促甲状腺激素受体 (original) (raw)

Thyroid stimulating hormone receptor促甲状腺激素受体
Rendering based on PDB 1XUM.
有效结构 PDB 直系同源检索：PDBe, RCSB PDB查询代码列表 2XWT, 3G04
标识
代号	TSHR; CHNG1; LGR3; hTSHR-I
扩展标识	遗传学：603372 鼠基因：98849 同源基因：315 IUPHAR: TSH ChEMBL: 1963 GeneCards: TSHR Gene
基因本体论描述分子功能 · thyroid-stimulating hormone receptor activity · protein binding 细胞成分 · plasma membrane · integral to plasma membrane 生物过程 · G-protein coupled receptor signaling pathway · G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger · cell-cell signaling · positive regulation of cell proliferation Sources: Amigo / QuickGO
RNA表达模式



更多表达数据
直系同源体
物种	人类	小鼠
Entrez	7253	22095
Ensembl	ENSG00000165409	ENSMUSG00000020963
UniProt	P16473	P47750
mRNA序列	NM_000369	NM_001113404
蛋白序列	NP_000360	NP_001106875
基因位置	Chr 14: 81.42 – 81.61 Mb	Chr 12: 91.4 – 91.54 Mb
PubMed查询	[1]	[2]
查论编

促甲状腺激素受体（英語：thyrotropin receptor，TSH receptor，TSHR）又称甲促素受体，是一种接受促甲状腺激素（甲促素，thyrotropin）信号，刺激细胞生成甲状腺激素（T4）和三碘甲状腺激素（T3）的跨膜受体。TSHR是整合膜蛋白中G蛋白偶联受体超家族的一员[1]，与Gs蛋白偶合[2]。

该受体主要出现在甲状腺上皮细胞的表面。

在结合血循的TSH后，G蛋白信号级联反应会激活腺苷酸环化酶（adenylyl cyclase）进而使胞内环腺苷酸（cAMP）浓度升高。环腺苷酸可活化甲状腺细胞各功能层面，包括：碘泵运，甲状腺球蛋白的合成、碘化、胞吞和蛋白酶解，甲狀腺过氧化物酶活性，以及甲狀腺激素释放。

弥漫性毒性甲状腺肿

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^ Calebiro D, Nikolaev VO, Lohse MJ. Imaging of persistent cAMP signaling by internalized G protein-coupled receptors. J. Mol. Endocrinol. July 2010, 45 (1): 1–8. PMID 20378719. doi:10.1677/JME-10-0014.

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Glycoprotein Hormone Receptors: TSH. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. （原始内容存档于2013-11-01）.
醫學主題詞表（MeSH）：Thyrotropin+Receptors
GRIS: Glycoprotein-hormone Receptor Information System

查论编細胞表面受體：G蛋白偶联受体
类型A：类视紫红质受体	神经递质肾上腺素 α1 A B D α2 A B C β1 β2 β3 嘌呤腺苷受體 A1 A2 A2A A2B A3 P2Y 1 2 4 5 6 8 9 10 11 12 13 14 血清素除5-HT3之外：5-HT1 A B D E F 5-HT2 A B C 5-HT 4 5A 6 7 其它乙酰胆碱 M1 M2 M3 M4 M5 多巴胺 D1 D2 D3 D4 D5 组胺 H1 H2 H3 H4 褪黑素 1A 1B 1C 痕量胺相关受体 1 2 3 5 6 8 9 代谢物及信号分子花生酸半胱氨酰白三烯素 1 2 LTB4 1 2 FPRL1 酮基花生酸前列腺素 D型 1 2 E型 1 2 3 4 FP 前列腺环素血栓素其它胆汁酸大麻碱 1 2 未命名 18 55 119 EB病毒诱导2 雌激素游离脂肪酸 1 2 3 4 乳酸溶血磷脂酸 1 2 3 4 5 6 溶血磷脂受体 1 2 3 4 5 6 7 8 烟酸 1 2 酮戊二酸血小板活化因子鞘氨醇基-1-磷酸盐 1 2 3 4 5 琥珀酸肽神经肽 B/W 1 2 FF 1 2 S Y 1 2 4 5 神经调节肽 B U 1 2 神经降压素 1 2 其它过敏毒素 C3a C5a 血管紧张素 1 2 爱佩琳铃蟾肽 BRS3 胃泌素释素 NMBR 缓激肽 B1 B2 趋化因子胆囊收缩素 A B 内皮素 A B 甲酰肽 1 2 3 促卵泡激素甘丙肽 1 2 3 γ-羟丁酸促性腺激素释素 1 2 生长素转移抑素黄体生成素/绒毛膜促性腺激素 MAS 1 1L D E F G X1 X2 X3 X4 黑素皮质素 1 2 3 4 5 黑色素浓集激素 1 2 胃动素阿片 δ κ μ 痛敏肽 & ζ 注意不包括σ受体丘脑分泌素 1 2 催产素激动素 1 2 催乳素释放肽松弛素 1 2 3 4 生长抑素 1 2 3 4 5 速激肽 1 2 3 促甲状腺激素促甲状腺激素释放激素尾加压素II 血管收缩素 1A 1B 2 杂项孤儿受体 G蛋白耦合受体 1 3 4 6 12 15 17 18 19 20 21 22 23 25 26 27 31 32 33 34 35 37 39 42 44 45 50 52 55 61 62 63 65 68 75 77 78 81 82 83 84 85 87 88 92 101 103 109A 109B 119 120 132 135 137B 139 141 142 146 148 149 150 151 152 153 160 161 162 171 173 174 176 177 182 183 其它肾上腺髓质素嗅觉视蛋白 3 4 5 1长波 1中波 1短波 RGR 类视色素受体(周视蛋白) 蛋白酶激活 1 2 3 4 大脑特异表达
类型B：类分泌素受体	孤儿受体 G蛋白耦合受体 56 64 97 98 110 111 112 113 114 115 116 123 124 125 126 128 133 143 144 155 157 其它脑血管生成抑制受体 1 2 3 钙粘蛋白 1 2 3 降钙素降钙素受体类似受体 CD97 促肾上腺皮质激素释放激素 1 2 EMR 1 2 3 胰高血糖激素胰高血糖激素抑胃多肽胰高血糖激素类肽1 胰高血糖激素类肽2 生长激素释放激素 PACAPR1 GPR 蛛毒素 1 2 3 表皮生长因子/蛛毒素/7跨膜域集合受体1 抗衰老类蛋白甲状旁腺激素 1 2 促胰液素血管活性肠肽 1 2
类型C：代谢型谷氨酸受体／信息素	味觉 TAS1R（甜味） 1 2 3 TAS2R（苦味） 1 3 4 5 8 9 10 12 13 14 16 19 20 30 31 38 39 40 41 42 43 45 46 50 60 其它钙敏感受体 γ-氨基丁酸B 1 2 谷氨酸受体代谢型 1 2 3 4 5 6 7 8 G蛋白耦合受体C族6组A型 GPR 156 158 179 RAIG 1 2 3 4
类型F：卷曲／平滑受体	卷曲卷曲受体 1 2 3 4 5 6 7 8 9 10 平滑平滑受体
信号转导索引描述胞外神經肽生长因子细胞因子激素細胞表面受體配体门控离子通道酶联受體 G蛋白偶聯受體免疫球蛋白超家族整合素神經肽受體生長因子受體细胞因子受體胞內受體蛋白 GTP-binding MAP激酶鈣信號脂質系號路徑hedgehog Wnt TGF-β MAPK ERK notch JAK-STAT 細胞凋亡 hippo TLR

查论编神经肽受体
G蛋白偶联受体	激素受體下丘脑促肾上腺皮质激素释放激素受体 · 促卵泡激素受体 · 促性腺激素释放激素受体 · 促甲状腺激素释放激素受体 · 生长抑素受体垂体抗利尿激素受体 (1A, 1B, 2) · 催产素受体 · LHCG · 促甲状腺激素受体其它Atrial natriuretic factor (NPR3) · 降钙素受体 · Cholecystokinin (A, B) · VIP 阿片样肽受体 Delta · Kappa · Mu · Nociceptin其它神经肽受体血管紧张素受体 · 缓激肽受体 (B1, B2) / 速激肽受体 (TACR1) · Calcitonin gene-related peptide · 甘丙肽受体 · GPCR neuropeptide (B/W, FF, S, Y) · 神经降压素受体
I型细胞因子受体	生长激素受体 · 催乳素受体
酶联受体	Atrial natriuretic factor (NPR1, NPR2)
其它	Sigma (1, 2)
信号转导索引描述胞外神經肽生长因子细胞因子激素細胞表面受體配体门控离子通道酶联受體 G蛋白偶聯受體免疫球蛋白超家族整合素神經肽受體生長因子受體细胞因子受體胞內受體蛋白 GTP-binding MAP激酶鈣信號脂質系號路徑hedgehog Wnt TGF-β MAPK ERK notch JAK-STAT 細胞凋亡 hippo TLR