Trimethoxyamphetamine (original) (raw)
Las trimetoxianfetaminas, también conocidas como TMA, son una familia de drogas alucinógenas isoméricas. Existen seis isómeros de TMA distintos que difieren solo en la posición de los tres grupos metoxilo: TMA, TMA-2, TMA-3, TMA-4, TMA-5 y TMA-6.
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| dbo:abstract | 3,4,5-Trimethoxyamphetamin (TMA) ist ein psychedelisches Halluzinogen aus der Familie der Phenethylamine. Es wurde zuerst 1948 von dem Chemiker P. Hey an der University of Leeds synthetisiert, bevor es 1960 von Alexander Shulgin wiederentdeckt und resynthetisiert wurde. TMA ist selten erhältlich, wesentlich seltener als TMA-2 oder TMA-6 (was wegen der wesentlich geringeren Potenz und dem ertragärmeren Absatz logisch erscheint), es wurde auf Freetekno- oder anderen Parties schon als TMA und "Meskalinpep" verkauft (also als Meskalin- und Amphetamin-Mischung). Mitte 2005 wurde von der Österreichischen Kriminalpolizei im Raum Niederösterreich eine große Menge TMA sichergestellt, die zum Verkauf bestimmt war. TMA ist in Deutschland ein nicht verkehrsfähiges Betäubungsmittel (BtMG, Anlage I). (de) Las trimetoxianfetaminas, también conocidas como TMA, son una familia de drogas alucinógenas isoméricas. Existen seis isómeros de TMA distintos que difieren solo en la posición de los tres grupos metoxilo: TMA, TMA-2, TMA-3, TMA-4, TMA-5 y TMA-6. (es) Les triméthoxyamphétamines (TMA) sont une famille d'isomères de substances psychotropes aux propriétés hallucinogènes. Le plus connu est le TMA-2. Elles ont été étudiées par Alexander Shulgin. Elles sont considérées comme des stupéfiants et figurent dans la Convention sur les substances psychotropes de 1971. (fr) Trimethoxyamphetamines (TMAs) are a family of isomeric psychedelic hallucinogenic drugs. There exist six different TMAs that differ only in the position of the three methoxy groups: TMA, TMA-2, TMA-3, TMA-4, TMA-5, and TMA-6. The TMAs are analogs of the phenethylamine cactus alkaloid mescaline. The TMAs are substituted amphetamines, however, their mechanism of action is more complex than that of the unsubstituted compound amphetamine, probably involving agonist activity on serotonin receptors such as the 5HT2A receptor in addition to the generalised dopamine receptor agonism typical of most amphetamines. This action on serotonergic receptors likely underlie the psychedelic effects of these compounds. It is reported that some TMAs elicit a range of emotions ranging from sadness to empathy and euphoria. TMA was first synthesized by Hey, in 1947. Synthesis data as well as human activity data has been published in the book PiHKAL. The most important TMA compound from a pharmacological standpoint is TMA-2, as this isomer has been much more widely used as a recreational drug and sold on the grey market as a so-called research chemical; TMA (sometimes referred to as "mescalamphetamine" or TMA-1) and TMA-6 have also been used in this way to a lesser extent. These three isomers are significantly more active as hallucinogenic drugs, and have consequently been placed onto the illegal drug schedules in some countries such as the Netherlands and Japan. The other three isomers TMA-3, TMA-4, and TMA-5 are not known to have been used as recreational drugs to any great extent. (en) 3,4,5-Trimethoxyamfetamine (afgekort TMA), is een zogenaamde designer drug die structureel verwant is aan mescaline (M). Deze laatste is een fenethylamine, terwijl TMA een amfetamine (d.i. alfa-methylfenethylamine) is. Het is een psychoactive drug waarvan de eerste resultaten in de wetenschappelijke literatuur verschenen in 1955. De US Army heeft in TMA (met als codenaam EA-1319) bestudeerd als potentieel chemisch wapen. TMA is een trimethoxyamfetamine. Er zijn in totaal zes isomeren mogelijk waarbij de methoxygroepen onderling van plaats veranderen op de fenylring. Al deze isomeren zijn gesynthetiseerd en farmacologisch getest geweest. Verder is TMA een zogenaamd . Essentieel is een anglicisme dat duidt op "essence": Engels voor extract. Het is via synthetische weg namelijk mogelijk TMA te bereiden vanuit , een dat men kan terugvinden in . (nl) TMA – grupa psychodelicznych substancji psychoaktywnych znanych też jako trimetoksyamfetaminy. Istnieje 6 substancji w grupie TMA – TMA, TMA-2, TMA-3, TMA-4, TMA-5 i TMA-6, różnią się od siebie tylko położeniem grup metoksy przy pierścieniu benzenowym. TMA są analogami naturalnego psychodelika występującego w kaktusach Peyotl i San pedro – meskaliny. TMA bywa czasem nazywane meskalamfetaminą, jednak to TMA-2 zyskało największą sławę i popularność na rynku designer drugs. (pl) 3,4,5-триметоксиамфетамин (TMA, 3,4,5-TMA, α-метилмескалин) — химическое соединение класса амфетаминов, психоделик. По структуре и фармакологическим свойствам аналогичен мескалину, от которого отличается метильной группой в позиции α. Механизм действия 3,4,5-TMA аналогичен механизму действия других классических психоделиков и основан на агонизме к 5-HT2A-рецепторам. Типичная оральная доза составляет 100—250 мг, продолжительность действия — 6-8 ч. (ru) |
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| rdfs:comment | Las trimetoxianfetaminas, también conocidas como TMA, son una familia de drogas alucinógenas isoméricas. Existen seis isómeros de TMA distintos que difieren solo en la posición de los tres grupos metoxilo: TMA, TMA-2, TMA-3, TMA-4, TMA-5 y TMA-6. (es) Les triméthoxyamphétamines (TMA) sont une famille d'isomères de substances psychotropes aux propriétés hallucinogènes. Le plus connu est le TMA-2. Elles ont été étudiées par Alexander Shulgin. Elles sont considérées comme des stupéfiants et figurent dans la Convention sur les substances psychotropes de 1971. (fr) TMA – grupa psychodelicznych substancji psychoaktywnych znanych też jako trimetoksyamfetaminy. Istnieje 6 substancji w grupie TMA – TMA, TMA-2, TMA-3, TMA-4, TMA-5 i TMA-6, różnią się od siebie tylko położeniem grup metoksy przy pierścieniu benzenowym. TMA są analogami naturalnego psychodelika występującego w kaktusach Peyotl i San pedro – meskaliny. TMA bywa czasem nazywane meskalamfetaminą, jednak to TMA-2 zyskało największą sławę i popularność na rynku designer drugs. (pl) 3,4,5-триметоксиамфетамин (TMA, 3,4,5-TMA, α-метилмескалин) — химическое соединение класса амфетаминов, психоделик. По структуре и фармакологическим свойствам аналогичен мескалину, от которого отличается метильной группой в позиции α. Механизм действия 3,4,5-TMA аналогичен механизму действия других классических психоделиков и основан на агонизме к 5-HT2A-рецепторам. Типичная оральная доза составляет 100—250 мг, продолжительность действия — 6-8 ч. (ru) 3,4,5-Trimethoxyamphetamin (TMA) ist ein psychedelisches Halluzinogen aus der Familie der Phenethylamine. Es wurde zuerst 1948 von dem Chemiker P. Hey an der University of Leeds synthetisiert, bevor es 1960 von Alexander Shulgin wiederentdeckt und resynthetisiert wurde. TMA ist in Deutschland ein nicht verkehrsfähiges Betäubungsmittel (BtMG, Anlage I). (de) Trimethoxyamphetamines (TMAs) are a family of isomeric psychedelic hallucinogenic drugs. There exist six different TMAs that differ only in the position of the three methoxy groups: TMA, TMA-2, TMA-3, TMA-4, TMA-5, and TMA-6. The TMAs are analogs of the phenethylamine cactus alkaloid mescaline. The TMAs are substituted amphetamines, however, their mechanism of action is more complex than that of the unsubstituted compound amphetamine, probably involving agonist activity on serotonin receptors such as the 5HT2A receptor in addition to the generalised dopamine receptor agonism typical of most amphetamines. This action on serotonergic receptors likely underlie the psychedelic effects of these compounds. It is reported that some TMAs elicit a range of emotions ranging from sadness to empathy a (en) 3,4,5-Trimethoxyamfetamine (afgekort TMA), is een zogenaamde designer drug die structureel verwant is aan mescaline (M). Deze laatste is een fenethylamine, terwijl TMA een amfetamine (d.i. alfa-methylfenethylamine) is. Het is een psychoactive drug waarvan de eerste resultaten in de wetenschappelijke literatuur verschenen in 1955. De US Army heeft in TMA (met als codenaam EA-1319) bestudeerd als potentieel chemisch wapen. (nl) |
| rdfs:label | 3,4,5-Trimethoxyamphetamin (de) Trimetoxianfetamina (es) Triméthoxyamphétamine (fr) Trimethoxyamfetamine (nl) Trimetoksyamfetaminy (pl) Trimethoxyamphetamine (en) 3,4,5-Триметоксиамфетамин (ru) |
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