Dr. Pushpendra Kumar Jain | ZEE College of Pharmacy (original) (raw)

Papers by Dr. Pushpendra Kumar Jain

Herbal Cosmetics have growing demand on the earth market and is a precious gift of nature. Herbal... more Herbal Cosmetics have growing demand on the earth market and is a precious gift of nature. Herbal formulations continuously have attracted gigantic concentration on the grounds that of their good endeavor and comparatively lesser or nil side effect with synthetic medications. Herbs and spices have been used in retaining and embellishing human magnificence because time immemorial. Hair loss problem is of great significance to both men & women. The essential issues associated with hair loss are hair fading, dandruff & falling of hair. Alopecia is the medical term for hair loss or baldness. It is an embarrassing condition for any person, as he/she looks extra aged than ordinary. Many forms of medication are available to treat alopecia in special procedure of medication like Allopathic, Homeopathic, Ayurveda or can also be surgical like hair transplantation however none of them is wholly ample. This hindrance could be solved by the use of natural medicines obtained from herbs. Various h...

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Int. J. Pharm. Sci. Rev. Res, 2018

During the past few years herbal medicine has gained exponential growth in the field of medicine ... more During the past few years herbal medicine has gained exponential growth in the field of medicine in all over the world. In comparison to other countries India is the largest producer of herbal medicine. The current review focuses on herbal preparation and plant recently evaluated in the treatment of cancer disease in the world. This paper until focus on different beneficial aspects of herbal medicine as Anti Cancer.

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Herbal medicine is still the mainstay of about 70-80% of the world population mainly in the devel... more Herbal medicine is still the mainstay of about 70-80% of the world population mainly in the developing countries for Primary Health Care because of better cultural acceptability better, compatibility with the human body and lesser medicine or only palliative therapy is available. Even in this era of antibiotics, radiotherapy and strict drug laws, a very large number of herbal products are consumed and marketed throughout the world as health nutrients, food supplements, and curing agents for disease control. It has been observed that a number of herbs and their extract are used for hair growth activities some are described as follow: Petroleum ether extract of aerial parts of Tridax procumbens showed luxurious growth of hair in albino rats. Nearly 70% ethanolic extract of leaves of Ginko biloba was shown to be effective for hair growth activity. Methanolic extract of Potyporus umbellatus has shown excellent hair growth activity in rats. Combined extract Emblica officinalis, Lawsonia inermis, Nardostachys jatamansi, Cyperus rotundus and Corchorus prevent the falling of hairs and enhancement of hair growth activity. Proanthocyanidins from grape seeds promote the proliferation of mouse hair follicle cell in vitro and convert hair cycle in vivo similar to Minoxidil 2% solution which is synthetic and has numbers of side effect. Herbal cosmetics are in vogue these days. Nowadays, people have become aware of using herbal cosmetics. Now a day's cosmetology is a well-defined science based on experiences gathered over centuries. The safety and efficacy of natural herbs could not find any suitable match i.e., cannot be replaced by synthetics. There is once again revival of preference for natural products.

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Herbal cosmetics have growing demand on the earth market and are a precious gift of nature. Herba... more Herbal cosmetics have growing demand on the earth market and are a precious gift of nature. Herbal formulations continuously have attracted gigantic concentration on the grounds that of their good endeavor and comparatively lesser or nil side effect with synthetic medications. Herbs and spices have been used in retaining and embellishing human magnificence because time immemorial. Hair loss problem is of great significance to both men and women. The essential issues associated with hair loss are hair fading, dandruff, and falling of hair. Alopecia is the medical term for hair loss or baldness. It is an embarrassing condition for any person as he/she looks extra aged than ordinary. Many forms of medication are available to treat alopecia in special procedure of medication such as Allopathic, Homeopathic, and Ayurveda or can also be surgical like hair transplantation; however, none of them is wholly ample. This hindrance could be solved by the use of natural medicines obtained from herbs. Various herbs are being used to preclude the hair loss and remorse of hairs including Aloe vera, brahmi, nagarmotha, amla, bhringraj, and lots of different herbs. Being average medicines, there are various advantages of making use of them like patient compliance, less side results, convenient availability, inexpensive and multiple mode of applications to treat alopecia, and other hair diseases.

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The aim of performing this work is to study and evaluate Genotoxicity and Cytotoxicity of Prazosi... more The aim of performing this work is to study and evaluate Genotoxicity and Cytotoxicity of Prazosin HCL in mice. The animals were treated with Prazosin (PZ) at the doses of 5, 15, 25 mg/kg/body weight intraperitoneal (IP) for single dose (14 days) toxicity studies. Different methods were used to perform the study like Measurement of body weight, organ weight and food intake, Estimation of Malondialdehyde (MDA) level, Estimation of Reduced Glutathione (GSH) level, For evaluation of Genotoxicity following parameters has been evaluated: Micronucleus assay in bone marrow, Micronucleus assay in peripheral blood, Determination of DNA damage: Metaphase chromosome analysis, Determination of DNA damage: DNA fragmentation assay, Determination of Cytotoxicity: Histological examination.The results obtained clearly demonstrate that PZ produced toxic responses at the higher dose in the hepatocytes as evident from increased MDA level, decreased GSH level, DNA damage, increased DNA fragmentation in mice. Also, it is interesting that in bone marrow cells, PZ induced structural chromosomal aberrations, and significantly DNA strand breakage observed. So it is considered as Genotoxicity toward the bone marrow cells and to the hepatocytes of mice. The present study provided evidence that Prazosin induced significant genotoxic effects in mice at its equivalent hepatotoxic dose level.

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In present study, an attempt has been made to evaluate a Comparative study of powder v/s gel of p... more In present study, an attempt has been made to evaluate a Comparative study of powder v/s gel of proniosomal drug delivery system of flurbiprofen. Flurbiprofen, are nonsteroidal anti-inflammatory drug (NSAIDs) is used for the relief of pain and inflammation associated with rheumatoid arthritis and osteoarthritis. It exhibits anti-inflammatory, analgesic and antipyretic activities. It will be also effected the transdermal system rate because of its size, nature and chemistry, these systems give better drug permeability from biological bioavailability membranes and helps in solubilization of some practically insoluble drugs and hence solve problems of many drug. In the present study we are using various surfactants like span 20, 40, 60, 80, and brij 35 and studided in various proniosomal powder and gel formulation and studied in both result in following formulation. In this result proniosomal gel of formulation brij 35 show better entrapment and highest in vitro drug release. The best result obtain in which formulation which having equimolar ratio(1:1) of brij 35 and cholesterol.The release mechanism was explained with zero order, first order, higuchi equations. Thus it can be concluded that the proniosomes gel posses higher entrapment efficiency and utilizes alcohol, which itself act as penetration enhancer. The elicited an increase of the percutaneous permeation of flurbiprofen both in-vitro and in-vivo. In addition, in vivo experiments showed that flurbiprofen proniosomes gel can ensure a sustained release of the drug and hence a prolongation of its therapeutic activity, which can be related to an accumulation of flurbiprofen in the skin.

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Herbs & herbal drugs are clinically proved good for hair growth. Hair loss problem is of great co... more Herbs & herbal drugs are clinically proved good for hair growth. Hair loss problem is
of great concern to both males & females & the main problems associated with hair loss are hair fading, dandruff & falling of hair. Various synthetic medicines are available for hair loss which does not treat permanently & also shows severe side effects. The main objective of this work is to develop such an herbal hair oil formulation which can resolve the problem related to hair fall & other hair diseases. Herbal drugs like Emblica officinalis, Bacopa monniera and Cyperus rotundus were selected for the formulations of poly herbal hair oil. The hair oil was prepared individually and in a varying concentration of all three herbs and a mixture of all the three herbs in fixed proportion using coconut oil as base. The formulated oil in varying concentration was evaluated physical, chemical and hair growth properties of formulated oil by applying it topically on shaved skin of albino rats. Primary skin irritation test, hair length test were performed and the hair growth was compared with standard Minoxidil 2% ethanolic solution using healthy albino rats. It was observed that hair oil formulation (HF3) showed the best result among the other formulation evaluated by showing an enlargement of follicular size and prolongation of the anagen phase.

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Coumarins are classified as a member of the benzopyrone family. all of which consist of a benzene... more Coumarins are classified as a member of the benzopyrone family. all of which consist of a benzene ring joined to a pyrone ring. The benzopyrones can be subdivided into the benzo-alfa-pyrones to which the coumarins belong and the benzo-gama-pyrones, of which the flavonoids are principal members. Umbelliferone, esculetin and scopoletin are the most widespread coumarins in nature. During the synthesis of these compounds ortho-hydroxylation should respectively take place on p-coumaric, caffeic and ferulic acid. The coumarins are of great interest due to their pharmacological properties. In particular, their physiological, bacteriostatic and anti-tumor activity makes these compounds attractive backbone derivatisation and screening as novel therapeutic agents.

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Objective: The main objective of present study is to treat Alopecia. Alopecia areata is an unpred... more Objective: The main objective of present study is to treat Alopecia. Alopecia areata is an unpredictable hair-loss condition. Alopecia is a dermatological disorder with psychosocial implications on patients with hair loss. Herbal systems of medicine have become increasingly popular in recent years. Medicinal plants have been used for the treatment of hair diseases since antiquity. Herbs such as turmeric, fenugreek, ginger, Cyperus (Nagarmotha), and holy basil are integral parts of ayurvedic formulations. Cyperus rotundus is a well-known ayurvedic herb with purported claims of hair growth promotion. Methods: Extracts are prepared by separating the soluble matter from vegetable tissues by the application of a suitable solvent such as alcohol, water, or ether. The resultant liquid is concentrated by evaporation to obtain a liquid extract or concentrated almost to dryness to obtain the solid extract and its volatile oil. Hair formulation of C. rotundus belonging to family Cyperaceae in the form of herbal formulation (5% herbal cream and oil) was studied and it showed excellent hair growth activity with standard (2% minoxidil ethanolic solution) in Wister albino rats. Results: Hair growth initiation time was significantly reduced to half on treatment with the oil, as compared to control animals. The hair growth-promoting effect was evaluated against the control, standard, and test animals at 0, 10, 15, and 20 days with the formulated hair oil and hair cream prepared from the volatile oil extracted from the C. rotundus and the significant hair growth was observed, and the growth was compared with the standard drug used 2% solution of minoxidil. Conclusion: The results of treatment with oil were better than the positive control minoxidil 2% treatment. It holds the promise of potent herbal alternative for minoxidil.

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Objective: The present study was carried out in order to study the hair growth activity of some t... more Objective: The present study was carried out in order to study the hair growth activity of some traditional herbal medicinal plants. Herbal traditional drugs are used frequently in therapeutics; more often their chief principles are employed in a more specific manner. Method: Centella asiatica, Cyperus rotundus & Emblica officinalis alcoholic and aqueous extract were prepared and evaluated for the hair growth properties using albino rats. The hair growth formulation was formulated as hair oil and applied topically on shaved skin of rats. Primary skin irritation test, hair length, hair density test were performed. The hair growth-promoting efficacies were evaluated at 0 day, 10 days, 15 days, and 20 days after the application through the hair re-growth area significant hair growth was observed and the hair growth was compared with the standard drug used 2% solution of minoxidil. Result: The result revealed that the hair growth activity of each drug was found proportional to the concentration range tested and compared with standard (2% minoxidil ethanolic solution) by an enlargement of follicular size and prolongation of the anagen phase. It holds the promise of potent herbal alternative for minoxidil. Conclusion: Excellent results of hair growth were observed in formulations prepared by cloth pouch decoction method for preparation of hair oils.

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articles by Dr. Pushpendra Kumar Jain

It is said that the use of Bacopa monnieri (BM) for memory enhancement goes back 3000 years or mo... more It is said that the use of Bacopa monnieri (BM) for memory enhancement goes back 3000 years or more in India, when it was cited for its medicinal properties, especially the memory enhancing capacity, in the vedic texts " Athar-Ved Samhila " (3:1) of 800 BC and in Ayurveda. In the folklore of Indian medicine, several herbs have been used traditionally as brain or nerve tonics. One of the most popular of these neurotonics is BM, a well-known memory booster. Brahmi has been administered at religious institutions to help students to enhance their memory for learning ancient, religious hymns. It is also used as cardio-tonic, tranquilizer and sedative, improves the process of learning, restores memory, and enhances power of speech and imagination, diuretic and nervine tonic, antistress, for nervous and mental strain, use in insanity, epilepsy, hysteria, esthenia, nervous breakdown. It is a small, creeping succulent herb. The leaf and flower bearing stems are 10-30 cm long and arise from creeping stems that form roots at the nodes with pale blue or pinkish white flowers belonging to family Scrophulariaceae grown nearly banks of freshwater streams and ponds, paddy fields, and other damp places. The chief phytoconstituents present are brahmine, herpestine, alkaloids, and saponins.

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Electronic commerce (e-commerce) is widely considered the buying and selling of products over the... more Electronic commerce (e-commerce) is widely considered the buying and selling of products over the internet, but any transaction that is completed solely through electronic measures can be considered as e-commerce. E-commerce may have large economic effects in the future. Internet commerce will change the face of business forever. Moreover, it has affected the information technology, economic, social, and e-commerce has enhanced the productivity growth worldwide in the 21 st century. The impact of e-commerce on developing countries for reducing inefficiencies for trading and to increase productivity in terms of economies with competitors internationally. There are many ways to accelerate the growth of productivity by cutting costs, increasing efficiency and reducing time and distance, e-commerce could become an important tool for development and growth in all sectors. Information security framework is specifically applied to the components that affect e-commerce that includes computer security, data security, and other wider realms of the information security framework. E-commerce security has its own particular nuances and is one of the highest visible security components that affect the end user through to obtain e-trade finance and equity investment, tourism and its internet incarnation.

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The purpose of this article is to study and to verify the therapeutic effects and margin of safet... more The purpose of this article is to study and to verify the therapeutic effects and margin of safety of traditional medicines used by the tribal community for treating various diseases as described in ancient literature found in our country. Herbs have been important contributors to the quality of human life for thousands of years. Herbal medicine is the oldest and most widely used form of medicine in the world today. Throughout history plants have served humankind as valuable components of seasonings, teas, cosmetics, dyes, and medicines. Medicinal plants have a traditionally important position in the socio-cultural, spiritual, and medicinal arena of rural and tribal lives throughout the world; India is rich in indigenous herbal resources due to its diverse climatic and soil conditions and multiple ecological regions. In Himalayan region of India, more than 2000 medicinal plant species exist. Although medicinal plants have been used since long, their scientific substantiation has recently been initiated. Looking into the steady expansion in the global population and prevalence of various diseases, such studies are the need of time to ensure availability of drugs in sustainable manner from natural sources for future generations. Based on the therapeutic and commercial importance of medicinal plants, the Cyperus rotundus has been undertaken to evaluate various ethnopharmacological parameters, as it has been used by number of tribal communities in Central part and Southern part of India. According to the WHO estimates about 80% of the of the world's population (mostly in developing countries) rely on traditional medicine, almost plant-based drugs, for their primary healthcare needs. Plants products also play an important role in the health-care systems of the remaining 20% of the population residing in developed countries. Currently, at least 122 phytoconstituents, derived from 94 plant species, can be considered as important drugs that are in use in one or more countries as therapeutic agents.

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Peptic ulcer is a most common ulcer of the gastrointestinal tract that is usually acidic and thus... more Peptic ulcer is a most common ulcer of the gastrointestinal tract that is usually acidic and thus extremely painful. This pathological condition is caused by chronic inflammation due to Helicobacter pylori, excessive use of of NSAIDs like aspirin and smoking. This disorder also results in release of massive amount of toxic free radicals which results in oxidative stress. Ethnobotanically, the whole plant of Calendula officinalis has been reported to be used in the treatment of various disorders including stomach and other diseases. Antiulcer-activity of the 50% ethanolic extracts in order to validate ethnobotanical claims regarding the plant, used in the above disorders. Four groups of six albino rats in each group were used. They were pretreated with (0.25% w/v) carboxymethyl cellulose (negative control, 10 ml/kg), 50 mg/kg ranitidine (positive control), whole plant extract of Calendula officinalis (250 and 450 mg/kg/body weight) and their effect was studied on aspirin induced ulcer, cold-resistant stress-induced ulcers, pylorus ligation and ethanol-induced ulcers. The results of the present study showed that the whole plant extract of Calendula officinalis possessed gastroprotective activity as evidenced by its significant inhibition in the formation of ulcers induced by physical and chemical agents with a maximum of 87.15 % therapeutic efficiency (450 mg/kg b.w.) in cold resistant stress-induced ulcers. The present study was also aimed to investigate the effect of this extract on oxidative stress by measuring the level of various oxidative markers. The result of enzyme assay and lipid peroxidation clearly indicates the whole plant of Calendula officinalis extract have significant antioxidant effect on ulcer pathology. Whole plant extract have decreased LPO (p< 0.001) and SOD (p<0.01) with concomitant increase in catalyse activity in cold resistant stress-induced ulcers.

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The ethanolic extract of the leaves and bark of Annona squsmosa. (Annonaceae) was evaluated for h... more The ethanolic extract of the leaves and bark of Annona squsmosa. (Annonaceae) was evaluated for hepatoprotective activity in wistar rats with liver damage induced by carbon tetrachloride. The extract at an oral dose of 450 mg/kg exhibited a significant protective effect by lowering the serum levels of aspartate aminotransferase, alanine aminotransferase, total serum bilirubin, and malondialdehyde equivalent, an index of lipid peroxidation of the liver. These biochemical observations were supplemented by histopathological examination of liver sections. The activity of extract was also comparable to that of silymarin, a known hepatoprotective.

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Emblica officinalis (Amla, EO, and E. officinalis) is one of the most important herbs in the Indi... more Emblica officinalis (Amla, EO, and E. officinalis) is one of the most important herbs in the Indian traditional medicine system, especially Ayurveda and also known as the king of all medicinal plants. EO is famous ayurvedic herb (the name means sour in Sanskrit) is likely one of the most useful drug treatments within the Indian pharmacopoeia, and is considered to be one of the most strongest uvenatives (Rasayana), particularly for the blood, bones, liver, and heart. It is an exceptionally rich source of vitamin C containing 30 times the amount found in oranges. It is one of the oldest oriental medicines mentioned in Ayurveda as potential remedy for various ailments. EO (Amla) is widely used in the ayurvedic medicines and believed to increase defense or immune power against diseases. Several parts of the plant are used to treat a variety of diseases, but the most important is the " fruit. " The fruit is rich in quercetin, phyllemblic compounds, gallic acid, tannins, flavonoids, pectin, and vitamin C and also contains various polyphenolic compounds. A wide range of phytochemical components including terpenoids, alkaloids, flavonoids, carbohydrates, and tannins have been shown to possess useful biological activities. Many pharmacological studies have demonstrated the ability of EO as antioxidant, anticarcinogenic, antitumor, antigenotoxic, anti-inflammatory activities, anticancer, anti HIV-reverse transcriptase, antidiabetic, inhibitory effects, antidepressant, antiulcerogenic, hair growth tonic, wound healing activities, cardiovascular diseases, neurodegenerative diseases, cancer, and many other traditional uses of the plant. The present study also includes macroscopy, microscopy, preliminary phytoconstituent, and physico-chemical evaluation.

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In the last few decades, a curious thing has happened to Herbal medicines. Instead of being kille... more In the last few decades, a curious thing has happened to Herbal medicines. Instead of being killed off by medical science and pharmaceutical chemistry, it has made come back. Herbal medicine has benefited from the objective analysis of the medical science, while fanciful and emotional claims for herbal cures have been thrown out, herbal treatments and plant medicine that works have been acknowledge. Moreover, herbal medicine has been found to have impressive credentials. Developed empirically by trial and error, many herbal treatments were nevertheless remarkably effective. In a recent survey estimated that 39% of all 520 new approved drugs in 1983-1994 were natural products or derived from natural products and 60-80% of antibacterial and anticancer drugs were derived from natural products. Medicinal plants play an important role in the development of potent therapeutic agents. Plant-derived drugs came into use in the modern medicine through the uses of plant material as an indigenous cure in folklore or traditional systems of medicine. Bacopa monnieri, Cyperus rotundus, and Emblica officinalis (Brahmi, Nagarmotha, Amla) have several chemical compounds have been isolated from these herbs which are useful in treating number of diseases such as diarrhea, vomiting, indigestion, antibacterial, antifungal, antiviral, hair growth, hair wash, antioxidant, anticonvulsant, analgesic, anti-allergic, antifungal, cardiac depressant, and cardio-tonic. These reported therapeutic activities are due to the presence of phytochemicals present in these Herbs. Even Ayurveda has recognizes the nutritional elements derived from foods and Rasayanas which help to optimize the availability of " essential nutrients " in the body.

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Nyctanthes arbortristis (N. Arbortristis) is one of the most useful traditional medicinal plants ... more Nyctanthes arbortristis (N. Arbortristis) is one of the most useful traditional medicinal plants in India. It is distributed widely in sub-Himalayan regions and Southwards to Godavari. Each part of the plant has some important medicinal value and is thus commercially exploitable. It is now considered as a valuable source of several unique products for the medicines against various diseases and also for the development of some industrial products. The present review is to focus on the potential phyto-chemicals and pharmacological activity of plant N. Arbortristis. Various parts of the plant like seeds, leaves, flowers, bark and fruits have been investigated for their significant pharmacological activity. Phyto-chemicals like flavanoid, glycoside, oleanic acid, essential oils, tannic acid, carotene, friedeline, lupeol, glucose, benzoic acid have been reported for significant hair tonic, hepatoprotective, anti-leishmaniasis, anti-viral, anti-fungal, anti-pyretic, anti-histaminic, anti-malerial, anti-bacterial, anti-inflammatory and anti-oxidant activities of Night jasmine and emphasizes the need for further exploring available information.

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Epilepsy is not a disease, but a syndrome of different cerebral disorders of the CNS. This syndro... more Epilepsy is not a disease, but a syndrome of different cerebral disorders of the CNS. This syndrome is characterized by paroxysmal, excessive, and hypersynchronous discharges of large numbers of neurons. The first major division of epilepsy is localization-related (i.e., focal, local, partial) epilepsies, which account for about 60% of all epilepsies. The remainder, about 40%, is composed of generalized epilepsies. The most common, and most difficult to treat, seizures in Adult patients are complex partial seizures, whereas primary generalized tonic-clonic (formerly, “Grand mal" epilepsy) seizures respond in most patients to treatment with anticonvulsants. Thus a need for new drugs with a greater benefit as related to side effects and tolerability, even at the expense of efficacy, when compared to the existing antiepileptic agents.

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Hair is a major esthetic display feature of the human body, especially in social and sexual inter... more Hair is a major esthetic display feature of the human body, especially in social and sexual interactions. Diagnosis of hair diseases occurred as early as ancient Egyptian times and is one of the oldest medical disciplines. Today, hair loss or thinning, and hypertrichosis or hirsutism are common complaints in clinical dermatology, but patients seeking advice for their hair problem are not necessarily completely bald or overall haired. The difficult task in diagnosing hair and hair disorders is to distinguish between a true disorder and a subjective complaint and to analyze the underlying pathogenesis. Patients consult for focal or diffuse effluvium, non-scarring or scarring alopecia, changes in hair structure or color and hair graying. Establishing the correct diagnosis is the key feature of successfully managing a hair patient.

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Int. J. Pharm. Sci. Rev. Res, 2018

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