C-myc internal ribosome entry site (IRES) (original) (raw)

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dbo:abstract The c-myc internal ribosome entry site (IRES) is an RNA element present in the 5' UTR of the mRNA of C-myc and allows cap-independent translation. The mammalian c-myc gene is a proto-oncogene which is required for cell proliferation, transformation and death. c-myc mRNA has an alternative method of translation via internal ribosome entry where ribosomes are recruited to the IRES located in the 5' UTR thus bypassing the typical eukaryotic cap-dependent translation pathway. (en)
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dbo:wikiPageWikiLink dbr:C-myc dbr:Internal_ribosome_entry_site dbr:MRNA dbr:Eukaryota dbc:Cis-regulatory_RNA_elements dbr:Cis-regulatory_element dbr:Sequence_conservation dbr:Five_prime_untranslated_region dbr:Secondary_structure
dbp:altsymbols c-myc_IRES (en)
dbp:caption Predicted secondary structure and sequence conservation of IRES_c-myc (en)
dbp:id RF00216 (en)
dbp:name c-myc internal ribosome entry site (en)
dbp:rfam RF00216 (en)
dbp:rnaType dbr:Internal_ribosome_entry_site dbr:Cis-regulatory_element
dbp:symbol IRES_c-myc (en)
dbp:taxDomain dbr:Eukaryota
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dct:subject dbc:Cis-regulatory_RNA_elements
gold:hypernym dbr:Element
rdf:type yago:WikicatCis-regulatoryRNAElements yago:Abstraction100002137 yago:Cognition100023271 yago:Component105868954 yago:Concept105835747 yago:Content105809192 yago:Idea105833840 yago:Part105867413 yago:PsychologicalFeature100023100 dbo:MilitaryUnit
rdfs:comment The c-myc internal ribosome entry site (IRES) is an RNA element present in the 5' UTR of the mRNA of C-myc and allows cap-independent translation. The mammalian c-myc gene is a proto-oncogene which is required for cell proliferation, transformation and death. c-myc mRNA has an alternative method of translation via internal ribosome entry where ribosomes are recruited to the IRES located in the 5' UTR thus bypassing the typical eukaryotic cap-dependent translation pathway. (en)
rdfs:label C-myc internal ribosome entry site (IRES) (en)
owl:sameAs freebase:C-myc internal ribosome entry site (IRES) yago-res:C-myc internal ribosome entry site (IRES) wikidata:C-myc internal ribosome entry site (IRES) https://global.dbpedia.org/id/4eUQf
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