BD1031 (original) (raw)
BD1031 or (R)-2-[2-(3,4-dichlorophenyl)ethyl]octahydropyrrolo[1,2-a]pyrazine is a selective sigma receptor agonist, with a reported binding affinity of Ki = 1 ± 0.2 nM for the sigma-1 receptor and 80 times selectivity over the sigma-2 receptor. The enantiomer of BD1031 is known as BD1018. Consistent with other reported sigma receptor agonists, BD1031 increases the behavioural toxicity of cocaine in Swiss Webster mice.
| Property | Value |
|---|---|
| dbo:abstract | BD1031 or (R)-2-[2-(3,4-dichlorophenyl)ethyl]octahydropyrrolo[1,2-a]pyrazine is a selective sigma receptor agonist, with a reported binding affinity of Ki = 1 ± 0.2 nM for the sigma-1 receptor and 80 times selectivity over the sigma-2 receptor. The enantiomer of BD1031 is known as BD1018. Consistent with other reported sigma receptor agonists, BD1031 increases the behavioural toxicity of cocaine in Swiss Webster mice. (en) BD1031 o (R)-2-[2-(3,4-dichlorophenyl)ethyl]octahydropyrrolo[1,2-a]pyrazine es un agonista selectivo del receptor sigma, con una afinidad de unión informada de Ki = 1 ± 0.2 nM para el receptor sigma-1 y selectividad 80 veces superior al receptor sigma-2. El enantiómero de BD1031 se conoce como BD1018. De acuerdo con otros agonistas, del receptor sigma informados, BD1031 aumenta la toxicidad conductual de la cocaína en Swiss Webster. (es) |
| dbo:casNumber | 150208-44-9 |
| dbo:thumbnail | wiki-commons:Special:FilePath/BD1031.png?width=300 |
| dbo:wikiPageID | 36174167 (xsd:integer) |
| dbo:wikiPageLength | 2274 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID | 990235118 (xsd:integer) |
| dbo:wikiPageWikiLink | dbr:Binding_affinity dbr:BD1008 dbr:Agonist dbc:Sigma_agonists dbr:BD1018 dbr:Sigma_receptor dbr:Sigma-2_receptor dbr:Sigma-1_receptor |
| dbp:c | 15 (xsd:integer) |
| dbp:casNumber | 150208 (xsd:integer) |
| dbp:chemspiderid | 23166168 (xsd:integer) |
| dbp:cl | 2 (xsd:integer) |
| dbp:h | 20 (xsd:integer) |
| dbp:iupacName | -2 (xsd:integer) |
| dbp:n | 2 (xsd:integer) |
| dbp:smiles | c1ccCl (en) |
| dbp:stdinchi | 1 (xsd:integer) |
| dbp:stdinchikey | IGVDQXLOMXGWKN-CYBMUJFWSA-N (en) |
| dbp:wikiPageUsesTemplate | dbt:Drugbox dbt:Reflist dbt:Sigma_receptor_modulators |
| dct:subject | dbc:Sigma_agonists |
| gold:hypernym | dbr:Agonist |
| rdf:type | owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 dbo:Drug |
| rdfs:comment | BD1031 or (R)-2-[2-(3,4-dichlorophenyl)ethyl]octahydropyrrolo[1,2-a]pyrazine is a selective sigma receptor agonist, with a reported binding affinity of Ki = 1 ± 0.2 nM for the sigma-1 receptor and 80 times selectivity over the sigma-2 receptor. The enantiomer of BD1031 is known as BD1018. Consistent with other reported sigma receptor agonists, BD1031 increases the behavioural toxicity of cocaine in Swiss Webster mice. (en) BD1031 o (R)-2-[2-(3,4-dichlorophenyl)ethyl]octahydropyrrolo[1,2-a]pyrazine es un agonista selectivo del receptor sigma, con una afinidad de unión informada de Ki = 1 ± 0.2 nM para el receptor sigma-1 y selectividad 80 veces superior al receptor sigma-2. El enantiómero de BD1031 se conoce como BD1018. De acuerdo con otros agonistas, del receptor sigma informados, BD1031 aumenta la toxicidad conductual de la cocaína en Swiss Webster. (es) |
| rdfs:label | BD1031 (es) BD1031 (en) |
| owl:sameAs | freebase:BD1031 wikidata:BD1031 dbpedia-es:BD1031 dbpedia-sh:BD1031 dbpedia-sr:BD1031 https://global.dbpedia.org/id/4UiCM |
| prov:wasDerivedFrom | wikipedia-en:BD1031?oldid=990235118&ns=0 |
| foaf:depiction | wiki-commons:Special:FilePath/BD1031.png |
| foaf:isPrimaryTopicOf | wikipedia-en:BD1031 |
| is dbo:wikiPageRedirects of | dbr:BD-1031 |
| is dbo:wikiPageWikiLink of | dbr:BD1008 dbr:BD1067 dbr:LR132 dbr:BD1018 dbr:BD1052 dbr:BD1060 dbr:BD1063 dbr:C15H20Cl2N2 dbr:Sigma_receptor dbr:BD-1031 |
| is foaf:primaryTopic of | wikipedia-en:BD1031 |
