3,4-Dihydroxyphenylacetaldehyde (original) (raw)
4,3-ثنائي هيدروكسي فينيل أسيتالدهيد (اختصاراً DOPAL) هو مركب عضوي صيغته C8H8O3، والذي يمكن أن يصطنع مخبرياً؛ كما يصطنع حيوياً داخل الجسم، إذ هو مستقلب مهم للناقل العصبي دوبامين. تدل بعض الدراسات إلى وجود رابط بين هذا المركب وبين العوامل الممرضة في مرض باركنسون.
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| dbo:abstract | 4,3-ثنائي هيدروكسي فينيل أسيتالدهيد (اختصاراً DOPAL) هو مركب عضوي صيغته C8H8O3، والذي يمكن أن يصطنع مخبرياً؛ كما يصطنع حيوياً داخل الجسم، إذ هو مستقلب مهم للناقل العصبي دوبامين. تدل بعض الدراسات إلى وجود رابط بين هذا المركب وبين العوامل الممرضة في مرض باركنسون. (ar) 3,4-Dihydroxyphenylacetaldehyde (DOPAL) is an important metabolite of the major brain neurotransmitter dopamine. All of the enzymatic metabolism of dopamine in neurons passes through DOPAL. According to the "catecholaldehyde hypothesis," DOPAL plays a role in the pathogenesis of Parkinson's disease. DOPAL has been chemically synthesized. DOPAL is detoxified mainly by aldehyde dehydrogenase. DOPAL is a metabolite of dopamine by monoamine oxidase activity, or MAO, in differentiated neuronal cells of the PC12 line. Physiological concentrations of DOPAL in isolated mitochondria were highly potent in inducing a pathway associated with programmed cell death (or apoptosis), permeability transition. This suggests the cytotoxity of DOPAL and its role in the progression of Parkinson's disease, which has long been associated with mitochondrial abnormalities and neurotoxicity by way of dopaminergic compounds, while reducing the emphasis on other dopamine derivatives and metabolites. (en) 3,4-ジヒドロキシフェニルアセトアルデヒド(3,4-Dihydroxyphenylacetaldehyde, DOPAL)は、脳の主要な神経伝達物質であるドーパミンの重要な代謝物質の1つである。ニューロン中でのドーパミンの酵素代謝物質は全てDOPALを経由する。「カテコールアルデヒド仮説」によると、DOPALは、パーキンソン病の発病に対して重要な役割を果たす。DOPALは、化学的に合成されている。またDOPALは、主にアルデヒドデヒドロゲナーゼにより無毒化される。 (ja) 3,4-다이하이드록시페닐아세트알데하이드(영어: 3,4-dihydroxyphenylacetaldehyde, DOPAL)는 뇌의 주요 신경전달물질인 도파민의 대사 과정에서의 중요한 대사 중간생성물이다. 뉴런에서 도파민의 모든 효소 대사는 3,4-다이하이드록시페닐아세트알데하이드를 거친다. 카테콜알데하이드 가설에 따르면, 3,4-다이하이드록시페닐아세트알데하이드는 파킨슨병의 에 중요한 역할을 한다. 3,4-다이하이드록시페닐아세트알데하이드는 화학적으로 합성될 수 있다. 3,4-다이하이드록시페닐아세트알데하이드는 주로 알데하이드 탈수소효소에 의해 대사된다. (ko) 3,4-Diidroxifenilacetaldeído, ou 3,4-di-hidroxifenilacetaldeído, (DOPAL), é um fenilacetaldeído no qual as posições 3 e 4 do grupo fenil são substituídas por grupos hidroxi, um membro de catecóis, um aldeído contendo CH2 alfa. Tem um papel como metabólito humano, de Escherichia coli e de camundongos, sendo um metabólito do neurotransmissor dopamina. (pt) |
| dbo:alternativeName | Dopaldehyde (en) 2-(3,4-Dihydroxyphenyl)acetaldehyde (en) |
| dbo:iupacName | (3,4-Dihydroxyphenyl)acetaldehyde (en) |
| dbo:thumbnail | wiki-commons:Special:FilePath/Dihydroxyphenylacetaldehyde.png?width=300 |
| dbo:wikiPageID | 22778967 (xsd:integer) |
| dbo:wikiPageLength | 3874 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID | 1105209616 (xsd:integer) |
| dbo:wikiPageWikiLink | dbr:Metabolite dbr:Neurotransmitter dbc:Phenolic_human_metabolites dbr:Neuron dbr:Enzyme dbr:Parkinson's_disease dbc:Aldehydes dbc:Catechols dbr:Aldehyde_dehydrogenase dbr:Pathogenesis dbr:Dopamine dbr:Phenylacetaldehyde dbr:Phenylglyoxal dbr:Metabolism dbr:PC12_cell_line dbr:Catecholaldehyde_hypothesis |
| dbp:imagefile | Dihydroxyphenylacetaldehyde.png (en) |
| dbp:imagename | Kekulé, skeletal formula of 3,4-dihydroxyphenylacetaldehyde (en) |
| dbp:othernames | 2 (xsd:integer) Dopaldehyde (en) |
| dbp:pin | acetaldehyde (en) |
| dbp:verifiedfields | changed (en) |
| dbp:verifiedrevid | 477217464 (xsd:integer) |
| dbp:watchedfields | changed (en) |
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| dcterms:subject | dbc:Phenolic_human_metabolites dbc:Aldehydes dbc:Catechols |
| gold:hypernym | dbr:Metabolite |
| rdf:type | owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q11173 yago:Abstraction100002137 yago:Aldehyde114584765 yago:Chemical114806838 yago:Compound114818238 yago:Material114580897 yago:Matter100020827 yago:OrganicCompound114727670 yago:Part113809207 yago:PhysicalEntity100001930 yago:Relation100031921 dbo:ChemicalCompound yago:Substance100019613 yago:WikicatAldehydes umbel-rc:ChemicalSubstanceType |
| rdfs:comment | 4,3-ثنائي هيدروكسي فينيل أسيتالدهيد (اختصاراً DOPAL) هو مركب عضوي صيغته C8H8O3، والذي يمكن أن يصطنع مخبرياً؛ كما يصطنع حيوياً داخل الجسم، إذ هو مستقلب مهم للناقل العصبي دوبامين. تدل بعض الدراسات إلى وجود رابط بين هذا المركب وبين العوامل الممرضة في مرض باركنسون. (ar) 3,4-ジヒドロキシフェニルアセトアルデヒド(3,4-Dihydroxyphenylacetaldehyde, DOPAL)は、脳の主要な神経伝達物質であるドーパミンの重要な代謝物質の1つである。ニューロン中でのドーパミンの酵素代謝物質は全てDOPALを経由する。「カテコールアルデヒド仮説」によると、DOPALは、パーキンソン病の発病に対して重要な役割を果たす。DOPALは、化学的に合成されている。またDOPALは、主にアルデヒドデヒドロゲナーゼにより無毒化される。 (ja) 3,4-다이하이드록시페닐아세트알데하이드(영어: 3,4-dihydroxyphenylacetaldehyde, DOPAL)는 뇌의 주요 신경전달물질인 도파민의 대사 과정에서의 중요한 대사 중간생성물이다. 뉴런에서 도파민의 모든 효소 대사는 3,4-다이하이드록시페닐아세트알데하이드를 거친다. 카테콜알데하이드 가설에 따르면, 3,4-다이하이드록시페닐아세트알데하이드는 파킨슨병의 에 중요한 역할을 한다. 3,4-다이하이드록시페닐아세트알데하이드는 화학적으로 합성될 수 있다. 3,4-다이하이드록시페닐아세트알데하이드는 주로 알데하이드 탈수소효소에 의해 대사된다. (ko) 3,4-Diidroxifenilacetaldeído, ou 3,4-di-hidroxifenilacetaldeído, (DOPAL), é um fenilacetaldeído no qual as posições 3 e 4 do grupo fenil são substituídas por grupos hidroxi, um membro de catecóis, um aldeído contendo CH2 alfa. Tem um papel como metabólito humano, de Escherichia coli e de camundongos, sendo um metabólito do neurotransmissor dopamina. (pt) 3,4-Dihydroxyphenylacetaldehyde (DOPAL) is an important metabolite of the major brain neurotransmitter dopamine. All of the enzymatic metabolism of dopamine in neurons passes through DOPAL. According to the "catecholaldehyde hypothesis," DOPAL plays a role in the pathogenesis of Parkinson's disease. DOPAL has been chemically synthesized. DOPAL is detoxified mainly by aldehyde dehydrogenase. DOPAL is a metabolite of dopamine by monoamine oxidase activity, or MAO, in differentiated neuronal cells of the PC12 line. Physiological concentrations of DOPAL in isolated mitochondria were highly potent in inducing a pathway associated with programmed cell death (or apoptosis), permeability transition. This suggests the cytotoxity of DOPAL and its role in the progression of Parkinson's disease, which (en) |
| rdfs:label | 4،3-ثنائي هيدروكسي فينيل أسيتالدهيد (ar) 3,4-Dihydroxyphenylacetaldehyde (en) 3,4-다이하이드록시페닐아세트알데하이드 (ko) 3,4-ジヒドロキシフェニルアセトアルデヒド (ja) 3,4-di-hidroxifenilacetaldeído (pt) |
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