BD1018 (original) (raw)
BD1018 or (S)-2-[2-(3,4-dichlorophenyl)ethyl]octahydropyrrolo[1,2-a]pyrazine is a selective sigma receptor ligand, with a reported binding affinity of Ki = 5 ± 0.7 nM for the sigma-1 receptor and approximately 10 times selectivity over the sigma-2 receptor. Unlike its enantiomer, BD1031, BD1018 acts as a sigma receptor antagonist. Consistent with other reported sigma receptor antagonists, BD1018 decreases the behavioural toxicity of cocaine in Swiss Webster mice.
| Property | Value |
|---|---|
| dbo:abstract | BD1018 or (S)-2-[2-(3,4-dichlorophenyl)ethyl]octahydropyrrolo[1,2-a]pyrazine is a selective sigma receptor ligand, with a reported binding affinity of Ki = 5 ± 0.7 nM for the sigma-1 receptor and approximately 10 times selectivity over the sigma-2 receptor. Unlike its enantiomer, BD1031, BD1018 acts as a sigma receptor antagonist. Consistent with other reported sigma receptor antagonists, BD1018 decreases the behavioural toxicity of cocaine in Swiss Webster mice. (en) BD1018 o (S)-2-[2-(3,4-dichlorophenyl)ethyl]octahydropyrrolo[1,2-a]pyrazine es un ligando selectivo del receptor sigma, con una afinidad de unión informada de Ki = 5 ± 0.7 nM por el receptor sigma-1 y aproximadamente 10 veces la selectividad sobre el receptor sigma-2. A diferencia de su enantiómero, BD1031, BD1018 actúa como un antagonista de receptor sigma. De acuerdo con otros antagonistas del receptor sigma informados, BD1018 reduce la toxicidad conductual de la cocaína en Swiss Webster. (es) |
| dbo:casNumber | 150208-42-7 |
| dbo:pubchem | 9796317 |
| dbo:thumbnail | wiki-commons:Special:FilePath/BD1018.png?width=300 |
| dbo:wikiPageID | 36175064 (xsd:integer) |
| dbo:wikiPageLength | 2350 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID | 990115585 (xsd:integer) |
| dbo:wikiPageWikiLink | dbr:Antagonist dbr:Binding_affinity dbr:BD1008 dbc:Ligands_(biochemistry) dbr:BD1031 dbr:Sigma_receptor dbr:Sigma-2_receptor dbr:Sigma-1_receptor |
| dbp:c | 15 (xsd:integer) |
| dbp:casNumber | 150208 (xsd:integer) |
| dbp:chemspiderid | 7972083 (xsd:integer) |
| dbp:cl | 2 (xsd:integer) |
| dbp:h | 20 (xsd:integer) |
| dbp:iupacName | -2 (xsd:integer) |
| dbp:n | 2 (xsd:integer) |
| dbp:pubchem | 9796317 (xsd:integer) |
| dbp:smiles | Clc1cccCCN3C[C@H]2NCC3 (en) |
| dbp:stdinchi | 1 (xsd:integer) |
| dbp:stdinchikey | IGVDQXLOMXGWKN-ZDUSSCGKSA-N (en) |
| dbp:wikiPageUsesTemplate | dbt:Drugbox dbt:Reflist |
| dcterms:subject | dbc:Ligands_(biochemistry) |
| gold:hypernym | dbr:Ligand |
| rdf:type | owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 yago:WikicatLigands yago:WikicatMolecularFormulas yago:Abstraction100002137 yago:Communication100033020 yago:Formula106816935 yago:Ligand115110307 yago:Matter100020827 yago:Message106598915 yago:MolecularFormula106817173 yago:PhysicalEntity100001930 dbo:Drug yago:Statement106722453 yago:Substance100020090 |
| rdfs:comment | BD1018 or (S)-2-[2-(3,4-dichlorophenyl)ethyl]octahydropyrrolo[1,2-a]pyrazine is a selective sigma receptor ligand, with a reported binding affinity of Ki = 5 ± 0.7 nM for the sigma-1 receptor and approximately 10 times selectivity over the sigma-2 receptor. Unlike its enantiomer, BD1031, BD1018 acts as a sigma receptor antagonist. Consistent with other reported sigma receptor antagonists, BD1018 decreases the behavioural toxicity of cocaine in Swiss Webster mice. (en) BD1018 o (S)-2-[2-(3,4-dichlorophenyl)ethyl]octahydropyrrolo[1,2-a]pyrazine es un ligando selectivo del receptor sigma, con una afinidad de unión informada de Ki = 5 ± 0.7 nM por el receptor sigma-1 y aproximadamente 10 veces la selectividad sobre el receptor sigma-2. A diferencia de su enantiómero, BD1031, BD1018 actúa como un antagonista de receptor sigma. De acuerdo con otros antagonistas del receptor sigma informados, BD1018 reduce la toxicidad conductual de la cocaína en Swiss Webster. (es) |
| rdfs:label | BD1018 (en) BD1018 (es) |
| owl:sameAs | freebase:BD1018 yago-res:BD1018 wikidata:BD1018 dbpedia-es:BD1018 dbpedia-sh:BD1018 dbpedia-sr:BD1018 https://global.dbpedia.org/id/4UhbL |
| prov:wasDerivedFrom | wikipedia-en:BD1018?oldid=990115585&ns=0 |
| foaf:depiction | wiki-commons:Special:FilePath/BD1018.png |
| foaf:isPrimaryTopicOf | wikipedia-en:BD1018 |
| is dbo:wikiPageWikiLink of | dbr:BD1031 dbr:C15H20Cl2N2 |
| is foaf:primaryTopic of | wikipedia-en:BD1018 |
