ALOXE3 (original) (raw)
Epidermis-type lipoxygenase 3 (ALOXE3 or eLOX3) is a member of the lipoxygenase family of enzymes; in humans, it is encoded by the ALOXE3 gene. This gene is located on chromosome 17 at position 13.1 where it forms a cluster with two other lipoxygenases, ALOX12B and ALOX15B. Among the human lipoxygenases, ALOXE3 is most closely (54% identity) related in amino acid sequence to ALOX12B. ALOXE3, ALOX12B, and ALOX15B are often classified as epidermal lipoxygenases, in distinction to the other three human lipoxygenases (ALOX5, ALOX12, and ALOX15), because they were initially defined as being highly or even exclusively expressed and functioning in skin. The epidermis-type lipoxygenases are now regarded as a distinct subclass within the multigene family of mammalian lipoxygenases with mouse Aloxe3
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| dbo:abstract | Epidermis-type lipoxygenase 3 (ALOXE3 or eLOX3) is a member of the lipoxygenase family of enzymes; in humans, it is encoded by the ALOXE3 gene. This gene is located on chromosome 17 at position 13.1 where it forms a cluster with two other lipoxygenases, ALOX12B and ALOX15B. Among the human lipoxygenases, ALOXE3 is most closely (54% identity) related in amino acid sequence to ALOX12B. ALOXE3, ALOX12B, and ALOX15B are often classified as epidermal lipoxygenases, in distinction to the other three human lipoxygenases (ALOX5, ALOX12, and ALOX15), because they were initially defined as being highly or even exclusively expressed and functioning in skin. The epidermis-type lipoxygenases are now regarded as a distinct subclass within the multigene family of mammalian lipoxygenases with mouse Aloxe3 (also termed e-Lox-3) being the ortholog to human ALOXE3, mouse Alox12b being the ortholog to human ALOX12B (MIM 603741), and mouse Alox8 being the ortholog to human ALOX15B (MIM 603697)[supplied by OMIM]. ALOX12B and ALOXE3 in humans, Alox12b and Aloxe3 in mice, and comparable orthologs in other in other species are proposed to act sequentially in a multistep metabolic pathway that forms products that are structurally critical for creating and maintaining the skin's water barrier function. (en) ALOXE3 (англ. Arachidonate lipoxygenase 3) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 17-ї хромосоми. Довжина поліпептидного ланцюга білка становить 711 амінокислот, а молекулярна маса — 80 543. Послідовність амінокислот A: АланінC: ЦистеїнD: Аспарагінова кислотаE: Глутамінова кислотаF: ФенілаланінG: ГліцинH: ГістидинI: ІзолейцинK: ЛізинL: ЛейцинM: МетіонінN: АспарагінP: ПролінQ: ГлутамінR: АргінінS: СеринT: ТреонінV: ВалінW: Триптофан Y: Тирозин Кодований геном білок за функціями належить до оксидоредуктаз, ліаз, ізомераз. Задіяний у таких біологічних процесах, як метаболізм жирних кислот, метаболізм ліпідів, альтернативний сплайсинг. Білок має сайт для зв'язування з іонами металів, іоном заліза. Локалізований у цитоплазмі. (uk) |
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| dbo:wikiPageWikiLink | dbr:Psoriasis dbr:Epidermis dbr:Epoxide dbr:Nuclear_receptor dbr:Stratum_granulosum dbr:Allodynia dbr:Insulin_resistance dbr:MRNA dbc:Enzymes dbr:Gene_knockout dbr:Lung_microbiome dbr:Enzyme dbr:Gene dbr:Mutations dbr:Congenital_ichthyosiform_erythroderma dbr:Ligand dbr:Linoleic_acid dbr:Ichthyosis dbr:Ketone dbr:Leptin_receptor dbr:Autosomal_recessive dbr:Trehalose dbr:HEK_293_cells dbr:Lamellar_ichthyosis dbr:Lipoxygenase dbr:Stratum_corneum dbr:Adipocytes dbr:Amide dbr:Harlequin-type_ichthyosis dbr:Hepoxilin dbr:Hydrolysis dbr:Hyperalgesia dbr:ALOX12 dbr:ALOX12B dbr:ALOX15 dbr:ALOX15B dbr:Keratinocytes dbr:Eicosanoid dbr:Hepatocyte dbr:Dominance_(genetics) dbr:Sphingosine dbr:Fibroblast dbr:Embryogenesis dbr:Methyl_ester dbr:Ortholog dbr:Ceramide dbr:Hydroxyl dbr:Wax dbr:Congenital dbr:Thermogenesis dbr:Peroxisome_proliferator-activated_receptor_gamma dbr:Very_long_chain_fatty_acid dbr:Thiazolidinedione dbr:Polyunsaturated_fatty_acids dbr:Sugar_alcohol dbr:Orthologs dbr:Db/db_mouse dbr:Forestomach dbr:ALOX5 dbr:Diabetes_drugs dbr:Esterified dbr:SiRNA dbr:Hepatic_steatosis |
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| rdfs:comment | Epidermis-type lipoxygenase 3 (ALOXE3 or eLOX3) is a member of the lipoxygenase family of enzymes; in humans, it is encoded by the ALOXE3 gene. This gene is located on chromosome 17 at position 13.1 where it forms a cluster with two other lipoxygenases, ALOX12B and ALOX15B. Among the human lipoxygenases, ALOXE3 is most closely (54% identity) related in amino acid sequence to ALOX12B. ALOXE3, ALOX12B, and ALOX15B are often classified as epidermal lipoxygenases, in distinction to the other three human lipoxygenases (ALOX5, ALOX12, and ALOX15), because they were initially defined as being highly or even exclusively expressed and functioning in skin. The epidermis-type lipoxygenases are now regarded as a distinct subclass within the multigene family of mammalian lipoxygenases with mouse Aloxe3 (en) ALOXE3 (англ. Arachidonate lipoxygenase 3) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 17-ї хромосоми. Довжина поліпептидного ланцюга білка становить 711 амінокислот, а молекулярна маса — 80 543. Послідовність амінокислот A: АланінC: ЦистеїнD: Аспарагінова кислотаE: Глутамінова кислотаF: ФенілаланінG: ГліцинH: ГістидинI: ІзолейцинK: ЛізинL: ЛейцинM: МетіонінN: АспарагінP: ПролінQ: ГлутамінR: АргінінS: СеринT: ТреонінV: ВалінW: Триптофан Y: Тирозин (uk) |
| rdfs:label | ALOXE3 (en) ALOXE3 (uk) |
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