfactory functioning and the related pathological neuronal injuries in mice, we applied a weight-drop model of TBI and performed neuropathological examinations and electroencephalography (EEG) in olfactory-bulb-associated areas. Through neuropathological examinations, we found significant increases of amyloid precursor protein (APP) and phosphorylated Tau (p-Tau) (S202/T205) in olfactory-bulb-associated areas. Neuronal atrophy in the lateral anterior olfactory nucleus (AOL), granule layer olfactory bulb (GrO), and dorsal tenia tecta (DTT) was also found to be correlated with p-Ta...
A set of high-density EEG (electroencephalogram) recording obtained from awake, freely-moving mic... more A set of high-density EEG (electroencephalogram) recording obtained from awake, freely-moving mice (mus musculus). Details of experimental method are described in the original research article using the same dataset [Hwang et al., 2019, Brain Structure and Function].
A set of high-density EEG (electroencephalogram) recording obtained from awake, freely-moving mic... more A set of high-density EEG (electroencephalogram) recording obtained from awake, freely-moving mice (mus musculus). Details of experimental method are described in the original research article using the same dataset [Hwang et al., 2019, Brain Structure and Function].
Gamma band oscillations (GBO, 30 – 80 Hz, centered on 40 Hz) are related to cortical representati... more Gamma band oscillations (GBO, 30 – 80 Hz, centered on 40 Hz) are related to cortical representation of perceptual integration after binding sensory and/or perceptual elements. One question is how rapidly changing local features are bound together to one sensation and how GBO are distributed over the cortex during this process. Here, we designed visual stimuli paradigm for mice based on conventional random-dot kinematogram (RDK) display, and investigated the cortical GBO. RDK is composed on a number of rapidly moving particles with no preferred direction (incoherent stimulus) or with preferred direction (coherent stimulus). Static image was given as well. In coherent stimulus, randomly distributed particles moved to one direction, appearing an optic flow. We found that GBO are induced in RDK paradigm in mouse visual cortex for all types of stimuli, but in a stronger way for moving particles. No difference in visual GBO was observed between incoherent and coherent stimuli. On the other hand, GBO in frontal cortex were induced significantly only for coherent stimulus accompanied by statistically significant increase in frontal-visual connectivity and intra-frontal connectivity. These results indicate that frontal GBO are related to the representation of perceptual integration of fast moving local features into global motion, suggesting the involvement of frontal GBO in the global processing of optic flow. These observations are consistent with the previous findings in human RDK studies, but the first in mouse to the best of our knowledge.
International Journal of Neuropsychopharmacology, 2016
Experimental Neurobiology, 2016
SummaryThe medial prefrontal cortex (mPFC) and basolateral amygdala (BLA) are involved in the reg... more SummaryThe medial prefrontal cortex (mPFC) and basolateral amygdala (BLA) are involved in the regulation of defensive behavior under threat, but their engagement in flexible behavior shifts remains unclear. Here, we report the oscillatory activities of mPFC-BLA circuit in reaction to a naturalistic threat, created by a predatory robot in mice. Specifically, we found dynamic frequency tuning among two different theta rhythms (∼5 or ∼10 Hz) was accompanied by agile changes of two different defensive behaviors (freeze or flight). By analyzing flight trajectories, we also found that high beta (∼30 Hz) is engaged in the top-down process for goal-directed flights and accompanied by a reduction in fast gamma (60–120 Hz, peak near 70 Hz). The elevated beta nested the fast gamma activity by its phase more strongly. Our results suggest that the mPFC-BLA circuit has a potential role in oscillatory gear shifting allowing flexible information routing for behavior switches.HighlightsWhen threaten...
Traumatic brain injury (TBI) leads to long-term cognitive impairments with an increased risk for ... more Traumatic brain injury (TBI) leads to long-term cognitive impairments with an increased risk for neurodegenerative and psychiatric disorders. Among these various impairments, olfactory dysfunction is one of the most common symptoms in TBI patients. However, there are very few studies that show the association between olfactory dysfunction and repetitive TBI, which accounts for the majority of all head injuries. In this present study, we investigated the effects of repetitive TBI on olfactory functioning and the related pathological neuronal injuries in mice. Through pathological examination, we found a significant increase in p-Tau (S202/T205) in olfactory bulb-associated areas such as the Anterior Olfactory Nucleus (AON), Pyriform Cortex (PC), Tenia Tecta (TT), and Olfactory Tubercle (OT). Neuronal atrophy in the Lateral Anterior Olfactory Nucleus (AOL), Granule Layer Olfactory Bulb (GrO), and Dorsal Tenia Tecta (DTT) was also found to be correlated with p-Tau levels. Furthermore, ...
Science Advances
Social cognition requires neural processing, yet a unifying method linking particular brain activ... more Social cognition requires neural processing, yet a unifying method linking particular brain activities and social behaviors is lacking. Here, we embedded mobile edge computing (MEC) and light emitting diodes (LEDs) on a neurotelemetry headstage, such that a particular neural event of interest is processed by the MEC and subsequently an LED is illuminated, allowing simultaneous temporospatial visualization of that neural event in multiple, socially interacting mice. As a proof of concept, we configured our system to illuminate an LED in response to gamma oscillations in the basolateral amygdala (BLA gamma) in freely moving mice. We identified (i) BLA gamma responses to a spider robot, (ii) affect-related BLA gamma during conflict, and (iii) formation of defensive aggregation under a threat by the robot, and reduction of BLA gamma responses in the inner-located mice. Our system can provide an intuitive framework for examining brain-behavior connections in various ecological situations...
Scientific Data
We present high-density EEG datasets of auditory steady-state responses (ASSRs) recorded from the... more We present high-density EEG datasets of auditory steady-state responses (ASSRs) recorded from the cortex of freely moving mice with or without optogenetic stimulation of basal forebrain parvalbumin (BF-PV) neurons, known as a subcortical hub circuit for the global workspace. The dataset of ASSRs without BF-PV stimulation (dataset 1) contains raw 36-channel EEG epochs of ASSRs elicited by 10, 20, 30, 40, and 50 Hz click trains and time stamps of stimulations. The dataset of ASSRs with BF-PV stimulation (dataset 2) contains raw 36-channel EEG epochs of 40-Hz ASSRs during BF-PV stimulation with latencies of 0, 6.25, 12.5, and 18.75 ms and time stamps of stimulations. We provide the datasets and step-by-step tutorial analysis scripts written in Python, allowing for descriptions of the event-related potentials, spectrograms, and the topography of power. We complement this experimental dataset with simulation results using a time-dependent perturbation on coupled oscillators. This publicl...
SUMMARYThe complexity of human perceptual system has often been investigated through its atypical... more SUMMARYThe complexity of human perceptual system has often been investigated through its atypical function; the illusion. Here, I introduce a new visual illusion induced by rotational motion binding, which leads to a gestalt perception of illusory object rhythmically popping out and fading away. In this illusion, observers reported non-existing rhythm out of rotating Gabor patches (e.g., local rotation) that also have orbital trajectory with opposite direction (e.g., global rotation), only under the particular combinations of parameters. This illusory rhythmicity was four times faster than the average of global/local rotational speed. Image reconstruction using the response-triggered average revealed the rhythmicity is explained by the circular alignment of array, demonstrating the effect of repeated contour integration and its perceptual consequences.
Theta-band (4-12 Hz) activities in the frontal cortex have been thought to be a key mechanism of ... more Theta-band (4-12 Hz) activities in the frontal cortex have been thought to be a key mechanism of sustained attention and goal-related behaviors, forming a phase-coherent network with task-related sensory cortices for integrated neuronal ensembles. However, recent visual task studies found that selective attention attenuates stimulus-related theta power in the visual cortex, suggesting a functional dissociation of cortical theta oscillations. To investigate this contradictory behavior of cortical theta, a visual Go/No-Go task was performed with electroencephalogram recording in mice. During the No-Go period, transient theta oscillations were observed in both the frontal and visual cortices, but theta oscillations of the two areas were prominent in different trial epochs. By separating trial epochs based on subjects' short-term performance, we found that frontal theta was prominent in good-performance epochs, while visual theta was prominent in bad-performance epochs, exhibiting a...
Frontiers in Neuroscience
Brain Structure and Function