RNOmni: Rank Normal Transformation Omnibus Test (original) (raw)
Inverse normal transformation (INT) based genetic association testing. These tests are recommend for continuous traits with non-normally distributed residuals. INT-based tests robustly control the type I error in settings where standard linear regression does not, as when the residual distribution exhibits excess skew or kurtosis. Moreover, INT-based tests outperform standard linear regression in terms of power. These tests may be classified into two types. In direct INT (D-INT), the phenotype is itself transformed. In indirect INT (I-INT), phenotypic residuals are transformed. The omnibus test (O-INT) adaptively combines D-INT and I-INT into a single robust and statistically powerful approach. See McCaw ZR, Lane JM, Saxena R, Redline S, Lin X. "Operating characteristics of the rank-based inverse normal transformation for quantitative trait analysis in genome-wide association studies" <doi:10.1111/biom.13214>.
Version: | 1.0.1.2 |
---|---|
Depends: | R (≥ 3.2.2) |
Imports: | plyr, Rcpp, stats |
LinkingTo: | Rcpp, RcppArmadillo |
Suggests: | testthat (≥ 3.0.0), withr, R.rsp |
Published: | 2023-09-11 |
DOI: | 10.32614/CRAN.package.RNOmni |
Author: | Zachary McCaw [aut, cre] |
Maintainer: | Zachary McCaw |
License: | GPL-3 |
NeedsCompilation: | yes |
Materials: | NEWS |
CRAN checks: | RNOmni results |
Documentation:
Downloads:
Reverse dependencies:
Linking:
Please use the canonical formhttps://CRAN.R-project.org/package=RNOmnito link to this page.