Atrolysin A (original) (raw)

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dbo:abstract Atrolysin A (EC 3.4.24.1) is an enzyme that is one of six hemorrhagic toxins found in the venom of western diamondback rattlesnake. This endopeptidase has a length of 419 amino acid residues. The metalloproteinase disintegrin-like domain and the cysteine-rich domain of the enzyme are responsible for the enzyme's hemorrhagic effects on organisms via inhibition of platelet aggregation. This enzyme catalyzes the following chemical reactions: * cleavage of peptide bonds between amino acid residues Asn3-Gln4, His5-Leu6, His10-Leu11, Ala14-Leu15 and Tyr16-Leu17 in the insulin B chain * removal of the C-terminal Leu from small peptides (en) . Atrolisin A (bahasa Inggris: atrolysin A, Crotalus atrox metalloendopeptidase a; hemorrhagic toxin a; Crotalus atrox α-proteinase; Crotalus atrox proteinase; bothropasin, Crotalus atrox alpha-proteinase, Crotalus atrox metalloproteinase, Atroxase, ALA, EC 3.4.24.1) merupakan enzim yang diisolasi dari bisa ular western diamondback rattlesnake berjenis . ALA mengiris ikatan peptida pada antara gugus Asn3-Gln, His5-Leu, His10-Leu, Ala14-Leu dan Tyr16-Leu pada molekul insulin rantai B dan melepaskan atom C asam amino Leu yang terikat pada peptida. ALA merupakan protease yang tidak menyebabkan pendarahan, melainkan memiliki sifat fibrinolitik dengan aktivitas hidrolisis fibrinogen pada rantai A diikuti dengan pengirisan rantai B, dan dan rekanalisasi. bisa mentah bahkan menginduksi penggumpalan keping darah. (in) アトロリシンA(Atrolysin A、EC 3.4.24.1)は、酵素である。この酵素は、インスリンB鎖のAsn3-Gin、His5-Leu、His10-Leu、Ala14-Leu、Tyr16-Leu結合を切断する反応、また小ペプチドからC末端のロイシンを除去する反応を触媒する。 このエンドペプチダーゼは、ニシダイヤガラガラヘビの持つ6つの出血毒のうちの1つである。 (ja)
dbo:ecNumber 3.4.24.1
dbo:thumbnail wiki-commons:Special:FilePath/Atrolysin_A_structure.png?width=300
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dbo:wikiPageLength 10428 (xsd:nonNegativeInteger)
dbo:wikiPageRevisionID 1118194724 (xsd:integer)
dbo:wikiPageWikiLink dbr:Endopeptidase dbr:Metalloproteinase dbr:C-terminal dbr:GPVI dbr:Chemical_reaction dbr:Enzyme dbr:Convulxin dbr:Disintegrin dbr:Alpha_helix dbr:Cysteine dbr:K562_cells dbr:Atrolysin_B dbr:Atrolysin_C dbr:Atrolysin_E dbr:Atrolysin_F dbc:EC_3.4.24 dbr:Bleeding dbr:Cofactor_(biochemistry) dbr:Collagen_receptor dbr:Disulfide dbr:Fibrinogen dbr:Fibronectin dbr:Insulin dbr:Integrin dbr:Catalysis dbr:Venom dbr:Type_IV_collagen dbr:Western_diamondback_rattlesnake dbr:RGD_motif dbr:N-terminal dbr:Platelet_aggregation dbr:Atrolysin_D dbr:File:Atrolysin_A_structure.png
dbp:casNumber 37288 (xsd:integer)
dbp:ecNumber 3.400000 (xsd:double)
dbp:ecnumber 3.400000 (xsd:double)
dbp:iubmbEcNumber 3 (xsd:integer)
dbp:name Zinc metalloproteinase-disintegrin-like atrolysin-A (en) Atrolysin A (en)
dbp:organism Crotalus atrox (en)
dbp:symbol N/A (en)
dbp:taxid 8730 (xsd:integer)
dbp:uniprot Q92043 (en)
dbp:wikiPageUsesTemplate dbt:EC_number dbt:Enzymes dbt:Infobox_enzyme dbt:Infobox_nonhuman_protein dbt:MeshName dbt:Portal_bar dbt:Reflist dbt:Metalloendopeptidases
dct:subject dbc:EC_3.4.24
gold:hypernym dbr:Enzyme
rdf:type owl:Thing dbo:Biomolecule wikidata:Q206229 wikidata:Q8047 yago:Abstraction100002137 yago:Activator114723079 yago:Catalyst114723628 yago:Chemical114806838 yago:Compound114818238 yago:Enzyme114732946 yago:Macromolecule114944888 yago:Material114580897 yago:Matter100020827 yago:Molecule114682133 yago:OrganicCompound114727670 yago:Part113809207 yago:PhysicalEntity100001930 yago:Protein114728724 yago:Relation100031921 dbo:Enzyme dbo:Protein yago:Substance100019613 yago:Thing100002452 yago:Unit109465459
rdfs:comment アトロリシンA(Atrolysin A、EC 3.4.24.1)は、酵素である。この酵素は、インスリンB鎖のAsn3-Gin、His5-Leu、His10-Leu、Ala14-Leu、Tyr16-Leu結合を切断する反応、また小ペプチドからC末端のロイシンを除去する反応を触媒する。 このエンドペプチダーゼは、ニシダイヤガラガラヘビの持つ6つの出血毒のうちの1つである。 (ja) Atrolysin A (EC 3.4.24.1) is an enzyme that is one of six hemorrhagic toxins found in the venom of western diamondback rattlesnake. This endopeptidase has a length of 419 amino acid residues. The metalloproteinase disintegrin-like domain and the cysteine-rich domain of the enzyme are responsible for the enzyme's hemorrhagic effects on organisms via inhibition of platelet aggregation. This enzyme catalyzes the following chemical reactions: (en) . Atrolisin A (bahasa Inggris: atrolysin A, Crotalus atrox metalloendopeptidase a; hemorrhagic toxin a; Crotalus atrox α-proteinase; Crotalus atrox proteinase; bothropasin, Crotalus atrox alpha-proteinase, Crotalus atrox metalloproteinase, Atroxase, ALA, EC 3.4.24.1) merupakan enzim yang diisolasi dari bisa ular western diamondback rattlesnake berjenis . (in)
rdfs:label Atrolysin A (en) Atrolisin A (in) アトロリシンA (ja)
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foaf:name Atrolysin A (en)
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