3β-Hydroxysteroid dehydrogenase (original) (raw)
La 3β-idrossi-Δ5-steroide deidrogenasi è un enzima appartenente alla classe delle ossidoreduttasi, che catalizza la seguente reazione: a 3β-idrossi-Δ5-steroide + NAD+ ⇄ a 3-osso-Δ5-steroide + NADH + H+ L'enzima agisce sul 3β-idrossiandrost-5-en-17-one per formare androst-4-ene-3,17-dione e sul 3-idrossipregn-5-en-20-one per formare progesterone.
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| dbo:abstract | 3β-Hydroxysteroid dehydrogenase/Δ5-4 isomerase (3β-HSD) (EC 1.1.1.145) is an enzyme that catalyzes the biosynthesis of the steroid progesterone from pregnenolone, 17α-hydroxyprogesterone from 17α-hydroxypregnenolone, and androstenedione from dehydroepiandrosterone (DHEA) in the adrenal gland. It is the only enzyme in the adrenal pathway of corticosteroid synthesis that is not a member of the cytochrome P450 family. It is also present in other steroid-producing tissues, including the ovary, testis and placenta. In humans, there are two 3β-HSD isozymes encoded by the HSD3B1 and HSD3B2 genes. 3β-HSD is also known as delta Δ5-4-isomerase, which catalyzes the oxidative conversion of Δ5-3β-hydroxysteroids to the Δ4-3-keto configuration and is, therefore, essential for the biosynthesis of all classes of hormonal steroids, namely progesterone, glucocorticoids, mineralocorticoids, androgens, and estrogens. The 3β-HSD complex is responsible for the conversion of: * Pregnenolone to progesterone * 17α-Hydroxypregnenolone to 17α-hydroxyprogesterone * DHEA to androstenedione * Androstenediol to testosterone * Androstadienol to androstadienone (en) 3β-Hydroxysteroid-Dehydrogenasen (3β-HSD) sind Enzyme, die in Steroiden die 3β-Hydroxygruppe zum Keton oxidieren und gleichzeitig die Umlagerung der Doppelbindung von der 5- in die 4-Position katalysieren. Diese Reaktion wird in Wirbeltieren bei der Biosynthese von Progesteron aus Pregnenolon benötigt, genauso wie bei der Umwandlung von Dehydroepiandrosteron zu Androstendion oder von zu 17α-Hydroxyprogesteron. 3β-HSD sind Transmembranproteine und lokalisieren zum endoplasmatischen Retikulum und zu den Mitochondrien. Beim Menschen sind drei paraloge Isoformen bekannt, die in unterschiedlichen Gewebetypen exprimiert werden: 3β-HSD I hauptsächlich in den Brustdrüsen, der Plazenta und der Haut; 3β-HSD II vor allem in Nebennieren, Hoden und Eierstöcken. Mutationen im HSD3B2-Gen sind verantwortlich für ein adrenogenitales Syndrom Typ 2 (CAH durch 3-beta-Hydroxysteroid-Dehydrogenase-Mangel). Das dritte menschliche Enzym dieser Proteinfamilie ist 3β-HSD Typ 7, ein Enzym der Gallensäurebildung aus Cholesterin. (de) La 3β-hidroxiesteroide deshidrogenasa, 3β-HSD (3β-hidroxiesteroide deshidrogenasa/Δ-5-4 isomerasa) (EC 1.1.1.145) es una enzima que cataliza la síntesis de la progesterona desde la pregnenolona, la 17-hidroxiprogesterona desde la 17-hidroxipregnenolona, y la androstenediona desde la dehidroepiandrosterona en la glándula suprarrenal. Es la única enzima en la vía suprarrenal de síntesis de corticosteroides que no es miembro de familia citocromo P450. En humanos, existen dos isoenzimas de la 3β-HSD, codificados por los genes HSD3B1 y HSD3B2, respectivamente. También es conocida como 5-delta 4-isomerasa, que cataliza la conversión oxidativa de los -beta delta 5-3 a la configuración 4-3-ceto y es por tanto, esencial para la biosíntesis de todas las clases de esteroides hormonales, es decir la progesterona, glucocorticoides, mineralocorticoides, andrógenos, y estrógenos. El complejo 3β-HSD es responsable de la conversión de: * pregnenolona a progesterona * 17-alfa-pregnenolona a 17-alfa-progesterona * dehidroepiandrosterona (DHEA) a androstenediona * androstenediol a testosterona (es) La 3β-idrossi-Δ5-steroide deidrogenasi è un enzima appartenente alla classe delle ossidoreduttasi, che catalizza la seguente reazione: a 3β-idrossi-Δ5-steroide + NAD+ ⇄ a 3-osso-Δ5-steroide + NADH + H+ L'enzima agisce sul 3β-idrossiandrost-5-en-17-one per formare androst-4-ene-3,17-dione e sul 3-idrossipregn-5-en-20-one per formare progesterone. (it) 3β-ヒドロキシ-Δ5-ステロイドデヒドロゲナーゼ（3β-hydroxy-Δ5-steroid dehydrogenase, 3-β-HSD）は副腎において、プレグネノロンからプロゲステロン、17-ヒドロキシプレグネノロンから17-ヒドロキシプロゲステロン、デヒドロエピアンドロステロンからアンドロステンジオンの合成を触媒する酵素である。副腎皮質ホルモンの合成経路では唯一のシトクロムP450ファミリーに属さない酵素である。ヒトでは、2種の3-β-HSDアイソザイムがおよび遺伝子にそれぞれコードされている。 δ5-δ4-イソメラーゼとしても知られ、δ5-3β-ヒドロキシステロイドからδ4-3ケト型への酸化変換を触媒する。したがって、プロゲステロン、糖質コルチコイド、鉱質コルチコイド、アンドロゲン、エストロゲンといったステロイドホルモンの生合成に必須な酵素となっている。 (ja) 3-бета-гидроксистероиддегидрогеназа — фермент человека, катализирующий образование прогестерона из прегненолона, 17-гидроксипрогестерона из 17-гидроксипрегненолона, и андростендиона из дегидроэпиандростерона. Это единственный фермент в цепочке надпочечникового стероидогенеза, не принадлежащий к суперсемейству цитохромов P450. У человека имеется два гена, кодирующих разные изоформы фермента: HSD3B1 и HSD3B2. Оба гена расположены на 1-й хромосоме. (ru) |
| dbo:ecNumber | 1.1.1.145 |
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| dbp:altsymbols | HSDB3, HSD3B (en) |
| dbp:arm | p (en) |
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| dbp:casNumber | 9044 (xsd:integer) |
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| dbp:hgncid | 5217 (xsd:integer) 5218 (xsd:integer) |
| dbp:interpro | IPR002225 (en) |
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| dbp:locussupplementarydata | -p11 (en) |
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| dbp:pfam | PF01073 (en) |
| dbp:refseq | NM_000198 (en) NM_000862 (en) |
| dbp:symbol | dbr:HSD3B1 dbr:HSD3B2 HSD3B (en) |
| dbp:uniprot | P14060 (en) P26439 (en) |
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| dct:subject | dbc:EC_1.1.1 dbc:Enzymes_of_unknown_structure dbc:NADH-dependent_enzymes |
| rdf:type | owl:Thing dbo:Biomolecule wikidata:Q206229 wikidata:Q8047 dbo:Enzyme |
| rdfs:comment | La 3β-idrossi-Δ5-steroide deidrogenasi è un enzima appartenente alla classe delle ossidoreduttasi, che catalizza la seguente reazione: a 3β-idrossi-Δ5-steroide + NAD+ ⇄ a 3-osso-Δ5-steroide + NADH + H+ L'enzima agisce sul 3β-idrossiandrost-5-en-17-one per formare androst-4-ene-3,17-dione e sul 3-idrossipregn-5-en-20-one per formare progesterone. (it) 3β-ヒドロキシ-Δ5-ステロイドデヒドロゲナーゼ（3β-hydroxy-Δ5-steroid dehydrogenase, 3-β-HSD）は副腎において、プレグネノロンからプロゲステロン、17-ヒドロキシプレグネノロンから17-ヒドロキシプロゲステロン、デヒドロエピアンドロステロンからアンドロステンジオンの合成を触媒する酵素である。副腎皮質ホルモンの合成経路では唯一のシトクロムP450ファミリーに属さない酵素である。ヒトでは、2種の3-β-HSDアイソザイムがおよび遺伝子にそれぞれコードされている。 δ5-δ4-イソメラーゼとしても知られ、δ5-3β-ヒドロキシステロイドからδ4-3ケト型への酸化変換を触媒する。したがって、プロゲステロン、糖質コルチコイド、鉱質コルチコイド、アンドロゲン、エストロゲンといったステロイドホルモンの生合成に必須な酵素となっている。 (ja) 3-бета-гидроксистероиддегидрогеназа — фермент человека, катализирующий образование прогестерона из прегненолона, 17-гидроксипрогестерона из 17-гидроксипрегненолона, и андростендиона из дегидроэпиандростерона. Это единственный фермент в цепочке надпочечникового стероидогенеза, не принадлежащий к суперсемейству цитохромов P450. У человека имеется два гена, кодирующих разные изоформы фермента: HSD3B1 и HSD3B2. Оба гена расположены на 1-й хромосоме. (ru) 3β-Hydroxysteroid dehydrogenase/Δ5-4 isomerase (3β-HSD) (EC 1.1.1.145) is an enzyme that catalyzes the biosynthesis of the steroid progesterone from pregnenolone, 17α-hydroxyprogesterone from 17α-hydroxypregnenolone, and androstenedione from dehydroepiandrosterone (DHEA) in the adrenal gland. It is the only enzyme in the adrenal pathway of corticosteroid synthesis that is not a member of the cytochrome P450 family. It is also present in other steroid-producing tissues, including the ovary, testis and placenta. In humans, there are two 3β-HSD isozymes encoded by the HSD3B1 and HSD3B2 genes. (en) 3β-Hydroxysteroid-Dehydrogenasen (3β-HSD) sind Enzyme, die in Steroiden die 3β-Hydroxygruppe zum Keton oxidieren und gleichzeitig die Umlagerung der Doppelbindung von der 5- in die 4-Position katalysieren. Diese Reaktion wird in Wirbeltieren bei der Biosynthese von Progesteron aus Pregnenolon benötigt, genauso wie bei der Umwandlung von Dehydroepiandrosteron zu Androstendion oder von zu 17α-Hydroxyprogesteron. (de) La 3β-hidroxiesteroide deshidrogenasa, 3β-HSD (3β-hidroxiesteroide deshidrogenasa/Δ-5-4 isomerasa) (EC 1.1.1.145) es una enzima que cataliza la síntesis de la progesterona desde la pregnenolona, la 17-hidroxiprogesterona desde la 17-hidroxipregnenolona, y la androstenediona desde la dehidroepiandrosterona en la glándula suprarrenal. Es la única enzima en la vía suprarrenal de síntesis de corticosteroides que no es miembro de familia citocromo P450. En humanos, existen dos isoenzimas de la 3β-HSD, codificados por los genes HSD3B1 y HSD3B2, respectivamente. (es) |
| rdfs:label | 3β-Hydroxysteroid-Dehydrogenase (de) 3β-Hydroxysteroid dehydrogenase (en) 3beta-hidroxiesteroide deshidrogenasa (es) 3beta-idrossi-delta5-steroide deidrogenasi (it) 3β-ヒドロキシ-Δ5-ステロイドデヒドロゲナーゼ (ja) 3-бета-гидроксистероиддегидрогеназа (ru) |
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| foaf:name | 3β-hydroxysteroid dehydrogenase/Δ-5-4 isomerase (en) |
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