Arglabin is a sesquiterpene lactone belonging to the guaianolide subclass bearing a 5,7,5-tricyclic ring system which is known to inhibit farnesyl transferase. It is characterized by an epoxide on the cycloheptane as well as an exocyclic methylene group that is conjugated with the carbonyl of the lactone. Arglabin is extracted from , a species of wormwood, found in the Karaganda Region of Kazakhstan. Arglabin and its derivatives are biologically active and demonstrate promising antitumor activity and cytoxocity against varying tumor cell lines.
| Property |
Value |
| dbo:abstract |
Arglabin is a sesquiterpene lactone belonging to the guaianolide subclass bearing a 5,7,5-tricyclic ring system which is known to inhibit farnesyl transferase. It is characterized by an epoxide on the cycloheptane as well as an exocyclic methylene group that is conjugated with the carbonyl of the lactone. Arglabin is extracted from , a species of wormwood, found in the Karaganda Region of Kazakhstan. Arglabin and its derivatives are biologically active and demonstrate promising antitumor activity and cytoxocity against varying tumor cell lines. (en) |
| dbo:iupacName |
(3aR,4aS,6aS,9aS,9bR)-1,4a-Dimethyl-7-methylidene-5,6,6a,7,9a,9b-hexahydro-3H-oxireno[2′,3′:8,8a]azuleno[4,5-b]furan-8(4aH)-one (en) |
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wiki-commons:Special:FilePath/Arglabin.png?width=300 |
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dbr:Epoxide dbr:Methylene_group dbr:Mevalonate_pathway dbc:Gamma-lactones dbr:Carbonyl dbc:Epoxides dbc:Vinylidene_compounds dbr:Lactone dbr:Leukemia dbr:Artemisia_(genus) dbr:Acute_myeloid_leukemia dbr:Cycloheptane dbr:P388 dbr:Farnesyltransferase_inhibitor dbr:Isopentenyl_pyrophosphate dbc:Sesquiterpene_lactones dbr:Karaganda_Region dbr:Kazakhstan dbr:Biological_activity dbr:Dimethylallyl_pyrophosphate dbr:Guaianolide dbr:HL-60 dbr:Non-mevalonate_pathway dbr:Sesquiterpene_lactone dbr:Farnesyl_transferase dbr:Artemisia_glabella dbr:File:Costunolide_formation.png dbr:File:Germacrene_A_Biosynthesis.png dbr:File:Guaianolide_formation.png dbr:HL-60/A |
| dbp:imagefile |
Arglabin.png (en) Arglabin3D.png (en) |
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dbt:Chembox dbt:Chembox_Identifiers dbt:Chembox_Properties dbt:Commons_category-inline dbt:Reflist dbt:Cascite dbt:Chemspidercite dbt:Ebicite dbt:Fdacite |
| dct:subject |
dbc:Gamma-lactones dbc:Epoxides dbc:Vinylidene_compounds dbc:Sesquiterpene_lactones |
| rdf:type |
owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q11173 dbo:ChemicalCompound |
| rdfs:comment |
Arglabin is a sesquiterpene lactone belonging to the guaianolide subclass bearing a 5,7,5-tricyclic ring system which is known to inhibit farnesyl transferase. It is characterized by an epoxide on the cycloheptane as well as an exocyclic methylene group that is conjugated with the carbonyl of the lactone. Arglabin is extracted from , a species of wormwood, found in the Karaganda Region of Kazakhstan. Arglabin and its derivatives are biologically active and demonstrate promising antitumor activity and cytoxocity against varying tumor cell lines. (en) |
| rdfs:label |
Arglabin (en) |
| owl:sameAs |
wikidata:Arglabin dbpedia-hu:Arglabin https://global.dbpedia.org/id/2JcXk |
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wikipedia-en:Arglabin?oldid=1111176305&ns=0 |
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wiki-commons:Special:FilePath/Arglabin.png wiki-commons:Special:FilePath/Arglabin3D.png wiki-commons:Special:FilePath/Costunolide_formation.png wiki-commons:Special:FilePath/Germacrene_A_Biosynthesis.png wiki-commons:Special:FilePath/Guaianolide_formation.png |
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wikipedia-en:Arglabin |
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dbr:C15H18O3 dbr:Glossary_of_chemical_formulae |
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