CCL19 (original) (raw)
CCL19 (englisch CC-chemokine ligand 19) ist ein Zytokin aus der Familie der CC-Chemokine.
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| dbo:abstract | Chemokinový (C-C motiv) ligand 19 (CCL19) je protein, který je u lidí je kódován genem CCL19. CCL19 je specifickým ligandem pro chemokinový receptor CCR7. Gen CLL19 je jedním z několika genů pro CC chemokiny seskupených na krátkém ramenu chromozomu 9. CC chemokiny jsou skupina chemokinů obsahující ve své struktuře dva sousedící cysteiny na N-konci svého řetězce, odtud název CC. CCL19 hraje roli v recirkulaci lymfocytů a jejich cílení do sekundárních lymfoidních orgánů. Zajišťuje také průchod T lymfocytů brzlíkem. CCL19 je ve vysokých hladinách exprimován v brzlíku a lymfatických uzlinách, ve střední míře v průdušnici a tlustém střevě, a v nízkých hladinách v žaludku, tenkém střevě, plicích, ledvinách a slezině. Chemokin CCL19 vyvolává účinek na buňky vazbou na svůj chemokinový receptor CCR7. Tímto způsobem jsou přitahovány buňky imunitního systému, např. dendritické buňky, B lymfocyty s navázaným antigenem a centrální paměťové T lymfocyty (TCM). (cs) CCL19 (englisch CC-chemokine ligand 19) ist ein Zytokin aus der Familie der CC-Chemokine. (de) Chemokine (C-C motif) ligand 19 (CCL19) is a protein that in humans is encoded by the CCL19 gene. This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene may play a role in normal lymphocyte recirculation and homing. It also plays an important role in trafficking of T cells in thymus, and in T cell and B cell migration to secondary lymphoid organs. It specifically binds to chemokine receptor CCR7. Chemokine (C-C motif) ligand 19 (CCL19) is a small cytokine belonging to the CC chemokine family that is also known as EBI1 ligand chemokine (ELC) and macrophage inflammatory protein-3-beta (MIP-3-beta). CCL19 is expressed abundantly in thymus and lymph nodes, with moderate levels in trachea and colon and low levels in stomach, small intestine, lung, kidney and spleen. The gene for CCL19 is located on human chromosome 9. This chemokine elicits its effects on its target cells by binding to the chemokine receptor chemokine receptor CCR7. It attracts certain cells of the immune system, including dendritic cells and antigen-engaged B cells, central-memory T-Cells. (en) La chemochina CCL 19 è una proteina che negli esseri umani è codificata dal gene CCL19.Questo gene è uno di numerosi geni localizzati sul p-braccio del cromosoma 9 che codificano per il cluster delle citochine CC.Le citochine sono una famiglia di proteine che vengono secrete e coinvolte nei processi infiammatori ed immunoregolatori.Le citochine CC sono proteine caratterizzate da due cisteine adiacenti. La citochina codificata da questo gene può giocare un ruolo nel normale ricircolo dei linfociti.Essa svolge anche un ruolo importante nel movimento delle cellule T nel timo, e nella migrazione delle cellule T e delle cellule B negli organi linfatici secondari.La chemochina CCL 19 si lega in modo specifico al recettore per le chemochine CCR7. La chemochina ligando 19 (CCL19) è una piccola citochina appartenente alla famiglia delle chemochine CC che è nota anche come chemochina ligando EBI1 (ELC) e proteina macrofagica infiammatoria 3-beta (MIP-3-beta). CCL19 è espressa abbondantemente nel timo e nei linfonodi, mentre i suoi livelli nella trachea e nel colon sono moderati, decisamente più bassi nello stomaco, piccolo intestino, polmone, rene e milza.Il gene per il CCL19 si trova localizzato sul cromosoma 9 umano.Questo chemochina provoca i suoi effetti sulle sue cellule bersaglio legandosi al recettore della chemochina chiamato CCR7. CCL19 si dimostra in grado di attirare alcune cellule del sistema immunitario, comprese le cellule dendritiche e l'antigene legato alle cellule B, e le cellule T della memoria CCR7 +. (it) CCL19 (англ. C-C motif chemokine ligand 19) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 9-ї хромосоми. Довжина поліпептидного ланцюга білка становить 98 амінокислот, а молекулярна маса — 10 993. Послідовність амінокислот A: АланінC: ЦистеїнD: Аспарагінова кислотаE: Глутамінова кислотаF: ФенілаланінG: ГліцинH: ГістидинI: ІзолейцинK: ЛізинL: ЛейцинM: МетіонінN: АспарагінP: ПролінQ: ГлутамінR: АргінінS: СеринT: ТреонінV: ВалінW: Триптофан Y: Тирозин Кодований геном білок за функцією належить до цитокінів. Задіяний у таких біологічних процесах, як запальна відповідь, хемотаксис. Секретований назовні. (uk) |
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| rdfs:comment | CCL19 (englisch CC-chemokine ligand 19) ist ein Zytokin aus der Familie der CC-Chemokine. (de) Chemokinový (C-C motiv) ligand 19 (CCL19) je protein, který je u lidí je kódován genem CCL19. CCL19 je specifickým ligandem pro chemokinový receptor CCR7. Gen CLL19 je jedním z několika genů pro CC chemokiny seskupených na krátkém ramenu chromozomu 9. CC chemokiny jsou skupina chemokinů obsahující ve své struktuře dva sousedící cysteiny na N-konci svého řetězce, odtud název CC. (cs) Chemokine (C-C motif) ligand 19 (CCL19) is a protein that in humans is encoded by the CCL19 gene. This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene may play a role in normal lymphocyte recirculation and homing. It also plays an important role in trafficking of T cells in thymus, and in T cell and B cell migration to secondary lymphoid organs. It specifically binds to chemokine receptor CCR7. (en) La chemochina CCL 19 è una proteina che negli esseri umani è codificata dal gene CCL19.Questo gene è uno di numerosi geni localizzati sul p-braccio del cromosoma 9 che codificano per il cluster delle citochine CC.Le citochine sono una famiglia di proteine che vengono secrete e coinvolte nei processi infiammatori ed immunoregolatori.Le citochine CC sono proteine caratterizzate da due cisteine adiacenti. La citochina codificata da questo gene può giocare un ruolo nel normale ricircolo dei linfociti.Essa svolge anche un ruolo importante nel movimento delle cellule T nel timo, e nella migrazione delle cellule T e delle cellule B negli organi linfatici secondari.La chemochina CCL 19 si lega in modo specifico al recettore per le chemochine CCR7. (it) CCL19 (англ. C-C motif chemokine ligand 19) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 9-ї хромосоми. Довжина поліпептидного ланцюга білка становить 98 амінокислот, а молекулярна маса — 10 993. Послідовність амінокислот A: АланінC: ЦистеїнD: Аспарагінова кислотаE: Глутамінова кислотаF: ФенілаланінG: ГліцинH: ГістидинI: ІзолейцинK: ЛізинL: ЛейцинM: МетіонінN: АспарагінP: ПролінQ: ГлутамінR: АргінінS: СеринT: ТреонінV: ВалінW: Триптофан Y: Тирозин (uk) |
| rdfs:label | CCL19 (cs) CCL19 (de) CCL19 (en) CCL19 (it) CCL19 (uk) |
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