| dbo:abstract |
ألفيموبان (Alvimopan) (الاسم التجاري هو إنتيريغ) هو دواء يسلك سلوك مضادات الأفيونات-μ الفعالة بشكل محيطي. مع قدرة محدودة على عبور الحاجز الدموي الدماغي، فإن الكثير من التأثيرات الجانبية غير المرغوبة لمقلدات الأفيونات كالإمساك قد انخفضت بدون إعطاء تأثير فقدان الشعور بالألم أو الانسحاب السريع. قامت إدارة الغذاء والدواء باستعراض سلامة وفعالية الدواء ووافقت على استخدامه في أيار 2008. (ar) Alvimopan (trade name Entereg) is a drug which behaves as a peripherally acting μ-opioid receptor antagonist. With the limited ability to cross the blood–brain barrier and reach the μ-opioid receptors of the central nervous system, the clinically undesirable effects of centrally acting opioid antagonists (like reversal of opioid-mediated analgesia) are avoided without affecting the intended blockade of μ-opioid receptors in the gastrointestinal tract. It is currently only Food and Drug Administration approved for the treatment of postoperative ileus which it received in May 2008. (en) |
| dbo:alternativeName |
Entereg (en) |
| dbo:bioavailability |
6.000000 (xsd:float) |
| dbo:casNumber |
156053-89-3 |
| dbo:chEMBL |
270190 |
| dbo:drugbank |
DB06274 |
| dbo:fdaUniiCode |
Q153V49P3Z |
| dbo:medlinePlus |
a608051 |
| dbo:pubchem |
5488548 |
| dbo:thumbnail |
wiki-commons:Special:FilePath/Alvimopan2DCSD.svg?width=300 |
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| dbp:atcPrefix |
A06 (en) |
| dbp:atcSuffix |
AH02 (en) |
| dbp:bioavailability |
6.0 |
| dbp:c |
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| dbp:casNumber |
156053 (xsd:integer) |
| dbp:chembl |
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| dbp:chemspiderid |
4589864 (xsd:integer) |
| dbp:drugbank |
DB06274 (en) |
| dbp:eliminationHalfLife |
-61200.0 |
| dbp:excretion |
Faeces, urine (en) |
| dbp:h |
32 (xsd:integer) |
| dbp:image |
Alvimopan3DanJ.gif (en) |
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2 (xsd:integer) |
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7471 (xsd:integer) |
| dbp:legalUs |
Rx-only (en) |
| dbp:licenceUs |
Alvimopan (en) |
| dbp:medlineplus |
a608051 (en) |
| dbp:metabolism |
Gut microflora-mediated hydrolysis to active metabolite (en) |
| dbp:n |
2 (xsd:integer) |
| dbp:o |
4 (xsd:integer) |
| dbp:pregnancyUs |
B (en) |
| dbp:proteinBound |
80 (xsd:integer) |
| dbp:pubchem |
5488548 (xsd:integer) |
| dbp:routesOfAdministration |
Oral (en) |
| dbp:smiles |
O=CCNC[C@@H]CN3CC[C@@]C (en) |
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1 (xsd:integer) |
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UPNUIXSCZBYVBB-JVFUWBCBSA-N (en) |
| dbp:synonyms |
Alvimopan, Entereg (en) |
| dbp:tradename |
Entereg (en) |
| dbp:unii |
Q153V49P3Z (en) |
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changed (en) |
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| dcterms:subject |
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| gold:hypernym |
dbr:Drug |
| rdf:type |
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| rdfs:comment |
ألفيموبان (Alvimopan) (الاسم التجاري هو إنتيريغ) هو دواء يسلك سلوك مضادات الأفيونات-μ الفعالة بشكل محيطي. مع قدرة محدودة على عبور الحاجز الدموي الدماغي، فإن الكثير من التأثيرات الجانبية غير المرغوبة لمقلدات الأفيونات كالإمساك قد انخفضت بدون إعطاء تأثير فقدان الشعور بالألم أو الانسحاب السريع. قامت إدارة الغذاء والدواء باستعراض سلامة وفعالية الدواء ووافقت على استخدامه في أيار 2008. (ar) Alvimopan (trade name Entereg) is a drug which behaves as a peripherally acting μ-opioid receptor antagonist. With the limited ability to cross the blood–brain barrier and reach the μ-opioid receptors of the central nervous system, the clinically undesirable effects of centrally acting opioid antagonists (like reversal of opioid-mediated analgesia) are avoided without affecting the intended blockade of μ-opioid receptors in the gastrointestinal tract. It is currently only Food and Drug Administration approved for the treatment of postoperative ileus which it received in May 2008. (en) |
| rdfs:label |
Alvimopan (en) ألفيموبان (ar) |
| owl:sameAs |
freebase:Alvimopan yago-res:Alvimopan http://www4.wiwiss.fu-berlin.de/drugbank/resource/drugs/DB06274 wikidata:Alvimopan dbpedia-ar:Alvimopan http://or.dbpedia.org/resource/ଆଲଭିମୋପାନ dbpedia-sh:Alvimopan dbpedia-sr:Alvimopan dbpedia-vi:Alvimopan https://global.dbpedia.org/id/4PisB |
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wikipedia-en:Alvimopan?oldid=1102283137&ns=0 |
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wiki-commons:Special:FilePath/Alvimopan2DCSD.svg wiki-commons:Special:FilePath/Alvimopan3DanJ.gif |
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wikipedia-en:Alvimopan |
| is dbo:wikiPageRedirects of |
dbr:C25H32N2O4 dbr:Entereg dbr:ATC_code_A06AH02 dbr:ATCvet_code_QA06AH02 |
| is dbo:wikiPageWikiLink of |
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| is foaf:primaryTopic of |
wikipedia-en:Alvimopan |
