| dbo:abstract |
Branched-chain amino acid aminotransferase (BCAT), also known as branched-chain amino acid transaminase, is an aminotransferase enzyme (EC 2.6.1.42) which acts upon branched-chain amino acids (BCAAs). It is encoded by the BCAT2 gene in humans. The BCAT enzyme catalyzes the conversion of BCAAs and α-ketoglutarate into branched chain α-keto acids and glutamate. The structure to the right of branched chain amino acid aminotransferase was found using X-ray diffraction with a resolution of 2.20 Å. The branched-chain amino acid aminotransferase found in this image was isolated from mycobacteria. This protein is made up of two identical polypeptide chains, totaling 372 residues. The biological function of branched-chain amino acid aminotransferases is to catalyse the synthesis or degradation of the branched chain amino acids leucine, isoleucine, and valine. In humans, branched chain amino acids are essential and are degraded by BCATs. (en) |
| dbo:arm |
q |
| dbo:band |
13 |
| dbo:chromosome |
19 |
| dbo:ecNumber |
2.6.1.42 |
| dbo:entrezgene |
587 |
| dbo:hgncid |
977 |
| dbo:omim |
113530 (xsd:integer) |
| dbo:refseq |
NM_001190 |
| dbo:symbol |
BCT BCAT |
| dbo:thumbnail |
wiki-commons:Special:FilePath/Branched_Chain_Aminotransferase.png?width=300 |
| dbo:uniprot |
O15382 |
| dbo:wikiPageExternalLink |
http://www.rcsb.org/pdb/explore/explore.do%3FstructureId=3DTF |
| dbo:wikiPageID |
11393958 (xsd:integer) |
| dbo:wikiPageLength |
30503 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID |
1083111644 (xsd:integer) |
| dbo:wikiPageWikiLink |
dbr:Pyridoxal_phosphate dbr:Branched-chain_amino_acids dbr:Beta_sheet dbr:Valine dbc:EC_2.6.1 dbr:Essential_amino_acid dbr:Enzyme dbr:Gabapentin dbr:Gene dbr:Branched_chain_amino_acid_transaminase_1 dbr:Leucine dbr:Keto_acid dbr:Active_site dbr:Alpha_helix dbr:Redox dbr:Isoleucine dbr:X-ray_diffraction dbr:Schiff_base dbr:Mycobacterium_smegmatis dbr:Glutamate dbr:Aminotransferase dbr:Polypeptide_chains dbr:Mycobacteria dbr:Branched_chain_amino_acids dbr:Homodimer dbr:Α-ketoglutarate dbr:File:1ekp.jpg |
| dbp:altsymbols |
BCT (en) |
| dbp:arm |
q (en) |
| dbp:band |
13 (xsd:integer) |
| dbp:caption |
Crystallographic structure of branched-chain-amino-acid aminotransferase from Mycobacterium smegmatis (en) |
| dbp:chromosome |
19 (xsd:integer) |
| dbp:ecnumber |
2.600000 (xsd:double) |
| dbp:entrezgene |
587 (xsd:integer) |
| dbp:hgncid |
977 (xsd:integer) |
| dbp:name |
Branched-chain amino acid aminotransferase (en) |
| dbp:omim |
113530 (xsd:integer) |
| dbp:refseq |
NM_001190 (en) |
| dbp:symbol |
BCAT (en) |
| dbp:uniprot |
O15382 (en) |
| dbp:wikiPageUsesTemplate |
dbt:Amino_acid_metabolism_enzymes dbt:Cite_web dbt:Commons_category dbt:EC_number dbt:Enzymes dbt:MeshName dbt:Nitrogenous_transferases dbt:Reflist dbt:Short_description dbt:Infobox_protein |
| dcterms:subject |
dbc:EC_2.6.1 |
| rdf:type |
owl:Thing dbo:Biomolecule wikidata:Q206229 wikidata:Q8054 dbo:Protein |
| rdfs:comment |
Branched-chain amino acid aminotransferase (BCAT), also known as branched-chain amino acid transaminase, is an aminotransferase enzyme (EC 2.6.1.42) which acts upon branched-chain amino acids (BCAAs). It is encoded by the BCAT2 gene in humans. The BCAT enzyme catalyzes the conversion of BCAAs and α-ketoglutarate into branched chain α-keto acids and glutamate. (en) |
| rdfs:label |
Branched-chain amino acid aminotransferase (en) |
| owl:sameAs |
wikidata:Branched-chain amino acid aminotransferase dbpedia-sh:Branched-chain amino acid aminotransferase dbpedia-sr:Branched-chain amino acid aminotransferase https://global.dbpedia.org/id/2YZvQ |
| prov:wasDerivedFrom |
wikipedia-en:Branched-chain_amino_acid_aminotransferase?oldid=1083111644&ns=0 |
| foaf:depiction |
wiki-commons:Special:FilePath/1ekp.jpg wiki-commons:Special:FilePath/Branched_Chain_Aminotransferase.png |
| foaf:isPrimaryTopicOf |
wikipedia-en:Branched-chain_amino_acid_aminotransferase |
| foaf:name |
Branched-chain amino acid aminotransferase (en) |
| is dbo:wikiPageRedirects of |
dbr:Branched_chain_aminotransferase dbr:BCAT dbr:EC_2.6.1.42 dbr:Branched-chain-amino-acid:2-oxoglutarate_aminotransferase dbr:Branched-chain-amino-acid_transaminase dbr:Branched_Chain_Aminotransferase |
| is dbo:wikiPageWikiLink of |
dbr:Beta-Hydroxy_beta-methylbutyric_acid dbr:Branched_chain_aminotransferase dbr:Branched_chain_amino_acid_transaminase_1 dbr:Alpha-Ketoisocaproic_acid dbr:BCAT dbr:EC_2.6.1.42 dbr:Branched-chain-amino-acid:2-oxoglutarate_aminotransferase dbr:Branched-chain-amino-acid_transaminase dbr:Branched_Chain_Aminotransferase |
| is foaf:primaryTopic of |
wikipedia-en:Branched-chain_amino_acid_aminotransferase |
