20alpha-hydroxysteroid dehydrogenase (original) (raw)
La 20alfa-idrossisteroide deidrogenasi è un enzima appartenente alla classe delle ossidoreduttasi, che catalizza la seguente reazione: 17α,20α-diidrossipregn-4-en-3-one + NAD(P)+ ⇄ 17α-idrossiprogesterone + NAD(P)H + H+
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| dbo:abstract | In enzymology, a 20-α-hydroxysteroid dehydrogenase (EC 1.1.1.149) is an enzyme that catalyzes the chemical reaction 17alpha,20alpha-dihydroxypregn-4-en-3-one + NAD(P)+ 17alpha-hydroxyprogesterone + NAD(P)H + H+ The 3 substrates of this enzyme are , NAD+, and NADP+, whereas its 4 products are 17-alpha-hydroxyprogesterone, NADH, NADPH, and H+. This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 20alpha-hydroxysteroid:NAD(P)+ 20-oxidoreductase. Other names in common use include 20alpha-hydroxy steroid dehydrogenase, 20alpha-hydroxy steroid dehydrogenase, 20alpha-HSD, and 20alpha-HSDH. This enzyme participates in . 20alpha-HSD has been initially described as a progesterone metabolizing enzyme of the ovary. On a functional level, ovarian 20alpha-HSD is actively involved in the control of progesterone homeostasis in pregnancy of rats and mice. While 20alpha-HSD expression and activity is downregulated in the corpus luteum of pregnancy, 24 hrs prior to parturition ovarian 20alpha-HSD activity is acutely stimulated. Accordingly, in mice with targeted deletion of the 20alpha-HSD gene, progesterone blood concentration remain high throughout pregnancy which results in a delay of 2–4 days in parturition. Indicating that expression of 20alpha-HSD activity is mandatory for the induction of parturition through reduction of progesterone blood concentration. In mice, 20alpha-HSD is also expressed in the adrenals, kidneys, brain, thymus, T cells and bone marrow. Its induction in hematopoietic cells was used as an assay for the identification of T cell derived factor interleukin-3. In addition, the enzyme reduces and inactivates 17-deoxycorticosterone, the precursor of aldosterone and corticosterone. (en) La 20alfa-idrossisteroide deidrogenasi è un enzima appartenente alla classe delle ossidoreduttasi, che catalizza la seguente reazione: 17α,20α-diidrossipregn-4-en-3-one + NAD(P)+ ⇄ 17α-idrossiprogesterone + NAD(P)H + H+ (it) 20α-ヒドロキシステロイドデヒドロゲナーゼ（20α-hydroxysteroid dehydrogenase）は、次の化学反応を触媒する酸化還元酵素である。 17α,20α-ジヒドロキシプレグン-4-エン-3-オン + NAD(P)+ 17α-ヒドロキシプロゲステロン + NAD(P)H + H+ 反応式の通り、この酵素の基質はとNAD(P)+、生成物はとNAD(P)HとH+である。 組織名は20α-hydroxysteroid:NAD(P)+ 20-oxidoreductaseで、別名に20α-hydroxy steroid dehydrogenase, 20α-HSD, 20α-HSDHがある。 (ja) |
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| dbp:casNumber | 9040-08-08 (xsd:date) |
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| dct:subject | dbc:EC_1.1.1 dbc:Enzymes_of_known_structure dbc:NADH-dependent_enzymes dbc:NADPH-dependent_enzymes |
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| rdfs:comment | La 20alfa-idrossisteroide deidrogenasi è un enzima appartenente alla classe delle ossidoreduttasi, che catalizza la seguente reazione: 17α,20α-diidrossipregn-4-en-3-one + NAD(P)+ ⇄ 17α-idrossiprogesterone + NAD(P)H + H+ (it) 20α-ヒドロキシステロイドデヒドロゲナーゼ（20α-hydroxysteroid dehydrogenase）は、次の化学反応を触媒する酸化還元酵素である。 17α,20α-ジヒドロキシプレグン-4-エン-3-オン + NAD(P)+ 17α-ヒドロキシプロゲステロン + NAD(P)H + H+ 反応式の通り、この酵素の基質はとNAD(P)+、生成物はとNAD(P)HとH+である。 組織名は20α-hydroxysteroid:NAD(P)+ 20-oxidoreductaseで、別名に20α-hydroxy steroid dehydrogenase, 20α-HSD, 20α-HSDHがある。 (ja) In enzymology, a 20-α-hydroxysteroid dehydrogenase (EC 1.1.1.149) is an enzyme that catalyzes the chemical reaction 17alpha,20alpha-dihydroxypregn-4-en-3-one + NAD(P)+ 17alpha-hydroxyprogesterone + NAD(P)H + H+ The 3 substrates of this enzyme are , NAD+, and NADP+, whereas its 4 products are 17-alpha-hydroxyprogesterone, NADH, NADPH, and H+. (en) |
| rdfs:label | 20alpha-hydroxysteroid dehydrogenase (en) 20alfa-idrossisteroide deidrogenasi (it) 20α-ヒドロキシステロイドデヒドロゲナーゼ (ja) |
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