| dbo:abstract |
In eukaryotic cells, an aggresome refers to an aggregation of misfolded proteins in the cell, formed when the protein degradation system of the cell is overwhelmed. Aggresome formation is a highly regulated process that possibly serves to organize misfolded proteins into a single location. (en) Un aggresoma, nelle cellule eucariotiche, si riferisce ad un'aggregazione di proteine ripiegate in modo errato all'interno della cellula. Tale aggregazione proteica si viene a formare quando il fisiologico sistema di degradazione delle proteine della cellula viene sopraffatto, in genere per un eccesso di carico. Secondo gli studiosi l'aggresoma è un processo altamente regolato dalla cellula, verosimilmente una modalità con la quale la cellula organizza le proteine mal ripiegate in un unico locus. (it) |
| dbo:wikiPageExternalLink |
http://jcb.rupress.org/content/143/7/1883.long https://web.archive.org/web/20121022230010/http:/hmg.oxfordjournals.org/content/12/7/749.long https://web.archive.org/web/20130116002630/http:/www.pharm.emory.edu/lianli/lilabwebsitejhk/My%20Pdf%20paper/CMC%20review.pdf http://cancerres.aacrjournals.org/content/68/8/2557.abstract |
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dbr:HSP70 dbr:Huntington's_disease dbr:Hyperthermia dbr:Peptide dbr:Cystic_fibrosis_transmembrane_conductance_regulator dbr:Dynein dbr:Inclusion_bodies dbc:Cell_biology dbr:Constellation dbr:Proteolytic dbr:Apoptosis dbr:Lewy_bodies dbr:Chinese_hamster_ovary_cell dbr:P97 dbr:Mutant_protein dbr:Cell_(biology) dbr:Cytoplasmic dbr:Cytotoxic dbr:Amyotrophic_lateral_sclerosis dbr:Alpha-synuclein dbr:Alzheimer's_disease dbr:Eukaryote dbr:Parkin_(ligase) dbr:Parkinson's_disease dbr:Cell_nucleus dbr:Centrosome dbr:Protein_folding dbr:Protein dbr:JUNQ_and_IPOD dbr:Pathogenesis dbr:Autophagy dbr:BAG3 dbr:Microtubule_organizing_center dbr:Microtubules dbr:Chaperone_(protein) dbr:Mediator_(coactivator) dbr:Microtubule_motor dbr:Neurodegenerative dbr:Autophagic dbr:Protein_degradation dbr:Ataxin-3 dbr:Human_embryonic_kidney_cell dbr:Misfolded_proteins dbr:Polyubiquitination dbr:Denatured_protein dbr:Histone_deacetylase_6 dbr:Presenilin_1 dbr:Ubiquilin-1 |
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dbt:Cite_journal dbt:Further dbt:Reflist |
| dct:subject |
dbc:Cell_biology |
| rdfs:comment |
In eukaryotic cells, an aggresome refers to an aggregation of misfolded proteins in the cell, formed when the protein degradation system of the cell is overwhelmed. Aggresome formation is a highly regulated process that possibly serves to organize misfolded proteins into a single location. (en) Un aggresoma, nelle cellule eucariotiche, si riferisce ad un'aggregazione di proteine ripiegate in modo errato all'interno della cellula. Tale aggregazione proteica si viene a formare quando il fisiologico sistema di degradazione delle proteine della cellula viene sopraffatto, in genere per un eccesso di carico. Secondo gli studiosi l'aggresoma è un processo altamente regolato dalla cellula, verosimilmente una modalità con la quale la cellula organizza le proteine mal ripiegate in un unico locus. (it) |
| rdfs:label |
Aggresome (en) Aggresoma (it) |
| owl:sameAs |
freebase:Aggresome wikidata:Aggresome dbpedia-it:Aggresome https://global.dbpedia.org/id/4Lu2b |
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wikipedia-en:Aggresome?oldid=1079834059&ns=0 |
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wikipedia-en:Aggresome |
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dbr:Aggresomes |
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dbr:Inclusion_bodies dbr:Lewy_body dbr:Viroplasm dbr:Mitophagy dbr:Recombinant_subunit_vaccine dbr:Unfolded_protein_response dbr:Vimentin dbr:Aggresomes |
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wikipedia-en:Aggresome |