CD64 (biology) (original) (raw)
CD64 (англ. Cluster of Differentiation 64) — мембранный белок, гликопротеин, Fc-рецептор к мономерным иммуноглобулинам изотипа IgG с высокой аффинностью. Обозначается как Fc-гамма-рецептор 1 (FcγRI). После связывания IgG белок CD64 взаимодействует с гамма-цепью (γ-цепью), в которой расположен мотив , запускающий клеточную активацию. Существуют 3 типа CD64: CD64A, и .
| Property | Value |
|---|---|
| dbo:abstract | CD64 (Cluster of Differentiation 64) is a type of integral membrane glycoprotein known as an Fc receptor that binds monomeric IgG-type antibodies with high affinity. It is more commonly known as Fc-gamma receptor 1 (FcγRI). After binding IgG, CD64 interacts with an accessory chain known as the common γ chain (γ chain), which possesses an ITAM motif that is necessary for triggering cellular activation. Structurally CD64 is composed of a signal peptide that allows its transport to the surface of a cell, three extracellular immunoglobulin domains of the C2-type that it uses to bind antibody, a hydrophobic transmembrane domain, and a short cytoplasmic tail. CD64 is constitutively found on only macrophages and monocytes, but treatment of polymorphonuclear leukocytes with cytokines like IFNγ and G-CSF can induce CD64 expression on these cells. There are three distinct (but highly similar) genes in humans for CD64 called FcγRIA (CD64A), FcγRIB (CD64B), and FcγRIC (CD64C) that are located on chromosome 1. These three genes produce six different mRNA transcripts; two from CD64A, three from CD64B, and one from CD64C; by alternate splicing of the genes. (en) CD64 (англ. Cluster of Differentiation 64) — мембранный белок, гликопротеин, Fc-рецептор к мономерным иммуноглобулинам изотипа IgG с высокой аффинностью. Обозначается как Fc-гамма-рецептор 1 (FcγRI). После связывания IgG белок CD64 взаимодействует с гамма-цепью (γ-цепью), в которой расположен мотив , запускающий клеточную активацию. Существуют 3 типа CD64: CD64A, и . (ru) |
| dbo:arm | p q |
| dbo:band | 21.1 21.2 11.2 |
| dbo:chromosome | 1 |
| dbo:entrezgene | 2209 2210 2211 |
| dbo:hgncid | 3615 3613 3614 |
| dbo:locusSupplementaryData | -21.3 |
| dbo:omim | 146760 (xsd:integer) 601502 (xsd:integer) 601503 (xsd:integer) |
| dbo:refseq | NM_000566 NM_001004340 XM_001133198 |
| dbo:symbol | FCGR1A FCGR1B FCGR1C |
| dbo:uniprot | P12314 Q92637 |
| dbo:wikiPageID | 10535221 (xsd:integer) |
| dbo:wikiPageLength | 4603 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID | 1032281516 (xsd:integer) |
| dbo:wikiPageWikiLink | dbr:Monomer dbr:Integral_membrane_protein dbr:Signal_peptide dbr:MRNA dbr:Gene dbr:Antibody dbr:Fc_receptor dbr:Extracellular dbr:Chromosome_1 dbr:Glycoprotein dbc:Clusters_of_differentiation dbr:Affinity_(pharmacology) dbc:Fc_receptors dbr:Hydrophobic dbr:FCGR1A dbr:Immunoglobulin_G dbr:Immunoglobulin_domain dbr:Immunoreceptor_tyrosine-based_activation_motif dbr:IFNγ dbr:Polymorphonuclear_leukocyte dbr:G-CSF dbr:Wikt:constitutive |
| dbp:arm | p (en) q (en) |
| dbp:band | 11.200000 (xsd:double) 21.100000 (xsd:double) 21.200000 (xsd:double) |
| dbp:chromosome | 1 (xsd:integer) |
| dbp:entrezgene | 2209 (xsd:integer) 2210 (xsd:integer) 2211 (xsd:integer) |
| dbp:hgncid | 3613 (xsd:integer) 3614 (xsd:integer) 3615 (xsd:integer) |
| dbp:locussupplementarydata | -21.300000 (xsd:double) |
| dbp:name | dbr:FCGR1A Fc fragment of IgG, high affinity Ib, receptor (en) Fc fragment of IgG, high affinity Ic, receptor (en) |
| dbp:omim | 146760 (xsd:integer) 601502 (xsd:integer) 601503 (xsd:integer) |
| dbp:refseq | NM_000566 (en) NM_001004340 (en) XM_001133198 (en) |
| dbp:symbol | FCGR1A (en) FCGR1B (en) FCGR1C (en) |
| dbp:uniprot | P12314 (en) Q92637 (en) |
| dbp:wikiPageUsesTemplate | dbt:Immune_receptors dbt:MeshName dbt:Reflist dbt:Short_description dbt:Infobox_protein dbt:Clusters_of_differentiation dbt:Clusters_of_differentiation_by_lineage |
| dct:subject | dbc:Clusters_of_differentiation dbc:Fc_receptors |
| gold:hypernym | dbr:Glycoprotein |
| rdf:type | owl:Thing dbo:Biomolecule wikidata:Q206229 wikidata:Q8054 yago:WikicatClustersOfDifferentiation yago:Abstraction100002137 yago:Agglomeration107959269 yago:Bunch107959943 yago:Collection107951464 yago:Group100031264 dbo:Protein umbel-rc:ProteinMolecule |
| rdfs:comment | CD64 (англ. Cluster of Differentiation 64) — мембранный белок, гликопротеин, Fc-рецептор к мономерным иммуноглобулинам изотипа IgG с высокой аффинностью. Обозначается как Fc-гамма-рецептор 1 (FcγRI). После связывания IgG белок CD64 взаимодействует с гамма-цепью (γ-цепью), в которой расположен мотив , запускающий клеточную активацию. Существуют 3 типа CD64: CD64A, и . (ru) CD64 (Cluster of Differentiation 64) is a type of integral membrane glycoprotein known as an Fc receptor that binds monomeric IgG-type antibodies with high affinity. It is more commonly known as Fc-gamma receptor 1 (FcγRI). After binding IgG, CD64 interacts with an accessory chain known as the common γ chain (γ chain), which possesses an ITAM motif that is necessary for triggering cellular activation. CD64 is constitutively found on only macrophages and monocytes, but treatment of polymorphonuclear leukocytes with cytokines like IFNγ and G-CSF can induce CD64 expression on these cells. (en) |
| rdfs:label | CD64 (biology) (en) CD64 (ru) |
| owl:sameAs | freebase:CD64 (biology) yago-res:CD64 (biology) wikidata:CD64 (biology) dbpedia-ru:CD64 (biology) https://global.dbpedia.org/id/jz9G |
| prov:wasDerivedFrom | wikipedia-en:CD64_(biology)?oldid=1032281516&ns=0 |
| foaf:isPrimaryTopicOf | wikipedia-en:CD64_(biology) |
| foaf:name | Fc fragment of IgG, high affinity Ic, receptor (CD64) (en) Fc fragment of IgG, high affinity Ia, receptor (CD64) (en) Fc fragment of IgG, high affinity Ib, receptor (CD64) (en) |
| is dbo:wikiPageRedirects of | dbr:FCGR1B dbr:FCGR1C dbr:FcγRI |
| is dbo:wikiPageWikiLink of | dbr:CD64 dbr:List_of_human_clusters_of_differentiation dbr:Chronic_myelomonocytic_leukemia dbr:Fc_receptor dbr:FCGR1B dbr:FCGR1C dbr:Macrophage dbr:Neuvenge dbr:Immunoreceptor_tyrosine-based_activation_motif dbr:Non-catalytic_tyrosine-phosphorylated_receptor dbr:Pancreatic_islet_macrophage dbr:FcγRI |
| is foaf:primaryTopic of | wikipedia-en:CD64_(biology) |