Bio4241 - Advanced Topics in Genetics (original) (raw)

Bio4241 - Advanced Topics in Genetic Analysis

E-mail: scarr@mun.ca
Memorial University of Newfoundland Notes for Bio2250 (Principles of Genetics)

This course is an extension of Bio2250 toadvanced topics in experimental classical & modern genetics

Bio4241, Winter 2017 semester
Course Syllabus
Presentation rubric
Lectures Tu Th 1030-1145, C-2045 Lab Wed 2-5, Sn-3125

Introduction to Advanced Topics in Genetics

• 05 Jan: A History of DNA to 1953:
• smc [10 Jan] Luria & Delbruck (1943). Mutations of bacteria from virus sensitivity to virus resistance. Genetics 28:491.
  • [PDF of original] [PDF of presentation] Posted 03 Jan
  • Introduction to the Poisson Distribution
• 11 Jan LAB: Orientation & Organization [NOTE: Lab meets in Dept Seminar Room, Sn-3125]
• [12 & 17 Jan] Advanced Topics in Mutagenesis
  • Radiation Genetics: High-Energy mutagenesis
  • Ames Test: Environmental mutagenesis
  • Suppressor mutations: "Two wrong make a right"
• 18 Jan LAB: TBA Student Presentations
  See the Nobel e-Museum for biographies, summaries & other resources
  See PubMed at NCBI for papers
  Historical material & animations at Cold Spring Harbor Labs DNA Learning Center

• (1) [24 Jan] Structure & History of DNA : Watson, Crick, Wilkins, Franklin, Gosling, Chargaff et al.
  • Watson & Crick (1953) Molecular structure of nucleic acids.Nature 171: 737-738. [PDF of original] [PDF of presentation] Posted
  • Watson, Crick, Wilkins, Franklin, Gosling et al on DNAstructure, 1953 [3 PDFs]
• [25 Jan Lab] Sn-3125: "DNA: Secret of Photo 51" (Nova, 2007)
• (2) [26 Jan] Genetic function of DNA: "32P goes in, 35S stays out."
  • Hershey & Chase (1952). Independent functions of viral protein and nucleic acid in growth of bacteriophage. J Gen Physiol 36: 39-56 [PDF of original] [PDF of presentation] Posted
• (3) [31 Jan] Semi-Conservative Replication of DNA
  • Meselson & Stahl (1958). The replication of DNA in Escherichia coli. Proc Natl Acad Sci USA 44: 671-682. [PDF of original] [PDF of presentation] Posted
    • [Technical notes on analytical ultracentrifugation]
• [01 Feb lab] **HDM:**Introduction to Transposable Elements "Jumping Genes"
• (4) [02 Feb] Cancer Genetics
  • Knudson (1971). Genetics and cancer: statistical study of retinoblastoma. Proc Natl Acad Sci USA 68: 820-823. [PDF of original] [PDF of presentation] Posted
    • Knudson (2005) autobiography
• (5) [07 Feb] The Triplet Code
  • Nirenberg et al. (1966). The RNA code and protein synthesis. Cold Spring Harbor Symp Quant Biol 31: 11-24. [PDF of original] [PDF of presentation] [PPT presentation] Posted
    • [See introductory paper by FHC Crick; see also Nirenberg et al. in 1963 CSHSQB volume]
    • smc: "The Big ORF Theory"
• (6) [14 Feb] "Chimps and Humans are 99% similar"
  • King & Wilson(1975)Evolution at two levels in humans and chimpanzees. _Science_188:107-116. [PDF of original] [PDF of presentation] [PPT of presentation] Posted
• [15 Feb Lab] DARWIN DAY: Guest speaker
• (7) [16 Feb] DNA Fingerprinting
  • Gill et al. (1994)Identification of the remains of the Romanov family by DNA analysis. Nature 316:76-79. [PDF of original] [PPT of presentation] Posted

Part II: Advanced Topics from Gibson (2015) Primer of Human Genetics. Sinauer.

• [28 Feb] HDM:Quantitative Genetics [Modified 24 Mar 2016]

• [03 Mar] HDM: Gibson (2015) Chap 01: Conceptual Foundations of Genetics

• [08 Mar] HDM: Palaeogenetics: Origins of Human Genetic Diversity [PDF of presentation]

• [09 Mar lab] HDM: Linkage Analysis: Hamer et al. 1993. Science 261:321-327 [PDF of original][PDF of presentation] [revised 14 March]

• [10 Mar] HDM: Gibson (2015) Chap 01: Conceptual Foundations of Genetics, cont'd

• [15 Mar] [Group 1] Chap 02: The Human Genome [PDF of presentation] [posted 14 Mar]

• [15 Mar lab] Sn-3125: Screening of "Do You Really Want to Know?" (2012) [IMDB info] [Notes on Huntington Disease]

• [16 Mar] [Group 2] Chap 03: Human Evolution [PDF of Presentation] [posted16 Mar]

• [21 Mar] [Group 3] Chap 04: Normal Variation [link to Presentation] [posted 21 Mar]

• [22 Mar lab] [Group 4] CRISPR-cas9 technology [link to Presentation] [2016 New Yorker review] [posted 24 Mar]

• [23 Mar] [Group 5] Chap 06: Genome-Wide Association Studies (GWAS) [link to Presentation] [posted 24 Mar]

• [28 Mar] [Group 6] Nat'l Acad Sci Report on GMO Crops, Part 1 [Link to PDF Presentation] [posted Mar 28]

• [30 Mar] [Group 7] NAS Report on GMO Crops, Part 2 [Link to PDF Presentation] [posted Mar 30]

Last updated 06 April 2024 For Eowyn & Matilda.

All text material © 2024 by Steven M. Carr