| dbo:abstract |
K562 cells were the first human immortalised myelogenous leukemia cell line to be established. K562 cells are of the erythroleukemia type, and the cell line is derived from a 53-year-old female chronic myelogenous leukemia patient in blast crisis. The cells are non-adherent and rounded, are positive for the bcr:abl fusion gene, and bear some proteomic resemblance to both undifferentiated granulocytes and erythrocytes. In culture they exhibit much less clumping than many other suspension lines, presumably due to the downregulation of surface adhesion molecules by bcr:abl. However, another study suggests that bcr:abl over-expression may actually increase cell adherence to cell culture plastic. K562 cells can spontaneously develop characteristics similar to early-stage erythrocytes, granulocytes and monocytes and are easily killed by natural killer cells as they lack the MHC complex required to inhibit NK activity. They also lack any trace of Epstein-Barr virus and other herpesviruses. In addition to the Philadelphia chromosome they also exhibit a second reciprocal translocation between the long arm of chromosome 15 with chromosome 17. Two sub-lines are available which express MHC class-I A2 and A3. K562 cells are part of the NCI-60 cancer cell line panel used by the National Cancer Institute. (en) K-562是人類永生化骨髓性白血病細胞系，處於高度未分化狀態，並且屬於紅白血病（erythroleukemia）細胞系，具有惡性程度高、增殖速度快，以及可被一系列體外誘導劑誘導分化的特點。最初分離自一名處於急性期的53歲女性慢性骨髓性白血病（CML）患者的胸水。 (zh) |
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K-562是人類永生化骨髓性白血病細胞系，處於高度未分化狀態，並且屬於紅白血病（erythroleukemia）細胞系，具有惡性程度高、增殖速度快，以及可被一系列體外誘導劑誘導分化的特點。最初分離自一名處於急性期的53歲女性慢性骨髓性白血病（CML）患者的胸水。 (zh) K562 cells were the first human immortalised myelogenous leukemia cell line to be established. K562 cells are of the erythroleukemia type, and the cell line is derived from a 53-year-old female chronic myelogenous leukemia patient in blast crisis. The cells are non-adherent and rounded, are positive for the bcr:abl fusion gene, and bear some proteomic resemblance to both undifferentiated granulocytes and erythrocytes. Two sub-lines are available which express MHC class-I A2 and A3. K562 cells are part of the NCI-60 cancer cell line panel used by the National Cancer Institute. (en) |
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K562 cells (en) K-562 (zh) |
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