Bowei Jiang | York University (original) (raw)

Papers by Bowei Jiang

SID Symposium Digest of Technical Papers

Human haptic systems such as hand and skin are capable of material classification and texture rec... more Human haptic systems such as hand and skin are capable of material classification and texture recognition with a slight training effort where the mechanoreceptor first collects the tactile information, secondly, the nerves and neurons deliver the message and finally, the somatosensory cortex in the brain computes and makes a decision. In this work, we attempt to build a machine haptic system to mimic functions of skin and nervous system for material classification and recognition.

Frontiers in Bioengineering and Biotechnology

With the development of nanotechnology, nanomaterials are widely applied in different areas. Some... more With the development of nanotechnology, nanomaterials are widely applied in different areas. Some nanomaterials are designed to be biocompatible and can be used in the medical field, playing an important role in disease treatment. Exosomes are nanoscale vesicles with a diameter of 30–200 nm. Studies have shown that exosomes have the effect of angiogenesis, tissue (skin, tendon, cartilage, et al.) repair and reconstruction. Nano-hydrogels are hydrogels with a diameter of 200 nm or less and can be used as the carrier to transport the exosomes into the body. Some orthopedic diseases, such as bone defects and bone infections, are difficult to handle. The emergence of nano-hydrogels coated exosomes may provide a new idea to solve these problems, improving the prognosis of patients. This review summarizes the function of nano-hydrogels coated exosomes in bone tissue repair, intending to illustrate the potential use and application of nano-hydrogels coated exosomes in bone disease.

Forensic Sciences Research

The morphological changes based on deposition of secondary dentin and mineralization of the thi... more The morphological changes based on deposition of secondary dentin and mineralization of the third molar have been proven to be related to chronological age. However, Kvaal’s method on the theory of deposition of secondary dentin was controversial with respect to dental age estimation in the recent research. The aim of this study was to combine the parameters of Kvaal’s method with relatively high correlation coefficients and mineralization stages of the third molar to improve the accuracy of predicting the dental age of subadults in northern China. A total of 340 digital orthopantomograms of subadults aged from 15 to 21 years were analysed. A training group was used to test the accuracy of the original Kvaal’s method and to establish novel methods for subadults in northern China. A testing group was used to compare the accuracy of the newly established methods with the Kvaal’s original method and with published method specifically used in northern China. To increase the feasibilit...

arXiv (Cornell University), Mar 19, 2023

Multifold observations are common for different data modalities, e.g., a 3D shape can be represen... more Multifold observations are common for different data modalities, e.g., a 3D shape can be represented by multiview images and an image can be described with different captions. Existing cross-modal contrastive representation learning (XM-CLR) methods such as CLIP are not fully suitable for multifold data as they only consider one positive pair and treat other pairs as negative when computing the contrastive loss. In this paper, we propose MXM-CLR, a unified framework for contrastive learning of multifold cross-modal representations. MXM-CLR explicitly models and learns the relationships between multifold observations of instances from different modalities for more comprehensive representation learning. The key of MXM-CLR is a novel multifold-aware hybrid loss which considers multiple positive observations when computing the hard and soft relationships for the cross-modal data pairs. We conduct quantitative and qualitative comparisons with SOTA baselines for cross-modal retrieval tasks on the Text2Shape and Flickr30K datasets. We also perform extensive evaluations on the adaptability and generalizability of MXM-CLR, as well as ablation studies on the loss design and effects of batch sizes. The results show the superiority of MXM-CLR in learning better representations for the multifold data. The code is available at https://github.com/JLU-ICL/MXM-CLR. 2. Related Work Contrastive representation learning. The main idea of contrast learning is to pull data points in positive pairs together and push data in negative pairs away. Due to its

2022 IEEE International Flexible Electronics Technology Conference (IFETC)

Frontiers in Surgery

PurposeWith the application of navigation technology in Total Knee Arthroplasty (TKA), TKA proced... more PurposeWith the application of navigation technology in Total Knee Arthroplasty (TKA), TKA procedures have become various. Studies have shown that navigation can improve the alignment of patients' lower limbs. To verify this conclusion, we collected the clinical data from patients who underwent Brainlab knee 3 navigation-guided TKA. Brainlab knee 3 is a completely new software that takes a different approach to address the current challenges of navigated TKA. During the procedure, we applied the Adjusted Mechanical Alignment (AMA) principle and took soft tissue balance as a priority. We aim to explore the patients’ lower limb alignment changes who underwent the Brainlab knee 3 navigation-guided TKA using the AMA method.MethodsFifty consecutive patients who underwent total knee arthroplasty using the Brainlab knee3 knee navigation system (Smith&Nephew) from January to August 2021 by the same doctor (Yunsu Chen) in the Department of Joint Surgery of the Shanghai Sixth People's...

Flexible and Printed Electronics, 2022

Chronical cardiovascular decreases such as hypertension requires real-time and continuous monitor... more Chronical cardiovascular decreases such as hypertension requires real-time and continuous monitoring of blood pressures (BPs). Pulse wave that contains critical and ample information on cardiovascular dynamics is a direct vital sign to extract blood pressure and therefore an epidermal wearable device enabling real-time acquisition of pulse waves becomes necessary. In this work, we propose and study a flexible pulse wave sensory array aiming for real-time wearable pulse wave acquisition with robustness. A piezoelectric sensor together with a thin-film transistor-based sensor interface circuit is used to detect multiple pulse waveforms at the location of radial artery, which are input to a convolutional neural network (CNN) for a deep-learning BP estimation model training. The estimated BPs are assessed by a correlation study with the BPs measured by conventional sphygmomanometers. Our study shows a reasonable accuracy of mean deviation (MD) and standard deviation (STD) of 2.84±7.53 m...

ELECTROPHORESIS, 2021

The flanking region variants of nonbinary SNPs and phenotype‐informative SNPs (piSNPs) have been ... more The flanking region variants of nonbinary SNPs and phenotype‐informative SNPs (piSNPs) have been observed, which may greatly improve the discriminative ability after constituting microhaplotype. In this study, 30 microhaplotype loci based on the nonbinary SNPs and piSNPs (shown to be related to phenotypes such as hair and eye color) were selected. Genotyping were conducted on 100 unrelated northern Han Chinese, and the 26 populations from the 1000 Genome Project were also included for comparison of populations differentiation. The simulated study was conducted for evaluating the efficiency of kinship testing. These 30 microhaplotype loci we selected had good polymorphism, with a mean effective number of alleles (Ae) of 3.46. The average Ae increase was 1.27 compared with the target SNPs. The populations from the five regions worldwide could also be distinguished using these loci. The results of kinship testing showed that these microhaplotype loci had the similar ability as 15 STR l...

ELECTROPHORESIS, 2021

DNA genotyping from trace and highly degraded biological samples is one of the most significant c... more DNA genotyping from trace and highly degraded biological samples is one of the most significant challenges of forensic DNA identification. There is a lack of simple and effective methods for genotyping highly degraded samples. In this study, a multiple loci insertion/deletion polymorphisms (Multi‐InDels) panel was designed for detecting 18 autosomal Multi‐InDels through capillary electrophoresis (CE) with amplicon sizes no longer than 125 bp. Studies of sensitivity, degradation, and species specificity were performed and a population study was carried out using 192 samples from Han populations in Hunan province in the south of China. The combined random match probability (CMP) of these 18 Multi‐InDels was 3.23 × 10–12 and the cumulative probability of exclusion (CPE) was 0.9989, suggesting this panel could be used independently for human identification and could provide efficient supporting information for parentage testing. Complete profiles were obtained from as low as 62.5 pg of ...

SID Symposium Digest of Technical Papers, 2021

In this article, we propose an interface circuit formed by thin film transistor(TFT) for tactile ... more In this article, we propose an interface circuit formed by thin film transistor(TFT) for tactile sensing applications. This interface circuit is composed of two TFTs and a capacitor, in connection with a polyvinylidenefluoride (PVDF) transducer for force sensing. An analytical model is presented to explain the working principle of the interface circuit, and an experimental study of a 10×10 tactile sensing array is built to evaluate the feasibility of the circuit. Our study shows such interface circuit is promising to obtain the dynamic and static force sensing.

International Journal of Legal Medicine, 2021

DNA profiling of short tandem repeats (STRs) is the primary method for genotyping forensic sample... more DNA profiling of short tandem repeats (STRs) is the primary method for genotyping forensic samples. However, degraded DNA and trace samples are still major problems for commercial 5- or 6-dye STR kits. In order to improve the performance of this method, we developed a novel 8-dye STR multiplex system containing 18 autosomal loci (D3S1358, D1S1656, TPOX, D16S539, vWA, D6S1043, D2S1338, CSF1PO, D19S433, D7S820, FGA, D8S1179, D5S818, D13S317, TH01, D21S11, D12S391, and PentaD) and the sex-determining locus Amelogenin, with all fragments smaller than 330 bases. Validation was carried out as recommended by the Scientific Working Group on DNA Analysis Methods. The results showed that complete profiles were obtainable when the input DNA was as low as 0.0625 ng. Full profiles were obtained even in the presence of inhibitors such as humic acid (< 300 ng/μl), hematin (< 100 μM), and indigo (0.01%). The 8-dye STR multiplex system also showed good performance in the detection degraded DNA samples. These results indicate that the 8-dye STR multiplex system is suitable for human DNA genotyping, including for difficult forensic materials.

International Journal of Legal Medicine, 2021

Genotyping of short tandem repeat (STR) markers is the basic method of forensic science. Enhanced... more Genotyping of short tandem repeat (STR) markers is the basic method of forensic science. Enhanced technologies are needed to meet the requirements of databasing and casework samples. The STRscan-17LC kit is a 6 Dye STR kit which amplifies 16 STR loci: D3S1358, TPOX, D16S539, vWA, D2S1338, CSF1PO, D19S433, D7S820, FGA, D8S1179, D5S818, D13S317, D18S51, TH01, D12S391, and D21S11 and the sex-determinant locus amelogenin. This kit is designed for better tolerance to PCR inhibitors and analysis of mildly degraded samples with all fragments smaller than 330 bases. In this study, the STRscan-17LC kit is validated according to the SWGDAM (Scientific Working Group on DNA Analysis Methods) guidelines, including PCR-based studies, sensitivity, precision and accuracy, inhibitors, species specificity, DNA mixture studies, population, and concordance studies. The validation results suggest that the STRscan-17LC kit is a useful tool for forensic application.

Geotechnical and Geological Engineering, 2019

A drop hammer impact test on jointed rock masses is carried out in this study. According to the a... more A drop hammer impact test on jointed rock masses is carried out in this study. According to the analysis of the effect of different joints on the strength, the deformation and the damage of jointed rock masses, the law of the mechanical properties and crack propagation of jointed rock masses is observed under impact load. First, when the dip angle and the number of the joint are greater, the dynamic bearing capacity of rock masses will be weaker. Meanwhile the deformation and the damage of rock masses will increase. Then, when the impact load is small, the dynamic compression deformation of jointed rock mass is mainly due to the normal closure of joints. After the impact load increased, more microcracks are produced around the joints. These cracks will gradually spread along the joints and finally lead to the damage of jointed rock masses. Besides, the joint can increase the stress waves energy dissipation and weaken the propagation of the stress waves in the rock mass. The study provides a reference for the dynamic analysis of fractured rock masses and the excavation support of surrounding rock mass in deep mining of mines.

IOP Conference Series: Earth and Environmental Science, 2017

2007 IEEE Asian Solid-State Circuits Conference, 2007

This paper presents a high performance AC-DC charge pump for RFID tags, with the self-bias feedba... more This paper presents a high performance AC-DC charge pump for RFID tags, with the self-bias feedback and threshold compensation technique. Compared with conventional charge pump, the influence of threshold is greatly reduced and output DC voltage and power conversion efficiency is greatly improved. This proposed charge pump with 5 stages is implemented in SMIC 0.18 mum standard CMOS process. Simulation

Proceedings of the 2nd International Conference on Education, Management and Social Science, 2014

Poverty alleviation has been one of the important work related to people's livelihood. Through th... more Poverty alleviation has been one of the important work related to people's livelihood. Through the analysis of achievements and problems of Heilongjiang poverty alleviation. This article puts forward the concrete ideas and measures to improve the work to achieve for Heilongjiang province government related part of its decision to provide the reference. At the same time it hopes to be able to achieve the effect of point to area in order to provide reference for other provinces to improve the effect of poverty alleviation work.

The Analyst, 2013

A novel fluorescent single nucleotide polymorphism (SNP) assay was developed by using Graphene Ox... more A novel fluorescent single nucleotide polymorphism (SNP) assay was developed by using Graphene Oxide (GO), which provides a fast, sensitive and simple method for SNP detection. The strategy was based on the single base extension reaction and different absorption capacity of fluorescein labeled dGTP (dGTP-Fl) and double-stranded DNA (dsDNA) to GO. dGTP-Fl is incorporated into the probe by extension reaction for the mutant target but not for the wild target, which leads to recovered fluorescence for the mutant target because of weak interaction between dsDNA and GO and weak fluorescence for the wild target because of the quenched fluorescence of dGTP-Fl by GO. The method shows a linear range for the mutant-type target from 3 nM to 50 nM and 3 nM is the detection limit. It was noted that as low as 10% mutant-type target could be detected in the presence of the wild-type target, in which the concentration is 9 times higher than that of the mutant-type target.

SID Symposium Digest of Technical Papers

Human haptic systems such as hand and skin are capable of material classification and texture rec... more Human haptic systems such as hand and skin are capable of material classification and texture recognition with a slight training effort where the mechanoreceptor first collects the tactile information, secondly, the nerves and neurons deliver the message and finally, the somatosensory cortex in the brain computes and makes a decision. In this work, we attempt to build a machine haptic system to mimic functions of skin and nervous system for material classification and recognition.

Frontiers in Bioengineering and Biotechnology

With the development of nanotechnology, nanomaterials are widely applied in different areas. Some... more With the development of nanotechnology, nanomaterials are widely applied in different areas. Some nanomaterials are designed to be biocompatible and can be used in the medical field, playing an important role in disease treatment. Exosomes are nanoscale vesicles with a diameter of 30–200 nm. Studies have shown that exosomes have the effect of angiogenesis, tissue (skin, tendon, cartilage, et al.) repair and reconstruction. Nano-hydrogels are hydrogels with a diameter of 200 nm or less and can be used as the carrier to transport the exosomes into the body. Some orthopedic diseases, such as bone defects and bone infections, are difficult to handle. The emergence of nano-hydrogels coated exosomes may provide a new idea to solve these problems, improving the prognosis of patients. This review summarizes the function of nano-hydrogels coated exosomes in bone tissue repair, intending to illustrate the potential use and application of nano-hydrogels coated exosomes in bone disease.

Forensic Sciences Research

The morphological changes based on deposition of secondary dentin and mineralization of the thi... more The morphological changes based on deposition of secondary dentin and mineralization of the third molar have been proven to be related to chronological age. However, Kvaal’s method on the theory of deposition of secondary dentin was controversial with respect to dental age estimation in the recent research. The aim of this study was to combine the parameters of Kvaal’s method with relatively high correlation coefficients and mineralization stages of the third molar to improve the accuracy of predicting the dental age of subadults in northern China. A total of 340 digital orthopantomograms of subadults aged from 15 to 21 years were analysed. A training group was used to test the accuracy of the original Kvaal’s method and to establish novel methods for subadults in northern China. A testing group was used to compare the accuracy of the newly established methods with the Kvaal’s original method and with published method specifically used in northern China. To increase the feasibilit...

arXiv (Cornell University), Mar 19, 2023

Multifold observations are common for different data modalities, e.g., a 3D shape can be represen... more Multifold observations are common for different data modalities, e.g., a 3D shape can be represented by multiview images and an image can be described with different captions. Existing cross-modal contrastive representation learning (XM-CLR) methods such as CLIP are not fully suitable for multifold data as they only consider one positive pair and treat other pairs as negative when computing the contrastive loss. In this paper, we propose MXM-CLR, a unified framework for contrastive learning of multifold cross-modal representations. MXM-CLR explicitly models and learns the relationships between multifold observations of instances from different modalities for more comprehensive representation learning. The key of MXM-CLR is a novel multifold-aware hybrid loss which considers multiple positive observations when computing the hard and soft relationships for the cross-modal data pairs. We conduct quantitative and qualitative comparisons with SOTA baselines for cross-modal retrieval tasks on the Text2Shape and Flickr30K datasets. We also perform extensive evaluations on the adaptability and generalizability of MXM-CLR, as well as ablation studies on the loss design and effects of batch sizes. The results show the superiority of MXM-CLR in learning better representations for the multifold data. The code is available at https://github.com/JLU-ICL/MXM-CLR. 2. Related Work Contrastive representation learning. The main idea of contrast learning is to pull data points in positive pairs together and push data in negative pairs away. Due to its

2022 IEEE International Flexible Electronics Technology Conference (IFETC)

Frontiers in Surgery

PurposeWith the application of navigation technology in Total Knee Arthroplasty (TKA), TKA proced... more PurposeWith the application of navigation technology in Total Knee Arthroplasty (TKA), TKA procedures have become various. Studies have shown that navigation can improve the alignment of patients' lower limbs. To verify this conclusion, we collected the clinical data from patients who underwent Brainlab knee 3 navigation-guided TKA. Brainlab knee 3 is a completely new software that takes a different approach to address the current challenges of navigated TKA. During the procedure, we applied the Adjusted Mechanical Alignment (AMA) principle and took soft tissue balance as a priority. We aim to explore the patients’ lower limb alignment changes who underwent the Brainlab knee 3 navigation-guided TKA using the AMA method.MethodsFifty consecutive patients who underwent total knee arthroplasty using the Brainlab knee3 knee navigation system (Smith&Nephew) from January to August 2021 by the same doctor (Yunsu Chen) in the Department of Joint Surgery of the Shanghai Sixth People's...

Flexible and Printed Electronics, 2022

Chronical cardiovascular decreases such as hypertension requires real-time and continuous monitor... more Chronical cardiovascular decreases such as hypertension requires real-time and continuous monitoring of blood pressures (BPs). Pulse wave that contains critical and ample information on cardiovascular dynamics is a direct vital sign to extract blood pressure and therefore an epidermal wearable device enabling real-time acquisition of pulse waves becomes necessary. In this work, we propose and study a flexible pulse wave sensory array aiming for real-time wearable pulse wave acquisition with robustness. A piezoelectric sensor together with a thin-film transistor-based sensor interface circuit is used to detect multiple pulse waveforms at the location of radial artery, which are input to a convolutional neural network (CNN) for a deep-learning BP estimation model training. The estimated BPs are assessed by a correlation study with the BPs measured by conventional sphygmomanometers. Our study shows a reasonable accuracy of mean deviation (MD) and standard deviation (STD) of 2.84±7.53 m...

ELECTROPHORESIS, 2021

The flanking region variants of nonbinary SNPs and phenotype‐informative SNPs (piSNPs) have been ... more The flanking region variants of nonbinary SNPs and phenotype‐informative SNPs (piSNPs) have been observed, which may greatly improve the discriminative ability after constituting microhaplotype. In this study, 30 microhaplotype loci based on the nonbinary SNPs and piSNPs (shown to be related to phenotypes such as hair and eye color) were selected. Genotyping were conducted on 100 unrelated northern Han Chinese, and the 26 populations from the 1000 Genome Project were also included for comparison of populations differentiation. The simulated study was conducted for evaluating the efficiency of kinship testing. These 30 microhaplotype loci we selected had good polymorphism, with a mean effective number of alleles (Ae) of 3.46. The average Ae increase was 1.27 compared with the target SNPs. The populations from the five regions worldwide could also be distinguished using these loci. The results of kinship testing showed that these microhaplotype loci had the similar ability as 15 STR l...

ELECTROPHORESIS, 2021

DNA genotyping from trace and highly degraded biological samples is one of the most significant c... more DNA genotyping from trace and highly degraded biological samples is one of the most significant challenges of forensic DNA identification. There is a lack of simple and effective methods for genotyping highly degraded samples. In this study, a multiple loci insertion/deletion polymorphisms (Multi‐InDels) panel was designed for detecting 18 autosomal Multi‐InDels through capillary electrophoresis (CE) with amplicon sizes no longer than 125 bp. Studies of sensitivity, degradation, and species specificity were performed and a population study was carried out using 192 samples from Han populations in Hunan province in the south of China. The combined random match probability (CMP) of these 18 Multi‐InDels was 3.23 × 10–12 and the cumulative probability of exclusion (CPE) was 0.9989, suggesting this panel could be used independently for human identification and could provide efficient supporting information for parentage testing. Complete profiles were obtained from as low as 62.5 pg of ...

SID Symposium Digest of Technical Papers, 2021

In this article, we propose an interface circuit formed by thin film transistor(TFT) for tactile ... more In this article, we propose an interface circuit formed by thin film transistor(TFT) for tactile sensing applications. This interface circuit is composed of two TFTs and a capacitor, in connection with a polyvinylidenefluoride (PVDF) transducer for force sensing. An analytical model is presented to explain the working principle of the interface circuit, and an experimental study of a 10×10 tactile sensing array is built to evaluate the feasibility of the circuit. Our study shows such interface circuit is promising to obtain the dynamic and static force sensing.

International Journal of Legal Medicine, 2021

DNA profiling of short tandem repeats (STRs) is the primary method for genotyping forensic sample... more DNA profiling of short tandem repeats (STRs) is the primary method for genotyping forensic samples. However, degraded DNA and trace samples are still major problems for commercial 5- or 6-dye STR kits. In order to improve the performance of this method, we developed a novel 8-dye STR multiplex system containing 18 autosomal loci (D3S1358, D1S1656, TPOX, D16S539, vWA, D6S1043, D2S1338, CSF1PO, D19S433, D7S820, FGA, D8S1179, D5S818, D13S317, TH01, D21S11, D12S391, and PentaD) and the sex-determining locus Amelogenin, with all fragments smaller than 330 bases. Validation was carried out as recommended by the Scientific Working Group on DNA Analysis Methods. The results showed that complete profiles were obtainable when the input DNA was as low as 0.0625 ng. Full profiles were obtained even in the presence of inhibitors such as humic acid (< 300 ng/μl), hematin (< 100 μM), and indigo (0.01%). The 8-dye STR multiplex system also showed good performance in the detection degraded DNA samples. These results indicate that the 8-dye STR multiplex system is suitable for human DNA genotyping, including for difficult forensic materials.

International Journal of Legal Medicine, 2021

Genotyping of short tandem repeat (STR) markers is the basic method of forensic science. Enhanced... more Genotyping of short tandem repeat (STR) markers is the basic method of forensic science. Enhanced technologies are needed to meet the requirements of databasing and casework samples. The STRscan-17LC kit is a 6 Dye STR kit which amplifies 16 STR loci: D3S1358, TPOX, D16S539, vWA, D2S1338, CSF1PO, D19S433, D7S820, FGA, D8S1179, D5S818, D13S317, D18S51, TH01, D12S391, and D21S11 and the sex-determinant locus amelogenin. This kit is designed for better tolerance to PCR inhibitors and analysis of mildly degraded samples with all fragments smaller than 330 bases. In this study, the STRscan-17LC kit is validated according to the SWGDAM (Scientific Working Group on DNA Analysis Methods) guidelines, including PCR-based studies, sensitivity, precision and accuracy, inhibitors, species specificity, DNA mixture studies, population, and concordance studies. The validation results suggest that the STRscan-17LC kit is a useful tool for forensic application.

Geotechnical and Geological Engineering, 2019

A drop hammer impact test on jointed rock masses is carried out in this study. According to the a... more A drop hammer impact test on jointed rock masses is carried out in this study. According to the analysis of the effect of different joints on the strength, the deformation and the damage of jointed rock masses, the law of the mechanical properties and crack propagation of jointed rock masses is observed under impact load. First, when the dip angle and the number of the joint are greater, the dynamic bearing capacity of rock masses will be weaker. Meanwhile the deformation and the damage of rock masses will increase. Then, when the impact load is small, the dynamic compression deformation of jointed rock mass is mainly due to the normal closure of joints. After the impact load increased, more microcracks are produced around the joints. These cracks will gradually spread along the joints and finally lead to the damage of jointed rock masses. Besides, the joint can increase the stress waves energy dissipation and weaken the propagation of the stress waves in the rock mass. The study provides a reference for the dynamic analysis of fractured rock masses and the excavation support of surrounding rock mass in deep mining of mines.

IOP Conference Series: Earth and Environmental Science, 2017

2007 IEEE Asian Solid-State Circuits Conference, 2007

This paper presents a high performance AC-DC charge pump for RFID tags, with the self-bias feedba... more This paper presents a high performance AC-DC charge pump for RFID tags, with the self-bias feedback and threshold compensation technique. Compared with conventional charge pump, the influence of threshold is greatly reduced and output DC voltage and power conversion efficiency is greatly improved. This proposed charge pump with 5 stages is implemented in SMIC 0.18 mum standard CMOS process. Simulation

Proceedings of the 2nd International Conference on Education, Management and Social Science, 2014

Poverty alleviation has been one of the important work related to people's livelihood. Through th... more Poverty alleviation has been one of the important work related to people's livelihood. Through the analysis of achievements and problems of Heilongjiang poverty alleviation. This article puts forward the concrete ideas and measures to improve the work to achieve for Heilongjiang province government related part of its decision to provide the reference. At the same time it hopes to be able to achieve the effect of point to area in order to provide reference for other provinces to improve the effect of poverty alleviation work.

The Analyst, 2013

A novel fluorescent single nucleotide polymorphism (SNP) assay was developed by using Graphene Ox... more A novel fluorescent single nucleotide polymorphism (SNP) assay was developed by using Graphene Oxide (GO), which provides a fast, sensitive and simple method for SNP detection. The strategy was based on the single base extension reaction and different absorption capacity of fluorescein labeled dGTP (dGTP-Fl) and double-stranded DNA (dsDNA) to GO. dGTP-Fl is incorporated into the probe by extension reaction for the mutant target but not for the wild target, which leads to recovered fluorescence for the mutant target because of weak interaction between dsDNA and GO and weak fluorescence for the wild target because of the quenched fluorescence of dGTP-Fl by GO. The method shows a linear range for the mutant-type target from 3 nM to 50 nM and 3 nM is the detection limit. It was noted that as low as 10% mutant-type target could be detected in the presence of the wild-type target, in which the concentration is 9 times higher than that of the mutant-type target.