ADAMTS (original) (raw)
ADAMTS (« A And Metalloproteinase with Thrombospondin Motifs ») est une famille de protéines jouant un rôle de peptidases. Les membres de la famille sont : * * * * * (= ADAMTS11) * * ADAMTS7 * (ouMETH-2), un antiangiogène * * * * ADAMTS13 * * * * * * *
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| dbo:abstract | ADAMTS (short for a disintegrin and metalloproteinase with thrombospondin motifs) is a family of multidomain extracellular protease enzymes. 19 members of this family have been identified in humans, the first of which, ADAMTS1, was described in 1997. Known functions of the ADAMTS proteases include processing of procollagens and von Willebrand factor as well as cleavage of aggrecan, versican, brevican and neurocan, making them key remodeling enzymes of the extracellular matrix. They have been demonstrated to have important roles in connective tissue organization, coagulation, inflammation, arthritis, angiogenesis and cell migration. Homologous subfamily of ADAMTSL (ADAMTS-like) proteins, which lack enzymatic activity, has also been described. Most cases of thrombotic thrombocytopenic purpura arise from autoantibody-mediated inhibition of ADAMTS13. Like ADAMs, the name of the ADAMTS family refers to its disintegrin and metalloproteinase activity, and in the case of ADAMTS, the presence of a thrombospondin motif. (en) ADAMTS (« A And Metalloproteinase with Thrombospondin Motifs ») est une famille de protéines jouant un rôle de peptidases. Les membres de la famille sont : * * * * * (= ADAMTS11) * * ADAMTS7 * (ouMETH-2), un antiangiogène * * * * ADAMTS13 * * * * * * * (fr) ADAMTS ("ADAM-протеазы, содержащие мотив тромбоспондина") - семейство белков, осуществляющих множество функций в процессах морфогенеза тканей, патологического преобразования тканей, в процессах воспаления и в процессах построения сосудов. В организме человека по состоянию на 2021 год было обнаружено 19 белков семейства ADAMTS, которым присвоены индексы от 1 до 20 (номер 11 пропущен, т.к. было обнаружено, что этот же белок ранее получил индекс 5). (ru) |
| dbo:thumbnail | wiki-commons:Special:FilePath/Clinical_findings_and...ent_ADAMTS_family_genes.jpg?width=300 |
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| dbo:wikiPageWikiLink | dbr:A_disintegrin_and_metalloproteinase dbr:Metalloproteinase dbc:Human_proteins dbr:Versican dbr:Enzymes dbr:Thrombospondin dbr:Aggrecan dbr:Thrombotic_thrombocytopenic_purpura dbr:Disintegrin dbr:Angiogenesis dbr:Brevican dbr:Protease dbr:ADAMTS6 dbr:Arthritis dbr:ADAMTS1 dbr:ADAMTS10 dbr:ADAMTS12 dbr:ADAMTS13 dbr:ADAMTS14 dbr:ADAMTS17 dbr:ADAMTS2 dbr:ADAMTS3 dbr:ADAMTS4 dbr:ADAMTS5 dbr:ADAMTS7 dbr:ADAMTS8 dbr:ADAMTS9 dbc:ADAMTS dbc:EC_3.4.24 dbr:Coagulation dbr:Von_Willebrand_factor dbr:Neurocan dbr:Extracellular_matrix dbr:Antiangiogenic dbr:ADAMTS15 dbr:ADAMTS16 dbr:ADAMTS18 dbr:ADAMTS19 dbr:ADAMTS20 dbr:ADAMTSL dbr:File:Clinical_findings_and_distributio..._in_different_ADAMTS_family_genes.jpg |
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| gold:hypernym | dbr:Family |
| rdf:type | yago:Abstraction100002137 yago:Chemical114806838 yago:Compound114818238 yago:Macromolecule114944888 yago:Material114580897 yago:Matter100020827 yago:Molecule114682133 yago:OrganicCompound114727670 yago:Part113809207 yago:PhysicalEntity100001930 yago:Protein114728724 yago:Relation100031921 yago:WikicatHumanProteins yago:Substance100019613 yago:Thing100002452 yago:Unit109465459 |
| rdfs:comment | ADAMTS (« A And Metalloproteinase with Thrombospondin Motifs ») est une famille de protéines jouant un rôle de peptidases. Les membres de la famille sont : * * * * * (= ADAMTS11) * * ADAMTS7 * (ouMETH-2), un antiangiogène * * * * ADAMTS13 * * * * * * * (fr) ADAMTS ("ADAM-протеазы, содержащие мотив тромбоспондина") - семейство белков, осуществляющих множество функций в процессах морфогенеза тканей, патологического преобразования тканей, в процессах воспаления и в процессах построения сосудов. В организме человека по состоянию на 2021 год было обнаружено 19 белков семейства ADAMTS, которым присвоены индексы от 1 до 20 (номер 11 пропущен, т.к. было обнаружено, что этот же белок ранее получил индекс 5). (ru) ADAMTS (short for a disintegrin and metalloproteinase with thrombospondin motifs) is a family of multidomain extracellular protease enzymes. 19 members of this family have been identified in humans, the first of which, ADAMTS1, was described in 1997. Known functions of the ADAMTS proteases include processing of procollagens and von Willebrand factor as well as cleavage of aggrecan, versican, brevican and neurocan, making them key remodeling enzymes of the extracellular matrix. They have been demonstrated to have important roles in connective tissue organization, coagulation, inflammation, arthritis, angiogenesis and cell migration. Homologous subfamily of ADAMTSL (ADAMTS-like) proteins, which lack enzymatic activity, has also been described. Most cases of thrombotic thrombocytopenic purpur (en) |
| rdfs:label | ADAMTS (en) ADAMTS (fr) ADAMTS (ru) |
| owl:sameAs | freebase:ADAMTS yago-res:ADAMTS wikidata:ADAMTS dbpedia-fr:ADAMTS dbpedia-ru:ADAMTS https://global.dbpedia.org/id/91YxN |
| prov:wasDerivedFrom | wikipedia-en:ADAMTS?oldid=1021389104&ns=0 |
| foaf:depiction | wiki-commons:Special:FilePath/Clinical_findings_and..._in_different_ADAMTS_family_genes.jpg |
| foaf:isPrimaryTopicOf | wikipedia-en:ADAMTS |
| is dbo:wikiPageRedirects of | dbr:Meth-2 |
| is dbo:wikiPageWikiLink of | dbr:Proteases_in_angiogenesis dbr:Zinc_transporter_ZIP8 dbr:Aggrecanase dbr:Disintegrin dbr:ADAMTS1 dbr:ADAMTS13 dbr:ADAMTS3 dbr:ADAMTS4 dbr:ADAMTS5 dbr:ADAMTS7 dbr:ADAM_(protein) dbr:Meth-2 dbr:Extracellular_space |
| is foaf:primaryTopic of | wikipedia-en:ADAMTS |
