| dbo:abstract |
Azaprocin ist ein opioides Analgetikum, welches etwa zehnmal so potent ist wie Morphin und einen schnellen Eintritt der Wirkung sowie eine kurze Wirkungszeit hat. Es wurde 1963 entdeckt, aber nie vermarktet. Jedoch ist für eine strukturverwandte Verbindung (Analogon), das (AP-237), die Verwendung in China gegen Schmerzen bei Krebs beschrieben. (de) Azaprocin is a drug which is an opioid analgesic with approximately ten times the potency of morphine, and a fast onset and short duration of action. It was discovered in 1963, but has never been marketed. The derivative substituted on the phenyl ring with a p-nitro group is more potent than the parent compound, around 25x the potency of morphine. The ring-opened 2,6-dimethylpiperazine analogues are also active, and a large family of opioid analgesic compounds derived from this parent structure have been developed over the last 40 years. One analogue, AP-237, has been used in China to treat the pain caused by cancer. (en) |
| dbo:casNumber |
140844-23-1 |
| dbo:chEMBL |
2105901 |
| dbo:fdaUniiCode |
D20F1K1BYP |
| dbo:pubchem |
6433185 |
| dbo:thumbnail |
wiki-commons:Special:FilePath/Azaprocin_1.svg?width=300 |
| dbo:wikiPageID |
18071201 (xsd:integer) |
| dbo:wikiPageLength |
8370 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID |
1084692348 (xsd:integer) |
| dbo:wikiPageWikiLink |
dbc:Alkene_derivatives dbc:Mu-opioid_receptor_agonists dbc:Piperazines dbr:Morphine dbr:Analgesic dbc:Propionamides dbc:Synthetic_opioids dbr:AP-237 dbr:Opioid |
| dbp:atcPrefix |
none (en) |
| dbp:c |
18 (xsd:integer) |
| dbp:casNumber |
140844 (xsd:integer) |
| dbp:chembl |
2105901 (xsd:integer) |
| dbp:chemspiderid |
16736583 (xsd:integer) |
| dbp:h |
24 (xsd:integer) |
| dbp:iupacName |
1 (xsd:integer) |
| dbp:meltingHigh |
175 (xsd:integer) |
| dbp:meltingPoint |
170 (xsd:integer) |
| dbp:n |
2 (xsd:integer) |
| dbp:o |
1 (xsd:integer) |
| dbp:pubchem |
6433185 (xsd:integer) |
| dbp:smiles |
CCC=O (en) |
| dbp:stdinchi |
1 (xsd:integer) |
| dbp:stdinchikey |
RKNSPEOBXHFNTD-DQCUJPBYSA-N (en) |
| dbp:unii |
D20F1K1BYP (en) |
| dbp:verifiedfields |
changed (en) |
| dbp:verifiedrevid |
458790006 (xsd:integer) |
| dbp:watchedfields |
changed (en) |
| dbp:wikiPageUsesTemplate |
dbt:Drugbox dbt:Opioidergics dbt:Reflist dbt:Short_description dbt:Cascite dbt:Chemspidercite dbt:Ebicite dbt:Fdacite dbt:Stdinchicite |
| dcterms:subject |
dbc:Alkene_derivatives dbc:Mu-opioid_receptor_agonists dbc:Piperazines dbc:Propionamides dbc:Synthetic_opioids |
| gold:hypernym |
dbr:Drug |
| rdf:type |
owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 yago:WikicatAmides yago:WikicatMolecularFormulas yago:Abstraction100002137 yago:AliphaticCompound114601294 yago:Alkene114713120 yago:Amide114724264 yago:Chemical114806838 yago:Communication100033020 yago:Compound114818238 yago:Formula106816935 yago:Material114580897 yago:Matter100020827 yago:Message106598915 yago:MolecularFormula106817173 yago:OrganicCompound114727670 yago:Part113809207 yago:PhysicalEntity100001930 yago:Relation100031921 dbo:Drug yago:Statement106722453 yago:Substance100019613 yago:WikicatAlkenes umbel-rc:DrugProduct |
| rdfs:comment |
Azaprocin ist ein opioides Analgetikum, welches etwa zehnmal so potent ist wie Morphin und einen schnellen Eintritt der Wirkung sowie eine kurze Wirkungszeit hat. Es wurde 1963 entdeckt, aber nie vermarktet. Jedoch ist für eine strukturverwandte Verbindung (Analogon), das (AP-237), die Verwendung in China gegen Schmerzen bei Krebs beschrieben. (de) Azaprocin is a drug which is an opioid analgesic with approximately ten times the potency of morphine, and a fast onset and short duration of action. It was discovered in 1963, but has never been marketed. (en) |
| rdfs:label |
Azaprocin (de) Azaprocin (en) |
| owl:sameAs |
freebase:Azaprocin yago-res:Azaprocin wikidata:Azaprocin dbpedia-de:Azaprocin dbpedia-sh:Azaprocin dbpedia-sr:Azaprocin https://global.dbpedia.org/id/4U5KB |
| prov:wasDerivedFrom |
wikipedia-en:Azaprocin?oldid=1084692348&ns=0 |
| foaf:depiction |
wiki-commons:Special:FilePath/Azaprocin_1.svg |
| foaf:isPrimaryTopicOf |
wikipedia-en:Azaprocin |
| is dbo:wikiPageRedirects of |
dbr:C18H24N2O |
| is dbo:wikiPageWikiLink of |
dbr:List_of_opioids dbr:Bucinnazine dbr:C18H24N2O dbr:AP-238 dbr:Diphenpipenol dbr:Opioid dbr:List_of_drugs:_As–Az |
| is foaf:primaryTopic of |
wikipedia-en:Azaprocin |
