| dbo:abstract |
Bulbocapnine is an alkaloid found in Corydalis (notably the European species C. cava) and Dicentra, genera of the plant family Fumariaceae which have caused (notably the American species ) the fatal poisoning of sheep and cattle. It has been shown to act as an acetylcholinesterase inhibitor, and inhibits biosynthesis of dopamine via inhibition of the enzyme tyrosine hydroxylase. Like apomorphine, it is reported to be an inhibitor of amyloid beta protein (Aβ) fiber formation, whose presence is a hallmark of Alzheimer's disease (AD). Bulbocapnine is thus a potential therapeutic under the amyloid hypothesis. According to the Dorlands Medical Dictionary, it "inhibits the reflex and motor activities of striated muscle. It has been used in the treatment of muscular tremors and vestibular nystagmus". A psychiatrist at Tulane University named Robert Heath carried out experiments on prisoners at the Louisiana State Penitentiary using bulbocapnine to induce stupor. This work at Tulane inspired, and was continued parallel to, experiments carried out at the behest of the Central Intelligence Agency. The bulbocapnine work Heath conducted for the government was one component of a large investigation into the potential of psychoactive compounds as aids to interrogation. (en) Bulbocapnin ist ein Aporphin-Alkaloid es ähnelt strukturell dem Apomorphin. (de) Bulbocapnine es un alcaloide que se encuentra en Corydalis (Papaveraceae) y Dicentra, plantas de la familia Fumariaceae que pueden causar intoxicación mortal en las ovejas y el ganado. Se ha demostrado que actúa como un inhibidor de la acetilcolinesterasa, e inhibe la biosíntesis de dopamina a través de la inhibición de la enzima tirosina hidroxilasa. Según el Diccionario Médico Dorlands, "inhibe las actividades reflejas y motoras de los músculos estriados. Se ha utilizado en el tratamiento de temblores musculares y vestibular nistagmo ". El psiquiatra Robert Heath llevó a cabo experimentos en prisioneros en la Penitenciaría Estatal de Luisiana usando la bulbocapnina para inducir estupor. El autor William S. Burroughs hace referencia a la droga en su libro El almuerzo desnudo, en el que el ficticio Dr. Benway lo utiliza para inducir la obediencia en las víctimas de tortura. La droga también aparece brevemente en la segunda temporada de la serie de televisión de Boss. (es) Bulbokapnina – organiczny związek chemiczny, alkaloid izochinolinowy typu , występujący m.in. w bulwach kokoryczy i serduszki. Może powodować śmiertelne zatrucia u owiec i bydła. Jest inhibitorem acetylocholinoesterazy oraz butyrylocholinoesterazy. Hamuje też syntezę dopaminy na drodze inhibicji hydroksylazy tyrozynowej. Wykazano także, że bulbokapnina jest antagonistą D1, D2 i D3. (pl) |
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298-45-3 |
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3211 |
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157912 |
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O0TGI865QO |
| dbo:kegg |
C09367 |
| dbo:pubchem |
12441 |
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wiki-commons:Special:FilePath/Bulbocapnine_skeletal.svg?width=300 |
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Bulbocapnine (en) |
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Racemate 213-214 °C (en) |
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O1c4cc3c2ccccc2C[C@H]5c3cCCN5C (en) |
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1 (xsd:integer) |
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LODGIKWNLDQZBM-LBPRGKRZSA-N (en) |
| dbp:synonyms |
Bulbokaprin (en) |
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O0TGI865QO (en) |
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| gold:hypernym |
dbr:Alkaloid |
| rdf:type |
owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 yago:Abstraction100002137 yago:Alkaloid114712692 yago:Chemical114806838 yago:Compound114818238 yago:Element114840755 yago:Material114580897 yago:Matter100020827 yago:OrganicCompound114727670 yago:Part113809207 yago:Phenol114989545 yago:PhysicalEntity100001930 yago:Quintessence114847103 yago:Relation100031921 dbo:ChemicalCompound dbo:Drug yago:Substance100019613 yago:WikicatAlkaloids yago:WikicatPhenolEthers yago:WikicatPhenols umbel-rc:ChemicalSubstanceType |
| rdfs:comment |
Bulbocapnin ist ein Aporphin-Alkaloid es ähnelt strukturell dem Apomorphin. (de) Bulbokapnina – organiczny związek chemiczny, alkaloid izochinolinowy typu , występujący m.in. w bulwach kokoryczy i serduszki. Może powodować śmiertelne zatrucia u owiec i bydła. Jest inhibitorem acetylocholinoesterazy oraz butyrylocholinoesterazy. Hamuje też syntezę dopaminy na drodze inhibicji hydroksylazy tyrozynowej. Wykazano także, że bulbokapnina jest antagonistą D1, D2 i D3. (pl) Bulbocapnine is an alkaloid found in Corydalis (notably the European species C. cava) and Dicentra, genera of the plant family Fumariaceae which have caused (notably the American species ) the fatal poisoning of sheep and cattle. It has been shown to act as an acetylcholinesterase inhibitor, and inhibits biosynthesis of dopamine via inhibition of the enzyme tyrosine hydroxylase. Like apomorphine, it is reported to be an inhibitor of amyloid beta protein (Aβ) fiber formation, whose presence is a hallmark of Alzheimer's disease (AD). Bulbocapnine is thus a potential therapeutic under the amyloid hypothesis. According to the Dorlands Medical Dictionary, it "inhibits the reflex and motor activities of striated muscle. It has been used in the treatment of muscular tremors and vestibular nystagm (en) Bulbocapnine es un alcaloide que se encuentra en Corydalis (Papaveraceae) y Dicentra, plantas de la familia Fumariaceae que pueden causar intoxicación mortal en las ovejas y el ganado. Se ha demostrado que actúa como un inhibidor de la acetilcolinesterasa, e inhibe la biosíntesis de dopamina a través de la inhibición de la enzima tirosina hidroxilasa. (es) |
| rdfs:label |
Bulbocapnine (en) Bulbocapnin (de) Bulbocapnina (es) Bulbokapnina (pl) |
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freebase:Bulbocapnine yago-res:Bulbocapnine wikidata:Bulbocapnine http://azb.dbpedia.org/resource/بولبوکاپنین dbpedia-de:Bulbocapnine dbpedia-es:Bulbocapnine dbpedia-fa:Bulbocapnine dbpedia-pl:Bulbocapnine dbpedia-sh:Bulbocapnine dbpedia-sk:Bulbocapnine dbpedia-sr:Bulbocapnine https://global.dbpedia.org/id/6Xqa |
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wikipedia-en:Bulbocapnine?oldid=1100450636&ns=0 |
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wiki-commons:Special:FilePath/Bulbocapnine_skeletal.svg wiki-commons:Special:FilePath/Bulbocapnine.png |
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wikipedia-en:Bulbocapnine |
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Bulbocapnine (en) |
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dbr:Pukateine dbr:List_of_adrenergic_drugs dbr:List_of_dopaminergic_drugs dbr:Aporphine dbr:Aporphine_alkaloids dbr:List_of_psychoactive_plants dbr:C19H19NO4 dbr:Glaucine dbr:Corydalis dbr:Corydalis_cava dbr:Stepholidine dbr:Nuciferine dbr:Tetrahydropalmatine dbr:Nantenine dbr:Catalepsy dbr:In_a_Glass_Darkly dbr:Unethical_human_experimentation_in_the_United_States dbr:Robert_Galbraith_Heath |
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wikipedia-en:Bulbocapnine |
