LTFGRS: Implementation of Several Phenotype-Based Family Genetic Risk Scores (original) (raw)
Implementation of several phenotype-based family genetic risk scores with unified input data and data preparation functions to help facilitate the required data preparation and management. The implemented family genetic risk scores are the extended liability threshold model conditional on family history from Pedersen (2022) <doi:10.1016/j.ajhg.2022.01.009> and Pedersen (2023) <https://www.nature.com/articles/s41467-023-41210-z>, Pearson-Aitken Family Genetic Risk Scores from Krebs (2024) <doi:10.1016/j.ajhg.2024.09.009>, and family genetic risk score from Kendler (2021) <doi:10.1001/jamapsychiatry.2021.0336>.
| Version: | 1.0.1 |
|---|---|
| Imports: | batchmeans, dplyr, future.apply, future, lubridate, purrr, Rcpp, rlang, stats, stringr, tibble, tmvtnorm, tidyselect, igraph, xgboost, tidyr |
| LinkingTo: | Rcpp |
| Suggests: | knitr, rmarkdown, testthat (≥ 3.0.0), MASS |
| Published: | 2025-08-28 |
| DOI: | 10.32614/CRAN.package.LTFGRS |
| Author: | Emil Michael Pedersen [aut, cre], Jette Steinbach [aut], Lucas Rasmussen [ctb], Morten Dybdahl Krebs [aut] |
| Maintainer: | Emil Michael Pedersen |
| BugReports: | https://github.com/EmilMiP/LTFGRS/issues |
| License: | GPL (≥ 3) |
| URL: | https://emilmip.github.io/LTFGRS/ |
| NeedsCompilation: | yes |
| Language: | en-GB |
| Materials: | README, NEWS |
| CRAN checks: | LTFGRS results |
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