Diphenpipenol (original) (raw)
Diphenpipenol is an opioid analgesic drug invented in the 1970s by Dainippon Pharmaceutical Co. It is chemically a 1-substituted-4-(1,2-diphenylethyl)piperazine derivative related to compounds such as MT-45 and AD-1211, but diphenpipenol is the most potent compound in the series, with the more active (S) enantiomer being around 105 times the potency of morphine in animal studies. This makes it a similar strength to fentanyl and its analogues, and consequently diphenpipenol can be expected to pose a significant risk of producing life-threatening respiratory depression, as well as other typical opioid side effects such as sedation, itching, nausea and vomiting.
| Property | Value |
|---|---|
| dbo:abstract | Diphenpipenol is an opioid analgesic drug invented in the 1970s by Dainippon Pharmaceutical Co. It is chemically a 1-substituted-4-(1,2-diphenylethyl)piperazine derivative related to compounds such as MT-45 and AD-1211, but diphenpipenol is the most potent compound in the series, with the more active (S) enantiomer being around 105 times the potency of morphine in animal studies. This makes it a similar strength to fentanyl and its analogues, and consequently diphenpipenol can be expected to pose a significant risk of producing life-threatening respiratory depression, as well as other typical opioid side effects such as sedation, itching, nausea and vomiting. Diphenpipenol has been offered for sale online as a designer drug, though analysis of a sample of supposed diphenpipenol found it to instead contain a structural isomer with much weaker opioid activity, and it is unclear if genuine diphenpipenol has actually been sold. (en) |
| dbo:casNumber | 83374-54-3 |
| dbo:chEMBL | 1189795 |
| dbo:fdaUniiCode | ZK4VB64WSR |
| dbo:pubchem | 13236269 |
| dbo:thumbnail | wiki-commons:Special:FilePath/Diphenpipenol_Structure.svg?width=300 |
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| dbp:atcPrefix | None (en) |
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| dbp:smiles | COc4ccccc4N1CCNCc3ccccc3 (en) |
| dbp:stdinchi | 1 (xsd:integer) |
| dbp:stdinchikey | ILCZMFSACNEMGK-UHFFFAOYSA-N (en) |
| dbp:unii | ZK4VB64WSR (en) |
| dbp:wikiPageUsesTemplate | dbt:Clear-left dbt:Drugbox dbt:Opioidergics dbt:Piperazines dbt:Reflist dbt:Cascite dbt:Fdacite |
| dcterms:subject | dbc:Designer_drugs dbc:Mu-opioid_receptor_agonists dbc:Synthetic_opioids dbc:Diphenylethylpiperazines |
| rdf:type | owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 dbo:Drug |
| rdfs:comment | Diphenpipenol is an opioid analgesic drug invented in the 1970s by Dainippon Pharmaceutical Co. It is chemically a 1-substituted-4-(1,2-diphenylethyl)piperazine derivative related to compounds such as MT-45 and AD-1211, but diphenpipenol is the most potent compound in the series, with the more active (S) enantiomer being around 105 times the potency of morphine in animal studies. This makes it a similar strength to fentanyl and its analogues, and consequently diphenpipenol can be expected to pose a significant risk of producing life-threatening respiratory depression, as well as other typical opioid side effects such as sedation, itching, nausea and vomiting. (en) |
| rdfs:label | Diphenpipenol (en) |
| owl:sameAs | wikidata:Diphenpipenol https://global.dbpedia.org/id/9LAwg |
| prov:wasDerivedFrom | wikipedia-en:Diphenpipenol?oldid=1051003057&ns=0 |
| foaf:depiction | wiki-commons:Special:FilePath/Diphenpipenol-isomer_structure.png wiki-commons:Special:FilePath/Diphenpipenol_Structure.svg |
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| is foaf:primaryTopic of | wikipedia-en:Diphenpipenol |
