| dbo:abstract |
أميفوستين يعرف بسيتوبروتيكتيفي يستخدم مساعدا في العلاج الكيميائي للسرطان والعلاج الإشعاعي المتعلقة بعوامل العلاج الكيميائي المرتبطة بالحمض النووي (DNA-binding). يتم تسويقه من قبل مجموعة (Group Clinigen) تحت الاسم التجاري Ethyol. (ar) Amifostine (ethiofos) is a cytoprotective adjuvant used in cancer chemotherapy and radiotherapy involving DNA-binding chemotherapeutic agents. It is marketed by Clinigen Group under the trade name Ethyol. (en) Amifostin ist der Internationale Freiname für einen zytoprotektiv wirksamen Arzneistoff. (de) L'amifostine est un adjuvant cytoprotecteur utilisé en chimiothérapie du cancer impliquant des agents chimiothérapeutiques liant l'ADN. Portion de texte anglais à traduire en français Texte anglais à traduire :Amifostine is used therapeutically to reduce the incidence of neutropenia-related fever and infection induced by DNA-binding chemotherapeutic agents including (e.g. cyclophosphamide) and platinum-containing agents (e.g. ). It is also used to decrease the cumulative nephrotoxicity associated with platinum-containing agents. Amifostine is also indicated to reduce the incidence of xerostomia in patients undergoing radiotherapy for head and neck cancer. Amifostine is an organic thiophosphate which is dephosphorylated in vivo by to the active cytoprotective thiol metabolite. The selective protection of non-malignant tissues is believed to be due to higher alkaline phosphatase activity, higher pH, and vascular permeation of normal tissues. Traduire ce texte • Outils • (+) (fr) A amifostina (WR-2721) é um fármaco da classe das anfetaminas substituídas que age na citoproteção. É utilizado em pacientes com câncer com a finalidade de proteção dos tecidos sadios devido ao tratamento quimioterápico. (pt) |
| dbo:casNumber |
112901-68-5 20537-88-6 |
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2636 |
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1006 |
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DB01143 |
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ILA426L95O M487QF2F4V |
| dbo:kegg |
C06819 |
| dbo:pubchem |
2141 |
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anhydrous (en) |
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dbr:Adjuvant |
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| rdfs:comment |
أميفوستين يعرف بسيتوبروتيكتيفي يستخدم مساعدا في العلاج الكيميائي للسرطان والعلاج الإشعاعي المتعلقة بعوامل العلاج الكيميائي المرتبطة بالحمض النووي (DNA-binding). يتم تسويقه من قبل مجموعة (Group Clinigen) تحت الاسم التجاري Ethyol. (ar) Amifostine (ethiofos) is a cytoprotective adjuvant used in cancer chemotherapy and radiotherapy involving DNA-binding chemotherapeutic agents. It is marketed by Clinigen Group under the trade name Ethyol. (en) Amifostin ist der Internationale Freiname für einen zytoprotektiv wirksamen Arzneistoff. (de) A amifostina (WR-2721) é um fármaco da classe das anfetaminas substituídas que age na citoproteção. É utilizado em pacientes com câncer com a finalidade de proteção dos tecidos sadios devido ao tratamento quimioterápico. (pt) L'amifostine est un adjuvant cytoprotecteur utilisé en chimiothérapie du cancer impliquant des agents chimiothérapeutiques liant l'ADN. Portion de texte anglais à traduire en français Texte anglais à traduire :Amifostine is used therapeutically to reduce the incidence of neutropenia-related fever and infection induced by DNA-binding chemotherapeutic agents including (e.g. cyclophosphamide) and platinum-containing agents (e.g. ). It is also used to decrease the cumulative nephrotoxicity associated with platinum-containing agents. Amifostine is also indicated to reduce the incidence of xerostomia in patients undergoing radiotherapy for head and neck cancer. (fr) |
| rdfs:label |
أميفوستين (ar) Amifostin (de) Amifostine (en) Amifostine (fr) Amifostina (pt) |
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