AdipoRon (original) (raw)
AdipoRon is a selective, orally active, synthetic small-molecule agonist of the adiponectin receptor 1 (AdipoR1) and adiponectin receptor 2 (AdipoR2) (Kd = 1.8 μM and 3.1 μM, respectively). It activates AMPK and PPARα signaling and ameliorates insulin resistance, dyslipidemia, and glucose intolerance in db/db mice (an animal model for type II diabetes and obesity). Moreover, AdipoRon has been found to extend the lifespans of db/db mice fed a high-fat diet, as well as improve exercise endurance. The compound was discovered by Japanese researchers in 2013 via screening of a compound library, and is the first orally active, small-molecule agonist of the adiponectin receptors to be identified.
| Property | Value |
|---|---|
| dbo:abstract | AdipoRon is a selective, orally active, synthetic small-molecule agonist of the adiponectin receptor 1 (AdipoR1) and adiponectin receptor 2 (AdipoR2) (Kd = 1.8 μM and 3.1 μM, respectively). It activates AMPK and PPARα signaling and ameliorates insulin resistance, dyslipidemia, and glucose intolerance in db/db mice (an animal model for type II diabetes and obesity). Moreover, AdipoRon has been found to extend the lifespans of db/db mice fed a high-fat diet, as well as improve exercise endurance. The compound was discovered by Japanese researchers in 2013 via screening of a compound library, and is the first orally active, small-molecule agonist of the adiponectin receptors to be identified. Adiponectin receptor agonists such as AdipoRon have attracted interest as potential therapies for obesity, diabetes, cardiovascular disease, non-alcoholic fatty liver disease, and a panoply of other conditions. In addition, adiponectin has recently been elucidated to mediate the antidepressant, anxiolytic, and neurogenic effects of physical exercise. Dysregulation of adiponectin expression has also been implicated in the pathology of mood disorders, anxiety disorders, eating disorders, neurodegenerative disorders, and various other neuropsychiatric disorders. Also, it has been determined that exercise improves insulin resistance via activation of AdipoR1. As such, adiponectin receptor agonists are a highly interesting therapeutic target for a variety of different conditions. Moreover, it has been suggested they could potentially be used as a substitute for exercise to achieve similar physical and mental health benefits.In 2016, the University of Tokyo announced that it would launch an investigation into claims of fabrication of AdipoR1, AdipoR2, and AdipoRon identification data, as accused by an anonymous person/group called Ordinary_researchers. (en) |
| dbo:casNumber | 924416-43-3 |
| dbo:fdaUniiCode | ND7UVH6GKJ |
| dbo:pubchem | 16307093 |
| dbo:thumbnail | wiki-commons:Special:FilePath/AdipoRon.svg?width=300 |
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| dbp:atcPrefix | None (en) |
| dbp:c | 27 (xsd:integer) |
| dbp:casNumber | 924416 (xsd:integer) |
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| dbp:n | 2 (xsd:integer) |
| dbp:o | 3 (xsd:integer) |
| dbp:pubchem | 16307093 (xsd:integer) |
| dbp:routesOfAdministration | dbr:Oral_administration |
| dbp:smiles | C1CNCC4=CC=CC=C4 (en) |
| dbp:unii | ND7UVH6GKJ (en) |
| dbp:width | 250 (xsd:integer) |
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| dct:subject | dbc:Acetamides dbc:Piperidines dbc:Adiponectin_receptor_agonists dbc:Anti-diabetic_drugs dbc:Antidepressants dbc:Antiobesity_drugs |
| rdf:type | owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 dbo:Drug |
| rdfs:comment | AdipoRon is a selective, orally active, synthetic small-molecule agonist of the adiponectin receptor 1 (AdipoR1) and adiponectin receptor 2 (AdipoR2) (Kd = 1.8 μM and 3.1 μM, respectively). It activates AMPK and PPARα signaling and ameliorates insulin resistance, dyslipidemia, and glucose intolerance in db/db mice (an animal model for type II diabetes and obesity). Moreover, AdipoRon has been found to extend the lifespans of db/db mice fed a high-fat diet, as well as improve exercise endurance. The compound was discovered by Japanese researchers in 2013 via screening of a compound library, and is the first orally active, small-molecule agonist of the adiponectin receptors to be identified. (en) |
| rdfs:label | AdipoRon (en) |
| owl:sameAs | yago-res:AdipoRon wikidata:AdipoRon https://global.dbpedia.org/id/2MwAY |
| prov:wasDerivedFrom | wikipedia-en:AdipoRon?oldid=1095739786&ns=0 |
| foaf:depiction | wiki-commons:Special:FilePath/AdipoRon.svg |
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| is dbo:wikiPageRedirects of | dbr:ADIPO-RON dbr:ADIPORON dbr:ADIPO_RON dbr:Adipo-Ron dbr:Adipo-ron dbr:Adipo_Ron dbr:Adipo_ron dbr:Adiporon |
| is dbo:wikiPageWikiLink of | dbr:C27H28N2O3 dbr:Adiponectin dbr:Adiponectin_receptor_1 dbr:Adiponectin_receptor_2 dbr:List_of_signaling_peptide/protein_receptor_modulators dbr:Signaling_peptide_receptor dbr:ADIPO-RON dbr:ADIPORON dbr:ADIPO_RON dbr:Adipo-Ron dbr:Adipo-ron dbr:Adipo_Ron dbr:Adipo_ron dbr:Adiporon |
| is foaf:primaryTopic of | wikipedia-en:AdipoRon |
