Interaction of IL-2R beta and gamma c chains with Jak1 and Jak3: implications for XSCID and XCID (original) (raw)

Published November 11, 1994 | Version v1

Journal article Open

Creators

• Russell, S.
• Johnston, J.
• Noguchi, M.
• Kawamura, M.
• Bacon, C.
• Friedmann, M.
• Berg, M.
• McVicar, D.
• Witthuhn, B.
• Silvennoinen, O.
• Et, A.-L.

Description

Interleukin-2 (IL-2) signaling requires the dimerization of the IL-2 receptor beta.(IL-2R beta) and common gamma (gamma c) chains. Mutations of gamma c can result in X-linked severe combined immunodeficiency (XSCID). IL-2, IL-4, IL-7 (whose receptors are known to contain gamma c), and IL-9 (whose receptor is shown here to contain gamma c) induced the tyrosine phosphorylation and activation of the Janus family tyrosine kinases Jak1 and Jak3. Jak1 and Jak3 associated with IL-2R beta and gamma c, respectively; IL-2 induced Jak3-IL-2R beta and increased Jak3-gamma c associations. Truncations of gamma c, and a gamma c, point mutation causing moderate X-linked combined immunodeficiency (XCID), decreased gamma c-Jak3 association. Thus, gamma c mutations in at least some XSCID and XCID patients prevent normal Jak3 activation, suggesting that mutations of Jak3 may result in an XSCID-like phenotype.

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