waleed albalat | Zagazig University (original) (raw)

Papers by waleed albalat

The Egyptian Journal of Hospital Medicine, Apr 1, 2023

Background: Vitiligo is a dermatological disorder characterized by functional melanocyte loss, af... more Background: Vitiligo is a dermatological disorder characterized by functional melanocyte loss, affecting 1% of the global population. The prevalence and impact of thyroid hormone and autoantibody levels on pediatric patients with vitiligo remain unclear. Aim: This study aims to assess the incidence of autoimmune thyroid disorder in pediatric vitiligo patients and investigate the impact of thyroid hormone and autoantibody levels on vitiligo activity. Subjects and Methods: A total of 68 children with vitiligo participated in this cross-sectional study, which included measurements of thyroid function, autoantibody tests, and examinations of the patients' vitiligo type, duration, activity, and onset. Results: Autoimmune thyroiditis was detected in 33.8% of patients. Positive anti-thyroglobulin antibodies were significantly associated with a family history, duration, and activity of vitiligo. Positive anti-thyroid peroxidase antibodies were significantly related to active vitiligo, sudden onset, and higher TSH levels. Anti-thyroglobulin antibodies correlated positively with age, duration, and TSH levels but negatively with T3 and T4 levels. Anti-thyroid peroxidase antibodies were positively correlated with TSH. Positive anti-thyroglobulin antibodies extended disease duration. Active vitiligo and rapid onset were more frequent with positive anti-thyroid peroxidase antibodies. Conclusions: This study concluded that pediatric vitiligo patients, particularly females and those with a family history of autoimmune diseases, have a higher frequency of thyroid dysfunction and autoantibodies. Moreover, regular monitoring of thyroid function and autoantibodies among pediatric patients with vitiligo is important to detect progression to overt hypothyroidism. Consequently, practitioners should recognize and treat thyroid-related conditions early and be aware of the relationship between vitiligo and autoimmune thyroid disease.

Journal of Cosmetic Dermatology, Dec 27, 2022

Dermatologic Therapy, Dec 6, 2020

Acne scarring causes cosmetic discomfort, depression, low self‐esteem and reduced quality of life... more Acne scarring causes cosmetic discomfort, depression, low self‐esteem and reduced quality of life. Microneedling is an established treatment for scars. A multimodality approach to scar treatment is usually necessary to achieve the best cosmetic results. The objective of this study was to evaluate the efficacy and safety of platelet rich plasma (PRP) combined with microneedling in comparison with microneedling with non‐cross‐linked hyaluronic acid for the treatment of atrophic acne scars. Forty‐one patients of 20‐40 years of age with atrophic acne scars were included. Microneedling was performed on both halves of the face. Topical application of PRP was given on right half of the face, while the left half of the face was treated with topical application of non‐cross‐linked hyaluronic acid. Four treatment sessions were given at an interval of 1 month consecutively. Goodman's Qualitative scale and the quartile grading scale are used for the final evaluation of results. There was a statistically significant improvement in acne scars after treatment among the studied group. Right and left halves showed 85.4% and 82.9% improvement, So the difference of the improvement between the two modalities is statistically insignificant P > 0.05 We conclude that microneedling has efficacy in the management of atrophic acne scars. It can be combined with either PRP or noncross‐linked hyaluronic acid to enhance the final clinical outcomes in comparison with microneedling alone. The difference between the two modalities is insignificant.

Dermatologic Therapy, 2021

Treatment of vitiligo represents a highly therapeutic challenge in spite of the continuous develo... more Treatment of vitiligo represents a highly therapeutic challenge in spite of the continuous development of new modalities. Combination therapies of vitiligo can help improve treatment response, and reduce recurrence potential. To compare the efficacy and adverse effects of microneedling combined with‐fluorouracil, pimecrolimus, and trichloroacetic acid (TCA) in the treatment of localized, stable vitiligo. The study included 75 patients with non‐segmental, stable vitiligo who were randomly assigned to three equal groups: group received a combination of microneedling and ‐FU, group 2 received microneedling and pimecrolimus, and group 3 received microneedling and TCA. The procedure was done every 2 weeks for a maximum of six sessions. Combined microneedling and TCA was associated with the highest + 5‐fluorouracil, and lastly combined microneedling + pimecrolimus. The difference between the three groups was statistically significant in favor of the combined microneedling and TCA. Pain, erythema, post‐inflammatory hyperpigmentation, infection, and scarring were variably reported adverse effects in the three groups. Combination therapy seems to be a promising modality for the treatment of vitiligo. Combined microneedling and TCA is superior to combined microneedling with either‐fluorouracil or pimecrolimus.

Journal of Indian Academy of Oral Medicine and Radiology

Archives of Dermatological Research, Nov 5, 2022

Background Atrophic post-acne scarring constitutes a troublesome cosmetic concern for both patien... more Background Atrophic post-acne scarring constitutes a troublesome cosmetic concern for both patients and dermatologists. Old and new therapies as well as combinations are being introduced to achieve a satisfactory response. Microneedling has been used either alone or under different combinations for its treatment. The aim was to compare its combination with topical platelet-rich plasma versus its combination with topical Botulinum Toxin-A. Methods 30 subjects with different types and grades of atrophic post-acne scars completed the study. Right side of the face was treated with microneedling and platelet-rich plasma while the left side was treated microneedling and Botox. Response was assessed using two different scales. Patient satisfaction and pain were also assessed. Results Regarding response to therapy and according to the quartile grading scale, there was no statistically significant difference between the two sides where (23.4% & 13.3%) of the right and left sides, respectively, had an excellent response. Regarding the difference in the qualitative global scarring grading system before and after treatment, there was a highly statistically significant improvement on both sides with higher improvement on the right side than left side but in a nonstatistically significant way. Conclusions Both combinations present efficacious options for treating acne scars with comparable efficacy. Trial registration Registered and approved prospectively by the ethical review board of the faculty of medicine, Zagazig University.

Journal of Cosmetic Dermatology, 2019

Androgenetic alopecia is the most common type of hair loss in men (in about 50% of Caucasian men)... more Androgenetic alopecia is the most common type of hair loss in men (in about 50% of Caucasian men), which is manifested by a progressive terminal hair loss in specific areas of scalp (such as anterior scalp, mid-scalp, temporal scalp, and vertex). The clinical presentation is different between men and women; as in the men, hair loss progression is mostly dominant in bilateral temporal and vertex areas. 1,2 Hair follicles have complex biological structures and growth. Development of mature hair follicles begins from anagen (proliferation phase) through catagen (involution phase) and subsequently telogen (resting phase). Many growth factors play fundamental roles

International Journal of Dermatology, 2016

Kaposi sarcoma (KS) is the most common vascular neoplasm. Any skin area could be involved, includ... more Kaposi sarcoma (KS) is the most common vascular neoplasm. Any skin area could be involved, including the genitalia. Traditionally, classic KS lesions have a general distribution, often involving skin of the feet and legs, and to a lesser extent, that of the hands, arms, and trunk. KS limited to the external genitalia is extremely rare in HIV seronegative individuals. We report six patients of classic KS with generalized dermal KS lesions. Two of them presenting with unusual KS lesions on the penis and scrotum beside the other dermal lesions. Patients were HIV negative and human herpes virus eight positive. Histological examination showed classical KS. Primary KS of the penis and scrotum is rare but could occur in HIV-negative patients.

Journal of cosmetic dermatology, Jan 8, 2016

Acne scarring causes cosmetic discomfort, depression, low self-esteem and reduced quality of life... more Acne scarring causes cosmetic discomfort, depression, low self-esteem and reduced quality of life. Microneedling is an established treatment for scars, although the efficacy of platelet-rich plasma (PRP) has not been explored much. The objective of this study was to evaluate the efficacy and safety of platelet-rich plasma (PRP) combined with microneedling for the treatment of atrophic acne scars. Fifty patients of 17-32 years of age with atrophic acne scars were enrolled. Microneedling was performed on both halves of the face. Intradermal injections as well as topical application of PRP was given on right half of the face, while the left half of the face was treated with intradermal administration of distilled water. Three treatment sessions were given at an interval of 1 month consecutively. Goodman's Quantitative scale and Quantitative scale were used for the final evaluation of results. Right and left halves showed 62.20% and 45.84% improvement, respectively, on Goodman's...

Zagazig University Medical Journal, 2021

Following surgical treatments, repigmentation can improve by ≥ 68% with one treatment session onl... more Following surgical treatments, repigmentation can improve by ≥ 68% with one treatment session only [10;11] . Even though surgery cannot stop disease progression, achieving a cosmetically acceptable repigmentation of the affected area is the primary goal for surgery [12] .There are many mechanisms for repigmentation after vitiligo surgery. In the injury and healing process during recipient site preparation, the melanocytes dissociate from the basal layer, proliferate, migrate, and are repositioned in the basal layer, essentially the normal physiologic process for melanocyte homeostasis. The healing process is stimulating the pro-melanogenic factors like hepatocyte growth factor, FGF, and keratinocyte growth factor to providing an appropriate environment for melanocyte stimulation [13;14] .

The Egyptian Journal of Hospital Medicine

Background: One to two percent of the population globally suffers from vitiligo, an acquired depi... more Background: One to two percent of the population globally suffers from vitiligo, an acquired depigmentation condition of multifactorial etiology. Macules and patches of depigmentation characterize vitiligo. People's moods are affected greatly and depressingly by it. As a result, prompt and effective therapy is necessary. Many individuals are able to slow the advancement of the disease, acquire repigmentation, and achieve cosmetically appealing results with proper therapy. There is a wide range of treatments for vitiligo, including topical corticosteroids (TCS) as monotherapy (as for vitiligo local therapy) or in conjunction with phototherapy or other topical medications in generalized vitiligo. Intermittent administration of large (pharmacological) dosages to maximize therapeutic benefit and prevent side effects is known as dexamethasone oral mini pulse (OMP) treatment. Objective: to determine the success of oral dexamethasone in vitiligo management. Conclusion: In vitiligo patients, when corticosteroids are provided at the onset or at early stages of disease, they can reduce disease progression and promote repigmentation and in some cases total repigmentation.

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG, 2017

Die Diagnose des Sweet-Syndroms (SS) gründet sich auf eine Reihe von Kriterien, von denen mindest... more Die Diagnose des Sweet-Syndroms (SS) gründet sich auf eine Reihe von Kriterien, von denen mindestens zwei Haupt-und zwei Nebenkriterien erfüllt sein müssen. In einigen Fällen ist die Diagnose aufgrund des Fehlens bestimmter Kriterien jedoch nicht so einfach. Ziel der vorliegenden Studie war es, die klinischen, histopathologischen und Labormerkmale der aktuellen Diagnosekriterien für das SS zu überprüfen und ihre Aussagekraft anhand der publizierten Fälle sowie bei 40 in unserem Institut behandelten Patienten zu beurteilen. Unsere umfassende Prüfung der aktuellen Kriterien für das SS ergab, dass seit seiner Erstbeschreibung im Jahr 1964 die beiden Hauptkriterien bei allen Fällen-einschließlich unserer-durchweg vorhanden waren. Andererseits gab es hinsichtlich der Nebenkriterien deutliche Unterschiede zwischen den verschiedenen Studien und bei vielen Patienten war die Bedingung, dass zwei Nebenkriterien vorhanden sein müssen, nicht erfüllt. Wir schlagen hier zwei Gruppen von revidierten Diagnosekriterien für das SS vor. Dies geschieht mit dem Ziel, die Diagnose zu vereinfachen, Fehldiagnosen zu vermeiden und eine sofortige Behandlung zu ermöglichen. Die erste Gruppe umfasst konstante klinische und histopathologische Merkmale, die vorhanden sein müssen und die per se für die Diagnose eines SS ausreichen. Die zweite Gruppe enthält veränderliche Merkmale, deren Fehlen es nicht erlaubt, ein SS auszuschließen.

Background: Acne vulgaris is a chronic inflammatory disease of the pilosebaceous unit. Ductal hyp... more Background: Acne vulgaris is a chronic inflammatory disease of the pilosebaceous unit. Ductal hyperkeratinization, increased secretion of sebum, and colonization of Propionibacterium Acnes (P. acnes) around the pilosebaceous gland are among the factors responsible for the etiopathogenesis of acne vulgaris. Interleukin(IL-) 19 is a cytokine expressed by epithelial cells with proinflammatory stimulation. A distinctive feature of IL19 is their ability of giving positive feedback loop to amplify themselves; once they are activated in inflammatory process, they will continuously produce the cytokine. The study aimed to identify the relation between blood levels of IL-19 and acne vulgaris. Methods: 36 acne patients and 12 healthy subjects were included in our study. All of patients and controls were subjected to full history, full general and dermatological examination. Serum IL-19 level was measured from each subject using quantitative sandwich enzyme-linked immunosorbent assay (ELISA) s...

The Egyptian Journal of Hospital Medicine

Background: Psoriasis is a chronic inflammatory disease that is mediated by the immune system. It... more Background: Psoriasis is a chronic inflammatory disease that is mediated by the immune system. It was thought to be a specific skin condition, but numerous studies have shown that it is a systemic disorder, as well as psychological difficulties like shyness, low self-esteem, and anxiety are related with it. Resistin is considered to be an important modulator of chronic inflammation. Objective: To determine serum level of resistin and C-reactive protien (CRP) in psoriasis vulgaris patients with metabolic syndrome (MetS). Patients and Methods: Clinical examinations were performed on 40 patients ranging in age from 28 to 53, and venous blood samples were collected. Tests were performed on the blood samples to identify levels of, resistin, and C-reactive protein (CRP). Results: levels of resistin were elevated with increased severity of psoriasis as measured by Psoriasis Area/Severity Index (PASI) score with statistically significant relation; p value (0.04), PASI score also was positively associated with elevated CRP levels; p value (0.001). Conclusion We conclude that resistin levels provide important value to optimize medical treatment and improve clinical outcomes in patients with psoriasis .

The Egyptian Journal of Hospital Medicine

Background: Trace elements are the basic components of biological enzyme system or the structural... more Background: Trace elements are the basic components of biological enzyme system or the structural components of very low concentration bioactive components. There are a number of trace elements in foods, such as iron, iodine, fluorine, copper and zinc, as well as chromium and cobalt. Other trace elements include tin and vanadium. Nickel and silicon are two examples of metals. Some of the trace elements are toxic to reproductive health at high doses. Trace amounts of these substances are rarely used for various physiological functions of the body. Many metal ions (copper, arsenic, cadmium, chromium, nickel, lithium vanadium, lead, and mercury) have many adverse effects on reproduction and development, fertility of men and women, abortion, and deformity. Exposure timing and duration, metal ions' distribution and accumulation in various organs, and interference with specific developmental processes; all have an impact on the consequences of metal ions. Objective: To assess the trace element's role in male infertility especially the role of zinc. Conclusion: Trace elements are very important for the sperm production and quality and could affect the male fertility by one way or another.

The Egyptian Journal of Hospital Medicine

Background: Hair follicle and sebaceous gland inflammation causes acne, which is a long-term, chr... more Background: Hair follicle and sebaceous gland inflammation causes acne, which is a long-term, chronic skin condition. The androgen-induced sebum overproduction leads to first acne appearance. It is caused by altered and aberrant keratinization, inflammation and the colonization of facial hair follicles by the bacteria Propionibacterium acnes. Acne also has a delayed immune response, as well as influences from the environment and genetics. Treatments for post-acne scarring have included topical preparations such as chemical peels, dermabrasion, laser resurfacing and punch excision and punch elevation, as well as fat transfer, implantation of autologous collagen and cultured and expanded autologous fibroblasts. Other treatments have included trichloroacetic acid focal treatment and skin microneedling to improve the dermal extracellular matrix (ECM) proteins. Objective: To determine the updated treatment modalities in atrophic post-acne scars. Conclusion: In most types of atrophic acne scars combination therapies typically provide superior outcomes than solo treatments.

Journal of Dermatological Treatment

AIM Intralesional triamcinolone is a gold standard in treating the keloids to comparation its eff... more AIM Intralesional triamcinolone is a gold standard in treating the keloids to comparation its effectiveness versus intralesional 5-fluorouracil intralesional verapamil and intralesional platelet-rich plasma. PATIENTS AND METHODS Several 160-cases were categorized into four groups of each Group-Containing 40 cases. Group-A (control) treated with intralesional triamcinolone and Group-B intralesional verapamil, Group-C intralesional 5-fluorouracil, and Group-D intralesional platelet-rich plasma. Patients were assessed for clinical response based on a decrease in the patient and observer scar assessment scale (POSAS) at baseline and the end of treatment. RESULTS The mean base-line POSAS score was 91 ± 10.98 SD check-in Group-A, 90 ± 10.85 in Group-B, 89 ± 10.06 in Group-C, and 92 ± 10.84 in Group-D.POSAS score after 24 weeks 36 ± 12.74 in Group-A, 29 ± 10.91 in Group-B, 39 ± 13.74 in Group-C, 36 ± 12.74 in Group-D. Statistically, a significant difference was observed between groups. CONCLUSION Intralesional verapamil reported to be the most effective therapy and platelet-rich plasma was effective as intralesional triamcinolone acetonide with no serious side effects and 5-fluorouracil was less effective in treating the keloids.

Journal of Cosmetic Dermatology

International Journal of Dermatology, 2016

Kaposi sarcoma (KS) is the most common vascular neoplasm. Any skin area could be involved, includ... more Kaposi sarcoma (KS) is the most common vascular neoplasm. Any skin area could be involved, including the genitalia. Traditionally, classic KS lesions have a general distribution, often involving skin of the feet and legs, and to a lesser extent, that of the hands, arms, and trunk. KS limited to the external genitalia is extremely rare in HIV seronegative individuals. We report six patients of classic KS with generalized dermal KS lesions. Two of them presenting with unusual KS lesions on the penis and scrotum beside the other dermal lesions. Patients were HIV negative and human herpes virus eight positive. Histological examination showed classical KS. Primary KS of the penis and scrotum is rare but could occur in HIV-negative patients.

The Egyptian Journal of Hospital Medicine, Apr 1, 2023

Background: Vitiligo is a dermatological disorder characterized by functional melanocyte loss, af... more Background: Vitiligo is a dermatological disorder characterized by functional melanocyte loss, affecting 1% of the global population. The prevalence and impact of thyroid hormone and autoantibody levels on pediatric patients with vitiligo remain unclear. Aim: This study aims to assess the incidence of autoimmune thyroid disorder in pediatric vitiligo patients and investigate the impact of thyroid hormone and autoantibody levels on vitiligo activity. Subjects and Methods: A total of 68 children with vitiligo participated in this cross-sectional study, which included measurements of thyroid function, autoantibody tests, and examinations of the patients' vitiligo type, duration, activity, and onset. Results: Autoimmune thyroiditis was detected in 33.8% of patients. Positive anti-thyroglobulin antibodies were significantly associated with a family history, duration, and activity of vitiligo. Positive anti-thyroid peroxidase antibodies were significantly related to active vitiligo, sudden onset, and higher TSH levels. Anti-thyroglobulin antibodies correlated positively with age, duration, and TSH levels but negatively with T3 and T4 levels. Anti-thyroid peroxidase antibodies were positively correlated with TSH. Positive anti-thyroglobulin antibodies extended disease duration. Active vitiligo and rapid onset were more frequent with positive anti-thyroid peroxidase antibodies. Conclusions: This study concluded that pediatric vitiligo patients, particularly females and those with a family history of autoimmune diseases, have a higher frequency of thyroid dysfunction and autoantibodies. Moreover, regular monitoring of thyroid function and autoantibodies among pediatric patients with vitiligo is important to detect progression to overt hypothyroidism. Consequently, practitioners should recognize and treat thyroid-related conditions early and be aware of the relationship between vitiligo and autoimmune thyroid disease.

Journal of Cosmetic Dermatology, Dec 27, 2022

Dermatologic Therapy, Dec 6, 2020

Acne scarring causes cosmetic discomfort, depression, low self‐esteem and reduced quality of life... more Acne scarring causes cosmetic discomfort, depression, low self‐esteem and reduced quality of life. Microneedling is an established treatment for scars. A multimodality approach to scar treatment is usually necessary to achieve the best cosmetic results. The objective of this study was to evaluate the efficacy and safety of platelet rich plasma (PRP) combined with microneedling in comparison with microneedling with non‐cross‐linked hyaluronic acid for the treatment of atrophic acne scars. Forty‐one patients of 20‐40 years of age with atrophic acne scars were included. Microneedling was performed on both halves of the face. Topical application of PRP was given on right half of the face, while the left half of the face was treated with topical application of non‐cross‐linked hyaluronic acid. Four treatment sessions were given at an interval of 1 month consecutively. Goodman's Qualitative scale and the quartile grading scale are used for the final evaluation of results. There was a statistically significant improvement in acne scars after treatment among the studied group. Right and left halves showed 85.4% and 82.9% improvement, So the difference of the improvement between the two modalities is statistically insignificant P > 0.05 We conclude that microneedling has efficacy in the management of atrophic acne scars. It can be combined with either PRP or noncross‐linked hyaluronic acid to enhance the final clinical outcomes in comparison with microneedling alone. The difference between the two modalities is insignificant.

Dermatologic Therapy, 2021

Treatment of vitiligo represents a highly therapeutic challenge in spite of the continuous develo... more Treatment of vitiligo represents a highly therapeutic challenge in spite of the continuous development of new modalities. Combination therapies of vitiligo can help improve treatment response, and reduce recurrence potential. To compare the efficacy and adverse effects of microneedling combined with‐fluorouracil, pimecrolimus, and trichloroacetic acid (TCA) in the treatment of localized, stable vitiligo. The study included 75 patients with non‐segmental, stable vitiligo who were randomly assigned to three equal groups: group received a combination of microneedling and ‐FU, group 2 received microneedling and pimecrolimus, and group 3 received microneedling and TCA. The procedure was done every 2 weeks for a maximum of six sessions. Combined microneedling and TCA was associated with the highest + 5‐fluorouracil, and lastly combined microneedling + pimecrolimus. The difference between the three groups was statistically significant in favor of the combined microneedling and TCA. Pain, erythema, post‐inflammatory hyperpigmentation, infection, and scarring were variably reported adverse effects in the three groups. Combination therapy seems to be a promising modality for the treatment of vitiligo. Combined microneedling and TCA is superior to combined microneedling with either‐fluorouracil or pimecrolimus.

Journal of Indian Academy of Oral Medicine and Radiology

Archives of Dermatological Research, Nov 5, 2022

Background Atrophic post-acne scarring constitutes a troublesome cosmetic concern for both patien... more Background Atrophic post-acne scarring constitutes a troublesome cosmetic concern for both patients and dermatologists. Old and new therapies as well as combinations are being introduced to achieve a satisfactory response. Microneedling has been used either alone or under different combinations for its treatment. The aim was to compare its combination with topical platelet-rich plasma versus its combination with topical Botulinum Toxin-A. Methods 30 subjects with different types and grades of atrophic post-acne scars completed the study. Right side of the face was treated with microneedling and platelet-rich plasma while the left side was treated microneedling and Botox. Response was assessed using two different scales. Patient satisfaction and pain were also assessed. Results Regarding response to therapy and according to the quartile grading scale, there was no statistically significant difference between the two sides where (23.4% & 13.3%) of the right and left sides, respectively, had an excellent response. Regarding the difference in the qualitative global scarring grading system before and after treatment, there was a highly statistically significant improvement on both sides with higher improvement on the right side than left side but in a nonstatistically significant way. Conclusions Both combinations present efficacious options for treating acne scars with comparable efficacy. Trial registration Registered and approved prospectively by the ethical review board of the faculty of medicine, Zagazig University.

Journal of Cosmetic Dermatology, 2019

Androgenetic alopecia is the most common type of hair loss in men (in about 50% of Caucasian men)... more Androgenetic alopecia is the most common type of hair loss in men (in about 50% of Caucasian men), which is manifested by a progressive terminal hair loss in specific areas of scalp (such as anterior scalp, mid-scalp, temporal scalp, and vertex). The clinical presentation is different between men and women; as in the men, hair loss progression is mostly dominant in bilateral temporal and vertex areas. 1,2 Hair follicles have complex biological structures and growth. Development of mature hair follicles begins from anagen (proliferation phase) through catagen (involution phase) and subsequently telogen (resting phase). Many growth factors play fundamental roles

International Journal of Dermatology, 2016

Kaposi sarcoma (KS) is the most common vascular neoplasm. Any skin area could be involved, includ... more Kaposi sarcoma (KS) is the most common vascular neoplasm. Any skin area could be involved, including the genitalia. Traditionally, classic KS lesions have a general distribution, often involving skin of the feet and legs, and to a lesser extent, that of the hands, arms, and trunk. KS limited to the external genitalia is extremely rare in HIV seronegative individuals. We report six patients of classic KS with generalized dermal KS lesions. Two of them presenting with unusual KS lesions on the penis and scrotum beside the other dermal lesions. Patients were HIV negative and human herpes virus eight positive. Histological examination showed classical KS. Primary KS of the penis and scrotum is rare but could occur in HIV-negative patients.

Journal of cosmetic dermatology, Jan 8, 2016

Acne scarring causes cosmetic discomfort, depression, low self-esteem and reduced quality of life... more Acne scarring causes cosmetic discomfort, depression, low self-esteem and reduced quality of life. Microneedling is an established treatment for scars, although the efficacy of platelet-rich plasma (PRP) has not been explored much. The objective of this study was to evaluate the efficacy and safety of platelet-rich plasma (PRP) combined with microneedling for the treatment of atrophic acne scars. Fifty patients of 17-32 years of age with atrophic acne scars were enrolled. Microneedling was performed on both halves of the face. Intradermal injections as well as topical application of PRP was given on right half of the face, while the left half of the face was treated with intradermal administration of distilled water. Three treatment sessions were given at an interval of 1 month consecutively. Goodman's Quantitative scale and Quantitative scale were used for the final evaluation of results. Right and left halves showed 62.20% and 45.84% improvement, respectively, on Goodman's...

Zagazig University Medical Journal, 2021

Following surgical treatments, repigmentation can improve by ≥ 68% with one treatment session onl... more Following surgical treatments, repigmentation can improve by ≥ 68% with one treatment session only [10;11] . Even though surgery cannot stop disease progression, achieving a cosmetically acceptable repigmentation of the affected area is the primary goal for surgery [12] .There are many mechanisms for repigmentation after vitiligo surgery. In the injury and healing process during recipient site preparation, the melanocytes dissociate from the basal layer, proliferate, migrate, and are repositioned in the basal layer, essentially the normal physiologic process for melanocyte homeostasis. The healing process is stimulating the pro-melanogenic factors like hepatocyte growth factor, FGF, and keratinocyte growth factor to providing an appropriate environment for melanocyte stimulation [13;14] .

The Egyptian Journal of Hospital Medicine

Background: One to two percent of the population globally suffers from vitiligo, an acquired depi... more Background: One to two percent of the population globally suffers from vitiligo, an acquired depigmentation condition of multifactorial etiology. Macules and patches of depigmentation characterize vitiligo. People's moods are affected greatly and depressingly by it. As a result, prompt and effective therapy is necessary. Many individuals are able to slow the advancement of the disease, acquire repigmentation, and achieve cosmetically appealing results with proper therapy. There is a wide range of treatments for vitiligo, including topical corticosteroids (TCS) as monotherapy (as for vitiligo local therapy) or in conjunction with phototherapy or other topical medications in generalized vitiligo. Intermittent administration of large (pharmacological) dosages to maximize therapeutic benefit and prevent side effects is known as dexamethasone oral mini pulse (OMP) treatment. Objective: to determine the success of oral dexamethasone in vitiligo management. Conclusion: In vitiligo patients, when corticosteroids are provided at the onset or at early stages of disease, they can reduce disease progression and promote repigmentation and in some cases total repigmentation.

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG, 2017

Die Diagnose des Sweet-Syndroms (SS) gründet sich auf eine Reihe von Kriterien, von denen mindest... more Die Diagnose des Sweet-Syndroms (SS) gründet sich auf eine Reihe von Kriterien, von denen mindestens zwei Haupt-und zwei Nebenkriterien erfüllt sein müssen. In einigen Fällen ist die Diagnose aufgrund des Fehlens bestimmter Kriterien jedoch nicht so einfach. Ziel der vorliegenden Studie war es, die klinischen, histopathologischen und Labormerkmale der aktuellen Diagnosekriterien für das SS zu überprüfen und ihre Aussagekraft anhand der publizierten Fälle sowie bei 40 in unserem Institut behandelten Patienten zu beurteilen. Unsere umfassende Prüfung der aktuellen Kriterien für das SS ergab, dass seit seiner Erstbeschreibung im Jahr 1964 die beiden Hauptkriterien bei allen Fällen-einschließlich unserer-durchweg vorhanden waren. Andererseits gab es hinsichtlich der Nebenkriterien deutliche Unterschiede zwischen den verschiedenen Studien und bei vielen Patienten war die Bedingung, dass zwei Nebenkriterien vorhanden sein müssen, nicht erfüllt. Wir schlagen hier zwei Gruppen von revidierten Diagnosekriterien für das SS vor. Dies geschieht mit dem Ziel, die Diagnose zu vereinfachen, Fehldiagnosen zu vermeiden und eine sofortige Behandlung zu ermöglichen. Die erste Gruppe umfasst konstante klinische und histopathologische Merkmale, die vorhanden sein müssen und die per se für die Diagnose eines SS ausreichen. Die zweite Gruppe enthält veränderliche Merkmale, deren Fehlen es nicht erlaubt, ein SS auszuschließen.

Background: Acne vulgaris is a chronic inflammatory disease of the pilosebaceous unit. Ductal hyp... more Background: Acne vulgaris is a chronic inflammatory disease of the pilosebaceous unit. Ductal hyperkeratinization, increased secretion of sebum, and colonization of Propionibacterium Acnes (P. acnes) around the pilosebaceous gland are among the factors responsible for the etiopathogenesis of acne vulgaris. Interleukin(IL-) 19 is a cytokine expressed by epithelial cells with proinflammatory stimulation. A distinctive feature of IL19 is their ability of giving positive feedback loop to amplify themselves; once they are activated in inflammatory process, they will continuously produce the cytokine. The study aimed to identify the relation between blood levels of IL-19 and acne vulgaris. Methods: 36 acne patients and 12 healthy subjects were included in our study. All of patients and controls were subjected to full history, full general and dermatological examination. Serum IL-19 level was measured from each subject using quantitative sandwich enzyme-linked immunosorbent assay (ELISA) s...

The Egyptian Journal of Hospital Medicine

Background: Psoriasis is a chronic inflammatory disease that is mediated by the immune system. It... more Background: Psoriasis is a chronic inflammatory disease that is mediated by the immune system. It was thought to be a specific skin condition, but numerous studies have shown that it is a systemic disorder, as well as psychological difficulties like shyness, low self-esteem, and anxiety are related with it. Resistin is considered to be an important modulator of chronic inflammation. Objective: To determine serum level of resistin and C-reactive protien (CRP) in psoriasis vulgaris patients with metabolic syndrome (MetS). Patients and Methods: Clinical examinations were performed on 40 patients ranging in age from 28 to 53, and venous blood samples were collected. Tests were performed on the blood samples to identify levels of, resistin, and C-reactive protein (CRP). Results: levels of resistin were elevated with increased severity of psoriasis as measured by Psoriasis Area/Severity Index (PASI) score with statistically significant relation; p value (0.04), PASI score also was positively associated with elevated CRP levels; p value (0.001). Conclusion We conclude that resistin levels provide important value to optimize medical treatment and improve clinical outcomes in patients with psoriasis .

The Egyptian Journal of Hospital Medicine

Background: Trace elements are the basic components of biological enzyme system or the structural... more Background: Trace elements are the basic components of biological enzyme system or the structural components of very low concentration bioactive components. There are a number of trace elements in foods, such as iron, iodine, fluorine, copper and zinc, as well as chromium and cobalt. Other trace elements include tin and vanadium. Nickel and silicon are two examples of metals. Some of the trace elements are toxic to reproductive health at high doses. Trace amounts of these substances are rarely used for various physiological functions of the body. Many metal ions (copper, arsenic, cadmium, chromium, nickel, lithium vanadium, lead, and mercury) have many adverse effects on reproduction and development, fertility of men and women, abortion, and deformity. Exposure timing and duration, metal ions' distribution and accumulation in various organs, and interference with specific developmental processes; all have an impact on the consequences of metal ions. Objective: To assess the trace element's role in male infertility especially the role of zinc. Conclusion: Trace elements are very important for the sperm production and quality and could affect the male fertility by one way or another.

The Egyptian Journal of Hospital Medicine

Background: Hair follicle and sebaceous gland inflammation causes acne, which is a long-term, chr... more Background: Hair follicle and sebaceous gland inflammation causes acne, which is a long-term, chronic skin condition. The androgen-induced sebum overproduction leads to first acne appearance. It is caused by altered and aberrant keratinization, inflammation and the colonization of facial hair follicles by the bacteria Propionibacterium acnes. Acne also has a delayed immune response, as well as influences from the environment and genetics. Treatments for post-acne scarring have included topical preparations such as chemical peels, dermabrasion, laser resurfacing and punch excision and punch elevation, as well as fat transfer, implantation of autologous collagen and cultured and expanded autologous fibroblasts. Other treatments have included trichloroacetic acid focal treatment and skin microneedling to improve the dermal extracellular matrix (ECM) proteins. Objective: To determine the updated treatment modalities in atrophic post-acne scars. Conclusion: In most types of atrophic acne scars combination therapies typically provide superior outcomes than solo treatments.

Journal of Dermatological Treatment

AIM Intralesional triamcinolone is a gold standard in treating the keloids to comparation its eff... more AIM Intralesional triamcinolone is a gold standard in treating the keloids to comparation its effectiveness versus intralesional 5-fluorouracil intralesional verapamil and intralesional platelet-rich plasma. PATIENTS AND METHODS Several 160-cases were categorized into four groups of each Group-Containing 40 cases. Group-A (control) treated with intralesional triamcinolone and Group-B intralesional verapamil, Group-C intralesional 5-fluorouracil, and Group-D intralesional platelet-rich plasma. Patients were assessed for clinical response based on a decrease in the patient and observer scar assessment scale (POSAS) at baseline and the end of treatment. RESULTS The mean base-line POSAS score was 91 ± 10.98 SD check-in Group-A, 90 ± 10.85 in Group-B, 89 ± 10.06 in Group-C, and 92 ± 10.84 in Group-D.POSAS score after 24 weeks 36 ± 12.74 in Group-A, 29 ± 10.91 in Group-B, 39 ± 13.74 in Group-C, 36 ± 12.74 in Group-D. Statistically, a significant difference was observed between groups. CONCLUSION Intralesional verapamil reported to be the most effective therapy and platelet-rich plasma was effective as intralesional triamcinolone acetonide with no serious side effects and 5-fluorouracil was less effective in treating the keloids.

Journal of Cosmetic Dermatology

International Journal of Dermatology, 2016

Kaposi sarcoma (KS) is the most common vascular neoplasm. Any skin area could be involved, includ... more Kaposi sarcoma (KS) is the most common vascular neoplasm. Any skin area could be involved, including the genitalia. Traditionally, classic KS lesions have a general distribution, often involving skin of the feet and legs, and to a lesser extent, that of the hands, arms, and trunk. KS limited to the external genitalia is extremely rare in HIV seronegative individuals. We report six patients of classic KS with generalized dermal KS lesions. Two of them presenting with unusual KS lesions on the penis and scrotum beside the other dermal lesions. Patients were HIV negative and human herpes virus eight positive. Histological examination showed classical KS. Primary KS of the penis and scrotum is rare but could occur in HIV-negative patients.