Fatma Zaiton | Zagazig University (original) (raw)
Papers by Fatma Zaiton
In daily clinical practice, radiologists and pulmonologists are faced with incidental radiographi... more In daily clinical practice, radiologists and pulmonologists are faced with incidental radiographic findings of pulmonary nodules. As the diagnosis of pulmonary nodules includes invasive procedures which can be relatively minimal, such as bronchoscopy or transthoracic aspiration or biopsy, but also more invasive procedures such as thoracic surgical biopsies, and as these procedures are linked to anxiety and to cost, it is important to have clearly defined algorithms for the description, management, and follow-up of these nodules. Pulmonary metastasis is seen in 20-54% of extra thoracic malignancies. Lungs are the second most frequent site of metastases from extra thoracic malignancies. Twenty percent of metastatic disease is isolated to the lungs. The development of pulmonary metastases in patients with known malignancies indicates disseminated disease and places the patient in stage IV in TNM (tumor, node, metastasis) staging systems. The aim of this article is to provide a comprehe...
Diffusion-weighted (DW) MRI is a rapid technique that measures the mobility of water molecules wi... more Diffusion-weighted (DW) MRI is a rapid technique that measures the mobility of water molecules within tissue, reflecting the cellular microenvironment. DW MRI produces images that are sensitive to water displacement at the diffusion scale and quantifies such diffusion according to an index that reflects the apparent freedom of diffusion, called the apparent diffusion coefficient (ADC). It has been reported to produce higher detection rates than conventional methods. [3]
The Egyptian Journal of Hospital Medicine, 2021
Background: Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer... more Background: Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer death among females worldwide. Obtaining an accurate diagnosis is of considerable importance as it informs the choice of treatment and the prognostic outcomes of the disease. Magnetic resonance imaging (MRI) has a higher sensitivity for the diagnosis of breast cancer than mammography and ultrasound. Objective: We aimed to assess the diagnostic efficacy and efficiency of unenhanced MRI sequences for detection and characterization of breast lesions. Accordingly, we evaluated the breast unenhanced-MRI (UE-MRI) protocol as a reliable alternative for dynamic contrast-enhanced MRI (DCE-MRI). Patients and Methods: 90 female patients underwent MR examination with a diagnostic protocol including UE-MRI sequences (T1WI, T2WI, short TI inversion recovery (STIR) and diffusion weighted imaging (DWI)) and CE-MRI. UE-MRI results were compared with DCE-MRI and the gold standard results having the latter as the reference standard. Results: UE-MRI results obtained sensitivity, specificity, positive predictive value, negative predictive value, and diagnostic accuracy of 90%, 80%, 90%, 80%, and 86.7% respectively. On the other hand, those for the DCE-MRI were 95%, 90%, 95%, 90%, and 93.3% respectively. It was revealed that there was no significant difference between the two methods. Conclusion: UE-MRI could be considered as a reliable diagnostic tool and an effective substitute for DCE-MRI when contrast administration is not feasible or contraindicated.
European Urology Supplements, 2015
The Egyptian Journal of Radiology and Nuclear Medicine, 2013
ABSTRACT
Zagazig University Medical Journal
Zagazig University Medical Journal
Aim: to evaluate the role of magnetic resonance imaging in the assessment of sport injuries of th... more Aim: to evaluate the role of magnetic resonance imaging in the assessment of sport injuries of the knee joint as an integral part of the musculoskeletal system. Methods: This study was done as a combined study between the
Urology, Jan 28, 2018
To compare the distance between the colon and the trajectory of PCNL access both in prone and FFM... more To compare the distance between the colon and the trajectory of PCNL access both in prone and FFMS positions as measured on CT and to study the effect of age, gender, BMI, side and previous renal surgery as influencing factors. In this prospective study, we included 367 patients scheduled for PCNL. All patients underwent low dose abdominal CT both in prone and FFMS positions. Patients<18 years and those with previous colonic surgery and/or renal congenital anomalies were excluded. The perpendicular distance between the imaginary line of the renal access and the colon was measured. Findings were correlated to different influencing factors. 219 patients were males, and 148 were females. BMI of <30 were reported in 158 patients while BMI > 30 in 209 patients. Data analysis showed that the mean perpendicular distance between colon and the renal access in FFMS and prone positions were 35.92±0.22 mm and 17.78±0.09 mm respectively. In prone position only obesity, age and overall i...
The Egyptian Journal of Radiology and Nuclear Medicine
The Egyptian Journal of Radiology and Nuclear Medicine, 2016
The Journal of Urology, 2016
The Egyptian Journal of Radiology and Nuclear Medicine, 2015
African Journal of Urology, 2015
Objectives: In this retrospective study we reviewed the outcome of non-operative management of hi... more Objectives: In this retrospective study we reviewed the outcome of non-operative management of high-grade blunt renal injuries (grade III–V) and evaluated the predictive indicators of management failure. Subjects and methods: The data review included the patients' demographics, the mechanism of trauma and the clinical characteristics, as well as the laboratory and imaging data upon admission and at follow-up. The data of the patients who were successfully managed non-operatively and of those who needed intervention for renal injuries were compared. Results: Two hundred and six patients were enrolled in this study. Grade III, grade IV and grade V renal injuries were found in 39.8%, 44.2% and 16% of the patients, respectively. The overall success rate of non-operative management was 87.9%, including all patients with grade III, 86.8% of patients with grade IV and 60.6% of those with grade V injuries. Multivariate analysis revealed that trauma secondary to motor vehicle accident, hypotension at presentation, associated injuries to other organs, grade V renal injury Predictors of non-operative management failure of high-grade blunt renal trauma 45 and computed tomography (CT) imaging features, namely medial renal parenchymal laceration, perirenal hematoma ≥3.5 cm and intravascular extravasation were significant predictors for failure of non-operative management. Conclusion: Our findings suggest that high-grade renal injuries in hemodynamically stable patients can be managed conservatively with a high success rate. Multiple clinical and radiological variables can predict the treatment outcome.
Please cite this article in press as: Maarouf AM, et al. Factors predicting the outcome of non-op... more Please cite this article in press as: Maarouf AM, et al. Factors predicting the outcome of non-operative management of high-grade blunt renal trauma. Afr J Urol (2015), http://dx.
European Urology Supplements, 2010
The Journal of Urology, 2015
angiographic findings requiring embolization. The average EBL was 6.5 liters (range 2.5-18) for t... more angiographic findings requiring embolization. The average EBL was 6.5 liters (range 2.5-18) for those 5 patients who bled massively during their index renal surgery. The average number of total units utilized was 12.8 for pRBC (median 8, range 4e28) and 8.3 for FFP (median 6.5, range 1e20). The average total pRBC to FFP ratio was 1.78:1 (median 1.4:1, range 4:1 e 1:1). One patient expired 3 days postoperatively due to multi-system organ failure. Results demonstrated a linear trend between the pRBC:FFP ratio and the percent decrease in serum bicarbonate. As the pRBC:FFP ratio increases from 1:1, the percent bicarbonate decreases proportionately. CONCLUSIONS: Recognizing massive hemorrhage in urologic surgeries and instituting a MTP as soon as an injury is identified yielded clinical benefits, as such MTP mobilizes blood products rapidly and in a pRBC:FFP ratio that approximates 1:1, which improved overall survival after excessive surgical bleeding.
International Journal of Oral and Maxillofacial Surgery, 2009
induce chondrogenesis and osteogenesis to a basal medium. DCM coupled with supplemented growth fa... more induce chondrogenesis and osteogenesis to a basal medium. DCM coupled with supplemented growth factors was tested for its ability to differentiate BMSCs into osteogenic and chondrogenic lineages in two-dimensional (2D) and three-dimensional (3D) cultures. When transforming growth factor-beta3 was added into DCM, BMSCs differentiated to chondrocyte-like cells evidenced by the expression of glycosaminoglycan and type II collagen, whereas osteogenic differentiation was induced by supplementing osteogenic protein-1 (OP-1) resulting detectable expression of osteopontin and osteocalcin. These chondrogenic and osteogenic differentiation markers were enhanced in the 3D cultures compared to the 2D monolayer cultures. The results achieved in this study lay a foundation for the future work on development of biphasic constructs, which may be applied in the treatment of full thickness defects comprising complex of osteochondral tissues.
The Egyptian Journal of Radiology and Nuclear Medicine, 2014
ABSTRACT
In daily clinical practice, radiologists and pulmonologists are faced with incidental radiographi... more In daily clinical practice, radiologists and pulmonologists are faced with incidental radiographic findings of pulmonary nodules. As the diagnosis of pulmonary nodules includes invasive procedures which can be relatively minimal, such as bronchoscopy or transthoracic aspiration or biopsy, but also more invasive procedures such as thoracic surgical biopsies, and as these procedures are linked to anxiety and to cost, it is important to have clearly defined algorithms for the description, management, and follow-up of these nodules. Pulmonary metastasis is seen in 20-54% of extra thoracic malignancies. Lungs are the second most frequent site of metastases from extra thoracic malignancies. Twenty percent of metastatic disease is isolated to the lungs. The development of pulmonary metastases in patients with known malignancies indicates disseminated disease and places the patient in stage IV in TNM (tumor, node, metastasis) staging systems. The aim of this article is to provide a comprehe...
Diffusion-weighted (DW) MRI is a rapid technique that measures the mobility of water molecules wi... more Diffusion-weighted (DW) MRI is a rapid technique that measures the mobility of water molecules within tissue, reflecting the cellular microenvironment. DW MRI produces images that are sensitive to water displacement at the diffusion scale and quantifies such diffusion according to an index that reflects the apparent freedom of diffusion, called the apparent diffusion coefficient (ADC). It has been reported to produce higher detection rates than conventional methods. [3]
The Egyptian Journal of Hospital Medicine, 2021
Background: Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer... more Background: Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer death among females worldwide. Obtaining an accurate diagnosis is of considerable importance as it informs the choice of treatment and the prognostic outcomes of the disease. Magnetic resonance imaging (MRI) has a higher sensitivity for the diagnosis of breast cancer than mammography and ultrasound. Objective: We aimed to assess the diagnostic efficacy and efficiency of unenhanced MRI sequences for detection and characterization of breast lesions. Accordingly, we evaluated the breast unenhanced-MRI (UE-MRI) protocol as a reliable alternative for dynamic contrast-enhanced MRI (DCE-MRI). Patients and Methods: 90 female patients underwent MR examination with a diagnostic protocol including UE-MRI sequences (T1WI, T2WI, short TI inversion recovery (STIR) and diffusion weighted imaging (DWI)) and CE-MRI. UE-MRI results were compared with DCE-MRI and the gold standard results having the latter as the reference standard. Results: UE-MRI results obtained sensitivity, specificity, positive predictive value, negative predictive value, and diagnostic accuracy of 90%, 80%, 90%, 80%, and 86.7% respectively. On the other hand, those for the DCE-MRI were 95%, 90%, 95%, 90%, and 93.3% respectively. It was revealed that there was no significant difference between the two methods. Conclusion: UE-MRI could be considered as a reliable diagnostic tool and an effective substitute for DCE-MRI when contrast administration is not feasible or contraindicated.
European Urology Supplements, 2015
The Egyptian Journal of Radiology and Nuclear Medicine, 2013
ABSTRACT
Zagazig University Medical Journal
Zagazig University Medical Journal
Aim: to evaluate the role of magnetic resonance imaging in the assessment of sport injuries of th... more Aim: to evaluate the role of magnetic resonance imaging in the assessment of sport injuries of the knee joint as an integral part of the musculoskeletal system. Methods: This study was done as a combined study between the
Urology, Jan 28, 2018
To compare the distance between the colon and the trajectory of PCNL access both in prone and FFM... more To compare the distance between the colon and the trajectory of PCNL access both in prone and FFMS positions as measured on CT and to study the effect of age, gender, BMI, side and previous renal surgery as influencing factors. In this prospective study, we included 367 patients scheduled for PCNL. All patients underwent low dose abdominal CT both in prone and FFMS positions. Patients<18 years and those with previous colonic surgery and/or renal congenital anomalies were excluded. The perpendicular distance between the imaginary line of the renal access and the colon was measured. Findings were correlated to different influencing factors. 219 patients were males, and 148 were females. BMI of <30 were reported in 158 patients while BMI > 30 in 209 patients. Data analysis showed that the mean perpendicular distance between colon and the renal access in FFMS and prone positions were 35.92±0.22 mm and 17.78±0.09 mm respectively. In prone position only obesity, age and overall i...
The Egyptian Journal of Radiology and Nuclear Medicine
The Egyptian Journal of Radiology and Nuclear Medicine, 2016
The Journal of Urology, 2016
The Egyptian Journal of Radiology and Nuclear Medicine, 2015
African Journal of Urology, 2015
Objectives: In this retrospective study we reviewed the outcome of non-operative management of hi... more Objectives: In this retrospective study we reviewed the outcome of non-operative management of high-grade blunt renal injuries (grade III–V) and evaluated the predictive indicators of management failure. Subjects and methods: The data review included the patients' demographics, the mechanism of trauma and the clinical characteristics, as well as the laboratory and imaging data upon admission and at follow-up. The data of the patients who were successfully managed non-operatively and of those who needed intervention for renal injuries were compared. Results: Two hundred and six patients were enrolled in this study. Grade III, grade IV and grade V renal injuries were found in 39.8%, 44.2% and 16% of the patients, respectively. The overall success rate of non-operative management was 87.9%, including all patients with grade III, 86.8% of patients with grade IV and 60.6% of those with grade V injuries. Multivariate analysis revealed that trauma secondary to motor vehicle accident, hypotension at presentation, associated injuries to other organs, grade V renal injury Predictors of non-operative management failure of high-grade blunt renal trauma 45 and computed tomography (CT) imaging features, namely medial renal parenchymal laceration, perirenal hematoma ≥3.5 cm and intravascular extravasation were significant predictors for failure of non-operative management. Conclusion: Our findings suggest that high-grade renal injuries in hemodynamically stable patients can be managed conservatively with a high success rate. Multiple clinical and radiological variables can predict the treatment outcome.
Please cite this article in press as: Maarouf AM, et al. Factors predicting the outcome of non-op... more Please cite this article in press as: Maarouf AM, et al. Factors predicting the outcome of non-operative management of high-grade blunt renal trauma. Afr J Urol (2015), http://dx.
European Urology Supplements, 2010
The Journal of Urology, 2015
angiographic findings requiring embolization. The average EBL was 6.5 liters (range 2.5-18) for t... more angiographic findings requiring embolization. The average EBL was 6.5 liters (range 2.5-18) for those 5 patients who bled massively during their index renal surgery. The average number of total units utilized was 12.8 for pRBC (median 8, range 4e28) and 8.3 for FFP (median 6.5, range 1e20). The average total pRBC to FFP ratio was 1.78:1 (median 1.4:1, range 4:1 e 1:1). One patient expired 3 days postoperatively due to multi-system organ failure. Results demonstrated a linear trend between the pRBC:FFP ratio and the percent decrease in serum bicarbonate. As the pRBC:FFP ratio increases from 1:1, the percent bicarbonate decreases proportionately. CONCLUSIONS: Recognizing massive hemorrhage in urologic surgeries and instituting a MTP as soon as an injury is identified yielded clinical benefits, as such MTP mobilizes blood products rapidly and in a pRBC:FFP ratio that approximates 1:1, which improved overall survival after excessive surgical bleeding.
International Journal of Oral and Maxillofacial Surgery, 2009
induce chondrogenesis and osteogenesis to a basal medium. DCM coupled with supplemented growth fa... more induce chondrogenesis and osteogenesis to a basal medium. DCM coupled with supplemented growth factors was tested for its ability to differentiate BMSCs into osteogenic and chondrogenic lineages in two-dimensional (2D) and three-dimensional (3D) cultures. When transforming growth factor-beta3 was added into DCM, BMSCs differentiated to chondrocyte-like cells evidenced by the expression of glycosaminoglycan and type II collagen, whereas osteogenic differentiation was induced by supplementing osteogenic protein-1 (OP-1) resulting detectable expression of osteopontin and osteocalcin. These chondrogenic and osteogenic differentiation markers were enhanced in the 3D cultures compared to the 2D monolayer cultures. The results achieved in this study lay a foundation for the future work on development of biphasic constructs, which may be applied in the treatment of full thickness defects comprising complex of osteochondral tissues.
The Egyptian Journal of Radiology and Nuclear Medicine, 2014
ABSTRACT