Dopaminergic Fast Actors (original) (raw)

Dopaminergic hypothesis for retarded depression: a symptom profile for predicting therapeutical response
by
Rampello L; Nicoletti G; Raffaele R
Institute of Neurology, University of Catania, Italy.
Acta Psychiatr Scand, 1991 Dec, 84:6, 552-4

ABSTRACT

We assessed the therapeutical efficacy of various antidepressants (amineptine, minaprine and clomipramine) in patients affected by retarded depression. All patients exhibited symptoms of retardation, including hypokinesia, anergia, reduction of speech, increased salivation, hypersomnia, Parinaud's syndrome, reduced sexual activity, slowness, hypomimia, orthostatic hypotension, dysphagia and drowsiness. Antidepressant drugs were administered for a 6-week period in a randomized double-blind vs placebo design. The rank order of clinical effectiveness (amineptine much greater than minaprine greater than clomipramine greater than placebo) paralleled the specificity of antidepressants as dopaminomimetic agents. These results support the view that a reduced dopaminergic transmission contributes to the pathophysiology of retarded depression.

Metabolism Pharmacology Amineptine excess Amineptine and sex Mesolimbic dopamine Amineptine and the rat Amineptine and dopamine Amineptine and smart mice Amineptine and smarter dogs Dopamine: the pleasure and the pain Dopamine, opioids and learned helplessness

Refs and further reading

****HOME** HedWeb Nootropics cocaine.wiki Future Opioids BLTC Research MDMA/Ecstasy Superhapiness? Utopian Surgery? The Abolitionist Project The Hedonistic Imperative The Reproductive Revolution Critique of Huxley's Brave New World

****** The Good Drug Guide The Responsible Parent's Guide
To Healthy Mood Boosters For All The Family