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3-Methoxy-4-methylamphetamine (MMA) is an entactogen and psychedelic drug of the phenethylamine and amphetamine classes. It was first synthesized in 1970 and was encountered as a street drug in Italy in the same decade. MMA was largely forgotten until being reassayed by David E. Nichols as a non-neurotoxic MDMA analogue in 1991, and has subsequently been sold as a designer drug on the internet since the late 2000s (decade). In animal studies, MMA fully substitutes for MDMA and MBDB, partially substitutes for LSD, and does not substitute for amphetamine. Additionally, it has been shown to potently inhibit the reuptake of serotonin and does not produce serotonergic neurotoxicity in rodents. These data appear to confer a profile of MMA as a selective serotonin releasing agent (SSRA) and 5-HT2A receptor agonist. At high doses, such as 120 mg, the effects are psychedelic (comparable to DOM). (en) Metoximetilanfetamina ou 3-metoxi-4-metilanfetamina (MMA) é uma droga empatógena e psicodélica das classes das fenetilaminas e anfetaminas substituídas. Foi sintetizada pela primeira vez em 1970 e detectada como droga recreativa nas ruas da Itália na mesma década. A MMA foi amplamente negligenciada até ser reavaliada por David E. Nichols em 1991, que avaliou a droga como um análogo não neurotóxico da MDMA. Em estudos com roedores, o MMA substitui completamente a MDMA e MBDB, substitui parcialmente o LSD e não possui semelhanças com a anfetamina . Além disso, demonstrou inibir de forma potente a recaptação da serotonina e, ainda, não produziu neurotoxicidade serotonérgica em ratos. Os estudos realizado sugerem que a MMA atue como um agente de liberação de serotonina (SSRA) e agonista do receptor 5-HT2A. (pt) 3-метокси-4-метиламфетамин (MMA) — эмпатоген и психоделик семейства фенэтиламинов и амфетаминов. (ru) |
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3-метокси-4-метиламфетамин (MMA) — эмпатоген и психоделик семейства фенэтиламинов и амфетаминов. (ru) 3-Methoxy-4-methylamphetamine (MMA) is an entactogen and psychedelic drug of the phenethylamine and amphetamine classes. It was first synthesized in 1970 and was encountered as a street drug in Italy in the same decade. MMA was largely forgotten until being reassayed by David E. Nichols as a non-neurotoxic MDMA analogue in 1991, and has subsequently been sold as a designer drug on the internet since the late 2000s (decade). At high doses, such as 120 mg, the effects are psychedelic (comparable to DOM). (en) Metoximetilanfetamina ou 3-metoxi-4-metilanfetamina (MMA) é uma droga empatógena e psicodélica das classes das fenetilaminas e anfetaminas substituídas. Foi sintetizada pela primeira vez em 1970 e detectada como droga recreativa nas ruas da Itália na mesma década. A MMA foi amplamente negligenciada até ser reavaliada por David E. Nichols em 1991, que avaliou a droga como um análogo não neurotóxico da MDMA. (pt) |
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3-Methoxy-4-methylamphetamine (en) 3-Metoxi-4-metilanfetamina (pt) 3-Метокси-4-метиламфетамин (ru) |
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