Catch bond (original) (raw)
A catch bond is a type of noncovalent bond whose dissociation lifetime increases with tensile force applied to the bond. Normally, bond lifetimes are expected to diminish with force. In the case of catch bonds, the lifetime of the bond actually increases up to a maximum before it decreases like in a normal bond. Catch bonds work in a way that is conceptually similar to that of a Chinese finger trap. While catch bonds are strengthened by an increase in force, the force increase is not necessary for the bond to work. Catch bonds were suspected for many years to play a role in the rolling of leukocytes, being strong enough to roll in presence of high forces caused by high shear stresses, while avoiding getting stuck in capillaries where the fluid flow, and therefore shear stress, is low. The
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| dbo:abstract | A catch bond is a type of noncovalent bond whose dissociation lifetime increases with tensile force applied to the bond. Normally, bond lifetimes are expected to diminish with force. In the case of catch bonds, the lifetime of the bond actually increases up to a maximum before it decreases like in a normal bond. Catch bonds work in a way that is conceptually similar to that of a Chinese finger trap. While catch bonds are strengthened by an increase in force, the force increase is not necessary for the bond to work. Catch bonds were suspected for many years to play a role in the rolling of leukocytes, being strong enough to roll in presence of high forces caused by high shear stresses, while avoiding getting stuck in capillaries where the fluid flow, and therefore shear stress, is low. The existence of catch bonds was debated for many years until strong evidence of their existence was found in bacteria. Definite proof of their existence came shortly thereafter in leukocytes. (en) |
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| dbo:wikiPageWikiLink | dbr:Endothelium dbr:Proceedings_of_the_Royal_Society dbr:Noncovalent_bond dbr:Hydrogen_bond dbr:Perpendicular dbr:Van_der_Waals_force dbr:Inflammation dbr:Intermolecular_force dbr:Atomic_force_microscope dbr:Binding_affinity dbr:Leukocyte_extravasation dbr:Ligand_(biochemistry) dbc:Biophysics dbr:Endothelial_cells dbc:Chemical_bonding dbr:Leukocyte dbr:Leukocytes dbr:Los_Alamos_National_Laboratory dbr:Chinese_finger_trap dbr:Lectin dbr:Escherichia_coli dbr:Force_spectroscopy dbr:Dissociation_(chemistry) dbr:Mannose dbr:Domain_(protein) dbr:Integrin dbc:Cell_adhesion dbr:Shear_stress dbr:X-ray_crystallography dbr:Noncovalent_bonding dbr:P-selectin_glycoprotein_ligand-1 dbr:Microvilli dbr:Ionic_bond dbr:P-selectin dbr:Slip_bond dbr:Selectin dbr:PSGL-1 dbr:Hydrodynamic_drag dbr:Decays_exponentially dbr:EGF_domain dbr:File:Allosteric_figure.png dbr:File:Leukocyte_rolling.png dbr:File:Shear_Threshold_Phenomenon.png |
| dbp:wikiPageUsesTemplate | dbt:Citation_needed dbt:Reflist |
| dcterms:subject | dbc:Biophysics dbc:Chemical_bonding dbc:Cell_adhesion |
| gold:hypernym | dbr:Bond |
| rdf:type | dbo:Album |
| rdfs:comment | A catch bond is a type of noncovalent bond whose dissociation lifetime increases with tensile force applied to the bond. Normally, bond lifetimes are expected to diminish with force. In the case of catch bonds, the lifetime of the bond actually increases up to a maximum before it decreases like in a normal bond. Catch bonds work in a way that is conceptually similar to that of a Chinese finger trap. While catch bonds are strengthened by an increase in force, the force increase is not necessary for the bond to work. Catch bonds were suspected for many years to play a role in the rolling of leukocytes, being strong enough to roll in presence of high forces caused by high shear stresses, while avoiding getting stuck in capillaries where the fluid flow, and therefore shear stress, is low. The (en) |
| rdfs:label | Catch bond (en) |
| owl:sameAs | freebase:Catch bond wikidata:Catch bond https://global.dbpedia.org/id/4gKdG |
| prov:wasDerivedFrom | wikipedia-en:Catch_bond?oldid=1069449052&ns=0 |
| foaf:depiction | wiki-commons:Special:FilePath/Allosteric_figure.png wiki-commons:Special:FilePath/Leukocyte_rolling.png wiki-commons:Special:FilePath/Shear_Threshold_Phenomenon.png |
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| is foaf:primaryTopic of | wikipedia-en:Catch_bond |
