NCI-H929 (original) (raw)

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NCI-H929 (human, Caucasian, myeloma)

SPECIES: human, Caucasian
TUMOR: myeloma

ECACC catalog code: 95050415
Morphology: Lymphoid
Description: Human Caucasian IgA-producing plasmacytoma
Viruses: See Properties
Depositor: Obtained from ATCC, USA
No restrictions. Patent: None Specified By Depositor
Properties: Receptors: Transferrin, CD38 Products: Immunoglobulin A (IgA) Applications: Chemotherapeutic agent studies, receptor studies, carcinogenesis assays.

Available in the following LABORATORY:

• Part of the Business Division of the Health Protection Agency (ECACC, Salisbury, Wiltshire)
  RPMI 1640 + 2mM Glutamine + 0.05mM 2-Mercaptoethanol (2ME) + 10% Fetal Bovine Serum (FBS). Maintain cultures between 2-4 x 100,000 cells/ml; 5% CO2; 37C.
  Karyotype: Near-tetraploid (8q+)
  This IgA-producing cell line has been established from a malignant effusion in a 62-year-old Caucasian woman with myeloma. They are positive for plasma cell antigen 1 (PCA-1), transferrin receptor and CD38 but negative for early B cell developmental markers. HLA DR and CALLA. NCI-H929 is negative for Epstein-Barr virus nuclear antigen. A rearrangement of the c-myc proto-oncogene has been observed as well as the expression of c-myc RNA and an activated ras allele.
  Research council deposit: No; Price Code: C;
  Validated by: isoenzymes (species confirmation)

Availability in cell line catalogues: ATCC: CRL 9068, DSMZ: ACC 163

Bibliographic references:

• Blood 1986;67:1542-1549 - PMID: 2423157
• ibid 1988;72:1163
• Mol Cell Biol 1988;8:124 - PMID: 3275865

See homonymous cell lines in other collections and catalogues.