Wanda Voteva | Zaporizhzhia State Medical University (original) (raw)
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Papers by Wanda Voteva
Aim. To determine the expression level of angiogenesis markers VEGF and VEGFR-1 in different hist... more Aim. To determine the expression level of angiogenesis markers VEGF and VEGFR-1 in different histological
subtypes of benign and in anaplastic meningiomas.
Materials and methods. 32 cases of meningiomas which were removed during neurosurgical operations
were analyzed. We studied peculiarities of the expression of angiogenesis markers in benign and malignant
brain meningiomas.
Results. VEGF expression was observed in tumor cells as well as in endothelial cells in 38, 8% of all cases.
Tumors with weak, focal expression and also with immunonegative areas comprised 22, 2% of investigated
cases. Expression of VEGFR-1 in microvessel endothelial cells was present in 61, 1% of analysed cases.
Conclusions: 1. The expression level of VEGF signifiantly differs among various subtypes of benign
meningiomas with the most intensive expression in transitional subtypes.
2. Fibroblastic subtypes of benign meningiomas are characterized by the least expression level of VEGF
and VEGFR-1.
3. The relationship between the grade of meningiomas according to the WHO classifiation (2007) and the
expression level of VEGF was not determined. Thus, the angiogenic potential depends upon the histological
structure and does not depend on the degree of malignancy.
4. The expression level of VEGFR-1 doesn’t significantly differ between benign and anaplastic
meningiomas.
Key words: meningioma, angiogenesis, vascular endothelial growth factor, vascular endothelial growth
factor receptor-1.
Aim. Meningiomas are widespread neoplasms of the brain, constituting 24-30% of all primary intrac... more Aim. Meningiomas are widespread neoplasms of the brain, constituting 24-30% of all primary intracranial tumors. In order to determine
the expression level of cell adhesion molecules β-catenin and E-cadherin in 20 specimens of brain with the help of immunohistochemical
methods the expression of these molecules in benign and malignant meningiomas was investigated.
Methods and results. The correlation relationship between the expression level ofβ-catenin and E-cadherin in malignant and benign
meningiomas was determined. It is shown that the expression level ofβ-catenin in the different subtypes of benign meningiomas differs
and, conversely, they have a similar expression level of E-cadherin.
Conclusion. Most of benign meningiomas are characterized by signi fi cantly higher expression levels of cell adhesion molecules than
anaplastic ones.
Key words: Meningioma, Cell Adhesion, E-cadherin, β-catenin.
Meningiomas of the brain are the second most common tumor of the CNS in adults, accounting about ... more Meningiomas of the brain are the second most common tumor of the CNS in adults, accounting about 30% of all primary tumors.
Aim. In order to determine the presence and to assess the expression level of cytokeratin (CK) in benign and malignant brain meningiomas
tissue samples were obtained during neurosurgical operations from 30 patients.
Methods and results. Tissue samples were studied immunohistochemically by using monoclonal antibodies Mo a-Hu Cytokeratine
(PanCK), Clone AE1/AE3 («DAKO», Denmark). It was established that anaplastic meningiomas expressed CK in 80% of cases. Among
benign meningiomas positive expression was found in 40% of fi broblastic subtypes.
Aim. To determine the expression level of angiogenesis markers VEGF and VEGFR-1 in different hist... more Aim. To determine the expression level of angiogenesis markers VEGF and VEGFR-1 in different histological
subtypes of benign and in anaplastic meningiomas.
Materials and methods. 32 cases of meningiomas which were removed during neurosurgical operations
were analyzed. We studied peculiarities of the expression of angiogenesis markers in benign and malignant
brain meningiomas.
Results. VEGF expression was observed in tumor cells as well as in endothelial cells in 38, 8% of all cases.
Tumors with weak, focal expression and also with immunonegative areas comprised 22, 2% of investigated
cases. Expression of VEGFR-1 in microvessel endothelial cells was present in 61, 1% of analysed cases.
Conclusions: 1. The expression level of VEGF signifiantly differs among various subtypes of benign
meningiomas with the most intensive expression in transitional subtypes.
2. Fibroblastic subtypes of benign meningiomas are characterized by the least expression level of VEGF
and VEGFR-1.
3. The relationship between the grade of meningiomas according to the WHO classifiation (2007) and the
expression level of VEGF was not determined. Thus, the angiogenic potential depends upon the histological
structure and does not depend on the degree of malignancy.
4. The expression level of VEGFR-1 doesn’t significantly differ between benign and anaplastic
meningiomas.
Key words: meningioma, angiogenesis, vascular endothelial growth factor, vascular endothelial growth
factor receptor-1.
Aim. Meningiomas are widespread neoplasms of the brain, constituting 24-30% of all primary intrac... more Aim. Meningiomas are widespread neoplasms of the brain, constituting 24-30% of all primary intracranial tumors. In order to determine
the expression level of cell adhesion molecules β-catenin and E-cadherin in 20 specimens of brain with the help of immunohistochemical
methods the expression of these molecules in benign and malignant meningiomas was investigated.
Methods and results. The correlation relationship between the expression level ofβ-catenin and E-cadherin in malignant and benign
meningiomas was determined. It is shown that the expression level ofβ-catenin in the different subtypes of benign meningiomas differs
and, conversely, they have a similar expression level of E-cadherin.
Conclusion. Most of benign meningiomas are characterized by signi fi cantly higher expression levels of cell adhesion molecules than
anaplastic ones.
Key words: Meningioma, Cell Adhesion, E-cadherin, β-catenin.
Meningiomas of the brain are the second most common tumor of the CNS in adults, accounting about ... more Meningiomas of the brain are the second most common tumor of the CNS in adults, accounting about 30% of all primary tumors.
Aim. In order to determine the presence and to assess the expression level of cytokeratin (CK) in benign and malignant brain meningiomas
tissue samples were obtained during neurosurgical operations from 30 patients.
Methods and results. Tissue samples were studied immunohistochemically by using monoclonal antibodies Mo a-Hu Cytokeratine
(PanCK), Clone AE1/AE3 («DAKO», Denmark). It was established that anaplastic meningiomas expressed CK in 80% of cases. Among
benign meningiomas positive expression was found in 40% of fi broblastic subtypes.